Incidental Mutation 'R0505:Plxna4'
| ID |
47463 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Plxna4
|
| Ensembl Gene |
ENSMUSG00000029765 |
| Gene Name |
plexin A4 |
| Synonyms |
Plxa4 |
| MMRRC Submission |
038700-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.616)
|
| Stock # |
R0505 (G1)
|
| Quality Score |
188 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
32121478-32565127 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 32179054 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Lysine
at position 987
(M987K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000110748
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000115096]
|
| AlphaFold |
Q80UG2 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115096
AA Change: M987K
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000110748
Gene: ENSMUSG00000029765
AA Change: M987K
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
Sema
|
50 |
490 |
2.3e-131 |
SMART |
|
PSI
|
508 |
558 |
2.21e-14 |
SMART |
|
PSI
|
654 |
701 |
2.44e-7 |
SMART |
|
PSI
|
802 |
855 |
1.2e-6 |
SMART |
|
IPT
|
856 |
950 |
7.25e-16 |
SMART |
|
IPT
|
952 |
1036 |
4.1e-15 |
SMART |
|
IPT
|
1038 |
1138 |
2.86e-14 |
SMART |
|
IPT
|
1140 |
1229 |
6.88e-1 |
SMART |
|
transmembrane domain
|
1237 |
1259 |
N/A |
INTRINSIC |
|
Pfam:Plexin_cytopl
|
1310 |
1863 |
1.8e-264 |
PFAM |
|
| Meta Mutation Damage Score |
0.1060 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 94.1%
|
| Validation Efficiency |
98% (119/121) |
| MGI Phenotype |
PHENOTYPE: Homozygous null mice exhibit defective trajecotory and projection of peripheral sensory axons and sympathetic ganglion axons and the formation of the anterior commissure and the barrels. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(2) : Targeted, knock-out(2) |
| Other mutations in this stock |
Total: 117 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca13 |
T |
C |
11: 9,241,058 (GRCm39) |
Y974H |
probably benign |
Het |
| Abca2 |
G |
T |
2: 25,324,906 (GRCm39) |
G300V |
probably benign |
Het |
| Abi1 |
A |
G |
2: 22,852,516 (GRCm39) |
|
probably benign |
Het |
| Actr10 |
T |
A |
12: 71,006,738 (GRCm39) |
Y332N |
probably damaging |
Het |
| Adam25 |
G |
T |
8: 41,208,261 (GRCm39) |
C509F |
probably damaging |
Het |
| Adck1 |
A |
T |
12: 88,338,461 (GRCm39) |
|
probably benign |
Het |
| Adgra3 |
A |
G |
5: 50,166,676 (GRCm39) |
|
probably null |
Het |
| Adgrl1 |
G |
T |
8: 84,661,279 (GRCm39) |
|
probably benign |
Het |
| Akr1c21 |
A |
G |
13: 4,626,306 (GRCm39) |
Y110C |
probably damaging |
Het |
| Arhgef25 |
T |
C |
10: 127,019,566 (GRCm39) |
I463V |
probably null |
Het |
| Atp6v1e2 |
C |
T |
17: 87,252,006 (GRCm39) |
V131M |
probably benign |
Het |
| Bdnf |
A |
G |
2: 109,505,688 (GRCm39) |
|
probably null |
Het |
| Bltp3b |
T |
C |
10: 89,627,305 (GRCm39) |
S145P |
probably damaging |
Het |
| C7 |
A |
T |
15: 5,023,624 (GRCm39) |
|
probably benign |
Het |
| Cdc27 |
T |
C |
11: 104,419,114 (GRCm39) |
T273A |
probably benign |
Het |
| Cdo1 |
T |
A |
18: 46,848,678 (GRCm39) |
I187F |
probably benign |
Het |
| Cep104 |
A |
T |
4: 154,080,761 (GRCm39) |
T742S |
probably benign |
Het |
| Ckm |
A |
T |
7: 19,153,377 (GRCm39) |
K223* |
probably null |
Het |
| Cmtr1 |
C |
T |
17: 29,895,259 (GRCm39) |
P586L |
probably benign |
Het |
| Csmd1 |
C |
T |
8: 16,042,758 (GRCm39) |
R2325Q |
probably damaging |
Het |
| Dcpp1 |
A |
T |
17: 24,101,568 (GRCm39) |
I106L |
possibly damaging |
Het |
| Diaph3 |
A |
C |
14: 87,328,400 (GRCm39) |
|
probably benign |
Het |
| Dnah11 |
A |
G |
12: 118,070,245 (GRCm39) |
V1520A |
probably damaging |
