Mutagenetix > Incidental Mutation

Incidental Mutation 'R0499:Lyst'

47044

Institutional Source

Beutler Lab

Gene Symbol

Lyst

Ensembl Gene

ENSMUSG00000019726

Gene Name

lysosomal trafficking regulator

Synonyms

D13Sfk13

MMRRC Submission

038695-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.414) question?

Stock #

R0499 (G1)

Quality Score

199

Status

Validated

Chromosome

Chromosomal Location

13764982-13953388 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 13791298 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Isoleucine at position 54 (L54I)

Ref Sequence

ENSEMBL: ENSMUSP00000106188 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000110559]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000110559
AA Change: L54I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000106188
Gene: ENSMUSG00000019726
AA Change: L54I

Domain	Start	End	E-Value	Type
low complexity region	26	36	N/A	INTRINSIC
low complexity region	72	82	N/A	INTRINSIC
low complexity region	399	412	N/A	INTRINSIC
low complexity region	1333	1344	N/A	INTRINSIC
low complexity region	2295	2307	N/A	INTRINSIC
low complexity region	2427	2445	N/A	INTRINSIC
low complexity region	2534	2546	N/A	INTRINSIC
Pfam:PH_BEACH	3006	3101	5.8e-25	PFAM
Beach	3118	3408	1.25e-193	SMART
Blast:Beach	3441	3478	9e-13	BLAST
WD40	3539	3579	5.75e-1	SMART
WD40	3591	3630	2.89e-5	SMART
WD40	3633	3676	1.38e0	SMART
WD40	3724	3765	1.27e-1	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000220937

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000223053

Meta Mutation Damage Score

0.1123

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.8%
20x: 94.2%

Validation Efficiency

99% (97/98)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that regulates intracellular protein trafficking in endosomes, and may be involved in pigmentation. Mutations in this gene are associated with Chediak-Higashi syndrome, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants, though the full-length nature of some of these variants has not been determined. [provided by RefSeq, Apr 2013]
PHENOTYPE: Homozygous mice have a phenotype similar to human Chediak-Higashi syndrome patients, exhibiting lysosomal dysfunction with resultant protein storage; diluted coat color; abnormal melanogenesis; immune cell dysfunction resulting in increased susceptibility to bacterial, viral, and parasitic infections and decreased cytotoxic activity against tumor cells. [provided by MGI curators]

Allele List at MGI

All alleles(52) : Targeted(3) Gene trapped(34) Spontaneous(8) Chemically induced(6) Radiation induced(1)

