Incidental Mutation 'R0504:Ptpn4'
ID 47284
Institutional Source Beutler Lab
Gene Symbol Ptpn4
Ensembl Gene ENSMUSG00000026384
Gene Name protein tyrosine phosphatase, non-receptor type 4
Synonyms testis-enriched phosphatase, protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte), hPTP-MEG, TEP, PTPMEG, TEP/mPTPMEG
MMRRC Submission 038699-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.291) question?
Stock # R0504 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 119580197-119765281 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 119693645 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 126 (Y126H)
Ref Sequence ENSEMBL: ENSMUSP00000127713 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000064091] [ENSMUST00000163179] [ENSMUST00000163435] [ENSMUST00000166422] [ENSMUST00000168303]
AlphaFold Q9WU22
Predicted Effect probably damaging
Transcript: ENSMUST00000064091
AA Change: Y126H

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000067614
Gene: ENSMUSG00000026384
AA Change: Y126H

DomainStartEndE-ValueType
B41 25 222 7.33e-80 SMART
FERM_C 226 316 6.48e-34 SMART
FA 322 368 3.28e-12 SMART
PDZ 526 605 2.47e-14 SMART
PTPc 654 913 1.38e-120 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000163179
Predicted Effect probably damaging
Transcript: ENSMUST00000163435
AA Change: Y126H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000127713
Gene: ENSMUSG00000026384
AA Change: Y126H

DomainStartEndE-ValueType
B41 25 222 7.33e-80 SMART
FERM_C 226 316 6.48e-34 SMART
FA 322 368 3.28e-12 SMART
PDB:3NFL|D 499 552 4e-30 PDB
Predicted Effect probably benign
Transcript: ENSMUST00000166422
AA Change: V85A

PolyPhen 2 Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000129180
Gene: ENSMUSG00000026384
AA Change: V85A

DomainStartEndE-ValueType
Pfam:FERM_N 33 85 1.1e-13 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000168303
SMART Domains Protein: ENSMUSP00000129521
Gene: ENSMUSG00000026384

DomainStartEndE-ValueType
Pfam:FERM_N 11 75 2.7e-9 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000168429
SMART Domains Protein: ENSMUSP00000130299
Gene: ENSMUSG00000026384

DomainStartEndE-ValueType
B41 13 142 9.36e-14 SMART
Meta Mutation Damage Score 0.4882 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.3%
  • 20x: 92.6%
Validation Efficiency 99% (145/147)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele exhibit impaired coordination, abnormal eye blink conditioning behavior, and reduced long term depression. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 145 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921539E11Rik A G 4: 103,128,057 (GRCm39) probably benign Het
Adamts6 T C 13: 104,563,438 (GRCm39) probably benign Het
Adamts9 T A 6: 92,889,626 (GRCm39) Y316F probably damaging Het
Agl A T 3: 116,580,433 (GRCm39) F374I probably damaging Het
Akr1c19 A G 13: 4,286,250 (GRCm39) T83A possibly damaging Het
Ankrd36 T A 11: 5,579,274 (GRCm39) S179R probably damaging Het
Appbp2 A G 11: 85,082,513 (GRCm39) S573P probably benign Het
Arid4a T A 12: 71,093,988 (GRCm39) F254I probably damaging Het
Bin3 T C 14: 70,361,336 (GRCm39) probably null Het
Bmi1 T C 2: 18,688,883 (GRCm39) probably null Het