Het |
| Dnajc25 |
T |
A |
4: 59,020,438 (GRCm39) |
M168K |
|
Het |
| Dpp3 |
T |
C |
19: 4,964,682 (GRCm39) |
N542D |
probably damaging |
Het |
| Ebf2 |
A |
T |
14: 67,609,185 (GRCm39) |
K199* |
probably null |
Het |
| Eeig2 |
T |
C |
3: 108,887,520 (GRCm39) |
E248G |
probably benign |
Het |
| Efcab11 |
T |
A |
12: 99,685,294 (GRCm39) |
Q160L |
probably benign |
Het |
| Eif2ak4 |
T |
A |
2: 118,261,517 (GRCm39) |
S686T |
probably benign |
Het |
| Epha6 |
C |
T |
16: 60,026,095 (GRCm39) |
S449N |
possibly damaging |
Het |
| Ercc4 |
T |
C |
16: 12,944,331 (GRCm39) |
V329A |
probably benign |
Het |
| Faf1 |
T |
C |
4: 109,697,600 (GRCm39) |
F309L |
possibly damaging |
Het |
| G6pd2 |
C |
A |
5: 61,966,910 (GRCm39) |
D228E |
probably benign |
Het |
| Ggt1 |
T |
G |
10: 75,421,791 (GRCm39) |
V546G |
probably damaging |
Het |
| Gpatch4 |
G |
T |
3: 87,958,524 (GRCm39) |
V3F |
probably damaging |
Het |
| Gprin3 |
A |
G |
6: 59,330,372 (GRCm39) |
L645P |
probably damaging |
Het |
| Hyal2 |
A |
G |
9: 107,449,270 (GRCm39) |
Y342C |
probably benign |
Het |
| Igf2bp2 |
A |
G |
16: 21,907,849 (GRCm39) |
I16T |
possibly damaging |
Het |
| Inca1 |
T |
C |
11: 70,581,025 (GRCm39) |
Y61C |
probably damaging |
Het |
| Ipo5 |
T |
C |
14: 121,180,145 (GRCm39) |
W860R |
possibly damaging |
Het |
| Kcnj9 |
C |
T |
1: 172,150,591 (GRCm39) |
A341T |
probably benign |
Het |
| Kdm5b |
T |
C |
1: 134,530,309 (GRCm39) |
V440A |
probably damaging |
Het |
| L3mbtl1 |
C |
T |
2: 162,789,255 (GRCm39) |
|
probably benign |
Het |
| Lin54 |
G |
A |
5: 100,600,152 (GRCm39) |
T307I |
probably damaging |
Het |
| Lrrc18 |
C |
A |
14: 32,731,096 (GRCm39) |
Q212K |
probably benign |
Het |
| Lrrc37a |
A |
G |
11: 103,393,851 (GRCm39) |
S525P |
probably benign |
Het |
| Lrrc71 |
T |
A |
3: 87,653,006 (GRCm39) |
S137C |
probably damaging |
Het |
| Lrrk1 |
A |
T |
7: 65,940,656 (GRCm39) |
|
probably null |
Het |
| Man2b2 |
G |
A |
5: 36,973,542 (GRCm39) |
S58L |
probably benign |
Het |
| Masp1 |
T |
A |
16: 23,276,888 (GRCm39) |
H539L |
probably benign |
Het |
| Med1 |
G |
A |
11: 98,047,730 (GRCm39) |
P1022L |
probably damaging |
Het |
| Meis1 |
T |
A |
11: 18,961,360 (GRCm39) |
H171L |
probably damaging |
Het |
| Mier1 |
T |
A |
4: 103,012,820 (GRCm39) |
|
probably benign |
Het |
| Mmp13 |
A |
T |
9: 7,272,929 (GRCm39) |
R96S |
probably damaging |
Het |
| Mms19 |
G |
A |
19: 41,942,173 (GRCm39) |
T38I |
probably damaging |
Het |
| Mrc1 |
G |
A |
2: 14,314,843 (GRCm39) |
C976Y |
probably damaging |
Het |
| Mrtfb |
C |
T |
16: 13,230,390 (GRCm39) |
T1025I |
possibly damaging |
Het |
| Naalad2 |
A |
G |
9: 18,297,191 (GRCm39) |
Y32H |
probably benign |
Het |
| Ndufs1 |
A |
G |
1: 63,183,085 (GRCm39) |
|
probably benign |
Het |
| Nefm |
C |
T |
14: 68,361,608 (GRCm39) |
D219N |
probably damaging |
Het |
| Nwd1 |
C |
T |
8: 73,388,965 (GRCm39) |
P172L |
probably damaging |
Het |
| Nwd2 |
T |
A |
5: 63,962,454 (GRCm39) |
D679E |
probably damaging |
Het |
| Ogdh |
T |
A |
11: 6,289,936 (GRCm39) |
|
probably benign |
Het |
| Olfm3 |
T |
A |
3: 114,916,330 (GRCm39) |
S421T |
possibly damaging |
Het |
| Opn5 |
T |
G |
17: 42,903,844 (GRCm39) |
T164P |
possibly damaging |
Het |
| Or4k37 |
A |
T |
2: 111,159,673 (GRCm39) |
N303I |
probably benign |
Het |
| Or51a25 |
T |
A |
7: 102,373,236 (GRCm39) |
I154F |
probably damaging |
Het |
| Or52a24 |
T |
C |
7: 103,381,583 (GRCm39) |
V150A |
probably benign |
Het |
| Or5ak20 |
A |
G |
2: 85,184,093 (GRCm39) |
M59T |
possibly damaging |
Het |
| Or5b12b |
T |
C |
19: 12,861,443 (GRCm39) |
L66P |
probably damaging |
Het |
| Or5b12b |
A |
