Mutagenetix > Incidental Mutation

Incidental Mutation 'R5961:Nrxn1'

471856

Institutional Source

Beutler Lab

Gene Symbol

Nrxn1

Ensembl Gene

ENSMUSG00000024109

Gene Name

neurexin I

Synonyms

alpha-latrotoxin receptor (calcium-dependent), 1700062G21Rik, neurexin I alpha, neurexin I alpha, 9330127H16Rik, neurexin I beta, neurexin I beta, A230068P09Rik, neurexin I alpha, neurexin I beta

MMRRC Submission

043247-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R5961 (G1)

Quality Score

141

Status

Not validated

Chromosome

Chromosomal Location

90341059-91400499 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 90762371 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Arginine at position 37 (L37R)

Ref Sequence

ENSEMBL: ENSMUSP00000134402 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000054059] [ENSMUST00000072671] [ENSMUST00000159778] [ENSMUST00000160800] [ENSMUST00000160844] [ENSMUST00000172466] [ENSMUST00000174337] [ENSMUST00000176118] [ENSMUST00000161402] [ENSMUST00000174331]

AlphaFold

Q9CS84

Predicted Effect

probably benign
Transcript: ENSMUST00000054059

SMART Domains

Protein: ENSMUSP00000057294
Gene: ENSMUSG00000024109

Domain	Start	End	E-Value	Type
low complexity region	9	23	N/A	INTRINSIC
LamG	50	192	2.29e-31	SMART
EGF	216	256	4.26e0	SMART
LamG	304	438	2.3e-36	SMART
LamG	492	644	2.74e-43	SMART
EGF	671	705	1.58e-3	SMART
LamG	730	869	7.27e-25	SMART
LamG	917	1053	8.46e-35	SMART
EGF	1078	1112	1.87e1	SMART
LamG	1140	1297	7.74e-20	SMART
low complexity region	1324	1355	N/A	INTRINSIC
low complexity region	1426	1441	N/A	INTRINSIC
4.1m	1444	1462	1.19e-6	SMART
low complexity region	1481	1493	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000072671

SMART Domains

Protein: ENSMUSP00000072458
Gene: ENSMUSG00000024109

Domain	Start	End	E-Value	Type
low complexity region	9	23	N/A	INTRINSIC
LamG	50	192	2.29e-31	SMART
EGF	216	256	4.26e0	SMART
LamG	304	438	2.3e-36	SMART
LamG	492	644	2.74e-43	SMART
EGF	671	705	1.58e-3	SMART
LamG	730	869	7.27e-25	SMART
LamG	917	1053	8.46e-35	SMART
EGF	1078	1112	1.87e1	SMART
LamG	1140	1297	7.74e-20	SMART
low complexity region	1324	1355	N/A	INTRINSIC
low complexity region	1423	1438	N/A	INTRINSIC
4.1m	1441	1459	1.19e-6	SMART
low complexity region	1478	1490	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000097270

Predicted Effect

probably benign
Transcript: ENSMUST00000159778
AA Change: L37R

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)

SMART Domains

Protein: ENSMUSP00000125561
Gene: ENSMUSG00000024109
AA Change: L37R

Domain	Start	End	E-Value	Type
low complexity region	9	23	N/A	INTRINSIC
LamG	50	192	2.29e-31	SMART
EGF	216	256	4.26e0	SMART
LamG	284	418	2.3e-36	SMART
LamG	472	624	2.74e-43	SMART
EGF	651	685	1.58e-3	SMART
LamG	710	849	7.27e-25	SMART
LamG	897	1033	8.46e-35	SMART
EGF	1058	1092	1.87e1	SMART
LamG	1120	1277	7.74e-20	SMART
low complexity region	1304	1335	N/A	INTRINSIC
low complexity region	1403	1418	N/A	INTRINSIC
4.1m	1421	1439	1.19e-6	SMART
low complexity region	1458	1470	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000160800

