Incidental Mutation 'R3729:Igkv4-90'
ID 473395
Institutional Source Beutler Lab
Gene Symbol Igkv4-90
Ensembl Gene ENSMUSG00000076533
Gene Name immunoglobulin kappa chain variable 4-90
Synonyms Gm16906
MMRRC Submission 040719-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.087) question?
Stock # R3729 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 68784164-68784692 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 68784665 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 10 (F10L)
Ref Sequence ENSEMBL: ENSMUSP00000100135 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103334]
AlphaFold A0A075B5L3
Predicted Effect probably benign
Transcript: ENSMUST00000103334
AA Change: F10L

PolyPhen 2 Score 0.431 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000100135
Gene: ENSMUSG00000076533
AA Change: F10L

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
IGv 40 111 9.2e-23 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000197261
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency 100% (48/48)
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acacb A G 5: 114,345,409 (GRCm39) D954G probably damaging Het
Acvr1 T C 2: 58,352,925 (GRCm39) K345R probably null Het
Aldoart2 A G 12: 55,613,104 (GRCm39) Y343C probably damaging Het
Arpp21 T A 9: 111,895,047 (GRCm39) Y739F possibly damaging Het
Cachd1 C A 4: 100,832,077 (GRCm39) Y746* probably null Het
Card14 T C 11: 119,224,758 (GRCm39) V595A probably damaging Het
Dhx33 T C 11: 70,879,978 (GRCm39) D344G probably benign Het
Dnah12 T A 14: 26,427,220 (GRCm39) D171E probably benign Het
Fat3 A G 9: 16,158,337 (GRCm39) probably benign Het
Fmnl3 A G 15: 99,219,745 (GRCm39) F668L probably damaging Het
Frmpd4 G A X: 166,269,803 (GRCm39) T493M probably damaging Het
Gcn1 A T 5: 115,721,453 (GRCm39) probably benign Het
Hspbp1 G T 7: 4,680,808 (GRCm39) Q223K probably damaging Het
Ighv1-19 C A 12: 114,672,497 (GRCm39) C40F probably damaging Het
Kctd5 T C 17: 24,278,212 (GRCm39) D146G probably benign Het
Kif4-ps A G 12: 101,112,369 (GRCm39) E166G probably damaging Het
Lemd3 T C 10: 120,763,920 (GRCm39) D780G probably damaging Het
Manba G A 3: 135,260,611 (GRCm39) V599I probably benign Het
Map2 A G 1: 66,451,605 (GRCm39) E247G possibly damaging Het
Mfsd1 T C 3: 67,490,298 (GRCm39) F50L probably benign Het
Mier2 T C 10: 79,380,876 (GRCm39) probably benign Het
Mslnl G A 17: 25,961,908 (GRCm39) V128M probably damaging Het
Nol10 A T 12: 17,474,674 (GRCm39) K622I probably benign Het
Or5p62 A T 7: 107,771,516 (GRCm39) I145N probably benign Het
Or8d2b T C 9: 38,788,547 (GRCm39) F25S probably damaging Het
Phtf1 A G 3: 103,893,095 (GRCm39) M120V probably benign Het
Prrx1 A G 1: 163,089,446 (GRCm39) L127P probably damaging Het
Rbsn T C 6: 92,168,316 (GRCm39) M373V possibly damaging Het
Sec24b T C 3: 129,827,482 (GRCm39) K203R possibly damaging Het
Shroom3 G T 5: 93,090,945 (GRCm39) V1151F probably damaging Het
Slc16a10 G C 10: 39,932,620 (GRCm39) H314D possibly damaging Het
Slc4a7 A T 14: 14,729,276 (GRCm38) E47D probably damaging Het
Taf12 C A 4: 132,010,265 (GRCm39) P78Q probably damaging Het
Tnn A G 1: 159,973,810 (GRCm39) C186R probably damaging Het
Trim46 T A 3: 89,142,256 (GRCm39) T721S probably benign Het
Trip4 T C 9: 65,788,224 (GRCm39) N74D possibly damaging Het
Tssk5 C T 15: 76,257,096 (GRCm39) R262H probably benign Het
Vegfa T C 17: 46,335,446 (GRCm39) I105V possibly damaging Het
Vmn2r14 T C 5: 109,364,095 (GRCm39) Y607C probably damaging Het
Wdr83 G T 8: 85,806,968 (GRCm39) H66Q probably damaging Het
Zfp280b A G 10: 75,874,936 (GRCm39) T272A probably benign Het
Zfp960 T A 17: 17,308,633 (GRCm39) L449H probably damaging Het
Other mutations in Igkv4-90
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03154:Igkv4-90 APN 6 68,784,256 (GRCm39) missense probably damaging 0.97
R4259:Igkv4-90 UTSW 6 68,784,461 (GRCm39) missense possibly damaging 0.60
R5873:Igkv4-90 UTSW 6 68,784,453 (GRCm39) missense probably benign 0.00
R6843:Igkv4-90 UTSW 6 68,784,670 (GRCm39) missense possibly damaging 0.87
R9250:Igkv4-90 UTSW 6 68,784,331 (GRCm39) nonsense probably null
Predicted Primers
Posted On 2017-04-14