Other mutations in this stock

Total: 94 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acad9	T	C	3: 36,139,564 (GRCm39)	V388A	probably damaging	Het
Acp3	T	C	9: 104,197,201 (GRCm39)	E146G	probably damaging	Het
Adap2	A	T	11: 80,066,905 (GRCm39)	R276S	probably damaging	Het
Agbl3	A	T	6: 34,816,270 (GRCm39)	M727L	probably benign	Het
Ahnak	T	A	19: 8,977,628 (GRCm39)		probably benign	Het
Ankmy1	G	T	1: 92,813,948 (GRCm39)	D410E	probably damaging	Het
Ankra2	T	C	13: 98,402,962 (GRCm39)	S70P	probably damaging	Het
Aox4	T	C	1: 58,302,556 (GRCm39)		probably null	Het
Arl13b	G	A	16: 62,622,096 (GRCm39)	T399I	probably benign	Het
Atad2	A	T	15: 57,966,636 (GRCm39)	D652E	possibly damaging	Het
Atad2	T	G	15: 57,984,345 (GRCm39)	M328L	probably benign	Het
Ccnb1	T	C	13: 100,916,642 (GRCm39)		probably null	Het
Ccr2	G	C	9: 123,905,976 (GRCm39)	K85N	possibly damaging	Het
Ccr2	A	T	9: 123,906,163 (GRCm39)	T148S	possibly damaging	Het
Cdc20b	T	C	13: 113,192,484 (GRCm39)	V59A	probably benign	Het
Cdin1	C	T	2: 115,473,172 (GRCm39)	R101W	probably damaging	Het
Cdkl3	T	C	11: 51,923,243 (GRCm39)	S507P	possibly damaging	Het
Celf6	C	A	9: 59,510,161 (GRCm39)	T86K	probably benign	Het
Ces1g	A	G	8: 94,060,317 (GRCm39)	F101L	probably benign	Het
Cimap1d	T	C	10: 79,476,099 (GRCm39)	D155G	probably damaging	Het
Cntnap3	C	T	13: 65,006,492 (GRCm39)	D107N	probably benign	Het
Col15a1	A	T	4: 47,262,950 (GRCm39)	D534V	probably damaging	Het
Col27a1	A	G	4: 63,218,978 (GRCm39)		probably benign	Het
Csmd3	T	C	15: 47,710,527 (GRCm39)	T1687A	probably benign	Het
Cstf3	A	G	2: 104,479,950 (GRCm39)	I272M	possibly damaging	Het
Cyp2d40	T	C	15: 82,645,418 (GRCm39)	T150A	probably benign	Het
Dnah8	T	A	17: 30,934,483 (GRCm39)	F1489L	possibly damaging	Het
Dop1b	A	T	16: 93,567,325 (GRCm39)	T1251S	probably benign	Het
Dtx2	G	A	5: 136,057,957 (GRCm39)	G421R	probably damaging	Het
Epb41l3	T	A	17: 69,554,654 (GRCm39)	D251E	probably benign	Het
Erg	A	C	16: 95,161,842 (GRCm39)	Y305*	probably null	Het
Exosc4	G	A	15: 76,213,766 (GRCm39)	A197T	probably benign	Het
Fam227b	T	A	2: 125,942,829 (GRCm39)	I323L	probably benign	Het
Far1	G	T	7: 113,153,503 (GRCm39)		probably benign	Het
Fmod	A	G	1: 133,968,934 (GRCm39)	I325V	possibly damaging	Het
Fshr	C	G	17: 89,316,713 (GRCm39)	S169T	probably benign	Het
Gm4076	G	T	13: 85,275,345 (GRCm39)		noncoding transcript	Het
Gm5134	A	T	10: 75,828,359 (GRCm39)	Y313F	probably benign	Het
H2-Q6	T	A	17: 35,644,179 (GRCm39)	F54I	probably damaging	Het
Hcrtr2	C	A	9: 76,161,954 (GRCm39)	L145F	probably damaging	Het
Hepacam2	A	G	6: 3,476,121 (GRCm39)	L268P	probably damaging	Het
Herc2	C	A	7: 55,834,117 (GRCm39)	C3107*	probably null	Het
Herc4	T	C	10: 63,099,811 (GRCm39)	V78A	probably damaging	Het
Hyal5	T	C	6: 24,877,920 (GRCm39)	W339R	probably damaging	Het
Igfbp6	T	A	15: 102,056,419 (GRCm39)		probably null	Het
Il18rap	A	T	1: 40,564,218 (GRCm39)	H112L	probably benign	Het
Il1r2	T	A	1: 40,162,309 (GRCm39)	Y317*	probably null	Het