SMART Domains

Protein: ENSMUSP00000124561
Gene: ENSMUSG00000024109

Domain	Start	End	E-Value	Type
low complexity region	9	23	N/A	INTRINSIC
LamG	50	192	2.29e-31	SMART
EGF	216	256	4.26e0	SMART
LamG	300	434	2.3e-36	SMART
LamG	488	640	2.74e-43	SMART
EGF	667	701	1.58e-3	SMART
LamG	726	865	7.27e-25	SMART
LamG	913	1049	8.46e-35	SMART
EGF	1074	1108	1.87e1	SMART
LamG	1136	1293	7.74e-20	SMART
low complexity region	1320	1351	N/A	INTRINSIC
low complexity region	1422	1437	N/A	INTRINSIC
4.1m	1440	1458	1.19e-6	SMART
low complexity region	1477	1489	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000160844

SMART Domains

Protein: ENSMUSP00000125407
Gene: ENSMUSG00000024109

Domain	Start	End	E-Value	Type
low complexity region	9	23	N/A	INTRINSIC
LamG	50	192	2.29e-31	SMART
EGF	216	256	4.26e0	SMART
LamG	304	446	1.24e-32	SMART
LamG	500	652	2.74e-43	SMART
EGF	679	713	1.58e-3	SMART
LamG	738	877	7.27e-25	SMART
LamG	925	1061	8.46e-35	SMART
EGF	1086	1120	1.87e1	SMART
LamG	1148	1305	7.74e-20	SMART
low complexity region	1332	1363	N/A	INTRINSIC
low complexity region	1434	1449	N/A	INTRINSIC
4.1m	1452	1470	1.19e-6	SMART
low complexity region	1489	1501	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000161102

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000198899

Predicted Effect

probably damaging
Transcript: ENSMUST00000172466
AA Change: L37R

PolyPhen 2 Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000134402
Gene: ENSMUSG00000024109
AA Change: L37R

Domain	Start	End	E-Value	Type
transmembrane domain	27	49	N/A	INTRINSIC
LamG	109	266	7.74e-20	SMART
low complexity region	293	324	N/A	INTRINSIC
low complexity region	395	410	N/A	INTRINSIC
4.1m	413	431	1.19e-6	SMART
low complexity region	450	462	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000174337
AA Change: L37R

PolyPhen 2 Score 0.662 (Sensitivity: 0.86; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000133724
Gene: ENSMUSG00000024109
AA Change: L37R

Domain	Start	End	E-Value	Type
transmembrane domain	27	49	N/A	INTRINSIC
LamG	109	236	3.29e-23	SMART
low complexity region	263	294	N/A	INTRINSIC
low complexity region	365	380	N/A	INTRINSIC
4.1m	383	401	1.19e-6	SMART
low complexity region	420	432	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000196269

Predicted Effect

probably benign
Transcript: ENSMUST00000176118

SMART Domains

Protein: ENSMUSP00000135241
Gene: ENSMUSG00000024109

Domain	Start	End	E-Value	Type
Pfam:Laminin_G_2	1	95	3.1e-18	PFAM
Pfam:Laminin_G_1	1	98	3.7e-12	PFAM
EGF	129	163	1.87e1	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000161402

SMART Domains

Protein: ENSMUSP00000124116
Gene: ENSMUSG00000024109

Domain	Start	End	E-Value	Type
low complexity region	9	23	N/A	INTRINSIC
LamG	50	192	2.29e-31	SMART
EGF	216	256	4.26e0	SMART
LamG	304	453	3.46e-31	SMART
LamG	507	659	2.74e-43	SMART
EGF	686	720	1.58e-3	SMART
LamG	745	884	7.27e-25	SMART
LamG	932	1068	8.46e-35	SMART
EGF	1093	1127	1.87e1	SMART
LamG	1155	1312	7.74e-20	SMART
low complexity region	1339	1370	N/A	INTRINSIC
low complexity region	1441	1456	N/A	INTRINSIC
4.1m	1459	1477	1.19e-6	SMART
low complexity region	1496	1508	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000174331

SMART Domains

Protein: ENSMUSP00000133491
Gene: ENSMUSG00000024109

Domain	Start	End	E-Value	Type
signal peptide	1	30	N/A	INTRINSIC
LamG	50	192	2.29e-31	SMART
EGF	216	256	4.26e0	SMART
LamG	304	446	1.24e-32	SMART
LamG	500	652	2.74e-43	SMART
EGF	679	713	1.58e-3	SMART
LamG	738	877	7.27e-25	SMART
LamG	925	1061	8.46e-35	SMART
EGF	1086	1120	1.87e1	SMART
LamG	1148	1275	3.29e-23	SMART
low complexity region	1302	1333	N/A	INTRINSIC
low complexity region	1404	1419	N/A	INTRINSIC
4.1m	1422	1440	1.19e-6	SMART
low complexity region	1459	1471	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000196559

