Incidental Mutation 'R5249:Rapgef6'
ID |
472488 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Rapgef6
|
Ensembl Gene |
ENSMUSG00000037533 |
Gene Name |
Rap guanine nucleotide exchange factor (GEF) 6 |
Synonyms |
PDZ-GEF2, C030018K18Rik, Pdzgef2, RA-GEF-2 |
MMRRC Submission |
042820-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R5249 (G1)
|
Quality Score |
55 |
Status
|
Validated
|
Chromosome |
11 |
Chromosomal Location |
54413673-54590111 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 54413943 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Glutamic Acid to Glycine
at position 23
(E23G)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000098766
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000046835]
[ENSMUST00000101206]
[ENSMUST00000102743]
[ENSMUST00000108895]
[ENSMUST00000207429]
|
AlphaFold |
Q5NCJ1 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000046835
|
SMART Domains |
Protein: ENSMUSP00000049026 Gene: ENSMUSG00000035992
Domain | Start | End | E-Value | Type |
Pfam:FNIP_N
|
41 |
159 |
1.7e-29 |
PFAM |
Pfam:FNIP_M
|
316 |
549 |
9.9e-92 |
PFAM |
Pfam:FNIP_C
|
975 |
1161 |
7.6e-73 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000101206
AA Change: E23G
PolyPhen 2
Score 0.190 (Sensitivity: 0.92; Specificity: 0.87)
|
SMART Domains |
Protein: ENSMUSP00000098766 Gene: ENSMUSG00000037533 AA Change: E23G
Domain | Start | End | E-Value | Type |
internal_repeat_1
|
10 |
82 |
1.45e-5 |
PROSPERO |
low complexity region
|
187 |
205 |
N/A |
INTRINSIC |
low complexity region
|
231 |
239 |
N/A |
INTRINSIC |
cNMP
|
280 |
398 |
4.8e-13 |
SMART |
RasGEFN
|
412 |
525 |
4.35e-33 |
SMART |
PDZ
|
540 |
612 |
8.86e-16 |
SMART |
low complexity region
|
694 |
705 |
N/A |
INTRINSIC |
RA
|
749 |
835 |
1.47e-20 |
SMART |
RasGEF
|
856 |
1095 |
5.35e-87 |
SMART |
low complexity region
|
1237 |
1250 |
N/A |
INTRINSIC |
low complexity region
|
1270 |
1293 |
N/A |
INTRINSIC |
low complexity region
|
1345 |
1364 |
N/A |
INTRINSIC |
low complexity region
|
1368 |
1380 |
N/A |
INTRINSIC |
low complexity region
|
1444 |
1452 |
N/A |
INTRINSIC |
low complexity region
|
1555 |
1568 |
N/A |
INTRINSIC |
low complexity region
|
1591 |
1604 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000102743
AA Change: E23G
PolyPhen 2
Score 0.112 (Sensitivity: 0.93; Specificity: 0.86)
|
SMART Domains |
Protein: ENSMUSP00000099804 Gene: ENSMUSG00000037533 AA Change: E23G
Domain | Start | End | E-Value | Type |
internal_repeat_1
|
10 |
82 |
1.42e-5 |
PROSPERO |
low complexity region
|
187 |
205 |
N/A |
INTRINSIC |
low complexity region
|
231 |
239 |
N/A |
INTRINSIC |
cNMP
|
280 |
398 |
4.8e-13 |
SMART |
RasGEFN
|
412 |
525 |
4.35e-33 |
SMART |
PDZ
|
540 |
612 |
8.86e-16 |
SMART |
low complexity region
|
694 |
705 |
N/A |
INTRINSIC |
RA
|
749 |
835 |
1.47e-20 |
SMART |
RasGEF
|
856 |
1138 |
3.88e-84 |
SMART |
low complexity region
|
1229 |
1242 |
N/A |
INTRINSIC |
low complexity region
|
1262 |
