Incidental Mutation 'R5963:Zcchc14'
ID 471883
Institutional Source Beutler Lab
Gene Symbol Zcchc14
Ensembl Gene ENSMUSG00000061410
Gene Name zinc finger, CCHC domain containing 14
Synonyms Bdg29
MMRRC Submission 044148-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5963 (G1)
Quality Score 225
Status Validated
Chromosome 8
Chromosomal Location 122325442-122379640 bp(-) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) A to T at 122355362 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000118564 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000046386] [ENSMUST00000127664]
AlphaFold Q8VIG0
Predicted Effect unknown
Transcript: ENSMUST00000046386
AA Change: S82T
SMART Domains Protein: ENSMUSP00000040360
Gene: ENSMUSG00000061410
AA Change: S82T

DomainStartEndE-ValueType
low complexity region 30 41 N/A INTRINSIC
low complexity region 129 145 N/A INTRINSIC
low complexity region 206 225 N/A INTRINSIC
low complexity region 246 265 N/A INTRINSIC
Blast:SAM 299 349 2e-25 BLAST
SCOP:d1kw4a_ 307 358 1e-6 SMART
low complexity region 422 432 N/A INTRINSIC
low complexity region 438 454 N/A INTRINSIC
low complexity region 532 543 N/A INTRINSIC
low complexity region 709 790 N/A INTRINSIC
low complexity region 791 808 N/A INTRINSIC
ZnF_C2HC 914 930 3.44e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000127664
SMART Domains Protein: ENSMUSP00000118564
Gene: ENSMUSG00000092329

