Incidental Mutation 'R3861:Scly'
ID 474267
Institutional Source Beutler Lab
Gene Symbol Scly
Ensembl Gene ENSMUSG00000026307
Gene Name selenocysteine lyase
Synonyms SCL, A930015N15Rik, Selenocysteine reductase, Scly2, Scly1
MMRRC Submission 040788-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.115) question?
Stock # R3861 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 91226060-91248797 bp(+) (GRCm39)
Type of Mutation utr 3 prime
DNA Base Change (assembly) C to T at 91230573 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000137796 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027532] [ENSMUST00000137074] [ENSMUST00000142488] [ENSMUST00000145843] [ENSMUST00000147523] [ENSMUST00000154045]
AlphaFold no structure available at present
Predicted Effect silent
Transcript: ENSMUST00000027532
SMART Domains Protein: ENSMUSP00000027532
Gene: ENSMUSG00000026307

DomainStartEndE-ValueType
Pfam:Aminotran_5 20 417 1.7e-58 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123651
Predicted Effect silent
Transcript: ENSMUST00000124832
SMART Domains Protein: ENSMUSP00000116382
Gene: ENSMUSG00000026307

DomainStartEndE-ValueType
Pfam:Aminotran_5 18 215 2e-25 PFAM
Predicted Effect unknown
Transcript: ENSMUST00000137074
AA Change: H19Y
SMART Domains Protein: ENSMUSP00000122449
Gene: ENSMUSG00000026307
AA Change: H19Y

DomainStartEndE-ValueType
Pfam:Aminotran_5 48 216 7.4e-30 PFAM
Predicted Effect silent
Transcript: ENSMUST00000142488
SMART Domains Protein: ENSMUSP00000119979
Gene: ENSMUSG00000026307

DomainStartEndE-ValueType
Pfam:Aminotran_5 42 238 2.2e-32 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142802
Predicted Effect silent
Transcript: ENSMUST00000145843
SMART Domains Protein: ENSMUSP00000116824
Gene: ENSMUSG00000026307

DomainStartEndE-ValueType
Pfam:Aminotran_5 1 68 1.5e-15 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153621
Predicted Effect silent
Transcript: ENSMUST00000147523
SMART Domains Protein: ENSMUSP00000114759
Gene: ENSMUSG00000026307

DomainStartEndE-ValueType
Pfam:Aminotran_5 22 249 2.5e-42 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000171768
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181737
Predicted Effect probably benign
Transcript: ENSMUST00000154045
SMART Domains Protein: ENSMUSP00000137796
Gene: ENSMUSG00000026307

