Incidental Mutation 'R5957:Fbxw13'
ID 471229
Institutional Source Beutler Lab
Gene Symbol Fbxw13
Ensembl Gene ENSMUSG00000049314
Gene Name F-box and WD-40 domain protein 13
Synonyms
MMRRC Submission 043246-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R5957 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 109008295-109025043 bp(-) (GRCm39)
Type of Mutation critical splice donor site (1 bp from exon)
DNA Base Change (assembly) C to T at 109021734 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000142352 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061456] [ENSMUST00000199102] [ENSMUST00000199102] [ENSMUST00000199118]
AlphaFold Q8BI57
Predicted Effect probably null
Transcript: ENSMUST00000061456
SMART Domains Protein: ENSMUSP00000053786
Gene: ENSMUSG00000049314

DomainStartEndE-ValueType
FBOX 5 45 9.33e-5 SMART
SCOP:d1gxra_ 128 249 8e-7 SMART
Blast:WD40 137 176 2e-7 BLAST
low complexity region 421 432 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000199102
SMART Domains Protein: ENSMUSP00000142352
Gene: ENSMUSG00000049314

DomainStartEndE-ValueType
SCOP:d1gxra_ 45 166 1e-7 SMART
Blast:WD40 54 93 7e-8 BLAST
Predicted Effect probably null
Transcript: ENSMUST00000199102
SMART Domains Protein: ENSMUSP00000142352
Gene: ENSMUSG00000049314

DomainStartEndE-ValueType
SCOP:d1gxra_ 45 166 1e-7 SMART
Blast:WD40 54 93 7e-8 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000199118
SMART Domains Protein: ENSMUSP00000143174
Gene: ENSMUSG00000049314