1285 |
N/A |
INTRINSIC |
low complexity region
|
1337 |
1356 |
N/A |
INTRINSIC |
low complexity region
|
1360 |
1372 |
N/A |
INTRINSIC |
low complexity region
|
1436 |
1444 |
N/A |
INTRINSIC |
low complexity region
|
1547 |
1560 |
N/A |
INTRINSIC |
low complexity region
|
1583 |
1596 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000108895
AA Change: E23G
PolyPhen 2
Score 0.160 (Sensitivity: 0.92; Specificity: 0.87)
|
SMART Domains |
Protein: ENSMUSP00000104523 Gene: ENSMUSG00000037533 AA Change: E23G
Domain | Start | End | E-Value | Type |
internal_repeat_1
|
10 |
82 |
1.95e-5 |
PROSPERO |
low complexity region
|
187 |
205 |
N/A |
INTRINSIC |
low complexity region
|
231 |
239 |
N/A |
INTRINSIC |
cNMP
|
280 |
398 |
4.8e-13 |
SMART |
RasGEFN
|
412 |
526 |
1.03e-25 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000139360
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000155132
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000207429
AA Change: E23G
PolyPhen 2
Score 0.041 (Sensitivity: 0.94; Specificity: 0.83)
|
Meta Mutation Damage Score |
0.0758 |
Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 97.1%
- 20x: 94.8%
|
Validation Efficiency |
98% (93/95) |
MGI Phenotype |
PHENOTYPE: Mice homozygous for a null allele exhibit an inlarged spleen, increased IgE and IgG levels and altered cytokine production. [provided by MGI curators]
|
Allele List at MGI |
All alleles(16) : Targeted, knock-out(1) Targeted, other(2) Gene trapped(13) |
Other mutations in this stock |
Total: 89 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
A4gnt |
A |
G |
9: 99,502,284 (GRCm39) |
H148R |
probably damaging |
Het |
Acrbp |
A |
G |
6: 125,037,885 (GRCm39) |
D394G |
probably damaging |
Het |
Adam18 |
T |
C |
8: 25,115,868 (GRCm39) |
T609A |
probably benign |
Het |
Adam25 |
T |
A |
8: 41,208,991 (GRCm39) |
N752K |
probably benign |
Het |
Ano6 |
A |
C |
15: 95,811,469 (GRCm39) |
S176R |
probably benign |
Het |
Ano7 |
T |
C |
1: 93,302,918 (GRCm39) |
S19P |
probably benign |
Het |
Ap1b1 |
A |
G |
11: 4,976,364 (GRCm39) |
E437G |
probably damaging |
Het |
Arfgap2 |
T |
A |
2: 91,095,982 (GRCm39) |
C46* |
probably null |
Het |
Arhgef26 |
T |
A |
3: 62,247,981 (GRCm39) |
L355Q |
probably damaging |
Het |
B4galnt4 |
C |
T |
7: 140,644,983 (GRCm39) |
T219I |
probably damaging |
Het |
Bap1 |
C |
T |
14: 30,979,243 (GRCm39) |
|
probably benign |
Het |
Catip |
T |
G |
1: 74,401,954 (GRCm39) |
L43R |
probably damaging |
Het |
Ccdc177 |
G |
A |
12: 80,805,282 (GRCm39) |
R331C |
unknown |
Het |
Cep85l |
T |
C |
10: 53,195,690 (GRCm39) |
|
probably null |
Het |
Cfap206 |
T |
A |
4: 34,714,502 (GRCm39) |
Q398L |
probably benign |
Het |
Clec18a |
A |
G |
8: 111,800,368 (GRCm39) |
C352R |
probably damaging |
Het |
Clic6 |
A |
T |
16: 92,336,339 (GRCm39) |
Y549F |
probably damaging |
Het |
Cpne9 |
C |
T |
6: 113,270,034 (GRCm39) |
|
probably benign |
Het |
Cyb5r3 |
A |
C |
15: 83,042,836 (GRCm39) |
|