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.0%
20x: 93.7%

Validation Efficiency

MGI Phenotype

FUNCTION: This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are synaptic transmembrane receptors that bind endogenous ligands that include neuroligins, dystroglycan, and neurexophilins. Neurexin complexes are required for efficient neurotransmission and are involved in synaptogenesis. In vertebrates, alternate promoter usage results in multiple isoform classes, of which the alpha and beta classes are the best characterized. In humans, allelic variants in this gene are associated with Pitt-Hopkins-like syndrome-2, while deletions have been associated with autism and schizophrenia. Mouse knockouts display decreased spontaneous and evoked vesicle release resulting in impaired synaptic transmission. In addition, knockout mice show altered social approach, reduced social investigation, reduced locomotor activity, and in males, increased aggression. Alternative splicing and promoter usage result in multiple transcript variants. [provided by RefSeq, Nov 2016]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced Ca(2+)-dependent binding of alpha-latrotoxin to brain membranes. Isolated synaptosomes display only a small reduction in alpha-latrotoxin -triggered glutamate release in the absence of Ca(2+) but show a major decrease in the presence of Ca(2+). [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ackr4	A	G	9: 103,976,338 (GRCm39)	L203P	probably damaging	Het
Aen	C	G	7: 78,556,907 (GRCm39)	H252D	probably damaging	Het
Alkbh6	T	A	7: 30,013,617 (GRCm39)		probably null	Het
Birc6	T	C	17: 74,953,596 (GRCm39)	V3286A	probably damaging	Het
Cacna1h	A	G	17: 25,596,246 (GRCm39)	M1925T	probably benign	Het
Caprin2	A	C	6: 148,765,038 (GRCm39)	S554R	probably damaging	Het
Celsr3	T	C	9: 108,708,993 (GRCm39)	S1280P	probably damaging	Het
Cfap57	T	C	4: 118,428,942 (GRCm39)	E1008G	probably benign	Het
Csmd1	A	G	8: 16,120,366 (GRCm39)	I1813T	probably damaging	Het
Dnah10	A	G	5: 124,888,546 (GRCm39)	E3050G	probably benign	Het
Dnah2	A	G	11: 69,321,974 (GRCm39)	F3782S	probably damaging	Het
Dnah2	C	T	11: 69,349,746 (GRCm39)	R2399Q	probably benign	Het
Dnajc17	T	C	2: 119,016,527 (GRCm39)	T64A	possibly damaging	Het
Dvl3	T	G	16: 20,349,729 (GRCm39)	S567R	possibly damaging	Het
Epb41l1	T	A	2: 156,363,706 (GRCm39)	S738R	probably benign	Het
Exph5	T	C	9: 53,288,555 (GRCm39)	W1879R	probably damaging	Het
Fam83a	T	A	15: 57,872,992 (GRCm39)	F274I	possibly damaging	Het
Ggt1	A	G	10: 75,421,736 (GRCm39)		probably null	Het
Ido2	C	T	8: 25,023,786 (GRCm39)	V351M	probably damaging	Het
Kcnt2	A	G	1: 140,435,440 (GRCm39)	E469G	possibly damaging	Het
Kdm2b	A	G	5: 123,070,724 (GRCm39)	S403P	probably benign	Het
Klhl2	C	T	8: 65,202,818 (GRCm39)	R460H	probably damaging	Het
Mfsd6l	A	G	11: 68,447,368 (GRCm39)	Y73C	possibly damaging	Het
Mlec	A	T	5: 115,288,159 (GRCm39)	C205*	probably null	Het
Mlx	T	C	11: 100,980,053 (GRCm39)	Y129H	probably damaging	Het
Mmadhc	T	C	2: 50,181,421 (GRCm39)	H83R	probably damaging	Het
Mmp16	T	C	4: 17,853,842 (GRCm39)	F41S	probably benign	Het
Mroh6	G	A	15: 75,759,617 (GRCm39)	Q187*	probably null	Het
Myh14	T	A	7: 44,272,518 (GRCm39)	E1437V	probably damaging	Het
Or6c209	T	C	10: 129,483,723 (GRCm39)	M242T	possibly damaging	Het
Pkhd1l1	A	C	15: 44,322,859 (GRCm39)	R48S	probably damaging	Het
Prokr2	A	G	2: 132,215,595 (GRCm39)	Y128H	possibly damaging	Het
Prtg	T	C	9: 72,764,228 (GRCm39)	V567A	probably benign	Het
Rbis	T	C	3: 14,676,124 (GRCm39)	T26A	possibly damaging	Het
Srrm2	G	A	17: 24,039,083 (GRCm39)		probably benign	Het
Stat4	A	T	1: 52,104,543 (GRCm39)	I115L	possibly damaging	Het
Tnxb	G	A	17: 34,937,609 (GRCm39)	V3833M	probably damaging	Het
Ugt2b36	C	T	5: 87,228,724 (GRCm39)		probably null	Het
Usp45	A	C	4: 21,810,797 (GRCm39)	D331A	probably damaging	Het
Usp47	T	C	7: 111,652,523 (GRCm39)	S47P	probably damaging	Het
Vps53	A	G	11: 75,939,316 (GRCm39)	Y696H	probably damaging	Het
Zfp384	T	C	6: 125,000,997 (GRCm39)	I23T	probably damaging	Het
Zfp804a	A	G	2: 82,088,346 (GRCm39)	Y725C	probably benign	Het

