Incidental Mutation 'R0502:Or51a5'
ID 47199
Institutional Source Beutler Lab
Gene Symbol Or51a5
Ensembl Gene ENSMUSG00000066268
Gene Name olfactory receptor family 51 subfamily A member 5
Synonyms MOR8-7, MOR8-2, GA_x6K02T2PBJ9-5836380-5835439, Olfr586
MMRRC Submission 038697-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.207) question?
Stock # R0502 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 102771036-102771989 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 102771643 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 112 (M112K)
Ref Sequence ENSEMBL: ENSMUSP00000149226 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084811] [ENSMUST00000211075] [ENSMUST00000213281] [ENSMUST00000215304]
AlphaFold Q8VH13
Predicted Effect possibly damaging
Transcript: ENSMUST00000084811
AA Change: M116K

PolyPhen 2 Score 0.936 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000081872
Gene: ENSMUSG00000066268
AA Change: M116K

DomainStartEndE-ValueType
Pfam:7tm_4 37 315 6.1e-111 PFAM
Pfam:7TM_GPCR_Srsx 41 312 1.6e-11 PFAM
Pfam:7tm_1 47 297 1.7e-21 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000211075
AA Change: M112K

PolyPhen 2 Score 0.936 (Sensitivity: 0.80; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000213281
AA Change: M112K

PolyPhen 2 Score 0.936 (Sensitivity: 0.80; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000215304
AA Change: M112K