probably benign |
Het |
Dnah6 |
C |
T |
6: 73,090,471 (GRCm39) |
R2293K |
probably damaging |
Het |
Dnmbp |
C |
A |
19: 43,890,879 (GRCm39) |
R296L |
probably damaging |
Het |
Dtwd1 |
C |
A |
2: 125,996,694 (GRCm39) |
Q60K |
probably benign |
Het |
Esyt1 |
C |
A |
10: 128,352,443 (GRCm39) |
V723L |
probably benign |
Het |
Fbxo42 |
T |
C |
4: 140,926,335 (GRCm39) |
L339P |
probably damaging |
Het |
Furin |
A |
T |
7: 80,043,169 (GRCm39) |
N347K |
probably damaging |
Het |
Fzd7 |
T |
C |
1: 59,522,522 (GRCm39) |
M135T |
probably damaging |
Het |
Garin1b |
A |
G |
6: 29,323,896 (GRCm39) |
D207G |
probably damaging |
Het |
Hlf |
A |
G |
11: 90,278,632 (GRCm39) |
M144T |
probably benign |
Het |
Hyal5 |
C |
T |
6: 24,876,648 (GRCm39) |
Q174* |
probably null |
Het |
Kcnb1 |
T |
A |
2: 166,947,103 (GRCm39) |
M582L |
possibly damaging |
Het |
Kdm5d |
T |
C |
Y: 916,692 (GRCm39) |
Y391H |
probably damaging |
Het |
Khdc4 |
T |
A |
3: 88,604,032 (GRCm39) |
I283N |
probably damaging |
Het |
Kif21b |
C |
T |
1: 136,096,966 (GRCm39) |
T1297M |
probably damaging |
Het |
Krt8 |
T |
G |
15: 101,906,875 (GRCm39) |
N317T |
possibly damaging |
Het |
Lctl |
G |
T |
9: 64,045,196 (GRCm39) |
V372L |
probably benign |
Het |
Lig1 |
C |
T |
7: 13,042,432 (GRCm39) |
H822Y |
possibly damaging |
Het |
Lrrc4b |
A |
G |
7: 44,111,988 (GRCm39) |
D620G |
possibly damaging |
Het |
Mboat4 |
C |
T |
8: 34,582,275 (GRCm39) |
H10Y |
probably benign |
Het |
Med1 |
A |
T |
11: 98,048,066 (GRCm39) |
M910K |
probably benign |
Het |
Mia2 |
A |
T |
12: 59,154,911 (GRCm39) |
D209V |
probably damaging |
Het |
Mpp4 |
C |
T |
1: 59,184,017 (GRCm39) |
|
probably benign |
Het |
Mrgprb1 |
A |
T |
7: 48,097,225 (GRCm39) |
V229E |
possibly damaging |
Het |
Mtor |
T |
A |
4: 148,548,189 (GRCm39) |
C485S |
probably damaging |
Het |
Mx1 |
T |
C |
16: 97,258,628 (GRCm39) |
D23G |
probably damaging |
Het |
Myrfl |
T |
C |
10: 116,619,138 (GRCm39) |
D740G |
probably benign |
Het |
Myt1l |
G |
A |
12: 29,882,331 (GRCm39) |
G509R |
unknown |
Het |
Nav2 |
G |
A |
7: 49,185,661 (GRCm39) |
V874I |
probably damaging |
Het |
Ntrk3 |
A |
T |
7: 78,110,914 (GRCm39) |
N262K |
possibly damaging |
Het |
Opa1 |
A |
T |
16: 29,437,077 (GRCm39) |
D699V |
probably damaging |
Het |
Or10u4 |
C |
T |
10: 129,802,078 (GRCm39) |
A164T |
probably benign |
Het |
Or8b51 |
A |
G |
9: 38,569,374 (GRCm39) |
C105R |
possibly damaging |
Het |
Otud7a |
A |
G |
7: 63,407,181 (GRCm39) |
N495D |
possibly damaging |
Het |
Pcsk9 |
T |
C |
4: 106,320,950 (GRCm39) |
D53G |
probably benign |
Het |
Pdcd5 |
A |
G |
7: 35,346,421 (GRCm39) |
|
probably benign |
Het |
Phf21a |
C |
T |
2: 92,058,822 (GRCm39) |
P28L |
probably damaging |
Het |
Pitpnm1 |
T |
A |
19: 4,158,130 (GRCm39) |
D573E |
probably damaging |
Het |
Ppp1r35 |
C |
T |
5: 137,777,406 (GRCm39) |
|
probably benign |
Het |
Ptprq |
T |
C |
10: 107,535,496 (GRCm39) |
Q423R |
probably damaging |
Het |
Pum1 |
A |
T |
4: 130,490,125 (GRCm39) |