G |
19: 12,861,910 (GRCm39) |
T222A |
probably damaging |
Het |
| Pde7b |
C |
T |
10: 20,314,492 (GRCm39) |
V166M |
probably damaging |
Het |
| Peds1 |
A |
T |
2: 167,486,907 (GRCm39) |
|
probably benign |
Het |
| Pik3ap1 |
T |
C |
19: 41,313,003 (GRCm39) |
N370S |
probably damaging |
Het |
| Pkhd1l1 |
A |
T |
15: 44,452,814 (GRCm39) |
D3913V |
probably damaging |
Het |
| Pld1 |
A |
G |
3: 28,174,971 (GRCm39) |
I90V |
possibly damaging |
Het |
| Plxna2 |
A |
G |
1: 194,326,656 (GRCm39) |
T197A |
possibly damaging |
Het |
| Pmch |
A |
G |
10: 87,927,221 (GRCm39) |
N75D |
probably benign |
Het |
| Prom2 |
T |
A |
2: 127,374,787 (GRCm39) |
Q583L |
possibly damaging |
Het |
| Pyroxd1 |
T |
A |
6: 142,299,288 (GRCm39) |
M148K |
possibly damaging |
Het |
| R3hdm2 |
C |
T |
10: 127,293,569 (GRCm39) |
L158F |
probably damaging |
Het |
| Rapgef6 |
A |
T |
11: 54,516,789 (GRCm39) |
T349S |
probably benign |
Het |
| Rfx5 |
C |
T |
3: 94,863,666 (GRCm39) |
T105I |
probably damaging |
Het |
| Rif1 |
C |
A |
2: 52,000,749 (GRCm39) |
P1401Q |
probably damaging |
Het |
| Robo3 |
G |
A |
9: 37,328,055 (GRCm39) |
|
probably benign |
Het |
| Rpn1 |
T |
A |
6: 88,067,224 (GRCm39) |
S195T |
probably benign |
Het |
| Rslcan18 |
C |
A |
13: 67,250,183 (GRCm39) |
K17N |
probably benign |
Het |
| Rsph3b |
A |
T |
17: 7,209,126 (GRCm39) |
I48N |
probably damaging |
Het |
| Sbf2 |
A |
T |
7: 109,998,550 (GRCm39) |
Y628N |
probably damaging |
Het |
| Sis |
T |
C |
3: 72,867,629 (GRCm39) |
T139A |
probably benign |
Het |
| Slc22a14 |
A |
G |
9: 119,001,100 (GRCm39) |
|
probably benign |
Het |
| Slitrk6 |
A |
T |
14: 110,987,364 (GRCm39) |
L781H |
probably damaging |
Het |
| Smarcb1 |
T |
C |
10: 75,732,900 (GRCm39) |
T372A |
probably damaging |
Het |
| Spidr |
T |
A |
16: 15,855,531 (GRCm39) |
H328L |
probably damaging |
Het |
| Sun5 |
T |
A |
2: 153,712,872 (GRCm39) |
D16V |
probably damaging |
Het |
| Syde2 |
G |
A |
3: 145,720,135 (GRCm39) |
E1053K |
possibly damaging |
Het |
| Syne2 |
T |
C |
12: 76,146,238 (GRCm39) |
S6419P |
probably damaging |
Het |
| Tenm3 |
G |
A |
8: 48,794,195 (GRCm39) |
|
probably benign |
Het |
| Timm44 |
C |
A |
8: 4,310,532 (GRCm39) |
E407* |
probably null |
Het |
| Tnpo2 |
A |
G |
8: 85,773,991 (GRCm39) |
T342A |
probably benign |
Het |
| Trio |
A |
G |
15: 27,767,993 (GRCm39) |
C1964R |
probably benign |
Het |
| Trip11 |
A |
C |
12: 101,851,931 (GRCm39) |
L711R |
probably damaging |
Het |
| Trp53bp1 |
A |
T |
2: 121,100,450 (GRCm39) |
H101Q |
probably damaging |
Het |
| Trpm6 |
A |
G |
19: 18,851,266 (GRCm39) |
|
probably benign |
Het |
| Ttn |
A |
T |
2: 76,680,335 (GRCm39) |
|
probably benign |
Het |
| Ucp1 |
T |
A |
8: 84,021,936 (GRCm39) |
M256K |
possibly damaging |
Het |
| Unc5a |
T |
A |
13: 55,152,767 (GRCm39) |
S838T |
probably damaging |
Het |
| Uxs1 |
T |
C |
1: 43,804,046 (GRCm39) |
|
probably null |
Het |
| Vmn2r108 |
A |
T |
17: 20,683,096 (GRCm39) |
C703S |
possibly damaging |
Het |
| Zc3hav1 |
C |
T |
6: 38,309,599 (GRCm39) |
G408R |
probably damaging |
Het |
| Zfp1004 |
T |
A |
2: 150,035,000 (GRCm39) |
C471* |
probably null |
Het |
| Zfp609 |
G |
A |
9: 65,610,744 (GRCm39) |
L740F |
possibly damaging |
Het |
| Zfp69 |
T |
C |
4: 120,788,292 (GRCm39) |
E341G |
probably damaging |
Het |
| Zfp707 |
A |
T |
15: 75,847,105 (GRCm39) |
H312L |
probably damaging |
Het |
| Zfp773 |
T |
C |
7: 7,136,023 (GRCm39) |
D191G |
probably benign |
Het |
| Zgrf1 |
C |
A |
3: 127,366,887 (GRCm39) |
D755E |
probably benign |
Het |
| Zscan5b |
T |
A |
7: 6,242,074 (GRCm39) |
I431N |
probably damaging |
Het |
|