Bmper G T 9: 23,317,983 (GRCm39) C534F probably damaging Het
Bora T A 14: 99,299,059 (GRCm39) C205* probably null Het
Btnl2 A G 17: 34,577,091 (GRCm39) E82G probably benign Het
Ccdc8 A T 7: 16,729,939 (GRCm39) D476V unknown Het
Ccr3 C A 9: 123,829,478 (GRCm39) T271K possibly damaging Het
Cd276 A G 9: 58,447,961 (GRCm39) L23P possibly damaging Het
Cd3e T C 9: 44,913,552 (GRCm39) Q61R probably benign Het
Cep97 A G 16: 55,726,142 (GRCm39) S582P probably benign Het
Chml A T 1: 175,514,748 (GRCm39) M391K probably damaging Het
Chst1 A G 2: 92,444,169 (GRCm39) N214D probably benign Het
Chuk T C 19: 44,070,377 (GRCm39) probably benign Het
Col12a1 G A 9: 79,588,750 (GRCm39) H1122Y possibly damaging Het
Cpne6 A G 14: 55,752,059 (GRCm39) K272R probably damaging Het
Cpsf2 T A 12: 101,956,262 (GRCm39) L355Q probably damaging Het
Cyp2c29 T A 19: 39,298,224 (GRCm39) D256E probably benign Het
Daglb G A 5: 143,479,952 (GRCm39) V420I probably benign Het
Ddx42 G T 11: 106,138,675 (GRCm39) G825C probably benign Het
Dis3 T C 14: 99,318,826 (GRCm39) probably benign Het
Dkk4 C T 8: 23,115,359 (GRCm39) R70C probably damaging Het
Dock6 G T 9: 21,713,732 (GRCm39) Q1933K probably damaging Het
Dpep2 T G 8: 106,716,620 (GRCm39) Q186H probably benign Het
Dzip3 A C 16: 48,780,006 (GRCm39) probably benign Het
Egflam T A 15: 7,252,239 (GRCm39) I853F probably damaging Het
Fastkd5 A G 2: 130,457,837 (GRCm39) I251T probably benign Het
Fbn2 T A 18: 58,172,532 (GRCm39) D2091V possibly damaging Het
Fem1al T C 11: 29,774,990 (GRCm39) I156V probably damaging Het
Fer1l4 C A 2: 155,894,115 (GRCm39) V63L probably benign Het
Frem1 T A 4: 82,830,874 (GRCm39) D2062V probably benign Het
Galnt6 A C 15: 100,594,538 (GRCm39) probably benign Het
Get3 A C 8: 85,745,236 (GRCm39) V277G probably damaging Het
Gm10972 A T 3: 94,550,440 (GRCm39) probably benign Het
Gm4846 G A 1: 166,319,114 (GRCm39) T208I probably benign Het
Gorab A G 1: 163,214,174 (GRCm39) L252P probably damaging Het
Gtsf2 A G 15: 103,352,988 (GRCm39) C63R probably damaging Het
Hal T C 10: 93,325,036 (GRCm39) V15A probably damaging Het
Hmcn1 A T 1: 150,752,170 (GRCm39) probably benign Het
Hormad2 A T 11: 4,358,833 (GRCm39) H191Q possibly damaging Het
Hspa2 A T 12: 76,451,990 (GRCm39) D228V probably damaging Het
Igfn1 A T 1: 135,896,267 (GRCm39) M1433K probably benign Het
Il18 A G 9: 50,486,628 (GRCm39) D19G probably damaging Het
Il1rl2 G A 1: 40,368,216 (GRCm39) V129I probably benign Het
Inpp5b C A 4: 124,676,201 (GRCm39) Y352* probably null Het
Insrr A T 3: 87,720,463 (GRCm39) M1034L possibly damaging Het
Jmjd1c T C 10: 67,061,534 (GRCm39) S1296P probably damaging Het
Kdm5b G T 1: 134,548,761 (GRCm39) probably null Het
Krba1 C T 6: 48,393,188 (GRCm39) T998I probably benign Het
L3mbtl4 A G 17: 69,084,907 (GRCm39) N606S probably benign Het
Lonrf1 T A 8: 36,698,313 (GRCm39) N395I possibly damaging Het
Lpp A G 16: 24,790,720 (GRCm39) D393G probably damaging Het
Lrrc17 A G 5: 21,765,528 (GRCm39) I3M probably benign Het
Lrrtm4 A T 6: 79,999,029 (GRCm39) Q147L probably damaging Het
Map1a A G 2: 121,133,422 (GRCm39) M1413V probably benign Het
Mapk8ip2 A G 15: 89,340,861 (GRCm39) E102G possibly damaging Het
Marf1 C T 16: 13,960,398 (GRCm39) A549T probably damaging Het
