Incidental Mutation 'R4768:Pilrb1'
ID 472930
Institutional Source Beutler Lab
Gene Symbol Pilrb1
Ensembl Gene ENSMUSG00000066684
Gene Name paired immunoglobin-like type 2 receptor beta 1
Synonyms Pilrb, Fdact
MMRRC Submission 042409-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.050) question?
Stock # R4768 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 137850409-137856368 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) G to A at 137855788 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000110978] [ENSMUST00000196195] [ENSMUST00000199387]
AlphaFold Q2YFS2
Predicted Effect silent
Transcript: ENSMUST00000110978
SMART Domains Protein: ENSMUSP00000106606
Gene: ENSMUSG00000066684

DomainStartEndE-ValueType
Blast:IG 45 156 3e-68 BLAST
Blast:IG_like 192 221 7e-6 BLAST
Predicted Effect unknown
Transcript: ENSMUST00000196195
AA Change: T44I
SMART Domains Protein: ENSMUSP00000143777
Gene: ENSMUSG00000066684
AA Change: T44I

DomainStartEndE-ValueType
signal peptide 1 31 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000196787
Predicted Effect noncoding transcript
Transcript: ENSMUST00000197403
Predicted Effect probably benign
Transcript: ENSMUST00000197914
Predicted Effect probably benign
Transcript: ENSMUST00000198703
Predicted Effect silent
Transcript: ENSMUST00000199387
SMART Domains Protein: ENSMUSP00000143379
Gene: ENSMUSG00000066684

DomainStartEndE-ValueType
Blast:IG 45 156 4e-68 BLAST
Blast:IG_like 192 221 8e-6 BLAST
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.7%
  • 20x: 93.7%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased susceptiblity to bacterial infection with S. aureus with decreased worm burden and mortality. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acadm A G 3: 153,628,579 (GRCm39) Y419H probably benign Het
Adam28 A G 14: 68,872,264 (GRCm39) V326A possibly damaging Het
Amdhd1 T A 10: 93,370,346 (GRCm39) E164V possibly damaging Het
Arhgap5 T C 12: 52,604,275 (GRCm39) L29S probably damaging Het
Asb5 G A 8: 55,038,031 (GRCm39) D185N probably benign Het
Ascc3 T C 10: 50,576,595 (GRCm39) I850T probably damaging Het
Atxn1 A G 13: 45,711,024 (GRCm39) V636A probably damaging Het
Bmp4 C T 14: 46,623,381 (GRCm39) R55Q probably damaging Het
Brd8dc T C 18: 34,714,005 (GRCm39) R207G probably damaging Het
Cmas T C 6: 142,710,157 (GRCm39) probably null Het
Dchs1 T C 7: 105,420,827 (GRCm39) D531G possibly damaging Het
Etv1 T C 12: 38,877,792 (GRCm39) L44P probably damaging Het
Fam13c T A 10: 70,387,580 (GRCm39) I448N probably damaging Het
Fcsk T C 8: 111,618,766 (GRCm39) T331A probably benign Het
Fut8 A G 12: 77,412,054 (GRCm39) K135E probably benign Het
Gabrg1 A G 5: 70,911,516 (GRCm39) F370S probably damaging Het
Ighv1-5 A T 12: 114,477,143 (GRCm39) M53K probably damaging Het
Igkv9-120 G T 6: 68,027,351 (GRCm39) R88S possibly damaging Het
Kansl1l A G 1: 66,840,292 (GRCm39) V336A probably damaging Het
Krt27 T A 11: 99,240,351 (GRCm39) D189V probably damaging Het
Marf1 A T 16: 13,949,461 (GRCm39) F1033I possibly damaging Het
Mdfi G A 17: 48,135,475 (GRCm39) T85M probably damaging Het
Mrgpra3 C A 7: 47,239,476 (GRCm39) R150L possibly damaging Het
Mst1r C A 9: 107,788,849 (GRCm39) T456K probably damaging Het
Myh14 A T 7: 44,263,099 (GRCm39) M1734K probably benign Het
Myo1e T C 9: 70,277,751 (GRCm39) I816T possibly damaging Het
Or7d10 A C 9: 19,831,841 (GRCm39) N112T possibly damaging Het
Or8b12 T C 9: 37,658,177 (GRCm39) L249P probably damaging Het
Or8b55 T A 9: 38,727,245 (GRCm39) Y149N probably damaging Het
Or8k28 A T 2: 86,285,994 (GRCm39) L207* probably null Het
Pde4d A G 13: 110,070,408 (GRCm39) R6G probably damaging Het
Prrx1 A G 1: 163,085,334 (GRCm39) Y199H probably damaging Het
Rxfp1 T C 3: 79,594,175 (GRCm39) D73G probably damaging Het
Ryr1 G T 7: 28,704,246 (GRCm39) probably benign Het
Shprh A G 10: 11,057,284 (GRCm39) E1068G probably damaging Het
Slc19a3 G A 1: 83,000,834 (GRCm39) T61I probably damaging Het
Slc9a2 G A 1: 40,765,534 (GRCm39) R308Q probably damaging Het
Suclg2 T G 6: 95,543,469 (GRCm39) I321L probably damaging Het
Top3a A G 11: 60,653,316 (GRCm39) F53L probably damaging Het
Ttn C T 2: 76,599,110 (GRCm39) probably benign Het
Upp2 T C 2: 58,667,907 (GRCm39) V182A probably damaging Het
Vmn2r65 A G 7: 84,596,602 (GRCm39) L151P probably damaging Het
Xylt2 T C 11: 94,561,298 (GRCm39) D155G probably benign Het
Zzz3 A G 3: 152,154,420 (GRCm39) D557G probably damaging Het
Other mutations in Pilrb1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02717:Pilrb1 APN 5 137,856,213 (GRCm39) utr 5 prime probably benign
IGL02989:Pilrb1 APN 5 137,855,492 (GRCm39) missense possibly damaging 0.92
IGL03191:Pilrb1 APN 5 137,853,227 (GRCm39) missense probably damaging 1.00
R0320:Pilrb1 UTSW 5 137,853,260 (GRCm39) missense probably benign 0.04
R2048:Pilrb1 UTSW 5 137,853,153 (GRCm39) missense possibly damaging 0.53
R3113:Pilrb1 UTSW 5 137,853,195 (GRCm39) missense possibly damaging 0.95
R3946:Pilrb1 UTSW 5 137,855,654 (GRCm39) missense probably benign 0.40
R5252:Pilrb1 UTSW 5 137,853,315 (GRCm39) missense probably benign 0.00
R5334:Pilrb1 UTSW 5 137,853,165 (GRCm39) missense probably benign 0.00
R6658:Pilrb1 UTSW 5 137,855,789 (GRCm39) missense probably benign 0.01
R9179:Pilrb1 UTSW 5 137,855,657 (GRCm39) missense probably damaging 1.00
R9421:Pilrb1 UTSW 5 137,853,296 (GRCm39) missense probably benign 0.01
Predicted Primers
Posted On 2017-04-14