Mutagenetix > Incidental Mutation

Incidental Mutation 'R5956:Or9g3'

471164

Institutional Source

Beutler Lab

Gene Symbol

Or9g3

Ensembl Gene

ENSMUSG00000075210

Gene Name

olfactory receptor family 9 subfamily G member 3

Synonyms

MOR213-6, Olfr1012, GA_x6K02T2Q125-47239120-47238185

MMRRC Submission

044144-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.076) question?

Stock #

R5956 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

85589783-85590718 bp(-) (GRCm39)

Type of Mutation

unclassified

DNA Base Change (assembly)

A to G at 85584183 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000148952 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000214255] [ENSMUST00000214958] [ENSMUST00000216831]

AlphaFold

Q8VFJ7

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000120884

Predicted Effect

probably benign
Transcript: ENSMUST00000214255

Predicted Effect

probably benign
Transcript: ENSMUST00000214958

Predicted Effect

silent
Transcript: ENSMUST00000216831

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 97.9%
20x: 93.5%

Validation Efficiency

98% (63/64)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 58 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2700049A03Rik	T	A	12: 71,203,893 (GRCm39)	I398K	possibly damaging	Het
Acad9	A	G	3: 36,129,323 (GRCm39)		probably benign	Het
Acsm2	T	C	7: 119,153,704 (GRCm39)	S5P	unknown	Het
Akp3	T	C	1: 87,054,667 (GRCm39)	I334T	probably damaging	Het
Amy1	C	T	3: 113,357,311 (GRCm39)	R176H	probably benign	Het
Ank2	A	T	3: 126,736,337 (GRCm39)		probably benign	Het
Cav1	C	A	6: 17,307,918 (GRCm39)	N23K	probably damaging	Het
Cep126	A	G	9: 8,112,120 (GRCm39)	V151A	probably benign	Het
Cnot1	A	G	8: 96,481,606 (GRCm39)		probably null	Het
Crim1	T	A	17: 78,623,146 (GRCm39)	V448E	probably damaging	Het
Csmd3	T	C	15: 48,655,278 (GRCm39)	E8G	possibly damaging	Het
Ddx31	A	T	2: 28,764,185 (GRCm39)	I464F	probably damaging	Het
Ddx54	A	G	5: 120,764,432 (GRCm39)		probably benign	Het
Dhx16	A	G	17: 36,193,762 (GRCm39)	E319G	probably damaging	Het
Efl1	A	G	7: 82,301,107 (GRCm39)	D37G	probably damaging	Het
Epha5	T	C	5: 84,298,228 (GRCm39)	R444G	probably damaging	Het
Exoc2	C	A	13: 31,004,606 (GRCm39)	C859F	probably benign	Het
Gbx2	T	C	1: 89,860,908 (GRCm39)		probably benign	Het
Gm12258	G	A	11: 58,750,285 (GRCm39)	A9T	probably benign	Het
Gpr141b	T	G	13: 19,913,300 (GRCm39)		noncoding transcript	Het
Grm4	A	G	17: 27,654,129 (GRCm39)	V607A	probably benign	Het
Gvin3	T	C	7: 106,200,677 (GRCm39)		noncoding transcript	Het
Ighv1-74	C	A	12: 115,766,455 (GRCm39)	W55L	probably damaging	Het
Irx4	C	A	13: 73,415,626 (GRCm39)	Y138*	probably null	Het
Itpr1	C	A	6: 108,482,988 (GRCm39)	T2352K	probably benign	Het
Kcnk3	T	G	5: 30,745,854 (GRCm39)	V65G	probably damaging	Het
Mctp2	T	C	7: 71,908,923 (GRCm39)	E130G	probably benign	Het
Mgat5	C	A	1: 127,310,676 (GRCm39)	R197S	probably benign	Het
Mpg	T	C	11: 32,177,951 (GRCm39)		probably null	Het
Muc5b	T	C	7: 141,417,910 (GRCm39)	C3619R	probably damaging	Het
Myo15b	G	A	11: 115,764,583 (GRCm39)	V1321I	probably benign	Het
Myo1b	T	C	1: 51,815,391 (GRCm39)	T658A	probably damaging	Het
Nomo1	T	C	7: 45,692,037 (GRCm39)	S154P	possibly damaging	Het
Nsd1	T	A	13: 55,411,217 (GRCm39)	F1423I	probably damaging	Het
Or1e16	AGCGGTCGTAGGC	AGC	11: 73,286,480 (GRCm39)		probably null	Het
Osbpl6	A	G	2: 76,379,856 (GRCm39)	R149G	probably damaging	Het
Pacc1	A	G	1: 191,080,568 (GRCm39)	S263G	probably damaging	Het
Papola	T	A	12: 105,777,300 (GRCm39)	W281R	probably damaging	Het
Pole	C	T	5: 110,485,153 (GRCm39)		probably benign	Het
Rptn	A	G	3: 93,305,334 (GRCm39)	N889S	possibly damaging	Het
Scn10a	A	G	9: 119,460,626 (GRCm39)	S1084P	probably damaging	Het
Scnm1	T	C	3: 95,037,596 (GRCm39)	I157V	probably benign	Het
Sertad2	G	A	11: 20,597,884 (GRCm39)	G27S	probably benign	Het
Siglece	T	C	7: 43,308,760 (GRCm39)	T198A	probably damaging	Het
Sptb	T	A	12: 76,650,942 (GRCm39)	M1678L	probably benign	Het
Taf8	A	T	17: 47,809,467 (GRCm39)	M98K	probably damaging	Het
Tead2	T	A	7: 44,870,138 (GRCm39)		probably benign	Het
Trrap	C	T	5: 144,744,201 (GRCm39)		silent	Het
Ttn	G	T	2: 76,775,914 (GRCm39)	N1709K	probably damaging	Het
Ube3a	T	C	7: 58,926,768 (GRCm39)		probably benign	Het
Ube3c	T	C	5: 29,804,054 (GRCm39)		probably benign	Het
Unc80	T	C	1: 66,567,123 (GRCm39)	S910P	probably damaging	Het
Usp30	G	A	5: 114,257,682 (GRCm39)	R280Q	possibly damaging	Het
Vsx1	T	C	2: 150,530,457 (GRCm39)	S142G	possibly damaging	Het
Wdr95	T	G	5: 149,517,947 (GRCm39)	C360G	probably benign	Het
Zbtb4	A	G	11: 69,669,040 (GRCm39)	I588V	probably benign	Het
Zdhhc4	A	T	5: 143,310,604 (GRCm39)		probably benign	Het
Zfp568	C	A	7: 29,697,288 (GRCm39)	N69K	probably damaging	Het