Y699F |
probably benign |
Het |
Rabgef1 |
A |
G |
5: 130,241,841 (GRCm39) |
D415G |
probably benign |
Het |
Rpia |
G |
T |
6: 70,760,563 (GRCm39) |
C121* |
probably null |
Het |
Sanbr |
A |
G |
11: 23,525,483 (GRCm39) |
*719Q |
probably null |
Het |
Serpinb13 |
T |
A |
1: 106,926,427 (GRCm39) |
W201R |
probably damaging |
Het |
Sh3bp4 |
T |
C |
1: 89,065,456 (GRCm39) |
C17R |
probably damaging |
Het |
Sh3d21 |
A |
G |
4: 126,055,858 (GRCm39) |
|
probably benign |
Het |
Slamf6 |
A |
C |
1: 171,764,249 (GRCm39) |
N214T |
probably damaging |
Het |
Slc7a2 |
T |
C |
8: 41,361,130 (GRCm39) |
Y365H |
possibly damaging |
Het |
Sox18 |
T |
C |
2: 181,312,971 (GRCm39) |
|
probably null |
Het |
Spink7 |
A |
T |
18: 62,725,507 (GRCm39) |
F79I |
possibly damaging |
Het |
Srpk3 |
C |
T |
X: 72,818,555 (GRCm39) |
R82* |
probably null |
Het |
Sspo |
A |
T |
6: 48,470,244 (GRCm39) |
H4561L |
probably damaging |
Het |
Tcaf1 |
T |
C |
6: 42,653,793 (GRCm39) |
K700R |
probably benign |
Het |
Tcf25 |
G |
T |
8: 124,115,372 (GRCm39) |
R203L |
probably damaging |
Het |
Tcp11 |
T |
C |
17: 28,290,757 (GRCm39) |
I201V |
possibly damaging |
Het |
Tex2 |
T |
C |
11: 106,437,615 (GRCm39) |
D685G |
unknown |
Het |
Themis |
G |
T |
10: 28,637,195 (GRCm39) |
E100* |
probably null |
Het |
Tmem52b |
G |
A |
6: 129,491,221 (GRCm39) |
|
probably null |
Het |
Tnr |
C |
T |
1: 159,512,226 (GRCm39) |
|
probably benign |
Het |
Tox3 |
T |
C |
8: 90,975,444 (GRCm39) |
I396V |
probably benign |
Het |
Tpm2 |
T |
A |
4: 43,514,828 (GRCm39) |
E269V |
probably benign |
Het |
Tulp1 |
C |
T |
17: 28,581,651 (GRCm39) |
|
probably benign |
Het |
Tymp |
GC |
GCC |
15: 89,258,567 (GRCm39) |
|
probably null |
Het |
Ube2j2 |
A |
C |
4: 156,033,515 (GRCm39) |
K30Q |
possibly damaging |
Het |
Usp19 |
T |
A |
9: 108,369,807 (GRCm39) |
M1K |
probably null |
Het |
Vmn2r52 |
C |
A |
7: 9,910,197 (GRCm39) |
R6L |
probably benign |
Het |
Zbed4 |
G |
A |
15: 88,665,290 (GRCm39) |
V453M |
probably benign |
Het |
Zfp319 |
T |
C |
8: 96,055,099 (GRCm39) |
E368G |
probably benign |
Het |
Zfp366 |
A |
C |
13: 99,366,117 (GRCm39) |
E426A |
probably damaging |
Het |
Zfp687 |
A |
T |
3: 94,916,777 (GRCm39) |
I783N |
probably damaging |
Het |
|
Other mutations in Rapgef6 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00436:Rapgef6
|
APN |
11 |
54,570,091 (GRCm39) |
missense |
probably benign |
0.00 |
IGL00507:Rapgef6
|
APN |
11 |
54,554,935 (GRCm39) |
nonsense |
probably null |
|
IGL00809:Rapgef6
|
APN |
11 |
54,540,126 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL00843:Rapgef6
|
APN |
11 |
54,582,099 (GRCm39) |
missense |
probably benign |
0.03 |
IGL00899:Rapgef6
|
APN |
11 |
54,510,844 (GRCm39) |
nonsense |
probably null |
|
IGL01372:Rapgef6
|
APN |
11 |
54,559,437 (GRCm39) |
splice site |
probably benign |
|
IGL01604:Rapgef6
|
APN |
11 |
54,585,389 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL01935:Rapgef6
|
APN |
11 |
54,501,668 (GRCm39) |
