Incidental Mutation 'R4363:Selenbp1'
ID 470053
Institutional Source Beutler Lab
Gene Symbol Selenbp1
Ensembl Gene ENSMUSG00000068874
Gene Name selenium binding protein 1
Synonyms Lp56, Lpsb
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4363 (G1)
Quality Score 225
Status Not validated
Chromosome 3
Chromosomal Location 94840394-94852069 bp(+) (GRCm39)
Type of Mutation splice site (3 bp from exon)
DNA Base Change (assembly) A to G at 94850060 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000088349 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090839] [ENSMUST00000134202] [ENSMUST00000140757]
AlphaFold P17563
Predicted Effect probably null
Transcript: ENSMUST00000090839
SMART Domains Protein: ENSMUSP00000088349
Gene: ENSMUSG00000068874

DomainStartEndE-ValueType
Pfam:SBP56 6 472 3.2e-225 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000134202
SMART Domains Protein: ENSMUSP00000120159
Gene: ENSMUSG00000068874

DomainStartEndE-ValueType
Pfam:SBP56 6 123 4.7e-56 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139949
Predicted Effect probably benign
Transcript: ENSMUST00000140757
SMART Domains Protein: ENSMUSP00000118563
Gene: ENSMUSG00000068874

DomainStartEndE-ValueType
Pfam:SBP56 6 123 4.7e-56 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145551
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit sex-specific changes in organ weights. Mice homozygous for a different allele lack methanethiol oxidase activity and exhibit an increase in dimethylsulfide and dimethyl-sulfone serum levels. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc2 G T 19: 43,787,575 (GRCm39) W207L possibly damaging Het
Adamts13 G A 2: 26,894,794 (GRCm39) C1034Y probably damaging Het
Adgrb3 A T 1: 25,151,303 (GRCm39) V1081E probably damaging Het
Apcdd1 T A 18: 63,085,003 (GRCm39) I400N possibly damaging Het
Bcan G T 3: 87,904,405 (GRCm39) T117K probably damaging Het
Bicc1 ATGTG ATG 10: 70,779,204 (GRCm39) probably null Het
Cmtr1 T C 17: 29,893,206 (GRCm39) L75P probably damaging Het
Cplane1 T A 15: 8,300,229 (GRCm39) S3179T unknown Het
Cplx2 A T 13: 54,526,630 (GRCm39) T13S probably benign Het
Drd3 A T 16: 43,582,722 (GRCm39) I72F probably damaging Het
Dsn1 A T 2: 156,841,062 (GRCm39) I214K probably benign Het
Ermp1 A T 19: 29,590,276 (GRCm39) W809R probably damaging Het
Fbn2 G A 18: 58,282,122 (GRCm39) S298L probably damaging Het
Fbxo33 T C 12: 59,251,648 (GRCm39) H289R probably damaging Het
Fcgbpl1 T C 7: 27,846,331 (GRCm39) S1008P probably damaging Het
Gli2 T C 1: 118,781,100 (GRCm39) N189S probably benign Het
Hus1 G T 11: 8,948,676 (GRCm39) L242I probably damaging Het
Hyou1 G A 9: 44,291,912 (GRCm39) probably null Het
Kirrel1 C A 3: 86,997,792 (GRCm39) E244* probably null Het
Mmrn2 C T 14: 34,119,934 (GRCm39) A268V probably damaging Het
Mycbp2 G T 14: 103,485,893 (GRCm39) A1023E probably damaging Het
Nedd9 A T 13: 41,471,429 (GRCm39) I184N probably damaging Het
Nmnat1 T C 4: 149,557,902 (GRCm39) I47V probably benign Het
