|Institutional Source||Beutler Lab|
|Gene Name||glutamate receptor, metabotropic 3|
|Synonyms||Gprc1c, mGlu3, mGluR3, 0710001G23Rik|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R5966 (G1)|
|Chromosomal Location||9485541-9725170 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to T at 9511930 bp|
|Amino Acid Change||Isoleucine to Asparagine at position 640 (I640N)|
|Ref Sequence||ENSEMBL: ENSMUSP00000004076 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000004076]|
|Predicted Effect||probably damaging
AA Change: I640N
PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
AA Change: I640N
|Meta Mutation Damage Score||0.054|
|Coding Region Coverage||
|Validation Efficiency||94% (79/84)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a targeted mutation display normal morphology, clinical chemistry, hematology, and behavior. Mice homozygous for a knock-out allele exhibit altered neuroprotection. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Grm3||
(F):5'- TTGCACCAGTATCAAACCCAGG -3'
(R):5'- CCAGAGGATTACATCAGGTGGG -3'
(F):5'- GCAGATAAAAACCTGAGAACTGG -3'
(R):5'- AATAGGCCCAGTCACTATTGCCTG -3'