Mdn1 T C 4: 32,698,916 (GRCm39) probably benign Het
Mfng A C 15: 78,641,514 (GRCm39) H294Q probably benign Het
Mical2 T A 7: 111,870,524 (GRCm39) N4K probably benign Het
Mov10l1 T A 15: 88,883,042 (GRCm39) V384E probably damaging Het
Myo18b A G 5: 113,021,442 (GRCm39) probably benign Het
Nlrp1b T G 11: 71,073,241 (GRCm39) I201L probably damaging Het
Nos2 C T 11: 78,830,903 (GRCm39) P249L probably damaging Het
Notch4 A G 17: 34,794,065 (GRCm39) T681A probably damaging Het
Nr1i3 C T 1: 171,044,805 (GRCm39) probably benign Het
Obscn A G 11: 58,899,333 (GRCm39) probably null Het
Onecut2 A T 18: 64,473,820 (GRCm39) I124F possibly damaging Het
Or10a49 C T 7: 108,468,057 (GRCm39) M101I possibly damaging Het
Or2a14 A T 6: 43,130,395 (GRCm39) H52L probably benign Het
Or2ag1 T A 7: 106,313,908 (GRCm39) probably benign Het
Or2f2 C T 6: 42,767,530 (GRCm39) R186* probably null Het
Or2t47 C A 11: 58,442,462 (GRCm39) C201F probably damaging Het
Or4a75 A T 2: 89,448,438 (GRCm39) Y33N probably damaging Het
Or4c123 C T 2: 89,127,083 (GRCm39) C177Y probably damaging Het
Or52u1 C T 7: 104,237,682 (GRCm39) R224* probably null Het
Or5m12 T A 2: 85,735,030 (GRCm39) M123L possibly damaging Het
Or8b35 A G 9: 37,904,438 (GRCm39) T217A probably benign Het
Otol1 G A 3: 69,934,937 (GRCm39) G310R probably damaging Het
Oxct2b T A 4: 123,010,633 (GRCm39) S184R possibly damaging Het
Oxct2b ACTG A 4: 123,010,705 (GRCm39) probably benign Het
P2rx6 A G 16: 17,385,291 (GRCm39) probably benign Het
Pde4a A G 9: 21,115,699 (GRCm39) N411S probably damaging Het
Phkb A T 8: 86,783,153 (GRCm39) D983V probably benign Het
Piezo2 G A 18: 63,157,522 (GRCm39) T2396I probably damaging Het
Pik3ap1 T A 19: 41,275,929 (GRCm39) D717V probably damaging Het
Plce1 T A 19: 38,766,465 (GRCm39) probably benign Het
Plekhg1 A G 10: 3,887,853 (GRCm39) I261V probably damaging Het
Ppfia4 T C 1: 134,251,851 (GRCm39) H441R probably damaging Het
Prpf8 T A 11: 75,392,768 (GRCm39) probably benign Het
Ptn T A 6: 36,718,388 (GRCm39) probably benign Het
Ptpn13 A G 5: 103,649,362 (GRCm39) Y255C possibly damaging Het
Ptprc T C 1: 138,016,435 (GRCm39) N505D probably damaging Het
Ptprs T A 17: 56,761,220 (GRCm39) I116F possibly damaging Het
Rab1a T G 11: 20,173,169 (GRCm39) V90G probably damaging Het
Rcor1 T C 12: 111,068,102 (GRCm39) V267A probably benign Het
Reep4 A G 14: 70,784,678 (GRCm39) probably null Het
Rere T A 4: 150,699,779 (GRCm39) probably benign Het
Rin3 T A 12: 102,353,823 (GRCm39) Y743* probably null Het
Rprm A G 2: 53,975,067 (GRCm39) S84P probably damaging Het
Sdhaf2 C T 19: 10,494,383 (GRCm39) E109K probably damaging Het
Sec31b G T 19: 44,523,225 (GRCm39) Q24K probably damaging Het
Sema5a T C 15: 32,574,949 (GRCm39) probably benign Het
Sh3pxd2a T C 19: 47,256,186 (GRCm39) Y844C probably damaging Het
Shmt2 A C 10: 127,355,941 (GRCm39) N134K probably damaging Het
Slc9a8 C T 2: 167,266,125 (GRCm39) A34V probably benign Het
Spidr A C 16: 15,957,936 (GRCm39) S64A possibly damaging Het
Stk10 A G 11: 32,567,882 (GRCm39) T895A probably benign Het
Syne2 A T 12: 76,080,365 (GRCm39) probably benign Het
Szt2 T C 4: 118,230,149 (GRCm39) probably null Het
Tecpr1 A T 5: 144,150,899 (GRCm39) V303D probably damaging Het