Ints8	C	A	4: 11,246,097 (GRCm39)	V190L	probably benign	Het
Ipo11	T	C	13: 107,061,595 (GRCm39)	T22A	probably benign	Het
Itgb4	C	A	11: 115,870,521 (GRCm39)	R117S	probably benign	Het
Lcorl	C	G	5: 45,891,711 (GRCm39)	G214A	probably benign	Het
Lgals3bp	T	A	11: 118,289,019 (GRCm39)		probably null	Het
Mcm9	T	C	10: 53,414,250 (GRCm39)	T1015A	probably benign	Het
Mef2d	T	A	3: 88,063,825 (GRCm39)	I84N	probably damaging	Het
Mmrn2	A	G	14: 34,119,913 (GRCm39)	N261S	probably damaging	Het
Mpdz	T	C	4: 81,210,768 (GRCm39)	T1693A	probably benign	Het
Mss51	T	A	14: 20,534,756 (GRCm39)	Q338L	possibly damaging	Het
Mstn	T	A	1: 53,103,143 (GRCm39)	Y160N	probably damaging	Het
Muc6	T	C	7: 141,226,735 (GRCm39)	T1431A	probably benign	Het
Nek9	A	T	12: 85,348,657 (GRCm39)	M959K	probably benign	Het
Or2ak6	G	A	11: 58,593,069 (GRCm39)	V181I	probably benign	Het
Or4f58	A	T	2: 111,851,777 (GRCm39)	C141S	probably damaging	Het
Or8b47	A	T	9: 38,435,801 (GRCm39)	M258L	probably benign	Het
Otog	G	T	7: 45,923,256 (GRCm39)	G1044W	probably damaging	Het
Pcdh9	G	A	14: 94,123,671 (GRCm39)	T833M	probably damaging	Het
Pdcd10	T	C	3: 75,434,958 (GRCm39)	K111R	probably damaging	Het
Pde5a	A	G	3: 122,542,107 (GRCm39)	N199S	probably damaging	Het
Plekhg1	T	C	10: 3,887,971 (GRCm39)	V355A	probably damaging	Het
Podn	G	T	4: 107,878,791 (GRCm39)	L359I	probably damaging	Het
Psd	T	C	19: 46,310,600 (GRCm39)	E483G	probably damaging	Het
Ptch2	T	A	4: 116,968,340 (GRCm39)	L905*	probably null	Het
Rxfp2	T	A	5: 149,989,880 (GRCm39)	N420K	probably damaging	Het
Scpppq1	C	A	5: 104,222,747 (GRCm39)	G24*	probably null	Het
Sde2	T	A	1: 180,689,992 (GRCm39)	D237E	probably benign	Het
Serpina1d	A	T	12: 103,732,016 (GRCm39)	L281Q	probably damaging	Het
Serpina9	T	C	12: 103,967,729 (GRCm39)	N222S	probably benign	Het
Sh3bgrl2	A	G	9: 83,459,612 (GRCm39)	K57E	probably damaging	Het
Shc3	C	T	13: 51,634,264 (GRCm39)		probably benign	Het
Sik3	T	C	9: 46,120,038 (GRCm39)	M659T	possibly damaging	Het
Slc23a2	A	G	2: 131,913,937 (GRCm39)	L280P	probably damaging	Het
Smchd1	G	T	17: 71,694,083 (GRCm39)	Q1221K	probably benign	Het
Spmip2	T	A	3: 79,313,093 (GRCm39)	W56R	probably damaging	Het
Spocd1	A	G	4: 129,849,263 (GRCm39)	N694S	possibly damaging	Het
Styxl2	C	A	1: 165,926,670 (GRCm39)	V981L	probably benign	Het
Tecta	T	C	9: 42,263,359 (GRCm39)	D1409G	probably damaging	Het
Tmem131	A	T	1: 36,880,754 (GRCm39)	V172D	probably damaging	Het
Trpm3	T	C	19: 22,964,237 (GRCm39)	M1244T	possibly damaging	Het
Ugcg	G	C	4: 59,217,036 (GRCm39)	V187L	possibly damaging	Het
Usp17le	T	C	7: 104,417,708 (GRCm39)	N478S	probably benign	Het
Usp36	A	G	11: 118,164,397 (GRCm39)	V205A	probably damaging	Het
Vmn1r25	T	A	6: 57,955,494 (GRCm39)	Q265L	probably damaging	Het
Vwf	A	T	6: 125,615,077 (GRCm39)	H1176L	probably benign	Het
Zfyve28	C	T	5: 34,389,550 (GRCm39)	D217N	possibly damaging	Het
Zranb3	A	C	1: 127,882,817 (GRCm39)		probably null	Het