| Other mutations in Plxna4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00429:Plxna4
|
APN |
6 |
32,139,026 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01395:Plxna4
|
APN |
6 |
32,216,368 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01506:Plxna4
|
APN |
6 |
32,493,470 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01606:Plxna4
|
APN |
6 |
32,134,936 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01753:Plxna4
|
APN |
6 |
32,287,413 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01767:Plxna4
|
APN |
6 |
32,214,613 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
IGL01968:Plxna4
|
APN |
6 |
32,192,139 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL02109:Plxna4
|
APN |
6 |
32,192,576 (GRCm39) |
missense |
probably benign |
|
|
IGL02299:Plxna4
|
APN |
6 |
32,142,091 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02306:Plxna4
|
APN |
6 |
32,183,059 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL02312:Plxna4
|
APN |
6 |
32,142,052 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL02326:Plxna4
|
APN |
6 |
32,129,840 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02658:Plxna4
|
APN |
6 |
32,162,346 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02683:Plxna4
|
APN |
6 |
32,494,541 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02701:Plxna4
|
APN |
6 |
32,494,494 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02995:Plxna4
|
APN |
6 |
32,493,530 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03030:Plxna4
|
APN |
6 |
32,179,160 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03264:Plxna4
|
APN |
6 |
32,155,337 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
IGL03304:Plxna4
|
APN |
6 |
32,141,986 (GRCm39) |
splice site |
probably benign |
|
|
IGL03382:Plxna4
|
APN |
6 |
32,179,129 (GRCm39) |
missense |
probably benign |
0.23 |
|
corona
|
UTSW |
6 |
32,494,199 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Disposed
|
UTSW |
6 |
32,493,440 (GRCm39) |
missense |
probably damaging |
1.00 |
|
inclined
|
UTSW |
6 |
32,214,658 (GRCm39) |
nonsense |
probably null |
|
|
Slope
|
UTSW |
6 |
32,211,541 (GRCm39) |
missense |
probably benign |
0.00 |
|
G4846:Plxna4
|
UTSW |
6 |
32,169,207 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0133:Plxna4
|
UTSW |
6 |
32,174,009 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0200:Plxna4
|
UTSW |
6 |
32,174,023 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0308:Plxna4
|
UTSW |
6 |
32,214,703 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0468:Plxna4
|
UTSW |
6 |
32,192,181 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0542:Plxna4
|
UTSW |
6 |
32,169,232 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0548:Plxna4
|
UTSW |
6 |
32,134,950 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0652:Plxna4
|
UTSW |
6 |
32,162,436 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1144:Plxna4
|
UTSW |
6 |
32,174,091 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R1190:Plxna4
|
UTSW |
6 |
32,228,071 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1228:Plxna4
|
UTSW |
6 |
32,201,087 (GRCm39) |
splice site |
probably null |
|
|
R1569:Plxna4
|
UTSW |
6 |
32,162,410 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R1803:Plxna4
|
UTSW |
6 |
32,494,379 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1832:Plxna4
|
UTSW |
6 |
32,174,761 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2068:Plxna4
|
UTSW |
6 |
32,494,551 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R2157:Plxna4
|
UTSW |
6 |
32,493,909 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2842:Plxna4
|
UTSW |