DomainStartEndE-ValueType
PDB:3A9Z|B 1 57 5e-30 PDB
SCOP:d1eg5a_ 20 57 3e-10 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency 100% (55/55)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Selenocysteine lyase (SCLY; EC 4.4.1.16) catalyzes the pyridoxal 5-prime phosphate-dependent conversion of L-selenocysteine to L-alanine and elemental selenium (Mihara et al., 2000 [PubMed 10692412]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice fed a selenium-deficient diet exhibit mild learning impairment. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5730507C01Rik G A 12: 18,583,411 (GRCm39) S157N probably benign Het
A830018L16Rik T C 1: 11,658,778 (GRCm39) probably benign Het
Akip1 C T 7: 109,306,613 (GRCm39) probably benign Het
Anxa5 T C 3: 36,504,807 (GRCm39) T252A probably benign Het
Arhgef10l A G 4: 140,242,798 (GRCm39) F1072L possibly damaging Het
Armc1 C T 3: 19,189,196 (GRCm39) R186Q probably damaging Het
Atxn2l A T 7: 126,101,123 (GRCm39) probably null Het
Cadps2 A G 6: 23,355,860 (GRCm39) I849T probably damaging Het
Ccdc28a T A 10: 18,100,743 (GRCm39) Q28L probably damaging Het
Cdh4 T A 2: 179,515,890 (GRCm39) V356D probably damaging Het
Chd8 T A 14: 52,474,578 (GRCm39) Q151L probably benign Het
Chgb T A 2: 132,635,064 (GRCm39) H335Q probably damaging Het
Col19a1 G A 1: 24,365,098 (GRCm39) P506S probably damaging Het
Col5a2 T C 1: 45,419,397 (GRCm39) T1228A probably damaging Het
Cpxm2 A G 7: 131,656,648 (GRCm39) V538A probably benign Het
Cramp1 A T 17: 25,216,588 (GRCm39) probably benign Het
Cttnbp2 T C 6: 18,423,832 (GRCm39) R831G probably benign Het
Cyp4f17 A G 17: 32,747,078 (GRCm39) D436G probably damaging Het
Dcaf6 A T 1: 165,256,838 (GRCm39) N48K probably damaging Het
Ddx50 C A 10: 62,478,725 (GRCm39) V154L possibly damaging Het
Dnah9 T C 11: 65,943,820 (GRCm39) probably benign Het
Dnm3 T A 1: 162,138,974 (GRCm39) I395L possibly damaging Het
Elp2 C T 18: 24,739,977 (GRCm39) R68C probably benign Het
Frg1 A T 8: 41,860,820 (GRCm39) probably null Het
Fsip2 G T 2: 82,815,120 (GRCm39) D3618Y probably damaging Het
Gabra2 T C 5: 71,130,886 (GRCm39) D314G probably damaging Het
Gramd1a A C 7: 30,835,365 (GRCm39) D407E possibly damaging Het
Grm5 T A 7: 87,779,202 (GRCm39) S881T possibly damaging Het
Ikbkb T A 8: 23,168,852 (GRCm39) I216F possibly damaging Het
Kif3a T C 11: 53,488,805 (GRCm39) V634A probably benign Het
Ltbp1 A T 17: 75,666,333 (GRCm39) Y1342F possibly damaging Het
Mia2 G T 12: 59,155,807 (GRCm39) V508L probably benign Het
Mtus2 C T 5: 148,250,223 (GRCm39) T155M probably damaging Het
Napepld A T 5: 21,888,287 (GRCm39) V54E probably benign Het
Nlrc4 T C 17: 74,752,616 (GRCm39) E589G probably benign Het
Nphp3 G T 9: 103,916,525 (GRCm39) probably benign Het
Nr2f1 T A 13: 78,343,794 (GRCm39) R10* probably null Het
Nsfl1c C A 2: 151,352,824 (GRCm39) probably null Het
Or14a258 A G 7: 86,035,331 (GRCm39) V179A possibly damaging Het
Pcdhgc3 A G 18: 37,941,581 (GRCm39) T661A probably damaging Het
Pdzrn3 A G 6: 101,149,332 (GRCm39) V332A possibly damaging Het
Pip4p2 A G 4: 14,902,506 (GRCm39) N169S probably damaging Het
Pkhd1 C T 1: 20,271,151 (GRCm39) C3134Y probably damaging Het
Ptprz1 T C 6: 23,036,894 (GRCm39) V1131A probably damaging Het
Rccd1 T C 7: 79,970,116 (GRCm39) E167G probably benign Het
Ror1 T C 4: 100,265,120 (GRCm39) I198T possibly damaging Het
Rpl31-ps17 C T 12: 54,748,397 (GRCm39) noncoding transcript Het
Scn4a T C 11: 106,216,950 (GRCm39) probably benign Het
Sh3rf2 T C 18: 42,286,384 (GRCm39) S594P probably damaging Het
Slc19a1 G A 10: 76,877,809 (GRCm39) V115M possibly damaging Het
Slc26a6 A T 9: 108,731,395 (GRCm39) probably benign Het
Smg7 C T 1: 152,728,349 (GRCm39) R439K probably null Het
Spata31e3 T C 13: 50,400,887 (GRCm39) K480E probably benign Het
Syne2 A G 12: 76,013,253 (GRCm39) R2815G probably damaging Het
Trim75 G A 8: 65,435,479 (GRCm39) R324C probably damaging Het
Ucp3 T C 7: 100,129,458 (GRCm39) S98P probably benign Het
Zscan29 G C 2: 120,991,212 (GRCm39) R859G probably benign Het
Other mutations in Scly
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02314:Scly APN 1 91,246,763 (GRCm39) missense probably benign 0.00
IGL02690:Scly APN 1 91,233,047 (GRCm39) missense probably benign
R0597:Scly UTSW 1 91,237,555 (GRCm39) missense probably damaging 1.00
R1782:Scly UTSW 1 91,236,102 (GRCm39) missense probably damaging 1.00
R1950:Scly UTSW 1 91,233,116 (GRCm39) missense probably benign 0.08
R1978:Scly UTSW 1 91,247,891 (GRCm39) missense probably damaging 0.98
R2290:Scly UTSW 1 91,226,172 (GRCm39) critical splice donor site probably null
R4508:Scly UTSW 1 91,236,047 (GRCm39) missense possibly damaging 0.95
R4876:Scly UTSW 1 91,247,850 (GRCm39) missense probably damaging 0.98
R7035:Scly UTSW 1 91,236,125 (GRCm39) missense probably damaging 0.98
R7701:Scly UTSW 1 91,236,030 (GRCm39) missense
R7887:Scly UTSW 1 91,228,363 (GRCm39) critical splice donor site probably null
R8079:Scly UTSW 1 91,236,089 (GRCm39) missense probably damaging 0.99
R8501:Scly UTSW 1 91,246,798 (GRCm39) missense probably damaging 1.00
R8828:Scly UTSW 1 91,244,830 (GRCm39) missense possibly damaging 0.83
R9533:Scly UTSW 1 91,228,413 (GRCm39) intron probably benign
X0021:Scly UTSW 1 91,247,828 (GRCm39) missense probably damaging 0.98
Z1176:Scly UTSW 1 91,233,035 (GRCm39) missense probably benign 0.00
Predicted Primers
Posted On 2017-04-14