Other mutations in Nrxn1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01310:Nrxn1	APN	17	90,366,902 (GRCm39)	critical splice donor site	probably null
IGL01644:Nrxn1	APN	17	90,928,301 (GRCm39)	missense	possibly damaging	0.94
IGL01820:Nrxn1	APN	17	90,950,531 (GRCm39)	missense	probably damaging	0.98
IGL01902:Nrxn1	APN	17	91,395,919 (GRCm39)	splice site	probably null
IGL02079:Nrxn1	APN	17	90,950,511 (GRCm39)	missense	probably damaging	0.99
IGL02089:Nrxn1	APN	17	91,395,829 (GRCm39)	missense	probably benign	0.01
IGL02133:Nrxn1	APN	17	90,950,671 (GRCm39)	missense	probably damaging	1.00
IGL02179:Nrxn1	APN	17	90,937,511 (GRCm39)	missense	probably damaging	0.99
IGL02199:Nrxn1	APN	17	90,344,686 (GRCm39)	missense	probably damaging	1.00
IGL02262:Nrxn1	APN	17	91,011,636 (GRCm39)	missense	probably damaging	1.00
IGL02941:Nrxn1	APN	17	90,515,811 (GRCm39)	missense	probably damaging	1.00
PIT4449001:Nrxn1	UTSW	17	90,905,007 (GRCm39)	missense	probably damaging	1.00
PIT4791001:Nrxn1	UTSW	17	90,762,931 (GRCm39)	intron	probably benign
R0123:Nrxn1	UTSW	17	91,302,915 (GRCm39)	splice site	probably null
R0212:Nrxn1	UTSW	17	90,670,186 (GRCm39)	unclassified	probably benign
R0277:Nrxn1	UTSW	17	91,008,170 (GRCm39)	critical splice donor site	probably null
R0323:Nrxn1	UTSW	17	91,008,170 (GRCm39)	critical splice donor site	probably null
R0384:Nrxn1	UTSW	17	90,515,775 (GRCm39)	missense	probably damaging	1.00
R0395:Nrxn1	UTSW	17	91,395,742 (GRCm39)	missense	possibly damaging	0.90
R0606:Nrxn1	UTSW	17	90,872,801 (GRCm39)	missense	probably damaging	1.00
R0616:Nrxn1	UTSW	17	90,670,285 (GRCm39)	missense	probably damaging	1.00
R0624:Nrxn1	UTSW	17	91,396,117 (GRCm39)	missense	unknown
R0633:Nrxn1	UTSW	17	91,011,609 (GRCm39)	missense	probably damaging	1.00
R0927:Nrxn1	UTSW	17	90,344,758 (GRCm39)	missense	probably damaging	1.00
R1035:Nrxn1	UTSW	17	90,471,302 (GRCm39)	missense	probably damaging	0.96
R1221:Nrxn1	UTSW	17	90,950,722 (GRCm39)	missense	probably damaging	0.97
R1403:Nrxn1	UTSW	17	90,950,481 (GRCm39)	missense	probably benign	0.11
R1403:Nrxn1	UTSW	17	90,950,481 (GRCm39)	missense	probably benign	0.11
R1691:Nrxn1	UTSW	17	90,469,717 (GRCm39)	missense	probably damaging	0.98
R1703:Nrxn1	UTSW	17	90,515,845 (GRCm39)	missense	probably damaging	1.00
R1709:Nrxn1	UTSW	17	90,344,615 (GRCm39)	missense	probably damaging	1.00
R1721:Nrxn1	UTSW	17	90,469,832 (GRCm39)	missense	probably damaging	1.00