DomainStartEndE-ValueType
Pfam:Glycos_transf_2 104 287 7.4e-31 PFAM
Pfam:Glyco_transf_7C 261 331 4.9e-8 PFAM
RICIN 406 531 9.28e-27 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134212
Meta Mutation Damage Score 0.0701 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.7%
  • 20x: 92.5%
Validation Efficiency 99% (68/69)
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alg8 A G 7: 97,029,037 (GRCm39) K131E probably benign Het
Ank3 T A 10: 69,823,056 (GRCm39) L575* probably null Het
Aqr T C 2: 113,957,442 (GRCm39) T819A probably damaging Het
Bbs2 A T 8: 94,807,659 (GRCm39) S407T probably benign Het
Bmper T A 9: 23,286,889 (GRCm39) C272S probably benign Het
Btbd9 C T 17: 30,553,192 (GRCm39) probably null Het
C5ar1 A G 7: 15,982,747 (GRCm39) V91A possibly damaging Het
Ccdc138 A G 10: 58,411,579 (GRCm39) H649R possibly damaging Het
Cfap43 A T 19: 47,734,013 (GRCm39) V1451E probably benign Het
Cfap46 T A 7: 139,231,511 (GRCm39) M901L probably damaging Het
Cherp G T 8: 73,215,379 (GRCm39) probably benign Het
D430041D05Rik C T 2: 104,078,630 (GRCm39) V1229I possibly damaging Het
Fat4 A C 3: 39,064,696 (GRCm39) D4884A probably damaging Het
Fcrl5 T C 3: 87,351,480 (GRCm39) F243L probably damaging Het
Garem1 T A 18: 21,262,487 (GRCm39) I776F probably benign Het
Gpr87 T A 3: 59,086,690 (GRCm39) R272* probably null Het
Gsdmc A T 15: 63,651,965 (GRCm39) probably null Het
Hydin T A 8: 111,220,926 (GRCm39) F1441I possibly damaging Het
Ints11 T A 4: 155,957,369 (GRCm39) C63* probably null Het
Kdm4b A T 17: 56,706,732 (GRCm39) T908S probably damaging Het
Lipn A G 19: 34,058,700 (GRCm39) D304G probably damaging Het
Man2a1 T G 17: 64,982,117 (GRCm39) N544K probably benign Het
Mapkapk5 G T 5: 121,676,544 (GRCm39) H66N probably damaging Het
Mog G A 17: 37,323,240 (GRCm39) R233* probably null Het
Mrps24 A T 11: 5,657,481 (GRCm39) probably benign Het
Nom1 T C 5: 29,642,768 (GRCm39) L423P probably damaging Het
Or51b6 T A 7: 103,556,168 (GRCm39) V174E probably benign Het
Pcdha1 T A 18: 37,064,224 (GRCm39) V296E probably damaging Het
Pdcd2 T C 17: 15,746,656 (GRCm39) K168E possibly damaging Het
Pdcd2 G T 17: 15,746,657 (GRCm39) H167Q probably damaging Het
Pla2g12b T A 10: 59,239,780 (GRCm39) V63D probably damaging Het
Pnn C T 12: 59,114,617 (GRCm39) R56* probably null Het
Primpol T A 8: 47,046,615 (GRCm39) E227V possibly damaging Het
Rad54l A T 4: 115,967,584 (GRCm39) W233R probably damaging Het
Rims2 A T 15: 39,300,578 (GRCm39) D103V probably damaging Het
Rttn T C 18: 89,091,819 (GRCm39) S1511P probably benign Het
Septin5 T C 16: 18,442,962 (GRCm39) probably null Het
Simc1 T A 13: 54,673,632 (GRCm39) I660K possibly damaging Het
Slc15a5 A G 6: 138,056,691 (GRCm39) L75P probably damaging Het
Slc9a2 A G 1: 40,721,196 (GRCm39) S55G possibly damaging Het
Slit3 C T 11: 35,591,063 (GRCm39) R1292C probably damaging Het
Slitrk3 A G 3: 72,958,046 (GRCm39) V242A probably benign Het
St14 A T 9: 31,017,853 (GRCm39) probably benign Het
Tnnt2 T C 1: 135,771,600 (GRCm39) probably benign Het
Traf5 G A 1: 191,731,977 (GRCm39) T288I probably benign Het
Trerf1 C T 17: 47,625,263 (GRCm39) noncoding transcript Het
Vegfc A G 8: 54,634,319 (GRCm39) N333D probably benign Het
Vmn1r65 T A 7: 6,011,608 (GRCm39) I209F probably damaging Het
Vps51 A G 19: 6,118,320 (GRCm39) L725P probably damaging Het
Vps8 T C 16: 21,288,871 (GRCm39) I408T possibly damaging Het
Wdr72 T C 9: 74,052,310 (GRCm39) Y114H probably damaging Het
Ybx2 A G 11: 69,831,918 (GRCm39) E164G probably damaging Het
Zfp383 A G 7: 29,615,103 (GRCm39) T453A possibly damaging Het
Zfp84 G T 7: 29,476,378 (GRCm39) G357C probably damaging Het
Zmynd11 G T 13: 9,745,931 (GRCm39) probably benign Het
Other mutations in Zcchc14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02035:Zcchc14 APN 8 122,331,354 (GRCm39) unclassified probably benign
IGL02060:Zcchc14 APN 8 122,330,634 (GRCm39) missense probably damaging 0.98
IGL02455:Zcchc14 APN 8 122,333,009 (GRCm39) unclassified probably benign
IGL03196:Zcchc14 APN 8 122,335,877 (GRCm39) unclassified probably benign
P0033:Zcchc14 UTSW 8 122,336,898 (GRCm39) intron probably benign
R0483:Zcchc14 UTSW 8 122,355,388 (GRCm39) intron probably benign
R0639:Zcchc14 UTSW 8 122,332,188 (GRCm39) nonsense probably null
R1013:Zcchc14 UTSW 8 122,333,664 (GRCm39) unclassified probably benign
R1129:Zcchc14 UTSW 8 122,335,154 (GRCm39) unclassified probably benign
R1546:Zcchc14 UTSW 8 122,331,002 (GRCm39) intron probably benign
R1563:Zcchc14 UTSW 8 122,330,718 (GRCm39) missense probably benign 0.10
R1861:Zcchc14 UTSW 8 122,335,990 (GRCm39) unclassified probably benign
R2200:Zcchc14 UTSW 8 122,332,167 (GRCm39) unclassified probably benign
R2419:Zcchc14 UTSW 8 122,330,675 (GRCm39) missense probably damaging 0.99
R4246:Zcchc14 UTSW 8 122,331,031 (GRCm39) small deletion probably benign
R4249:Zcchc14 UTSW 8 122,331,031 (GRCm39) small deletion probably benign
R4424:Zcchc14 UTSW 8 122,378,680 (GRCm39) intron probably benign
R4470:Zcchc14 UTSW 8 122,378,498 (GRCm39) intron probably benign
R4520:Zcchc14 UTSW 8 122,335,834 (GRCm39) unclassified probably benign
R4681:Zcchc14 UTSW 8 122,335,339 (GRCm39) unclassified probably benign
R5253:Zcchc14 UTSW 8 122,345,433 (GRCm39) intron probably benign
R5314:Zcchc14 UTSW 8 122,335,337 (GRCm39) unclassified probably benign
R5591:Zcchc14 UTSW 8 122,332,187 (GRCm39) unclassified probably benign
R5746:Zcchc14 UTSW 8 122,331,378 (GRCm39) unclassified probably benign
R5781:Zcchc14 UTSW 8 122,331,332 (GRCm39) unclassified probably benign
R5897:Zcchc14 UTSW 8 122,331,899 (GRCm39) unclassified probably benign
R5930:Zcchc14 UTSW 8 122,338,097 (GRCm39) intron probably benign
R6364:Zcchc14 UTSW 8 122,331,598 (GRCm39) unclassified probably benign
R6562:Zcchc14 UTSW 8 122,330,842 (GRCm39) missense probably damaging 0.99
R6579:Zcchc14 UTSW 8 122,331,206 (GRCm39) intron probably benign
R6592:Zcchc14 UTSW 8 122,331,378 (GRCm39) unclassified probably benign
R6699:Zcchc14 UTSW 8 122,335,355 (GRCm39) unclassified probably benign
R7195:Zcchc14 UTSW 8 122,335,200 (GRCm39) missense unknown
R7420:Zcchc14 UTSW 8 122,378,530 (GRCm39) intron probably benign
R7490:Zcchc14 UTSW 8 122,331,756 (GRCm39) missense unknown
R7597:Zcchc14 UTSW 8 122,335,239 (GRCm39) missense unknown
R7758:Zcchc14 UTSW 8 122,331,428 (GRCm39) missense unknown
R7773:Zcchc14 UTSW 8 122,378,514 (GRCm39) missense unknown
R7831:Zcchc14 UTSW 8 122,331,984 (GRCm39) missense not run
R7889:Zcchc14 UTSW 8 122,331,634 (GRCm39) missense unknown
R7919:Zcchc14 UTSW 8 122,330,912 (GRCm39) missense probably damaging 1.00
R9000:Zcchc14 UTSW 8 122,336,880 (GRCm39) missense unknown
R9124:Zcchc14 UTSW 8 122,331,969 (GRCm39) missense unknown
R9667:Zcchc14 UTSW 8 122,331,863 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- CCATCAGGAAGGTTGGTGAC -3'
(R):5'- AGTCAGAAGCCCAGGATCAC -3'

Sequencing Primer
(F):5'- TGGTGACCCAAGCTCTAGC -3'
(R):5'- AGCTCTCCTCAGGAAGTGTG -3'
Posted On 2017-03-31