Incidental Mutation 'R3905:Bcl7c'
ID 474484
Institutional Source Beutler Lab
Gene Symbol Bcl7c
Ensembl Gene ENSMUSG00000030814
Gene Name B cell CLL/lymphoma 7C
Synonyms C230096E12Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.112) question?
Stock # R3905 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 127260626-127307938 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 127266155 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glycine at position 198 (R198G)
Ref Sequence ENSEMBL: ENSMUSP00000145743 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000106282] [ENSMUST00000205977]
AlphaFold O08664
Predicted Effect probably benign
Transcript: ENSMUST00000106282
SMART Domains Protein: ENSMUSP00000101889
Gene: ENSMUSG00000030814

DomainStartEndE-ValueType
low complexity region 19 33 N/A INTRINSIC
low complexity region 119 130 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000205977
AA Change: R198G

PolyPhen 2 Score 0.533 (Sensitivity: 0.88; Specificity: 0.90)
Predicted Effect probably benign
Transcript: ENSMUST00000206200
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is identified by the similarity of its product to the N-terminal region of BCL7A protein. The BCL7A protein is encoded by the gene known to be directly involved in a three-way gene translocation in a Burkitt lymphoma cell line. The function of this gene has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 A T 1: 71,307,389 (GRCm39) I1964N possibly damaging Het
Abca12 A G 1: 71,318,616 (GRCm39) F1796L probably benign Het
Abca17 T A 17: 24,515,257 (GRCm39) M821L probably benign Het
Adamts3 C A 5: 90,009,214 (GRCm39) G150C probably damaging Het
Ap4b1 A T 3: 103,726,209 (GRCm39) I262F possibly damaging Het
Atp1a1 T A 3: 101,497,928 (GRCm39) E286D probably benign Het
Bard1 T C 1: 71,106,339 (GRCm39) I429M possibly damaging Het
Cacna1s T A 1: 136,012,007 (GRCm39) M483K probably damaging Het
Ccdc159 T A 9: 21,845,815 (GRCm39) probably null Het
Cct7 A T 6: 85,443,690 (GRCm39) I353F possibly damaging Het
Cfap57 A G 4: 118,453,036 (GRCm39) Y556H probably damaging Het
Fat1 G C 8: 45,476,072 (GRCm39) R1706T probably benign Het
Fn1 C T 1: 71,647,072 (GRCm39) G1482R probably damaging Het
Gcat T C 15: 78,927,531 (GRCm39) L324P possibly damaging Het
Hspa1a C T 17: 35,190,703 (GRCm39) V67M probably damaging Het
Il22 C T 10: 118,041,529 (GRCm39) R81* probably null Het
Impa1 T C 3: 10,381,094 (GRCm39) T263A probably benign Het
Kif13a T C 13: 46,956,166 (GRCm39) Y609C probably damaging Het
Kmt2e A G 5: 23,706,624 (GRCm39) N1396D probably benign Het
Lrfn1 G A 7: 28,166,294 (GRCm39) G563R possibly damaging Het
Mark1 A C 1: 184,640,632 (GRCm39) probably null Het
Mxd1 G T 6: 86,627,942 (GRCm39) Q199K probably benign Het
Myo3a T A 2: 22,448,227 (GRCm39) Y1N probably damaging Het
Nek3 T C 8: 22,623,107 (GRCm39) E309G probably benign Het
Or10h28 T C 17: 33,487,749 (GRCm39) F17S probably damaging Het
Otoa A T 7: 120,724,788 (GRCm39) Q489L probably damaging Het
Oxsr1 T C 9: 119,076,178 (GRCm39) E376G probably benign Het
Piezo1 C T 8: 123,208,882 (GRCm39) E2494K probably damaging Het
Pkd1l3 A G 8: 110,373,511 (GRCm39) H1349R probably benign Het
Psmd2 A G 16: 20,474,392 (GRCm39) D316G probably benign Het
Pwwp3a T C 10: 80,074,150 (GRCm39) V401A probably damaging Het
Robo4 T A 9: 37,314,801 (GRCm39) C218* probably null Het
Rxfp2 A T 5: 149,979,450 (GRCm39) probably null Het
Slc10a1 A G 12: 81,014,441 (GRCm39) I93T probably damaging Het
Tarbp1 C T 8: 127,154,891 (GRCm39) R1411Q probably damaging Het
Tbl3 C T 17: 24,921,006 (GRCm39) D563N probably damaging Het
Tec A G 5: 72,917,705 (GRCm39) S505P probably damaging Het
Toporsl A T 4: 52,611,750 (GRCm39) R548* probably null Het
Vmn1r39 G A 6: 66,781,479 (GRCm39) Q243* probably null Het
Vmn2r9 C A 5: 108,995,785 (GRCm39) A288S probably benign Het
Other mutations in Bcl7c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01322:Bcl7c APN 7 127,306,608 (GRCm39) missense probably damaging 1.00
R0189:Bcl7c UTSW 7 127,304,936 (GRCm39) missense probably damaging 1.00
R0345:Bcl7c UTSW 7 127,307,635 (GRCm39) missense possibly damaging 0.95
R0940:Bcl7c UTSW 7 127,306,503 (GRCm39) missense possibly damaging 0.74
R6217:Bcl7c UTSW 7 127,307,698 (GRCm39) start codon destroyed probably null 1.00
R9023:Bcl7c UTSW 7 127,306,504 (GRCm39) missense probably benign 0.25
R9149:Bcl7c UTSW 7 127,307,695 (GRCm39) missense probably damaging 1.00
R9190:Bcl7c UTSW 7 127,266,200 (GRCm39) missense probably benign 0.06
R9253:Bcl7c UTSW 7 127,306,403 (GRCm39) intron probably benign
Predicted Primers
Posted On 2017-04-14