R1792:Nrxn1	UTSW	17	90,896,252 (GRCm39)	missense	probably damaging	0.96
R1980:Nrxn1	UTSW	17	91,395,746 (GRCm39)	missense	probably benign	0.01
R2116:Nrxn1	UTSW	17	91,011,705 (GRCm39)	missense	probably damaging	1.00
R2117:Nrxn1	UTSW	17	91,011,705 (GRCm39)	missense	probably damaging	1.00
R2162:Nrxn1	UTSW	17	90,469,859 (GRCm39)	missense	probably damaging	1.00
R3119:Nrxn1	UTSW	17	90,904,947 (GRCm39)	nonsense	probably null
R3409:Nrxn1	UTSW	17	90,515,795 (GRCm39)	missense	probably damaging	1.00
R3683:Nrxn1	UTSW	17	90,930,880 (GRCm39)	missense	probably damaging	1.00
R3885:Nrxn1	UTSW	17	90,930,899 (GRCm39)	missense	probably damaging	1.00
R3939:Nrxn1	UTSW	17	90,515,849 (GRCm39)	missense	probably damaging	1.00
R4475:Nrxn1	UTSW	17	91,009,410 (GRCm39)	missense	probably damaging	0.98
R4640:Nrxn1	UTSW	17	90,868,196 (GRCm39)	missense	probably damaging	1.00
R4678:Nrxn1	UTSW	17	90,930,850 (GRCm39)	missense	probably damaging	1.00
R4690:Nrxn1	UTSW	17	90,344,509 (GRCm39)	missense	probably damaging	1.00
R4790:Nrxn1	UTSW	17	90,762,477 (GRCm39)	missense	possibly damaging	0.86
R4877:Nrxn1	UTSW	17	91,395,605 (GRCm39)	missense	probably benign	0.33
R4989:Nrxn1	UTSW	17	90,928,274 (GRCm39)	intron	probably benign
R5204:Nrxn1	UTSW	17	90,469,792 (GRCm39)	missense	probably damaging	1.00
R5205:Nrxn1	UTSW	17	90,471,302 (GRCm39)	missense	probably damaging	0.96
R5239:Nrxn1	UTSW	17	91,011,537 (GRCm39)	missense	probably damaging	1.00
R5250:Nrxn1	UTSW	17	90,842,869 (GRCm39)	intron	probably benign
R5473:Nrxn1	UTSW	17	90,897,520 (GRCm39)	missense	probably damaging	1.00
R5629:Nrxn1	UTSW	17	90,897,460 (GRCm39)	missense	possibly damaging	0.75
R5743:Nrxn1	UTSW	17	90,950,652 (GRCm39)	missense	probably damaging	1.00
R5910:Nrxn1	UTSW	17	91,011,746 (GRCm39)	nonsense	probably null
R5979:Nrxn1	UTSW	17	91,395,631 (GRCm39)	missense	possibly damaging	0.54
R5992:Nrxn1	UTSW	17	90,930,935 (GRCm39)	missense	probably benign	0.01
R6024:Nrxn1	UTSW	17	90,897,526 (GRCm39)	missense	possibly damaging	0.88
R6031:Nrxn1	UTSW	17	90,896,218 (GRCm39)	missense	probably damaging	1.00
R6031:Nrxn1	UTSW	17	90,896,218 (GRCm39)	missense	probably damaging	1.00
R6185:Nrxn1	UTSW	17	90,344,564 (GRCm39)	missense	probably damaging	1.00
R6220:Nrxn1	UTSW	17	91,395,904 (GRCm39)	missense	probably benign	0.14
R6306:Nrxn1	UTSW	17	90,872,874 (GRCm39)	missense	possibly damaging	0.55
R6621:Nrxn1	UTSW	17	90,469,610 (GRCm39)	missense	probably damaging	1.00