Other mutations in Lyst

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00156:Lyst	APN	13	13,823,463 (GRCm39)	missense	probably benign
IGL00474:Lyst	APN	13	13,818,121 (GRCm39)	missense	possibly damaging	0.48
IGL00484:Lyst	APN	13	13,884,188 (GRCm39)	missense	probably benign	0.02
IGL00492:Lyst	APN	13	13,852,760 (GRCm39)	missense	possibly damaging	0.54
IGL00807:Lyst	APN	13	13,825,008 (GRCm39)	missense	possibly damaging	0.91
IGL00949:Lyst	APN	13	13,810,070 (GRCm39)	missense	possibly damaging	0.87
IGL00952:Lyst	APN	13	13,852,692 (GRCm39)	missense	probably benign	0.05
IGL01305:Lyst	APN	13	13,852,641 (GRCm39)	missense	probably benign	0.01
IGL01317:Lyst	APN	13	13,845,455 (GRCm39)	missense	probably benign
IGL01419:Lyst	APN	13	13,810,423 (GRCm39)	missense	probably benign	0.00
IGL01445:Lyst	APN	13	13,826,299 (GRCm39)	missense	probably benign	0.00
IGL01690:Lyst	APN	13	13,917,831 (GRCm39)	missense	probably damaging	1.00
IGL01791:Lyst	APN	13	13,809,887 (GRCm39)	missense	probably damaging	1.00
IGL01809:Lyst	APN	13	13,812,388 (GRCm39)	missense	probably damaging	1.00
IGL01896:Lyst	APN	13	13,810,162 (GRCm39)	missense	probably benign	0.04
IGL01938:Lyst	APN	13	13,812,009 (GRCm39)	missense	possibly damaging	0.93
IGL01986:Lyst	APN	13	13,950,212 (GRCm39)	critical splice donor site	probably null
IGL02022:Lyst	APN	13	13,838,629 (GRCm39)	nonsense	probably null
IGL02044:Lyst	APN	13	13,887,431 (GRCm39)	missense	probably damaging	1.00
IGL02157:Lyst	APN	13	13,835,541 (GRCm39)	missense	probably benign
IGL02185:Lyst	APN	13	13,835,678 (GRCm39)	nonsense	probably null
IGL02215:Lyst	APN	13	13,835,541 (GRCm39)	missense	probably benign
IGL02245:Lyst	APN	13	13,835,541 (GRCm39)	missense	probably benign
IGL02246:Lyst	APN	13	13,835,541 (GRCm39)	missense	probably benign
IGL02247:Lyst	APN	13	13,835,541 (GRCm39)	missense	probably benign
IGL02297:Lyst	APN	13	13,812,677 (GRCm39)	nonsense	probably null
IGL02411:Lyst	APN	13	13,835,541 (GRCm39)	missense	probably benign
IGL02415:Lyst	APN	13	13,835,541 (GRCm39)	missense	probably benign
IGL02419:Lyst	APN	13	13,835,541 (GRCm39)	missense	probably benign
IGL02420:Lyst	APN	13	13,835,541 (GRCm39)	missense	probably benign
IGL02429:Lyst	APN	13	13,835,541 (GRCm39)	missense	probably benign
IGL02501:Lyst	APN	13	13,886,230 (GRCm39)	missense	probably benign	0.02
IGL02522:Lyst	APN	13	13,809,290 (GRCm39)	missense	possibly damaging	0.81
IGL02535:Lyst	APN	13	13,824,927 (GRCm39)	missense	probably benign	0.00
IGL02596:Lyst	APN	13	13,835,541 (GRCm39)	missense	probably benign
IGL02601:Lyst	APN	13	13,835,541 (GRCm39)	missense	probably benign
IGL02603:Lyst	APN	13	13,835,541 (GRCm39)	missense	probably benign
IGL02608:Lyst	APN	13	13,887,339 (GRCm39)	missense	probably damaging	0.98
IGL02622:Lyst	APN	13	13,855,975 (GRCm39)	missense	probably damaging	1.00
IGL02690:Lyst	APN	13	13,815,710 (GRCm39)	missense	possibly damaging	0.58
IGL02715:Lyst	APN	13	13,848,905 (GRCm39)	splice site	probably null
IGL02725:Lyst	APN	13	13,935,412 (GRCm39)	missense	probably damaging	1.00
IGL02729:Lyst	APN	13	13,921,194 (GRCm39)	missense	possibly damaging	0.95
IGL02729:Lyst	APN	13	13,848,924 (GRCm39)	missense	possibly damaging	0.81
IGL02820:Lyst	APN	13	13,812,643 (GRCm39)	missense	probably benign	0.03
IGL02945:Lyst	APN	13	13,935,783 (GRCm39)	missense	possibly damaging	0.48
IGL02981:Lyst	APN	13	13,809,496 (GRCm39)	missense	probably damaging	0.99
IGL03087:Lyst	APN	13	13,809,641 (GRCm39)	missense	probably damaging	1.00
IGL03149:Lyst	APN	13	13,856,029 (GRCm39)	missense	probably benign	0.14
IGL03158:Lyst	APN	13	13,826,337 (GRCm39)	critical splice donor site	probably null