PolyPhen 2 Score 0.936 (Sensitivity: 0.80; Specificity: 0.94)
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.0%
  • 20x: 94.7%
Validation Efficiency 100% (63/63)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9930111J21Rik1 T C 11: 48,838,322 (GRCm39) H755R possibly damaging Het
Ano1 A G 7: 144,150,952 (GRCm39) L821P probably damaging Het
Apol10b T A 15: 77,476,349 (GRCm39) probably benign Het
Atp2c2 A G 8: 120,461,316 (GRCm39) E279G probably null Het
Ccar2 A G 14: 70,378,431 (GRCm39) S625P probably benign Het
Ccdc110 A G 8: 46,387,761 (GRCm39) probably benign Het
Cep350 A T 1: 155,776,629 (GRCm39) probably null Het
Chd3 A G 11: 69,244,931 (GRCm39) V1203A probably damaging Het
Col24a1 A G 3: 145,251,071 (GRCm39) probably benign Het
Col6a6 A T 9: 105,644,550 (GRCm39) M1246K probably benign Het
Crot A G 5: 9,026,075 (GRCm39) V304A possibly damaging Het
Dapk1 T A 13: 60,878,662 (GRCm39) probably null Het
Dicer1 A T 12: 104,671,319 (GRCm39) S984T probably damaging Het
Dmbt1 G A 7: 130,699,403 (GRCm39) probably null Het
Dnah7b A T 1: 46,258,704 (GRCm39) E1965V probably damaging Het
Dpp4 G T 2: 62,195,332 (GRCm39) N315K probably damaging Het
Eeig2 G A 3: 108,900,001 (GRCm39) R116C probably damaging Het
Fat4 T A 3: 39,057,073 (GRCm39) S4256R probably damaging Het
Fcho1 C T 8: 72,165,204 (GRCm39) A418T probably benign Het
Gpatch4 A G 3: 87,962,672 (GRCm39) D295G probably benign Het
Gpbar1 A T 1: 74,318,551 (GRCm39) I265F probably benign Het
Gria1 T G 11: 57,080,542 (GRCm39) V175G probably damaging Het
Hacl1 A T 14: 31,344,941 (GRCm39) probably benign Het
Hnrnpc A G 14: 52,312,629 (GRCm39) probably benign Het
Hoxa13 CCG CCGCG 6: 52,237,618 (GRCm39) probably null Het
Ifnar1 T A 16: 91,298,639 (GRCm39) C419S probably damaging Het
Irx4 T A 13: 73,414,703 (GRCm39) probably null Het
Itga2 T G 13: 114,982,392 (GRCm39) N1038H probably benign Het
Kif16b C T 2: 142,554,075 (GRCm39) D908N probably benign Het
Lamc1 A G 1: 153,122,678 (GRCm39) probably benign Het
Lrig3 A G 10: 125,844,605 (GRCm39) T690A probably damaging Het
Lrp2 T C 2: 69,341,361 (GRCm39) K940E probably damaging Het
Macf1 A G 4: 123,363,608 (GRCm39) S1775P probably damaging Het
Mrps27 G T 13: 99,546,303 (GRCm39) probably benign Het
Ncam1 A G 9: 49,481,118 (GRCm39) probably benign Het
Nopchap1 A G 10: 83,197,920 (GRCm39) D42G probably damaging Het
Or2z2 T C 11: 58,346,140 (GRCm39) I212V possibly damaging Het
Pbrm1 T G 14: 30,786,777 (GRCm39) D631E probably benign Het
Pdc A T 1: 150,204,165 (GRCm39) probably benign Het
Pkd1 T C 17: 24,793,766 (GRCm39) S1818P probably damaging Het
Ptpru T C 4: 131,520,954 (GRCm39) N784S probably benign Het
Rab35 G A 5: 115,783,723 (GRCm39) R170Q probably benign Het
Rerg A T 6: 137,033,305 (GRCm39) C123* probably null Het
Ros1 A G 10: 52,070,919 (GRCm39) probably benign Het
Siglece A G 7: 43,309,355 (GRCm39) Y68H probably damaging Het
Slc28a2 T A 2: 122,288,762 (GRCm39) probably null Het
Slc4a11 T C 2: 130,530,077 (GRCm39) K234E probably damaging Het
Sqor C T 2: 122,639,970 (GRCm39) P158S probably benign Het
Tcerg1 C T 18: 42,656,021 (GRCm39) P110S unknown Het
Tm6sf2 T A 8: 70,530,591 (GRCm39) Y224N probably damaging Het
Tmem39b A C 4: 129,580,779 (GRCm39) Y238D possibly damaging Het
Ttll10 T C 4: 156,132,005 (GRCm39) probably benign Het
Ubap2l A T 3: 89,916,520 (GRCm39) L898Q probably damaging Het
Uggt1 A T 1: 36,199,027 (GRCm39) V1207E probably damaging Het
Uhrf2 A G 19: 30,070,176 (GRCm39) D775G probably damaging Het
Utp25 A T 1: 192,797,136 (GRCm39) probably benign Het
Vmn1r196 G A 13: 22,477,557 (GRCm39) M65I probably benign Het
Vmn1r87 T G 7: 12,865,583 (GRCm39) T235P probably damaging Het
Vmn2r96 T A 17: 18,804,262 (GRCm39) M504K probably benign Het
Zdbf2 A T 1: 63,344,449 (GRCm39) I943F possibly damaging Het
Zfp78 A G 7: 6,376,157 (GRCm39) D22G probably damaging Het
Zfp827 C T 8: 79,905,706 (GRCm39) probably null Het
Zfyve9 A T 4: 108,576,961 (GRCm39) L40* probably null Het
Other mutations in Or51a5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02708:Or51a5 APN 7 102,771,027 (GRCm39) utr 3 prime probably benign
R0503:Or51a5 UTSW 7 102,771,643 (GRCm39) missense possibly damaging 0.94
R0508:Or51a5 UTSW 7 102,771,193 (GRCm39) missense possibly damaging 0.93
R0882:Or51a5 UTSW 7 102,771,782 (GRCm39) missense probably benign 0.09
R0962:Or51a5 UTSW 7 102,771,217 (GRCm39) missense possibly damaging 0.50
R1112:Or51a5 UTSW 7 102,771,611 (GRCm39) missense probably damaging 1.00
R2226:Or51a5 UTSW 7 102,771,115 (GRCm39) missense probably benign 0.06
R4285:Or51a5 UTSW 7 102,771,867 (GRCm39) nonsense probably null
R5817:Or51a5 UTSW 7 102,771,115 (GRCm39) missense possibly damaging 0.94
R6342:Or51a5 UTSW 7 102,771,563 (GRCm39) missense probably damaging 0.99
R6380:Or51a5 UTSW 7 102,771,136 (GRCm39) missense probably benign 0.02
R6565:Or51a5 UTSW 7 102,771,445 (GRCm39) missense probably damaging 0.99
R7861:Or51a5 UTSW 7 102,771,899 (GRCm39) missense probably benign 0.03
R7921:Or51a5 UTSW 7 102,771,635 (GRCm39) missense probably damaging 0.99
RF020:Or51a5 UTSW 7 102,771,098 (GRCm39) missense probably benign 0.05
Z1177:Or51a5 UTSW 7 102,771,598 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCCTGTGAGAGCCACAAATAAGCC -3'
(R):5'- AATCGGAGCCTTCTCTGCATGAAC -3'

Sequencing Primer
(F):5'- GCAGGCCAGTTTCATGACATC -3'
(R):5'- GCATGAACCCATGTACTATTTCC -3'
Posted On 2013-06-12