6 |
32,192,566 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2849:Plxna4
|
UTSW |
6 |
32,162,467 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2892:Plxna4
|
UTSW |
6 |
32,493,972 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2930:Plxna4
|
UTSW |
6 |
32,142,715 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3892:Plxna4
|
UTSW |
6 |
32,192,589 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4065:Plxna4
|
UTSW |
6 |
32,213,300 (GRCm39) |
nonsense |
probably null |
|
|
R4276:Plxna4
|
UTSW |
6 |
32,177,883 (GRCm39) |
missense |
probably benign |
0.29 |
|
R4307:Plxna4
|
UTSW |
6 |
32,140,444 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4331:Plxna4
|
UTSW |
6 |
32,127,480 (GRCm39) |
nonsense |
probably null |
|
|
R4478:Plxna4
|
UTSW |
6 |
32,173,068 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4529:Plxna4
|
UTSW |
6 |
32,473,831 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4566:Plxna4
|
UTSW |
6 |
32,494,338 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4568:Plxna4
|
UTSW |
6 |
32,129,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4664:Plxna4
|
UTSW |
6 |
32,493,885 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R4685:Plxna4
|
UTSW |
6 |
32,142,779 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4701:Plxna4
|
UTSW |
6 |
32,493,623 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4939:Plxna4
|
UTSW |
6 |
32,142,697 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5153:Plxna4
|
UTSW |
6 |
32,201,094 (GRCm39) |
splice site |
probably null |
|
|
R5181:Plxna4
|
UTSW |
6 |
32,493,932 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5256:Plxna4
|
UTSW |
6 |
32,228,007 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5259:Plxna4
|
UTSW |
6 |
32,493,956 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R5306:Plxna4
|
UTSW |
6 |
32,183,056 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5487:Plxna4
|
UTSW |
6 |
32,494,218 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5510:Plxna4
|
UTSW |
6 |
32,155,293 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5542:Plxna4
|
UTSW |
6 |
32,183,165 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5567:Plxna4
|
UTSW |
6 |
32,134,915 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R5634:Plxna4
|
UTSW |
6 |
32,214,658 (GRCm39) |
nonsense |
probably null |
|
|
R5653:Plxna4
|
UTSW |
6 |
32,494,551 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R5665:Plxna4
|
UTSW |
6 |
32,192,657 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5845:Plxna4
|
UTSW |
6 |
32,214,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5909:Plxna4
|
UTSW |
6 |
32,494,181 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5938:Plxna4
|
UTSW |
6 |
32,211,541 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5973:Plxna4
|
UTSW |
6 |
32,228,000 (GRCm39) |
splice site |
probably null |
|
|
R6433:Plxna4
|
UTSW |
6 |
32,192,613 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6482:Plxna4
|
UTSW |
6 |
32,493,672 (GRCm39) |
missense |
probably benign |
|
|
R6560:Plxna4
|
UTSW |
6 |
32,192,613 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6721:Plxna4
|
UTSW |
6 |
32,177,794 (GRCm39) |
missense |
probably benign |
0.26 |
|
R6810:Plxna4
|
UTSW |
6 |
32,287,457 (GRCm39) |
missense |
probably benign |
0.18 |
|
R6985:Plxna4
|
UTSW |
6 |
32,214,643 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7024:Plxna4
|
UTSW |
6 |
32,169,204 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7046:Plxna4
|
UTSW |
6 |
32,493,440 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7137:Plxna4
|
UTSW |
6 |