IGL03226:Lyst	APN	13	13,884,144 (GRCm39)	missense	probably benign	0.01
IGL03242:Lyst	APN	13	13,831,466 (GRCm39)	nonsense	probably null
IGL03385:Lyst	APN	13	13,831,565 (GRCm39)	nonsense	probably null
50-cal	UTSW	13	13,882,797 (GRCm39)	critical splice donor site	probably null
charcoal	UTSW	13	13,871,346 (GRCm39)	nonsense	probably null
charlotte_gray	UTSW	13	13,602,026 (GRCm38)	intron	probably benign
charzard	UTSW	13	13,821,668 (GRCm39)	nonsense	probably null
grey_wolf	UTSW	13	0 ()	unclassified
lightspeed	UTSW	13	13,915,121 (GRCm39)	missense	possibly damaging	0.91
pardon	UTSW	13	13,852,537 (GRCm39)	missense	probably benign	0.00
robin	UTSW	13	13,823,387 (GRCm39)	nonsense	probably null
sooty	UTSW	13	0 ()	unclassified
souris	UTSW	13	13,857,808 (GRCm39)	unclassified	probably benign
Swallow	UTSW	13	13,932,007 (GRCm39)	missense	probably benign	0.00
vulpix	UTSW	13	13,871,379 (GRCm39)	splice site	probably null
ANU22:Lyst	UTSW	13	13,852,641 (GRCm39)	missense	probably benign	0.01
IGL02835:Lyst	UTSW	13	13,835,685 (GRCm39)	missense	possibly damaging	0.82
P0031:Lyst	UTSW	13	13,838,616 (GRCm39)	missense	probably damaging	1.00
R0012:Lyst	UTSW	13	13,862,279 (GRCm39)	missense	probably benign	0.10
R0012:Lyst	UTSW	13	13,862,279 (GRCm39)	missense	probably benign	0.10
R0031:Lyst	UTSW	13	13,882,741 (GRCm39)	missense	probably benign	0.14
R0115:Lyst	UTSW	13	13,852,537 (GRCm39)	missense	probably benign	0.00
R0212:Lyst	UTSW	13	13,810,570 (GRCm39)	missense	possibly damaging	0.93
R0386:Lyst	UTSW	13	13,882,799 (GRCm39)	splice site	probably benign
R0393:Lyst	UTSW	13	13,821,664 (GRCm39)	missense	probably benign	0.01
R0415:Lyst	UTSW	13	13,886,195 (GRCm39)	splice site	probably benign
R0446:Lyst	UTSW	13	13,812,633 (GRCm39)	missense	probably benign	0.00
R0481:Lyst	UTSW	13	13,852,537 (GRCm39)	missense	probably benign	0.00
R0506:Lyst	UTSW	13	13,812,600 (GRCm39)	missense	probably benign
R0530:Lyst	UTSW	13	13,931,891 (GRCm39)	splice site	probably benign
R0541:Lyst	UTSW	13	13,855,878 (GRCm39)	missense	probably benign	0.00
R0570:Lyst	UTSW	13	13,883,971 (GRCm39)	missense	probably benign	0.26
R0680:Lyst	UTSW	13	13,824,926 (GRCm39)	missense	probably benign	0.01
R0842:Lyst	UTSW	13	13,852,826 (GRCm39)	nonsense	probably null
R0848:Lyst	UTSW	13	13,809,515 (GRCm39)	missense	probably benign	0.00
R1014:Lyst	UTSW	13	13,808,645 (GRCm39)	missense	possibly damaging	0.49
R1205:Lyst	UTSW	13	13,854,787 (GRCm39)	missense	probably benign
R1251:Lyst	UTSW	13	13,809,068 (GRCm39)	missense	probably benign	0.00
R1304:Lyst	UTSW	13	13,926,569 (GRCm39)	nonsense	probably null
R1398:Lyst	UTSW	13	13,915,121 (GRCm39)	missense	possibly damaging	0.91
R1445:Lyst	UTSW	13	13,814,639 (GRCm39)	missense	possibly damaging	0.94
R1475:Lyst	UTSW	13	13,882,797 (GRCm39)	critical splice donor site	probably null
R1479:Lyst	UTSW	13	13,809,067 (GRCm39)	missense	probably benign	0.00
R1484:Lyst	UTSW	13	13,852,775 (GRCm39)	missense	probably benign	0.01
R1498:Lyst	UTSW	13	13,824,960 (GRCm39)	missense	possibly damaging	0.49
R1540:Lyst	UTSW	13	13,809,686 (GRCm39)	missense	possibly damaging	0.81
R1611:Lyst	UTSW	13	13,809,482 (GRCm39)	missense	probably damaging	0.97
R1653:Lyst	UTSW	13	13,809,811 (GRCm39)	missense	probably damaging	1.00
R1669:Lyst	UTSW	13	13,818,672 (GRCm39)	missense	possibly damaging	0.90
R1686:Lyst	UTSW	13	13,809,290 (GRCm39)	missense	possibly damaging	0.81
R1694:Lyst	UTSW	13	13,835,746 (GRCm39)	missense	probably damaging	0.98
R1747:Lyst	UTSW	13	13,932,007 (GRCm39)	missense	probably benign	0.00
R1793:Lyst	UTSW	13	13,821,668 (GRCm39)	nonsense	probably null
R1871:Lyst	UTSW	13	13,826,297 (GRCm39)	missense	probably benign	0.00