Tet3 A G 6: 83,350,776 (GRCm39) Y1048H probably damaging Het
Tfb2m A G 1: 179,373,396 (GRCm39) C101R probably damaging Het
Tg T C 15: 66,554,253 (GRCm39) V556A probably damaging Het
Thbs4 A C 13: 92,903,692 (GRCm39) I441M probably benign Het
Thsd7a A T 6: 12,379,593 (GRCm39) Y944N probably damaging Het
Tm9sf3 C A 19: 41,236,331 (GRCm39) probably benign Het
Tmem145 T C 7: 25,010,787 (GRCm39) F359S probably damaging Het
Ttc21b C T 2: 66,053,142 (GRCm39) probably benign Het
Ttn A G 2: 76,579,880 (GRCm39) V23671A probably damaging Het
Txnl4b T C 8: 110,298,103 (GRCm39) I78T probably benign Het
Ubr4 C A 4: 139,133,889 (GRCm39) L762I probably damaging Het
Ubr4 T C 4: 139,208,149 (GRCm39) probably null Het
Ugt1a8 C T 1: 88,016,079 (GRCm39) P164L probably damaging Het
Unc13b T C 4: 43,263,559 (GRCm39) S1594P probably damaging Het
Utrn A T 10: 12,278,639 (GRCm39) F912I probably benign Het
Vat1l T C 8: 114,963,319 (GRCm39) probably benign Het
Vmn1r50 T A 6: 90,084,863 (GRCm39) S203T probably damaging Het
Vmn2r4 A T 3: 64,296,784 (GRCm39) L667Q probably damaging Het
Vmn2r66 T G 7: 84,656,023 (GRCm39) Q331P probably damaging Het
Wdsub1 A T 2: 59,708,669 (GRCm39) V68D possibly damaging Het
Wnk2 C G 13: 49,238,870 (GRCm39) A564P possibly damaging Het
Wnk2 T A 13: 49,238,872 (GRCm39) K563M probably damaging Het
Zan T A 5: 137,468,580 (GRCm39) H297L probably damaging Het
Zfp426 A T 9: 20,381,327 (GRCm39) H539Q probably damaging Het
Zfp488 T A 14: 33,692,497 (GRCm39) N222I probably damaging Het
Zfp536 T A 7: 37,268,243 (GRCm39) H391L probably damaging Het
Zp1 T A 19: 10,893,571 (GRCm39) N31I probably damaging Het
Other mutations in Ptpn4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00825:Ptpn4 APN 1 119,587,655 (GRCm39) splice site probably benign
IGL00885:Ptpn4 APN 1 119,730,093 (GRCm39) missense possibly damaging 0.95
IGL00973:Ptpn4 APN 1 119,669,101 (GRCm39) missense probably benign 0.00
IGL01867:Ptpn4 APN 1 119,603,329 (GRCm39) missense probably benign
IGL01870:Ptpn4 APN 1 119,603,277 (GRCm39) critical splice donor site probably null
IGL02101:Ptpn4 APN 1 119,615,408 (GRCm39) missense probably damaging 1.00
IGL02344:Ptpn4 APN 1 119,700,990 (GRCm39) missense probably damaging 1.00
IGL02348:Ptpn4 APN 1 119,610,452 (GRCm39) missense probably damaging 1.00
IGL02693:Ptpn4 APN 1 119,643,699 (GRCm39) missense probably damaging 0.96
IGL03281:Ptpn4 APN 1 119,587,642 (GRCm39) missense probably damaging 1.00
alto UTSW 1 119,612,311 (GRCm39) nonsense probably null
blinding UTSW 1 119,649,592 (GRCm39) critical splice donor site probably null
botched UTSW 1 119,671,120 (GRCm39) missense probably damaging 1.00
bungled UTSW 1 119,615,335 (GRCm39) splice site probably null
Fovea UTSW 1 119,606,552 (GRCm39) missense possibly damaging 0.81
hash UTSW 1 119,693,649 (GRCm39) nonsense probably null
Hoechter UTSW 1 119,607,789 (GRCm39) missense probably damaging 1.00
Lumens UTSW 1 119,595,278 (GRCm39) missense probably damaging 1.00
BB008:Ptpn4 UTSW 1 119,607,925 (GRCm39) missense probably damaging 0.98
BB018:Ptpn4 UTSW 1 119,607,925 (GRCm39) missense probably damaging 0.98
R0105:Ptpn4 UTSW 1 119,615,335 (GRCm39) splice site probably null
R0105:Ptpn4 UTSW 1 119,615,335 (GRCm39) splice site probably null