missense |
possibly damaging |
0.78 |
IGL01991:Rapgef6
|
APN |
11 |
54,443,695 (GRCm39) |
missense |
probably benign |
0.37 |
IGL02243:Rapgef6
|
APN |
11 |
54,567,226 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02407:Rapgef6
|
APN |
11 |
54,567,181 (GRCm39) |
missense |
possibly damaging |
0.91 |
IGL02676:Rapgef6
|
APN |
11 |
54,540,172 (GRCm39) |
unclassified |
probably benign |
|
IGL02934:Rapgef6
|
APN |
11 |
54,516,690 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03076:Rapgef6
|
APN |
11 |
54,516,793 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03110:Rapgef6
|
APN |
11 |
54,586,915 (GRCm39) |
missense |
probably damaging |
0.97 |
IGL03256:Rapgef6
|
APN |
11 |
54,548,255 (GRCm39) |
missense |
probably damaging |
1.00 |
shocker
|
UTSW |
11 |
54,510,842 (GRCm39) |
missense |
probably damaging |
1.00 |
D4216:Rapgef6
|
UTSW |
11 |
54,559,572 (GRCm39) |
splice site |
probably benign |
|
PIT4305001:Rapgef6
|
UTSW |
11 |
54,570,203 (GRCm39) |
missense |
probably damaging |
1.00 |
PIT4366001:Rapgef6
|
UTSW |
11 |
54,582,446 (GRCm39) |
missense |
probably damaging |
0.98 |
R0047:Rapgef6
|
UTSW |
11 |
54,437,204 (GRCm39) |
missense |
possibly damaging |
0.65 |
R0047:Rapgef6
|
UTSW |
11 |
54,437,204 (GRCm39) |
missense |
possibly damaging |
0.65 |
R0125:Rapgef6
|
UTSW |
11 |
54,516,701 (GRCm39) |
nonsense |
probably null |
|
R0189:Rapgef6
|
UTSW |
11 |
54,582,075 (GRCm39) |
missense |
probably benign |
|
R0201:Rapgef6
|
UTSW |
11 |
54,510,767 (GRCm39) |
missense |
probably damaging |
1.00 |
R0505:Rapgef6
|
UTSW |
11 |
54,516,789 (GRCm39) |
missense |
probably benign |
0.00 |
R0524:Rapgef6
|
UTSW |
11 |
54,581,110 (GRCm39) |
missense |
probably benign |
0.32 |
R0853:Rapgef6
|
UTSW |
11 |
54,559,503 (GRCm39) |
missense |
probably damaging |
1.00 |
R1203:Rapgef6
|
UTSW |
11 |
54,582,525 (GRCm39) |
missense |
probably benign |
0.09 |
R1440:Rapgef6
|
UTSW |
11 |
54,517,534 (GRCm39) |
missense |
probably damaging |
1.00 |
R1453:Rapgef6
|
UTSW |
11 |
54,530,553 (GRCm39) |
splice site |
probably null |
|
R1530:Rapgef6
|
UTSW |
11 |
54,552,009 (GRCm39) |
missense |
probably damaging |
1.00 |
R1593:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
R1620:Rapgef6
|
UTSW |
11 |
54,517,420 (GRCm39) |
missense |
possibly damaging |
0.88 |
R1628:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
R1629:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
R1630:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
R1634:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
R1640:Rapgef6
|
UTSW |
11 |
54,548,231 (GRCm39) |
missense |
probably damaging |
1.00 |
R1686:Rapgef6
|
UTSW |
11 |
54,582,458 (GRCm39) |
missense |
possibly damaging |
0.81 |
R1722:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
R1743:Rapgef6
|
UTSW |
11 |
54,567,110 (GRCm39) |
missense |
probably damaging |
1.00 |
R1816:Rapgef6
|
UTSW |
11 |
54,585,314 (GRCm39) |
missense |
probably benign |
|
R1851:Rapgef6