DomainStartEndE-ValueType
FBOX 5 45 3.25e-4 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.6%
  • 20x: 92.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik A G 3: 137,775,922 (GRCm39) T1704A probably benign Het
Adgrg7 T A 16: 56,593,790 (GRCm39) N142I probably damaging Het
Aldh18a1 A T 19: 40,558,981 (GRCm39) Y286* probably null Het
Arpp21 T C 9: 112,014,754 (GRCm39) T17A probably benign Het
Bnip2 T C 9: 69,906,520 (GRCm39) I147T probably damaging Het
Ccr8 T C 9: 119,922,893 (GRCm39) Y3H probably damaging Het
Cenps C A 4: 149,214,658 (GRCm39) probably benign Het
Cul7 G A 17: 46,968,683 (GRCm39) G553S probably damaging Het
Cyp21a1 A G 17: 35,022,150 (GRCm39) I206T probably benign Het
Dennd4b A G 3: 90,178,272 (GRCm39) D488G probably damaging Het
Dip2b T C 15: 100,107,575 (GRCm39) L1195P probably benign Het
Dmac2l T C 12: 69,790,558 (GRCm39) V185A probably benign Het
Dock5 T A 14: 68,095,443 (GRCm39) H77L probably benign Het
Fmnl3 G A 15: 99,223,791 (GRCm39) R302W probably damaging Het
Gbf1 G T 19: 46,234,660 (GRCm39) probably null Het
Gm4846 T C 1: 166,314,522 (GRCm39) I374V probably benign Het
Gsk3b C A 16: 38,014,315 (GRCm39) P258T probably damaging Het
Igsf5 T C 16: 96,165,249 (GRCm39) V8A probably benign Het
Il22 T A 10: 118,041,071 (GRCm39) L59Q probably damaging Het
Ildr1 T C 16: 36,545,896 (GRCm39) *517Q probably null Het
Iqca1 T A 1: 90,008,670 (GRCm39) D450V probably damaging Het
Itga5 T C 15: 103,259,856 (GRCm39) D647G probably benign Het
Myh7 T G 14: 55,226,535 (GRCm39) N408T probably damaging Het
Mylk3 T C 8: 86,055,266 (GRCm39) M564V probably damaging Het
Nsd2 T A 5: 34,012,947 (GRCm39) M407K probably damaging Het
Odad2 T C 18: 7,285,706 (GRCm39) E219G probably benign Het
Oprd1 C T 4: 131,871,474 (GRCm39) V75I probably benign Het
Poli G A 18: 70,650,511 (GRCm39) H310Y probably benign Het
Pramel19 T C 4: 101,798,898 (GRCm39) F290L probably benign Het
Ptch1 C T 13: 63,672,929 (GRCm39) R755H probably damaging Het
Pygl A T 12: 70,246,494 (GRCm39) M351K probably damaging Het
Serpinb9b T C 13: 33,223,831 (GRCm39) L341P possibly damaging Het
Slc47a1 A G 11: 61,235,168 (GRCm39) V555A probably benign Het
Slc8a2 C A 7: 15,879,209 (GRCm39) T565K possibly damaging Het
Snx14 T C 9: 88,285,327 (GRCm39) I446V possibly damaging Het
Syde1 T C 10: 78,425,951 (GRCm39) Y72C probably damaging Het
Trim37 C T 11: 87,036,377 (GRCm39) R138C probably damaging Het
Tubgcp5 T A 7: 55,464,710 (GRCm39) S530R probably benign Het
Vps13c T C 9: 67,862,253 (GRCm39) S2957P probably damaging Het
Wdr41 T C 13: 95,133,695 (GRCm39) probably null Het
Zyg11b T C 4: 108,102,210 (GRCm39) K504E probably damaging Het
Other mutations in Fbxw13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02033:Fbxw13 APN 9 109,010,484 (GRCm39) missense probably damaging 0.99
IGL02455:Fbxw13 APN 9 109,012,255 (GRCm39) missense probably benign 0.26
IGL03154:Fbxw13 APN 9 109,010,533 (GRCm39) missense probably damaging 0.96
R0304:Fbxw13 UTSW 9 109,023,789 (GRCm39) missense probably benign 0.02
R1259:Fbxw13 UTSW 9 109,014,439 (GRCm39) missense probably damaging 1.00
R1710:Fbxw13 UTSW 9 109,010,586 (GRCm39) missense probably damaging 1.00
R1912:Fbxw13 UTSW 9 109,010,611 (GRCm39) missense probably benign 0.10
R2877:Fbxw13 UTSW 9 109,010,534 (GRCm39) missense probably damaging 1.00
R2878:Fbxw13 UTSW 9 109,010,534 (GRCm39) missense probably damaging 1.00
R3085:Fbxw13 UTSW 9 109,013,299 (GRCm39) nonsense probably null
R4321:Fbxw13 UTSW 9 109,010,503 (GRCm39) missense probably benign 0.10
R4969:Fbxw13 UTSW 9 109,010,592 (GRCm39) splice site probably null
R5024:Fbxw13 UTSW 9 109,008,403 (GRCm39) missense probably benign 0.00
R5450:Fbxw13 UTSW 9 109,013,225 (GRCm39) missense probably benign 0.41
R6801:Fbxw13 UTSW 9 109,023,795 (GRCm39) missense probably null 1.00
R7448:Fbxw13 UTSW 9 109,014,471 (GRCm39) missense unknown
R7710:Fbxw13 UTSW 9 109,024,968 (GRCm39) missense probably damaging 1.00
R8163:Fbxw13 UTSW 9 109,012,122 (GRCm39) missense probably benign 0.45
R8320:Fbxw13 UTSW 9 109,012,134 (GRCm39) missense probably benign 0.02
R8714:Fbxw13 UTSW 9 109,023,832 (GRCm39) missense probably benign 0.00
R8845:Fbxw13 UTSW 9 109,023,833 (GRCm39) missense possibly damaging 0.85
R8884:Fbxw13 UTSW 9 109,010,469 (GRCm39) missense probably benign 0.00
R8979:Fbxw13 UTSW 9 109,013,197 (GRCm39) missense probably damaging 0.96
R9223:Fbxw13 UTSW 9 109,024,116 (GRCm39) missense probably damaging 1.00
R9318:Fbxw13 UTSW 9 109,008,382 (GRCm39) missense probably benign 0.17
X0065:Fbxw13 UTSW 9 109,021,776 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- GCCCTGCACAGATGGCTAAG -3'
(R):5'- AACATACCTTCTTCGGTCTGAGTTG -3'

Sequencing Primer
(F):5'- AAGGGACCTGACATCCTCTTGTG -3'
(R):5'- TCGGTCTGAGTTGTCCCTC -3'
Posted On 2017-03-31