Incidental Mutation 'R5956:Kcnk3'
ID 471172
Institutional Source Beutler Lab
Gene Symbol Kcnk3
Ensembl Gene ENSMUSG00000049265
Gene Name potassium channel, subfamily K, member 3
Synonyms cTBAK-1, Task-1
MMRRC Submission 044144-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.126) question?
Stock # R5956 (G1)
Quality Score 104
Status Validated
Chromosome 5
Chromosomal Location 30745514-30782614 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 30745854 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glycine at position 65 (V65G)
Ref Sequence ENSEMBL: ENSMUSP00000098987 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000066295]
AlphaFold O35111
Predicted Effect probably damaging
Transcript: ENSMUST00000066295
AA Change: V65G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000098987
Gene: ENSMUSG00000049265
AA Change: V65G

DomainStartEndE-ValueType
transmembrane domain 9 26 N/A INTRINSIC
low complexity region 37 49 N/A INTRINSIC
Pfam:Ion_trans_2 58 134 2.9e-20 PFAM
Pfam:Ion_trans_2 165 248 1.4e-21 PFAM
low complexity region 272 286 N/A INTRINSIC
low complexity region 296 308 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000199326
Meta Mutation Damage Score 0.5615 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.9%
  • 20x: 93.5%
Validation Efficiency 98% (63/64)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. [provided by RefSeq, Aug 2008]
PHENOTYPE: Mice homozygous for a null alleles exhibit decreased pH sensitivitive of action potential in serotonergic neurons. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik T A 12: 71,203,893 (GRCm39) I398K possibly damaging Het
Acad9 A G 3: 36,129,323 (GRCm39) probably benign Het
Acsm2 T C 7: 119,153,704 (GRCm39) S5P unknown Het
Akp3 T C 1: 87,054,667 (GRCm39) I334T probably damaging Het
Amy1 C T 3: 113,357,311 (GRCm39) R176H probably benign Het
Ank2 A T 3: 126,736,337 (GRCm39) probably benign Het
Cav1 C A 6: 17,307,918 (GRCm39) N23K probably damaging Het
Cep126 A G 9: 8,112,120 (GRCm39) V151A probably benign Het
Cnot1 A G 8: 96,481,606 (GRCm39) probably null Het
Crim1 T A 17: 78,623,146 (GRCm39) V448E probably damaging Het
Csmd3 T C 15: 48,655,278 (GRCm39) E8G possibly damaging Het
Ddx31 A T 2: 28,764,185 (GRCm39) I464F probably damaging Het
Ddx54 A G 5: 120,764,432 (GRCm39) probably benign Het
Dhx16 A G 17: 36,193,762 (GRCm39) E319G probably damaging Het
Efl1 A G 7: 82,301,107 (GRCm39) D37G probably damaging Het
Epha5 T C 5: 84,298,228 (GRCm39) R444G probably damaging Het
Exoc2 C A 13: 31,004,606 (GRCm39) C859F probably benign Het
Gbx2 T C 1: 89,860,908 (GRCm39) probably benign Het
Gm12258 G A 11: 58,750,285 (GRCm39) A9T probably benign Het
Gpr141b T G 13: 19,913,300 (GRCm39) noncoding transcript Het
Grm4 A G 17: 27,654,129 (GRCm39) V607A probably benign Het
Gvin3 T C 7: 106,200,677 (GRCm39) noncoding transcript Het
Ighv1-74 C A 12: 115,766,455 (GRCm39) W55L probably damaging Het
Irx4 C A 13: 73,415,626 (GRCm39) Y138* probably null Het
Itpr1 C A 6: 108,482,988 (GRCm39) T2352K probably benign Het
Mctp2 T C 7: 71,908,923 (GRCm39) E130G probably benign Het
Mgat5 C A 1: 127,310,676 (GRCm39) R197S probably benign Het
Mpg T C 11: 32,177,951 (GRCm39) probably null Het
Muc5b T C 7: 141,417,910 (GRCm39) C3619R probably damaging Het
Myo15b G A 11: 115,764,583 (GRCm39) V1321I probably benign Het
Myo1b T C 1: 51,815,391 (GRCm39) T658A probably damaging Het
Nomo1 T C 7: 45,692,037 (GRCm39) S154P possibly damaging Het
Nsd1 T A 13: 55,411,217 (GRCm39) F1423I probably damaging Het
Or1e16 AGCGGTCGTAGGC AGC 11: 73,286,480 (GRCm39) probably null Het
Or9g3 A G 2: 85,584,183 (GRCm39) probably benign Het
Osbpl6 A G 2: 76,379,856 (GRCm39) R149G probably damaging Het
