Incidental Mutation 'R5949:Ifng'
ID 472334
Institutional Source Beutler Lab
Gene Symbol Ifng
Ensembl Gene ENSMUSG00000055170
Gene Name interferon gamma
Synonyms Ifg, IFN-gamma
MMRRC Submission 044139-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.394) question?
Stock # R5949 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 118276951-118281797 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to C at 118278529 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Isoleucine at position 63 (M63I)
Ref Sequence ENSEMBL: ENSMUSP00000063800 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068592]
AlphaFold P01580
Predicted Effect probably benign
Transcript: ENSMUST00000068592
AA Change: M63I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000063800
Gene: ENSMUSG00000055170
AA Change: M63I

DomainStartEndE-ValueType
Pfam:IFN-gamma 14 150 8.2e-57 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219775
Predicted Effect noncoding transcript
Transcript: ENSMUST00000220309
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.0%
  • 20x: 94.1%
Validation Efficiency 92% (58/63)
MGI Phenotype FUNCTION: This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mice deficient in this gene have increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]
PHENOTYPE: Mutants show immune system abnormalities including decreased inflammatory response in one line, and uncontrolled splenocyte proliferation and susceptibility to intracellular pathogens in another. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m A G 6: 121,655,032 (GRCm39) Y1452C probably damaging Het
Adcy10 A T 1: 165,367,386 (GRCm39) H552L possibly damaging Het
Alms1-ps1 A T 6: 85,698,943 (GRCm39) noncoding transcript Het
Arhgap21 A G 2: 20,853,852 (GRCm39) S1837P probably damaging Het
Atad5 G T 11: 79,986,835 (GRCm39) E641* probably null Het
Atp8b4 T A 2: 126,247,242 (GRCm39) T276S probably benign Het
Bptf A G 11: 107,001,915 (GRCm39) I399T probably damaging Het
Carf A C 1: 60,178,472 (GRCm39) K295T probably damaging Het
Cd209d T A 8: 3,927,949 (GRCm39) N52Y possibly damaging Het
Cdh2 T A 18: 16,734,687 (GRCm39) I779F probably damaging Het
Cdon G A 9: 35,398,247 (GRCm39) R988H probably benign Het
Cfhr4 A T 1: 139,660,887 (GRCm39) H600Q probably damaging Het
Cic C T 7: 24,971,730 (GRCm39) T487M probably damaging Het
Dcps A G 9: 35,036,557 (GRCm39) probably benign Het
Ddx41 A G 13: 55,679,874 (GRCm39) C427R probably damaging Het
Diras2 T C 13: 52,661,747 (GRCm39) K187E possibly damaging Het
Emb A G 13: 117,403,928 (GRCm39) I227V probably benign Het
Fam193a T A 5: 34,597,816 (GRCm39) S538T possibly damaging Het
Fchsd1 C T 18: 38,092,926 (GRCm39) probably benign Het
Galnt6 A T 15: 100,594,431 (GRCm39) N533K probably damaging Het
Grip1 A G 10: 119,886,147 (GRCm39) D499G probably benign Het
Ifih1 T C 2: 62,440,904 (GRCm39) N421D probably benign Het
Ighv1-43 A G 12: 114,910,002 (GRCm39) M1T probably null Het
Kif20a G A 18: 34,765,468 (GRCm39) A822T probably benign Het
Krt87 A T 15: 101,385,476 (GRCm39) C299S probably damaging Het
Lrrn1 G T 6: 107,544,465 (GRCm39) V88L probably benign Het
Mapkapk2 A G 1: 130,985,742 (GRCm39) V173A possibly damaging Het
Mrap2 T G 9: 87,064,658 (GRCm39) V133G probably benign Het
Nlrp1a T A 11: 70,989,815 (GRCm39) D984V probably damaging Het
Or4c125 A G 2: 89,170,229 (GRCm39) V139A probably damaging Het
Or5p59 T C 7: 107,703,404 (GRCm39) L296P probably damaging Het
Pcdh17 T C 14: 84,684,996 (GRCm39) Y488H probably damaging Het
Pih1d2 C T 9: 50,536,284 (GRCm39) P313L probably damaging Het
Ralgapb T C 2: 158,296,179 (GRCm39) C839R probably damaging Het
Rdh5 C A 10: 128,754,136 (GRCm39) R29L probably benign Het
Rfx6 A G 10: 51,554,429 (GRCm39) D90G probably benign Het
Rnf213 A G 11: 119,333,905 (GRCm39) Y3038C probably damaging Het
Sec14l2 A T 11: 4,058,972 (GRCm39) V191D probably damaging Het
Slc3a2 T C 19: 8,690,759 (GRCm39) Y118C probably damaging Het
Sorbs2 T C 8: 46,222,934 (GRCm39) probably null Het
Stab2 A G 10: 86,805,713 (GRCm39) L211P possibly damaging Het
Tbc1d9b T C 11: 50,038,876 (GRCm39) C289R probably benign Het
Tfpi T C 2: 84,275,092 (GRCm39) E172G probably benign Het
Tmem106b T A 6: 13,083,418 (GRCm39) M229K probably damaging Het
Tsfm G A 10: 126,864,244 (GRCm39) T157M probably damaging Het
Tshr G A 12: 91,503,992 (GRCm39) R310H probably damaging Het
Ttn G A 2: 76,608,244 (GRCm39) A17893V possibly damaging Het
Vps39 A G 2: 120,159,149 (GRCm39) Y380H probably benign Het
Xylt2 G A 11: 94,559,309 (GRCm39) R383C probably damaging Het
Zfp719 C T 7: 43,233,541 (GRCm39) probably benign Het
Other mutations in Ifng
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01096:Ifng APN 10 118,281,174 (GRCm39) utr 3 prime probably benign
IGL02351:Ifng APN 10 118,278,410 (GRCm39) missense possibly damaging 0.94
IGL02358:Ifng APN 10 118,278,410 (GRCm39) missense possibly damaging 0.94
IGL02428:Ifng APN 10 118,281,159 (GRCm39) missense probably damaging 0.99
IGL02864:Ifng APN 10 118,278,561 (GRCm39) missense probably damaging 1.00
R0295:Ifng UTSW 10 118,277,154 (GRCm39) missense possibly damaging 0.47
R9315:Ifng UTSW 10 118,278,588 (GRCm39) missense probably damaging 0.99
R9548:Ifng UTSW 10 118,277,128 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GTGACCATTATCAGCACTGAATTC -3'
(R):5'- CGTCTCACCTCAAACTTGGC -3'

Sequencing Primer
(F):5'- TCAGCACTGAATTCAACAAAACTTG -3'
(R):5'- CTTGGCAATACTCATGAATGCATCC -3'
Posted On 2017-03-31