|
UTSW |
11 |
54,533,637 (GRCm39) |
missense |
probably benign |
0.01 |
R1852:Rapgef6
|
UTSW |
11 |
54,533,637 (GRCm39) |
missense |
probably benign |
0.01 |
R1868:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
R1888:Rapgef6
|
UTSW |
11 |
54,551,654 (GRCm39) |
missense |
probably damaging |
1.00 |
R1888:Rapgef6
|
UTSW |
11 |
54,551,654 (GRCm39) |
missense |
probably damaging |
1.00 |
R1942:Rapgef6
|
UTSW |
11 |
54,548,089 (GRCm39) |
missense |
possibly damaging |
0.95 |
R1943:Rapgef6
|
UTSW |
11 |
54,548,089 (GRCm39) |
missense |
possibly damaging |
0.95 |
R2031:Rapgef6
|
UTSW |
11 |
54,443,684 (GRCm39) |
missense |
probably benign |
0.30 |
R2087:Rapgef6
|
UTSW |
11 |
54,522,075 (GRCm39) |
missense |
probably damaging |
1.00 |
R2106:Rapgef6
|
UTSW |
11 |
54,559,512 (GRCm39) |
missense |
probably benign |
0.17 |
R2362:Rapgef6
|
UTSW |
11 |
54,585,098 (GRCm39) |
missense |
probably damaging |
1.00 |
R2484:Rapgef6
|
UTSW |
11 |
54,533,582 (GRCm39) |
missense |
possibly damaging |
0.48 |
R2566:Rapgef6
|
UTSW |
11 |
54,578,537 (GRCm39) |
missense |
possibly damaging |
0.66 |
R2872:Rapgef6
|
UTSW |
11 |
54,552,001 (GRCm39) |
missense |
probably damaging |
1.00 |
R2872:Rapgef6
|
UTSW |
11 |
54,552,001 (GRCm39) |
missense |
probably damaging |
1.00 |
R3744:Rapgef6
|
UTSW |
11 |
54,516,760 (GRCm39) |
missense |
probably benign |
0.40 |
R3848:Rapgef6
|
UTSW |
11 |
54,582,134 (GRCm39) |
missense |
probably damaging |
0.97 |
R4823:Rapgef6
|
UTSW |
11 |
54,585,326 (GRCm39) |
missense |
probably benign |
0.08 |
R4859:Rapgef6
|
UTSW |
11 |
54,526,989 (GRCm39) |
missense |
probably benign |
|
R4906:Rapgef6
|
UTSW |
11 |
54,443,662 (GRCm39) |
missense |
probably damaging |
1.00 |
R4911:Rapgef6
|
UTSW |
11 |
54,513,143 (GRCm39) |
missense |
probably damaging |
0.97 |
R4937:Rapgef6
|
UTSW |
11 |
54,548,143 (GRCm39) |
missense |
probably damaging |
1.00 |
R5033:Rapgef6
|
UTSW |
11 |
54,582,207 (GRCm39) |
missense |
possibly damaging |
0.92 |
R5304:Rapgef6
|
UTSW |
11 |
54,548,200 (GRCm39) |
missense |
probably benign |
0.01 |
R5656:Rapgef6
|
UTSW |
11 |
54,526,962 (GRCm39) |
missense |
possibly damaging |
0.95 |
R5701:Rapgef6
|
UTSW |
11 |
54,567,220 (GRCm39) |
missense |
possibly damaging |
0.76 |
R5758:Rapgef6
|
UTSW |
11 |
54,559,470 (GRCm39) |
missense |
probably damaging |
1.00 |
R5973:Rapgef6
|
UTSW |
11 |
54,530,609 (GRCm39) |
missense |
probably damaging |
1.00 |
R6177:Rapgef6
|
UTSW |
11 |
54,510,842 (GRCm39) |
missense |
probably damaging |
1.00 |
R6268:Rapgef6
|
UTSW |
11 |
54,540,073 (GRCm39) |
missense |
probably damaging |
1.00 |
R6287:Rapgef6
|
UTSW |
11 |
54,517,164 (GRCm39) |
splice site |
probably null |
|
R6293:Rapgef6
|
UTSW |
11 |
54,525,607 (GRCm39) |
missense |
probably damaging |
1.00 |
R6471:Rapgef6
|
UTSW |
11 |
54,582,563 (GRCm39) |
missense |
probably damaging |
0.99 |
R6863:Rapgef6
|
UTSW |
11 |
54,437,206 (GRCm39) |
missense |
probably benign |
0.00 |
R6950:Rapgef6
|
UTSW |
11 |