32,494,199 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7163:Plxna4
|
UTSW |
6 |
32,473,691 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7199:Plxna4
|
UTSW |
6 |
32,192,113 (GRCm39) |
nonsense |
probably null |
|
|
R7248:Plxna4
|
UTSW |
6 |
32,139,095 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7260:Plxna4
|
UTSW |
6 |
32,216,455 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R7361:Plxna4
|
UTSW |
6 |
32,173,057 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7383:Plxna4
|
UTSW |
6 |
32,129,734 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7405:Plxna4
|
UTSW |
6 |
32,173,254 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7516:Plxna4
|
UTSW |
6 |
32,214,703 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7635:Plxna4
|
UTSW |
6 |
32,473,676 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7754:Plxna4
|
UTSW |
6 |
32,129,807 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7763:Plxna4
|
UTSW |
6 |
32,200,915 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7789:Plxna4
|
UTSW |
6 |
32,183,168 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R8167:Plxna4
|
UTSW |
6 |
32,493,981 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8191:Plxna4
|
UTSW |
6 |
32,493,885 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8225:Plxna4
|
UTSW |
6 |
32,139,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8284:Plxna4
|
UTSW |
6 |
32,129,789 (GRCm39) |
missense |
probably benign |
0.25 |
|
R8305:Plxna4
|
UTSW |
6 |
32,188,000 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R8438:Plxna4
|
UTSW |
6 |
32,179,115 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8493:Plxna4
|
UTSW |
6 |
32,192,647 (GRCm39) |
missense |
probably benign |
0.27 |
|
R8714:Plxna4
|
UTSW |
6 |
32,140,379 (GRCm39) |
nonsense |
probably null |
|
|
R8759:Plxna4
|
UTSW |
6 |
32,169,276 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8822:Plxna4
|
UTSW |
6 |
32,127,431 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8844:Plxna4
|
UTSW |
6 |
32,174,026 (GRCm39) |
missense |
probably benign |
0.11 |
|
R8974:Plxna4
|
UTSW |
6 |
32,216,447 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R9020:Plxna4
|
UTSW |
6 |
32,211,497 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9144:Plxna4
|
UTSW |
6 |
32,162,496 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R9206:Plxna4
|
UTSW |
6 |
32,494,379 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9208:Plxna4
|
UTSW |
6 |
32,494,379 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9257:Plxna4
|
UTSW |
6 |
32,139,018 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9269:Plxna4
|
UTSW |
6 |
32,155,315 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9411:Plxna4
|
UTSW |
6 |
32,159,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9469:Plxna4
|
UTSW |
6 |
32,494,526 (GRCm39) |
missense |
probably benign |
|
|
R9583:Plxna4
|
UTSW |
6 |
32,192,169 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R9647:Plxna4
|
UTSW |
6 |
32,228,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9695:Plxna4
|
UTSW |
6 |
32,183,056 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9801:Plxna4
|
UTSW |
6 |
32,140,526 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
V1024:Plxna4
|
UTSW |
6 |
32,211,509 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0027:Plxna4
|
UTSW |
6 |
32,493,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCCAGGAAATGCAGCAATTGGCTACTG -3'
(R):5'- TTTGCAGGCACCAGGAGGCTGTTTAC -3'
Sequencing Primer
(F):5'- TTGGCTACTGTCCTCAAACAAAG -3'
(R):5'- accttggagaacttagcgaac -3'
|
| Posted On |
2013-06-12 |
Incidental Mutation