Incidental Mutation 'R5968:Tmem92'
ID 470704
Institutional Source Beutler Lab
Gene Symbol Tmem92
Ensembl Gene ENSMUSG00000075610
Gene Name transmembrane protein 92
Synonyms
MMRRC Submission 043249-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.089) question?
Stock # R5968 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 94668043-94673529 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 94669564 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Arginine at position 85 (M85R)
Ref Sequence ENSEMBL: ENSMUSP00000128300 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100554] [ENSMUST00000143620] [ENSMUST00000162809]
AlphaFold B7ZWI3
Predicted Effect probably benign
Transcript: ENSMUST00000100554
AA Change: M85R

PolyPhen 2 Score 0.092 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000128300
Gene: ENSMUSG00000075610
AA Change: M85R

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
transmembrane domain 62 84 N/A INTRINSIC
low complexity region 87 102 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000143620
SMART Domains Protein: ENSMUSP00000129874
Gene: ENSMUSG00000075610

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000162809
AA Change: M133R

PolyPhen 2 Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000125159
Gene: ENSMUSG00000075610
AA Change: M133R

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
transmembrane domain 64 86 N/A INTRINSIC
low complexity region 135 150 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.0%
  • 20x: 93.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc10 T C 17: 46,621,077 (GRCm39) T978A probably benign Het
Adcy9 A G 16: 4,116,606 (GRCm39) L638P probably damaging Het
Adgrf2 A G 17: 43,026,063 (GRCm39) probably null Het
Anxa6 T C 11: 54,885,167 (GRCm39) I461V probably damaging Het
Arap1 T C 7: 101,043,945 (GRCm39) L668P probably damaging Het
Ces2e G T 8: 105,659,627 (GRCm39) G498W probably damaging Het
Crb1 A G 1: 139,170,739 (GRCm39) C823R probably damaging Het
Ehmt1 C T 2: 24,726,469 (GRCm39) R772H probably damaging Het
Enpep A G 3: 129,074,587 (GRCm39) L721S probably benign Het
Flii T G 11: 60,611,038 (GRCm39) I464L probably benign Het
Gm57858 T C 3: 36,064,840 (GRCm39) Q511R probably benign Het
Gtf2h3 C T 5: 124,722,360 (GRCm39) T121I probably benign Het
Ift172 T C 5: 31,418,828 (GRCm39) E1162G probably damaging Het
Meioc A G 11: 102,566,657 (GRCm39) S758G probably damaging Het
Ndst1 A C 18: 60,846,148 (GRCm39) S54A probably benign Het
Ndufaf8 G T 11: 119,990,055 (GRCm39) E56* probably null Het
Ndufb7 A G 8: 84,293,530 (GRCm39) D28G probably benign Het
Or1e16 T C 11: 73,286,018 (GRCm39) M277V possibly damaging Het
Or2a25 A G 6: 42,888,480 (GRCm39) I8V probably benign Het
Prkg1 A T 19: 30,570,324 (GRCm39) F443I probably damaging Het
Pspc1 C T 14: 57,001,693 (GRCm39) R227H probably benign Het
Ptpn21 A G 12: 98,677,149 (GRCm39) Y120H probably damaging Het
Runx1t1 A T 4: 13,841,890 (GRCm39) probably null Het
Ryr3 T C 2: 112,477,394 (GRCm39) D4449G probably benign Het
Sacs C A 14: 61,427,078 (GRCm39) A159E probably damaging Het
Slc16a14 T C 1: 84,890,226 (GRCm39) I360V possibly damaging Het
Tcstv5 T C 13: 120,411,618 (GRCm39) probably benign Het
Thop1 A G 10: 80,911,393 (GRCm39) D93G probably benign Het
Ttn T C 2: 76,688,017 (GRCm39) probably benign Het
Zdhhc5 T C 2: 84,524,719 (GRCm39) probably null Het
Zfp335 T C 2: 164,734,314 (GRCm39) H1291R probably damaging Het
Zfp957 C T 14: 79,451,496 (GRCm39) C101Y probably damaging Het
Other mutations in Tmem92
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00972:Tmem92 APN 11 94,673,254 (GRCm39) missense possibly damaging 0.71
IGL01674:Tmem92 APN 11 94,669,519 (GRCm39) missense probably damaging 0.96
IGL02959:Tmem92 APN 11 94,669,504 (GRCm39) missense possibly damaging 0.72
R0028:Tmem92 UTSW 11 94,669,778 (GRCm39) missense possibly damaging 0.84
R1905:Tmem92 UTSW 11 94,669,501 (GRCm39) missense probably benign 0.04
R2396:Tmem92 UTSW 11 94,673,233 (GRCm39) missense probably damaging 0.99
R3056:Tmem92 UTSW 11 94,669,873 (GRCm39) missense probably benign
R3116:Tmem92 UTSW 11 94,673,254 (GRCm39) missense possibly damaging 0.71
R5096:Tmem92 UTSW 11 94,669,862 (GRCm39) missense probably benign 0.05
R7570:Tmem92 UTSW 11 94,669,816 (GRCm39) missense probably benign 0.00
R7816:Tmem92 UTSW 11 94,669,784 (GRCm39) missense possibly damaging 0.93
Predicted Primers PCR Primer
(F):5'- TTAGCTCTCAGGACAAAAGGGG -3'
(R):5'- CAGTCAGGTGGGTCTTTCTGAC -3'

Sequencing Primer
(F):5'- GGAGGGGTCTTATCTGAATAAAAAC -3'
(R):5'- CCCAATACCTAATGTGTTTCATAGC -3'
Posted On 2017-03-31