R6669:Nrxn1	UTSW	17	90,366,991 (GRCm39)	missense	probably damaging	0.98
R6770:Nrxn1	UTSW	17	90,344,607 (GRCm39)	missense	probably damaging	1.00
R6798:Nrxn1	UTSW	17	90,937,378 (GRCm39)	missense	probably damaging	1.00
R6923:Nrxn1	UTSW	17	91,395,661 (GRCm39)	missense	probably benign	0.06
R7140:Nrxn1	UTSW	17	91,396,192 (GRCm39)	start gained	probably benign
R7374:Nrxn1	UTSW	17	90,896,097 (GRCm39)	critical splice donor site	probably null
R7564:Nrxn1	UTSW	17	90,670,334 (GRCm39)	missense	possibly damaging	0.64
R7570:Nrxn1	UTSW	17	90,469,807 (GRCm39)	missense	probably benign	0.35
R7800:Nrxn1	UTSW	17	91,396,635 (GRCm39)	unclassified	probably benign
R7828:Nrxn1	UTSW	17	90,366,979 (GRCm39)	missense	probably damaging	0.99
R7974:Nrxn1	UTSW	17	91,008,207 (GRCm39)	missense	probably damaging	1.00
R8001:Nrxn1	UTSW	17	91,395,964 (GRCm39)	missense	possibly damaging	0.49
R8189:Nrxn1	UTSW	17	91,011,637 (GRCm39)	missense	probably damaging	0.96
R8258:Nrxn1	UTSW	17	90,471,249 (GRCm39)	missense	probably damaging	0.99
R8259:Nrxn1	UTSW	17	90,471,249 (GRCm39)	missense	probably damaging	0.99
R8298:Nrxn1	UTSW	17	91,011,597 (GRCm39)	missense	probably damaging	1.00
R8801:Nrxn1	UTSW	17	91,009,393 (GRCm39)	critical splice donor site	probably benign
R8814:Nrxn1	UTSW	17	90,937,529 (GRCm39)	missense	probably damaging	1.00
R8873:Nrxn1	UTSW	17	90,872,821 (GRCm39)	nonsense	probably null
R8954:Nrxn1	UTSW	17	90,897,615 (GRCm39)	missense	probably damaging	1.00
R9086:Nrxn1	UTSW	17	90,469,792 (GRCm39)	missense	probably damaging	1.00
R9110:Nrxn1	UTSW	17	90,869,233 (GRCm39)	nonsense	probably null
R9498:Nrxn1	UTSW	17	90,897,397 (GRCm39)	missense	probably damaging	1.00
R9499:Nrxn1	UTSW	17	90,937,450 (GRCm39)	missense	probably damaging	1.00
R9552:Nrxn1	UTSW	17	90,937,450 (GRCm39)	missense	probably damaging	1.00
R9780:Nrxn1	UTSW	17	90,931,042 (GRCm39)	missense	possibly damaging	0.54
RF005:Nrxn1	UTSW	17	90,670,304 (GRCm39)	missense	probably damaging	1.00
RF024:Nrxn1	UTSW	17	90,670,304 (GRCm39)	missense	probably damaging	1.00
X0021:Nrxn1	UTSW	17	90,897,640 (GRCm39)	missense	probably damaging	1.00
X0063:Nrxn1	UTSW	17	90,670,259 (GRCm39)	missense	possibly damaging	0.54
Z1088:Nrxn1	UTSW	17	90,366,933 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GGATAACCCGCAAGAACTTGG -3'
(R):5'- CCTGAGAAGACTGTCCGAAG -3'

Sequencing Primer
(F):5'- CGCAAGAACTTGGCATTGC -3'
(R):5'- TAAGGCGGCCAATCCAGCAG -3'

Posted On

2017-03-31