54,567,206 (GRCm39) |
missense |
probably benign |
0.09 |
R7144:Rapgef6
|
UTSW |
11 |
54,548,191 (GRCm39) |
missense |
possibly damaging |
0.78 |
R7171:Rapgef6
|
UTSW |
11 |
54,567,189 (GRCm39) |
missense |
possibly damaging |
0.94 |
R7199:Rapgef6
|
UTSW |
11 |
54,437,252 (GRCm39) |
missense |
probably benign |
0.00 |
R7291:Rapgef6
|
UTSW |
11 |
54,582,065 (GRCm39) |
missense |
probably benign |
0.05 |
R7436:Rapgef6
|
UTSW |
11 |
54,501,747 (GRCm39) |
critical splice donor site |
probably null |
|
R7498:Rapgef6
|
UTSW |
11 |
54,510,830 (GRCm39) |
missense |
probably damaging |
1.00 |
R7506:Rapgef6
|
UTSW |
11 |
54,526,997 (GRCm39) |
missense |
probably benign |
0.00 |
R7527:Rapgef6
|
UTSW |
11 |
54,525,787 (GRCm39) |
missense |
unknown |
|
R7646:Rapgef6
|
UTSW |
11 |
54,516,780 (GRCm39) |
missense |
probably benign |
0.00 |
R7655:Rapgef6
|
UTSW |
11 |
54,585,279 (GRCm39) |
missense |
probably benign |
0.10 |
R7656:Rapgef6
|
UTSW |
11 |
54,585,279 (GRCm39) |
missense |
probably benign |
0.10 |
R7687:Rapgef6
|
UTSW |
11 |
54,551,901 (GRCm39) |
missense |
possibly damaging |
0.93 |
R7768:Rapgef6
|
UTSW |
11 |
54,517,414 (GRCm39) |
missense |
probably damaging |
1.00 |
R7788:Rapgef6
|
UTSW |
11 |
54,585,225 (GRCm39) |
missense |
probably damaging |
1.00 |
R7890:Rapgef6
|
UTSW |
11 |
54,517,549 (GRCm39) |
missense |
probably damaging |
1.00 |
R8113:Rapgef6
|
UTSW |
11 |
54,516,784 (GRCm39) |
missense |
probably benign |
0.03 |
R8337:Rapgef6
|
UTSW |
11 |
54,522,127 (GRCm39) |
nonsense |
probably null |
|
R8393:Rapgef6
|
UTSW |
11 |
54,578,487 (GRCm39) |
missense |
probably benign |
|
R8465:Rapgef6
|
UTSW |
11 |
54,582,308 (GRCm39) |
missense |
probably benign |
0.00 |
R8492:Rapgef6
|
UTSW |
11 |
54,581,063 (GRCm39) |
missense |
probably damaging |
0.99 |
R8791:Rapgef6
|
UTSW |
11 |
54,459,295 (GRCm39) |
missense |
probably benign |
0.15 |
R8866:Rapgef6
|
UTSW |
11 |
54,443,700 (GRCm39) |
critical splice donor site |
probably null |
|
R8917:Rapgef6
|
UTSW |
11 |
54,582,392 (GRCm39) |
nonsense |
probably null |
|
R8921:Rapgef6
|
UTSW |
11 |
54,570,065 (GRCm39) |
missense |
probably benign |
0.09 |
R9031:Rapgef6
|
UTSW |
11 |
54,578,667 (GRCm39) |
missense |
probably benign |
0.00 |
R9093:Rapgef6
|
UTSW |
11 |
54,487,912 (GRCm39) |
nonsense |
probably null |
|
R9354:Rapgef6
|
UTSW |
11 |
54,510,749 (GRCm39) |
missense |
possibly damaging |
0.66 |
R9514:Rapgef6
|
UTSW |
11 |
54,443,684 (GRCm39) |
missense |
probably benign |
0.14 |
R9516:Rapgef6
|
UTSW |
11 |
54,582,169 (GRCm39) |
missense |
probably damaging |
1.00 |
R9739:Rapgef6
|
UTSW |
11 |
54,513,189 (GRCm39) |
missense |
probably benign |
0.03 |
R9789:Rapgef6
|
UTSW |
11 |
54,540,097 (GRCm39) |
missense |
probably benign |
0.03 |
|
Predicted Primers |
PCR Primer
(F):5'- TTGAGTTTGGACCCTGCGAC -3'
(R):5'- ACTGGCTATGGTATGAACTGTC -3'
Sequencing Primer
(F):5'- GTTTGGACCCTGCGACAGTTC -3'
(R):5'- GCTATGGTATGAACTGTCTCTTACAC -3'
|
Posted On |
2017-04-14 |