R1905:Lyst	UTSW	13	13,808,719 (GRCm39)	missense	probably benign
R1958:Lyst	UTSW	13	13,791,203 (GRCm39)	missense	probably damaging	1.00
R1969:Lyst	UTSW	13	13,904,929 (GRCm39)	missense	probably damaging	0.99
R2040:Lyst	UTSW	13	13,815,807 (GRCm39)	missense	probably benign	0.00
R2109:Lyst	UTSW	13	13,887,405 (GRCm39)	missense	possibly damaging	0.46
R2116:Lyst	UTSW	13	13,810,286 (GRCm39)	missense	probably damaging	0.99
R2121:Lyst	UTSW	13	13,835,556 (GRCm39)	missense	probably damaging	1.00
R2127:Lyst	UTSW	13	13,809,847 (GRCm39)	missense	probably damaging	1.00
R2187:Lyst	UTSW	13	13,883,926 (GRCm39)	missense	possibly damaging	0.61
R2238:Lyst	UTSW	13	13,917,848 (GRCm39)	missense	probably benign	0.41
R2258:Lyst	UTSW	13	13,812,243 (GRCm39)	missense	probably benign	0.00
R2292:Lyst	UTSW	13	13,915,080 (GRCm39)	missense	probably damaging	1.00
R2368:Lyst	UTSW	13	13,871,248 (GRCm39)	missense	probably damaging	0.96
R2908:Lyst	UTSW	13	13,844,458 (GRCm39)	missense	probably benign	0.03
R3001:Lyst	UTSW	13	13,871,290 (GRCm39)	missense	probably benign
R3002:Lyst	UTSW	13	13,871,290 (GRCm39)	missense	probably benign
R3024:Lyst	UTSW	13	13,833,272 (GRCm39)	missense	probably benign
R3113:Lyst	UTSW	13	13,844,512 (GRCm39)	missense	probably benign	0.12
R3406:Lyst	UTSW	13	13,809,815 (GRCm39)	missense	possibly damaging	0.56
R3972:Lyst	UTSW	13	13,881,210 (GRCm39)	missense	possibly damaging	0.67
R3978:Lyst	UTSW	13	13,808,753 (GRCm39)	missense	possibly damaging	0.82
R4032:Lyst	UTSW	13	13,791,250 (GRCm39)	missense	probably damaging	1.00
R4192:Lyst	UTSW	13	13,915,098 (GRCm39)	missense	probably damaging	1.00
R4206:Lyst	UTSW	13	13,810,574 (GRCm39)	missense	probably benign	0.03
R4298:Lyst	UTSW	13	13,809,472 (GRCm39)	missense	probably damaging	1.00
R4344:Lyst	UTSW	13	13,873,051 (GRCm39)	missense	probably benign	0.06
R4441:Lyst	UTSW	13	13,809,968 (GRCm39)	missense	probably damaging	1.00
R4445:Lyst	UTSW	13	13,884,149 (GRCm39)	missense	probably benign	0.42
R4477:Lyst	UTSW	13	13,809,968 (GRCm39)	missense	probably damaging	1.00
R4493:Lyst	UTSW	13	13,809,968 (GRCm39)	missense	probably damaging	1.00
R4494:Lyst	UTSW	13	13,809,968 (GRCm39)	missense	probably damaging	1.00
R4495:Lyst	UTSW	13	13,809,968 (GRCm39)	missense	probably damaging	1.00
R4622:Lyst	UTSW	13	13,848,983 (GRCm39)	missense	probably benign	0.01
R4638:Lyst	UTSW	13	13,871,379 (GRCm39)	splice site	probably null
R4658:Lyst	UTSW	13	13,809,968 (GRCm39)	missense	probably damaging	1.00
R4675:Lyst	UTSW	13	13,809,968 (GRCm39)	missense	probably damaging	1.00
R4719:Lyst	UTSW	13	13,824,935 (GRCm39)	missense	probably benign
R4729:Lyst	UTSW	13	13,812,486 (GRCm39)	missense	probably damaging	1.00
R4774:Lyst	UTSW	13	13,915,182 (GRCm39)	missense	probably damaging	1.00
R4811:Lyst	UTSW	13	13,951,685 (GRCm39)	missense	probably benign	0.33
R4877:Lyst	UTSW	13	13,857,734 (GRCm39)	missense	probably damaging	1.00
R4920:Lyst	UTSW	13	13,821,645 (GRCm39)	missense	possibly damaging	0.79
R4933:Lyst	UTSW	13	13,933,963 (GRCm39)	missense	probably benign	0.12
R4933:Lyst	UTSW	13	13,812,349 (GRCm39)	missense	probably damaging	0.98
R4958:Lyst	UTSW	13	13,810,048 (GRCm39)	missense	probably benign	0.00
R4982:Lyst	UTSW	13	13,900,539 (GRCm39)	missense	probably damaging	1.00
R4992:Lyst	UTSW	13	13,835,748 (GRCm39)	missense	probably damaging	1.00
R5024:Lyst	UTSW	13	13,808,989 (GRCm39)	missense	probably benign
R5049:Lyst	UTSW	13	13,810,649 (GRCm39)	missense	probably damaging	1.00
R5079:Lyst	UTSW	13	13,931,938 (GRCm39)	missense	probably benign	0.08
R5254:Lyst	UTSW	13	13,857,655 (GRCm39)	missense	probably benign	0.00
R5266:Lyst	UTSW	13	13,835,555 (GRCm39)	missense	probably damaging	1.00