Pacc1 A G 1: 191,080,568 (GRCm39) S263G probably damaging Het
Papola T A 12: 105,777,300 (GRCm39) W281R probably damaging Het
Pole C T 5: 110,485,153 (GRCm39) probably benign Het
Rptn A G 3: 93,305,334 (GRCm39) N889S possibly damaging Het
Scn10a A G 9: 119,460,626 (GRCm39) S1084P probably damaging Het
Scnm1 T C 3: 95,037,596 (GRCm39) I157V probably benign Het
Sertad2 G A 11: 20,597,884 (GRCm39) G27S probably benign Het
Siglece T C 7: 43,308,760 (GRCm39) T198A probably damaging Het
Sptb T A 12: 76,650,942 (GRCm39) M1678L probably benign Het
Taf8 A T 17: 47,809,467 (GRCm39) M98K probably damaging Het
Tead2 T A 7: 44,870,138 (GRCm39) probably benign Het
Trrap C T 5: 144,744,201 (GRCm39) silent Het
Ttn G T 2: 76,775,914 (GRCm39) N1709K probably damaging Het
Ube3a T C 7: 58,926,768 (GRCm39) probably benign Het
Ube3c T C 5: 29,804,054 (GRCm39) probably benign Het
Unc80 T C 1: 66,567,123 (GRCm39) S910P probably damaging Het
Usp30 G A 5: 114,257,682 (GRCm39) R280Q possibly damaging Het
Vsx1 T C 2: 150,530,457 (GRCm39) S142G possibly damaging Het
Wdr95 T G 5: 149,517,947 (GRCm39) C360G probably benign Het
Zbtb4 A G 11: 69,669,040 (GRCm39) I588V probably benign Het
Zdhhc4 A T 5: 143,310,604 (GRCm39) probably benign Het
Zfp568 C A 7: 29,697,288 (GRCm39) N69K probably damaging Het
Other mutations in Kcnk3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02481:Kcnk3 APN 5 30,779,727 (GRCm39) missense probably damaging 0.99
IGL02719:Kcnk3 APN 5 30,779,324 (GRCm39) missense probably damaging 1.00
PIT4802001:Kcnk3 UTSW 5 30,779,712 (GRCm39) missense probably damaging 1.00
R0288:Kcnk3 UTSW 5 30,745,764 (GRCm39) missense probably benign
R0834:Kcnk3 UTSW 5 30,779,979 (GRCm39) missense probably damaging 1.00
R1740:Kcnk3 UTSW 5 30,779,321 (GRCm39) missense possibly damaging 0.95
R2656:Kcnk3 UTSW 5 30,780,015 (GRCm39) missense possibly damaging 0.55
R2923:Kcnk3 UTSW 5 30,779,414 (GRCm39) missense probably damaging 1.00
R3740:Kcnk3 UTSW 5 30,779,274 (GRCm39) missense possibly damaging 0.93
R4584:Kcnk3 UTSW 5 30,745,730 (GRCm39) missense probably damaging 0.99
R5010:Kcnk3 UTSW 5 30,780,149 (GRCm39) missense possibly damaging 0.79
R5070:Kcnk3 UTSW 5 30,779,730 (GRCm39) missense possibly damaging 0.77
R5427:Kcnk3 UTSW 5 30,779,639 (GRCm39) missense possibly damaging 0.86
R5669:Kcnk3 UTSW 5 30,779,693 (GRCm39) missense probably damaging 0.99
R5982:Kcnk3 UTSW 5 30,780,014 (GRCm39) missense probably benign 0.18
R5986:Kcnk3 UTSW 5 30,745,722 (GRCm39) missense possibly damaging 0.68
R6318:Kcnk3 UTSW 5 30,779,930 (GRCm39) missense probably damaging 0.98
R6860:Kcnk3 UTSW 5 30,779,397 (GRCm39) missense possibly damaging 0.86
R6919:Kcnk3 UTSW 5 30,779,744 (GRCm39) missense probably benign 0.00
R7350:Kcnk3 UTSW 5 30,779,310 (GRCm39) missense probably damaging 1.00
R7418:Kcnk3 UTSW 5 30,779,675 (GRCm39) missense possibly damaging 0.57
R7502:Kcnk3 UTSW 5 30,780,062 (GRCm39) missense possibly damaging 0.85
R7922:Kcnk3 UTSW 5 30,745,875 (GRCm39) missense probably damaging 1.00
R8899:Kcnk3 UTSW 5 30,779,580 (GRCm39) missense probably benign 0.37
R8953:Kcnk3 UTSW 5 30,779,382 (GRCm39) missense probably damaging 1.00
R9180:Kcnk3 UTSW 5 30,745,532 (GRCm39) start gained probably benign
R9570:Kcnk3 UTSW 5 30,779,433 (GRCm39) missense possibly damaging 0.94
Z1177:Kcnk3 UTSW 5 30,780,048 (GRCm39) missense possibly damaging 0.80
Z1177:Kcnk3 UTSW 5 30,779,837 (GRCm39) missense probably benign
Z1177:Kcnk3 UTSW 5 30,745,618 (GRCm39) start gained probably benign
Predicted Primers PCR Primer
(F):5'- TTGGCTCTCATCGTGTGCAC -3'
(R):5'- CTCACACACTTAAGTCCCCTGG -3'

Sequencing Primer
(F):5'- ATCGTGTGCACCTTCACCTAC -3'
(R):5'- ACTTAAGTCCCCTGGGGTCC -3'
Posted On 2017-03-31