Other mutations in Or9g3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01799:Or9g3	APN	2	85,589,986 (GRCm39)	missense	probably benign	0.30
IGL02334:Or9g3	APN	2	85,590,503 (GRCm39)	nonsense	probably null
IGL03050:Or9g3	UTSW	2	85,589,785 (GRCm39)	makesense	probably null
R0399:Or9g3	UTSW	2	85,590,248 (GRCm39)	missense	possibly damaging	0.53
R1730:Or9g3	UTSW	2	85,590,586 (GRCm39)	missense	possibly damaging	0.91
R2142:Or9g3	UTSW	2	85,590,021 (GRCm39)	missense	probably benign	0.07
R2185:Or9g3	UTSW	2	85,590,363 (GRCm39)	missense	probably damaging	1.00
R2412:Or9g3	UTSW	2	85,590,024 (GRCm39)	missense	probably damaging	0.99
R3552:Or9g3	UTSW	2	85,590,237 (GRCm39)	missense	possibly damaging	0.46
R3785:Or9g3	UTSW	2	85,589,797 (GRCm39)	missense	probably benign	0.00
R4096:Or9g3	UTSW	2	85,590,040 (GRCm39)	missense	possibly damaging	0.55
R4097:Or9g3	UTSW	2	85,590,040 (GRCm39)	missense	possibly damaging	0.55
R5199:Or9g3	UTSW	2	85,590,558 (GRCm39)	missense	probably damaging	1.00
R5206:Or9g3	UTSW	2	85,589,967 (GRCm39)	missense	probably benign	0.31
R5444:Or9g3	UTSW	2	85,590,263 (GRCm39)	missense	probably benign	0.39
R5567:Or9g3	UTSW	2	85,589,994 (GRCm39)	missense	probably damaging	1.00
R5570:Or9g3	UTSW	2	85,589,994 (GRCm39)	missense	probably damaging	1.00
R6406:Or9g3	UTSW	2	85,590,651 (GRCm39)	missense	possibly damaging	0.94
R7355:Or9g3	UTSW	2	85,584,023 (GRCm39)	missense	probably benign	0.03
R7534:Or9g3	UTSW	2	85,589,803 (GRCm39)	missense	probably benign	0.03
R7751:Or9g3	UTSW	2	85,583,836 (GRCm39)	missense	probably benign	0.25
R8260:Or9g3	UTSW	2	85,589,820 (GRCm39)	missense	probably damaging	1.00
R8983:Or9g3	UTSW	2	85,584,251 (GRCm39)	unclassified	probably benign
R9025:Or9g3	UTSW	2	85,589,879 (GRCm39)	missense	possibly damaging	0.61
R9373:Or9g3	UTSW	2	85,590,275 (GRCm39)	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- AGACAAAAGCATCTCCTTTGC -3'
(R):5'- GAGCGGATCTTCAGAATGGC -3'

Sequencing Primer
(F):5'- CTGGTTGCCTGGCTCAG -3'
(R):5'- CGGATCTTCAGAATGGCTACAATG -3'

Posted On

2017-03-31