R5279:Lyst	UTSW	13	13,823,387 (GRCm39)	nonsense	probably null
R5285:Lyst	UTSW	13	13,809,011 (GRCm39)	missense	probably benign	0.01
R5364:Lyst	UTSW	13	13,831,439 (GRCm39)	missense	probably benign	0.35
R5435:Lyst	UTSW	13	13,951,649 (GRCm39)	missense	possibly damaging	0.64
R5516:Lyst	UTSW	13	13,818,707 (GRCm39)	missense	probably benign	0.10
R5524:Lyst	UTSW	13	13,921,364 (GRCm39)	missense	probably benign	0.03
R5591:Lyst	UTSW	13	13,917,918 (GRCm39)	missense	probably damaging	0.99
R5592:Lyst	UTSW	13	13,917,918 (GRCm39)	missense	probably damaging	0.99
R5593:Lyst	UTSW	13	13,917,918 (GRCm39)	missense	probably damaging	0.99
R5594:Lyst	UTSW	13	13,917,918 (GRCm39)	missense	probably damaging	0.99
R5594:Lyst	UTSW	13	13,933,982 (GRCm39)	missense	probably benign	0.00
R5644:Lyst	UTSW	13	13,812,081 (GRCm39)	missense	possibly damaging	0.58
R5659:Lyst	UTSW	13	13,809,212 (GRCm39)	missense	possibly damaging	0.58
R5741:Lyst	UTSW	13	13,808,615 (GRCm39)	missense	probably benign	0.44
R5908:Lyst	UTSW	13	13,871,346 (GRCm39)	nonsense	probably null
R5969:Lyst	UTSW	13	13,862,398 (GRCm39)	splice site	probably null
R6128:Lyst	UTSW	13	13,933,964 (GRCm39)	missense	possibly damaging	0.67
R6271:Lyst	UTSW	13	13,833,339 (GRCm39)	missense	probably benign	0.30
R6315:Lyst	UTSW	13	13,818,089 (GRCm39)	missense	probably benign
R6318:Lyst	UTSW	13	13,917,896 (GRCm39)	missense	possibly damaging	0.88
R6555:Lyst	UTSW	13	13,823,510 (GRCm39)	missense	probably benign	0.01
R6663:Lyst	UTSW	13	13,838,701 (GRCm39)	splice site	probably null
R6701:Lyst	UTSW	13	13,856,070 (GRCm39)	missense	probably benign	0.06
R6711:Lyst	UTSW	13	13,809,820 (GRCm39)	missense	possibly damaging	0.80
R6909:Lyst	UTSW	13	13,917,960 (GRCm39)	missense	probably damaging	1.00
R6915:Lyst	UTSW	13	13,900,629 (GRCm39)	missense	probably benign	0.01
R6929:Lyst	UTSW	13	13,917,909 (GRCm39)	missense	probably damaging	1.00
R6960:Lyst	UTSW	13	13,808,663 (GRCm39)	missense	probably benign	0.12
R7018:Lyst	UTSW	13	13,918,044 (GRCm39)	critical splice donor site	probably null
R7037:Lyst	UTSW	13	13,791,251 (GRCm39)	missense	probably damaging	1.00
R7045:Lyst	UTSW	13	13,812,293 (GRCm39)	missense	probably damaging	1.00
R7045:Lyst	UTSW	13	13,809,485 (GRCm39)	missense	probably benign	0.34
R7070:Lyst	UTSW	13	13,932,029 (GRCm39)	missense	probably benign	0.23
R7188:Lyst	UTSW	13	13,926,675 (GRCm39)	missense	possibly damaging	0.66
R7201:Lyst	UTSW	13	13,883,885 (GRCm39)	nonsense	probably null
R7210:Lyst	UTSW	13	13,831,568 (GRCm39)	missense	probably damaging	1.00
R7229:Lyst	UTSW	13	13,818,094 (GRCm39)	missense	probably benign	0.00
R7293:Lyst	UTSW	13	13,854,822 (GRCm39)	missense	probably benign	0.01
R7318:Lyst	UTSW	13	13,932,028 (GRCm39)	missense	probably benign	0.13
R7344:Lyst	UTSW	13	13,881,140 (GRCm39)	missense	probably benign
R7426:Lyst	UTSW	13	13,812,109 (GRCm39)	missense	probably benign
R7522:Lyst	UTSW	13	13,821,668 (GRCm39)	nonsense	probably null
R7583:Lyst	UTSW	13	13,810,472 (GRCm39)	missense	probably damaging	1.00
R7606:Lyst	UTSW	13	13,812,060 (GRCm39)	missense	probably damaging	1.00
R7636:Lyst	UTSW	13	13,791,332 (GRCm39)	critical splice donor site	probably null
R7658:Lyst	UTSW	13	13,905,061 (GRCm39)	missense	possibly damaging	0.63
R7685:Lyst	UTSW	13	13,844,450 (GRCm39)	missense	probably benign	0.00
R7689:Lyst	UTSW	13	13,857,808 (GRCm39)	critical splice donor site	probably null
R7765:Lyst	UTSW	13	13,884,117 (GRCm39)	missense	possibly damaging	0.75
R7779:Lyst	UTSW	13	13,809,128 (GRCm39)	missense	probably damaging	1.00
R7871:Lyst	UTSW	13	13,810,637 (GRCm39)	nonsense	probably null
R7872:Lyst	UTSW	13	13,810,450 (GRCm39)	missense	probably benign	0.14