R1148:Ptpn4 UTSW 1 119,612,270 (GRCm39) missense probably damaging 0.99
R1148:Ptpn4 UTSW 1 119,612,270 (GRCm39) missense probably damaging 0.99
R1148:Ptpn4 UTSW 1 119,603,439 (GRCm39) splice site probably benign
R1662:Ptpn4 UTSW 1 119,692,788 (GRCm39) missense probably damaging 0.96
R1694:Ptpn4 UTSW 1 119,711,240 (GRCm39) missense probably damaging 0.99
R1733:Ptpn4 UTSW 1 119,643,773 (GRCm39) splice site probably null
R2083:Ptpn4 UTSW 1 119,615,489 (GRCm39) missense possibly damaging 0.63
R2226:Ptpn4 UTSW 1 119,610,515 (GRCm39) missense probably damaging 1.00
R2276:Ptpn4 UTSW 1 119,612,321 (GRCm39) missense probably damaging 1.00
R2277:Ptpn4 UTSW 1 119,612,321 (GRCm39) missense probably damaging 1.00
R3123:Ptpn4 UTSW 1 119,693,153 (GRCm39) splice site probably null
R3425:Ptpn4 UTSW 1 119,635,560 (GRCm39) missense probably benign 0.02
R4568:Ptpn4 UTSW 1 119,607,789 (GRCm39) missense probably damaging 1.00
R4716:Ptpn4 UTSW 1 119,649,598 (GRCm39) missense probably damaging 1.00
R4819:Ptpn4 UTSW 1 119,587,580 (GRCm39) missense probably benign
R4959:Ptpn4 UTSW 1 119,692,826 (GRCm39) nonsense probably null
R5161:Ptpn4 UTSW 1 119,635,593 (GRCm39) nonsense probably null
R5345:Ptpn4 UTSW 1 119,693,207 (GRCm39) missense probably benign
R5471:Ptpn4 UTSW 1 119,693,649 (GRCm39) nonsense probably null
R5826:Ptpn4 UTSW 1 119,612,246 (GRCm39) missense probably benign 0.32
R5933:Ptpn4 UTSW 1 119,615,453 (GRCm39) missense probably damaging 0.97
R6075:Ptpn4 UTSW 1 119,692,866 (GRCm39) missense probably damaging 1.00
R6286:Ptpn4 UTSW 1 119,649,592 (GRCm39) critical splice donor site probably null
R6389:Ptpn4 UTSW 1 119,649,684 (GRCm39) missense probably damaging 0.97
R6392:Ptpn4 UTSW 1 119,700,853 (GRCm39) missense probably benign
R6769:Ptpn4 UTSW 1 119,643,698 (GRCm39) missense probably benign 0.01
R6771:Ptpn4 UTSW 1 119,643,698 (GRCm39) missense probably benign 0.01
R6794:Ptpn4 UTSW 1 119,671,120 (GRCm39) missense probably damaging 1.00
R6933:Ptpn4 UTSW 1 119,700,878 (GRCm39) intron probably benign
R6967:Ptpn4 UTSW 1 119,612,311 (GRCm39) nonsense probably null
R6980:Ptpn4 UTSW 1 119,671,151 (GRCm39) missense possibly damaging 0.86
R7150:Ptpn4 UTSW 1 119,619,475 (GRCm39) critical splice donor site probably null
R7247:Ptpn4 UTSW 1 119,617,764 (GRCm39) makesense probably null
R7283:Ptpn4 UTSW 1 119,610,261 (GRCm39) missense possibly damaging 0.90
R7459:Ptpn4 UTSW 1 119,587,564 (GRCm39) missense probably damaging 0.99
R7732:Ptpn4 UTSW 1 119,620,532 (GRCm39) missense probably benign
R7794:Ptpn4 UTSW 1 119,653,767 (GRCm39) missense probably damaging 1.00
R8061:Ptpn4 UTSW 1 119,619,330 (GRCm39) critical splice donor site probably null
R8236:Ptpn4 UTSW 1 119,606,552 (GRCm39) missense possibly damaging 0.81
R8929:Ptpn4 UTSW 1 119,595,278 (GRCm39) missense probably damaging 1.00
R8979:Ptpn4 UTSW 1 119,671,120 (GRCm39) missense probably damaging 1.00
R9334:Ptpn4 UTSW 1 119,730,114 (GRCm39) missense probably benign
RF014:Ptpn4 UTSW 1 119,612,195 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- TGATGCTAAAAGGGCAGCAGTGTTAC -3'
(R):5'- TAAGTCTTTTCTCCCCGGCAGCAG -3'

Sequencing Primer
(F):5'- tggcacacaactatgatttcaac -3'
(R):5'- CAATTCACAAAATCCTATTTCTGGC -3'
Posted On 2013-06-12