Or1j11 A T 2: 36,311,544 (GRCm39) I45F probably damaging Het
Or51f5 T C 7: 102,424,463 (GRCm39) V244A probably benign Het
Otulinl C T 15: 27,664,429 (GRCm39) probably null Het
Pak1 T C 7: 97,532,793 (GRCm39) S198P possibly damaging Het
Pank1 A C 19: 34,804,532 (GRCm39) V208G probably damaging Het
Pcdhga12 C G 18: 37,899,214 (GRCm39) F15L probably benign Het
Recql4 T C 15: 76,590,244 (GRCm39) D723G probably benign Het
Rgs22 A T 15: 36,104,020 (GRCm39) I147N probably damaging Het
Sspo A G 6: 48,475,665 (GRCm39) Y4927C probably damaging Het
Syk A T 13: 52,794,766 (GRCm39) H477L probably damaging Het
Tnfrsf11b T A 15: 54,119,555 (GRCm39) T140S possibly damaging Het
Vmn2r-ps69 T C 7: 84,959,700 (GRCm39) noncoding transcript Het
Other mutations in Selenbp1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01970:Selenbp1 APN 3 94,844,313 (GRCm39) missense probably benign 0.24
IGL03281:Selenbp1 APN 3 94,844,621 (GRCm39) nonsense probably null
PIT4131001:Selenbp1 UTSW 3 94,844,607 (GRCm39) missense probably damaging 0.99
R0415:Selenbp1 UTSW 3 94,844,224 (GRCm39) missense possibly damaging 0.61
R1132:Selenbp1 UTSW 3 94,844,644 (GRCm39) missense probably benign 0.02
R1421:Selenbp1 UTSW 3 94,851,183 (GRCm39) missense probably benign
R1522:Selenbp1 UTSW 3 94,844,669 (GRCm39) missense probably damaging 1.00
R1676:Selenbp1 UTSW 3 94,851,854 (GRCm39) missense probably damaging 1.00
R1701:Selenbp1 UTSW 3 94,844,701 (GRCm39) missense probably damaging 1.00
R2152:Selenbp1 UTSW 3 94,851,441 (GRCm39) missense probably damaging 1.00
R3033:Selenbp1 UTSW 3 94,845,351 (GRCm39) missense probably benign 0.22
R4631:Selenbp1 UTSW 3 94,851,879 (GRCm39) makesense probably null
R4798:Selenbp1 UTSW 3 94,851,211 (GRCm39) missense probably benign 0.27
R4935:Selenbp1 UTSW 3 94,845,269 (GRCm39) missense probably benign 0.10
R5464:Selenbp1 UTSW 3 94,851,727 (GRCm39) missense probably benign
R6253:Selenbp1 UTSW 3 94,851,157 (GRCm39) missense possibly damaging 0.95
R6314:Selenbp1 UTSW 3 94,844,576 (GRCm39) missense probably damaging 1.00
R7199:Selenbp1 UTSW 3 94,851,745 (GRCm39) missense possibly damaging 0.79
R7330:Selenbp1 UTSW 3 94,847,021 (GRCm39) missense probably benign
R7637:Selenbp1 UTSW 3 94,844,659 (GRCm39) nonsense probably null
R7658:Selenbp1 UTSW 3 94,851,413 (GRCm39) missense probably benign 0.03
R8739:Selenbp1 UTSW 3 94,844,601 (GRCm39) missense probably damaging 0.99
R8803:Selenbp1 UTSW 3 94,851,821 (GRCm39) missense possibly damaging 0.88
R8987:Selenbp1 UTSW 3 94,847,425 (GRCm39) missense probably benign 0.10
R9145:Selenbp1 UTSW 3 94,851,414 (GRCm39) missense probably benign 0.38
R9209:Selenbp1 UTSW 3 94,847,079 (GRCm39) missense probably benign 0.08
R9747:Selenbp1 UTSW 3 94,844,648 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TTGATTCCTGGCCTGGGAAG -3'
(R):5'- GAGTTGTTGGCCTTATTAGAATCTC -3'

Sequencing Primer
(F):5'- CCTGGGAAGAGAGATAGACTCCTTAC -3'
(R):5'- GAAATTCCAGGCTGGTCTCGAAC -3'
Posted On 2017-03-06