R7884:Lyst	UTSW	13	13,882,268 (GRCm39)	missense	probably benign	0.09
R7890:Lyst	UTSW	13	13,915,154 (GRCm39)	missense	probably damaging	0.99
R7916:Lyst	UTSW	13	13,821,657 (GRCm39)	missense	possibly damaging	0.64
R7948:Lyst	UTSW	13	13,921,174 (GRCm39)	missense	possibly damaging	0.59
R7956:Lyst	UTSW	13	13,815,788 (GRCm39)	missense	possibly damaging	0.80
R8048:Lyst	UTSW	13	13,862,230 (GRCm39)	missense	probably benign	0.12
R8085:Lyst	UTSW	13	13,808,894 (GRCm39)	missense	probably damaging	0.98
R8165:Lyst	UTSW	13	13,872,945 (GRCm39)	missense	probably damaging	0.99
R8235:Lyst	UTSW	13	13,935,323 (GRCm39)	missense	possibly damaging	0.69
R8237:Lyst	UTSW	13	13,826,317 (GRCm39)	missense	probably benign	0.00
R8275:Lyst	UTSW	13	13,950,667 (GRCm39)	missense	probably benign	0.02
R8300:Lyst	UTSW	13	13,838,643 (GRCm39)	missense	possibly damaging	0.79
R8350:Lyst	UTSW	13	13,824,973 (GRCm39)	nonsense	probably null
R8526:Lyst	UTSW	13	13,935,391 (GRCm39)	missense	probably damaging	0.99
R8551:Lyst	UTSW	13	13,808,645 (GRCm39)	missense	possibly damaging	0.77
R8723:Lyst	UTSW	13	13,887,342 (GRCm39)	missense	possibly damaging	0.89
R8772:Lyst	UTSW	13	13,812,077 (GRCm39)	nonsense	probably null
R8778:Lyst	UTSW	13	13,903,152 (GRCm39)	missense	possibly damaging	0.89
R8778:Lyst	UTSW	13	13,810,361 (GRCm39)	missense	possibly damaging	0.89
R8801:Lyst	UTSW	13	13,835,595 (GRCm39)	missense	probably benign	0.10
R8837:Lyst	UTSW	13	13,852,548 (GRCm39)	missense	probably benign
R8874:Lyst	UTSW	13	13,812,147 (GRCm39)	missense	probably benign
R8878:Lyst	UTSW	13	13,815,661 (GRCm39)	missense	probably benign	0.00
R8891:Lyst	UTSW	13	13,887,435 (GRCm39)	missense	possibly damaging	0.67
R9077:Lyst	UTSW	13	13,857,693 (GRCm39)	missense	probably benign	0.02
R9127:Lyst	UTSW	13	13,808,827 (GRCm39)	missense	probably damaging	1.00
R9143:Lyst	UTSW	13	13,835,750 (GRCm39)	missense	probably damaging	0.98
R9216:Lyst	UTSW	13	13,823,188 (GRCm39)	missense	probably benign
R9217:Lyst	UTSW	13	13,871,245 (GRCm39)	missense	probably benign	0.01
R9291:Lyst	UTSW	13	13,883,938 (GRCm39)	missense	probably benign	0.01
R9302:Lyst	UTSW	13	13,904,947 (GRCm39)	missense	possibly damaging	0.46
R9370:Lyst	UTSW	13	13,935,333 (GRCm39)	missense	probably damaging	1.00
R9402:Lyst	UTSW	13	13,812,463 (GRCm39)	missense	probably benign
R9457:Lyst	UTSW	13	13,862,330 (GRCm39)	missense	possibly damaging	0.83
R9481:Lyst	UTSW	13	13,857,653 (GRCm39)	missense	possibly damaging	0.68
R9563:Lyst	UTSW	13	13,812,408 (GRCm39)	missense	probably benign	0.36
R9623:Lyst	UTSW	13	13,852,587 (GRCm39)	missense	probably benign
R9661:Lyst	UTSW	13	13,808,779 (GRCm39)	missense	probably benign	0.01
R9682:Lyst	UTSW	13	13,831,526 (GRCm39)	missense	probably benign	0.21
R9743:Lyst	UTSW	13	13,809,323 (GRCm39)	missense	possibly damaging	0.67
R9801:Lyst	UTSW	13	13,809,290 (GRCm39)	missense	probably damaging	0.97
RF001:Lyst	UTSW	13	13,810,426 (GRCm39)	missense	probably benign
RF002:Lyst	UTSW	13	13,808,948 (GRCm39)	missense	probably benign	0.05
X0024:Lyst	UTSW	13	13,809,033 (GRCm39)	missense	probably benign	0.00
X0026:Lyst	UTSW	13	13,926,555 (GRCm39)	missense	probably damaging	0.99
Z1088:Lyst	UTSW	13	13,918,018 (GRCm39)	missense	probably benign	0.09
Z1176:Lyst	UTSW	13	13,951,664 (GRCm39)	missense	probably benign	0.27
Z1176:Lyst	UTSW	13	13,814,692 (GRCm39)	missense	probably damaging	1.00
Z1177:Lyst	UTSW	13	13,854,719 (GRCm39)	missense	possibly damaging	0.73

Predicted Primers

PCR Primer
(F):5'- CCCTGAACTGCCACTGCTCACT -3'
(R):5'- ctgatgtgttcaaatcaactacaAAAAGCCT -3'

Sequencing Primer
(F):5'- CCTAATAAGGTCAGAGCTATTCCTG -3'
(R):5'- ACAAAACCTGTTTAGAAAAATGGC -3'

Posted On

2013-06-12