Incidental Mutation 'R3957:Igkv15-103'
ID 474925
Institutional Source Beutler Lab
Gene Symbol Igkv15-103
Ensembl Gene ENSMUSG00000076523
Gene Name immunoglobulin kappa chain variable 15-103
Synonyms Igk-V32
MMRRC Submission 040931-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.080) question?
Stock # R3957 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 68414452-68414909 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 68414903 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 114 (Y114F)
Ref Sequence ENSEMBL: ENSMUSP00000100125 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103324]
AlphaFold A0A140T8P3
Predicted Effect probably benign
Transcript: ENSMUST00000103324
AA Change: Y114F

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000100125
Gene: ENSMUSG00000076523
AA Change: Y114F

DomainStartEndE-ValueType
low complexity region 2 20 N/A INTRINSIC
IGv 38 110 1.51e-21 SMART
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.9%
  • 20x: 93.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9330159F19Rik A G 10: 29,100,805 (GRCm39) K393E possibly damaging Het
Acsm4 A T 7: 119,302,588 (GRCm39) M238L possibly damaging Het
Adam2 G A 14: 66,295,059 (GRCm39) S262L probably damaging Het
Atp13a5 T A 16: 29,117,012 (GRCm39) I579L probably benign Het
Canx A G 11: 50,199,210 (GRCm39) V153A probably damaging Het
Cdan1 A G 2: 120,556,113 (GRCm39) Y718H probably damaging Het
Cdan1 G A 2: 120,561,501 (GRCm39) probably benign Het
Cpsf3 A G 12: 21,363,806 (GRCm39) D632G probably benign Het
Dach1 T C 14: 98,077,545 (GRCm39) T561A probably damaging Het
Dennd5a A G 7: 109,504,906 (GRCm39) M868T probably benign Het
Dhx29 C T 13: 113,067,455 (GRCm39) A112V probably benign Het
Fanca G A 8: 124,043,102 (GRCm39) R95C probably benign Het
Fat4 C A 3: 39,036,495 (GRCm39) N3382K probably benign Het
Fkbp15 A C 4: 62,252,489 (GRCm39) F290L probably benign Het
Fkbp8 T G 8: 70,987,517 (GRCm39) S376A probably damaging Het
Hivep2 C A 10: 14,004,713 (GRCm39) T437K probably benign Het
Igfn1 A G 1: 135,894,918 (GRCm39) Y1883H possibly damaging Het
Ighv3-4 T A 12: 114,217,300 (GRCm39) Q97L probably damaging Het
Kera G A 10: 97,448,707 (GRCm39) R309H probably benign Het
Kif1a T A 1: 92,953,416 (GRCm39) H1256L probably damaging Het
Kremen1 CGGG CGGGGGG 11: 5,151,791 (GRCm39) probably benign Het
Lmx1b T C 2: 33,459,106 (GRCm39) E149G probably damaging Het
Me2 A G 18: 73,914,203 (GRCm39) F443L probably damaging Het
Med12l T A 3: 58,980,589 (GRCm39) S307R probably damaging Het
Mettl25b T C 3: 87,834,135 (GRCm39) K116R possibly damaging Het
Mocs2 T A 13: 114,961,803 (GRCm39) probably null Het
Nek7 C A 1: 138,462,127 (GRCm39) C79F probably damaging Het
Or14j6 A T 17: 38,214,500 (GRCm39) H21L probably benign Het
Or51f1 A G 7: 102,505,824 (GRCm39) C222R probably damaging Het
Or5al1 A G 2: 85,990,282 (GRCm39) V144A probably benign Het
Or5d43 A G 2: 88,105,348 (GRCm39) F15S probably damaging Het
Ovch2 G A 7: 107,388,318 (GRCm39) L421F probably damaging Het
Pan2 C T 10: 128,151,046 (GRCm39) R806C probably damaging Het
Plod3 A T 5: 137,023,046 (GRCm39) H616L probably damaging Het
Plxnb3 T C X: 72,814,826 (GRCm39) V1789A probably benign Het
Ptgir A G 7: 16,640,794 (GRCm39) M29V possibly damaging Het
Tbc1d9 C T 8: 83,960,161 (GRCm39) T138I probably damaging Het
Tdrkh A G 3: 94,335,556 (GRCm39) N383S probably damaging Het
Trim30d C T 7: 104,121,728 (GRCm39) G339D probably damaging Het
Trub1 G A 19: 57,473,798 (GRCm39) A239T possibly damaging Het
Tspan32 T A 7: 142,560,735 (GRCm39) M61K probably damaging Het
Ttc6 T C 12: 57,744,238 (GRCm39) V1290A probably benign Het
Ttn A G 2: 76,799,593 (GRCm39) V429A possibly damaging Het
Unc13b A G 4: 43,256,834 (GRCm39) Y3962C probably damaging Het
Usp3 T C 9: 66,469,873 (GRCm39) T83A probably benign Het
Vmn2r95 T A 17: 18,660,358 (GRCm39) Y257N possibly damaging Het
Zmym6 T C 4: 127,017,089 (GRCm39) S957P possibly damaging Het
Zmynd8 T C 2: 165,654,395 (GRCm39) T722A probably damaging Het
Other mutations in Igkv15-103
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02851:Igkv15-103 APN 6 68,414,674 (GRCm39) missense probably benign 0.13
R4165:Igkv15-103 UTSW 6 68,414,824 (GRCm39) nonsense probably null
R4494:Igkv15-103 UTSW 6 68,414,780 (GRCm39) missense probably benign 0.02
R5998:Igkv15-103 UTSW 6 68,414,489 (GRCm39) missense unknown
R6356:Igkv15-103 UTSW 6 68,414,441 (GRCm39) start gained probably benign
R6610:Igkv15-103 UTSW 6 68,414,617 (GRCm39) nonsense probably null
R8823:Igkv15-103 UTSW 6 68,414,855 (GRCm39) missense probably damaging 0.98
Predicted Primers
Posted On 2017-04-14