Incidental Mutation 'R0505:Trip11'
| ID |
47507 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Trip11
|
| Ensembl Gene |
ENSMUSG00000021188 |
| Gene Name |
thyroid hormone receptor interactor 11 |
| Synonyms |
3110031G15Rik, TRIP230, 2610511G22Rik, GMAP-210, 6030460N08Rik |
| MMRRC Submission |
038700-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R0505 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
12 |
| Chromosomal Location |
101800304-101879463 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to C
at 101851931 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Arginine
at position 711
(L711R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000021605
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000021605]
[ENSMUST00000176728]
[ENSMUST00000177183]
[ENSMUST00000177536]
|
| AlphaFold |
E9Q512 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000021605
AA Change: L711R
PolyPhen 2
Score 0.978 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000021605
Gene: ENSMUSG00000021188
AA Change: L711R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
26 |
N/A |
INTRINSIC |
|
coiled coil region
|
54 |
130 |
N/A |
INTRINSIC |
|
coiled coil region
|
167 |
194 |
N/A |
INTRINSIC |
|
coiled coil region
|
218 |
702 |
N/A |
INTRINSIC |
|
coiled coil region
|
754 |
990 |
N/A |
INTRINSIC |
|
coiled coil region
|
1022 |
1051 |
N/A |
INTRINSIC |
|
coiled coil region
|
1196 |
1261 |
N/A |
INTRINSIC |
|
low complexity region
|
1310 |
1322 |
N/A |
INTRINSIC |
|
coiled coil region
|
1336 |
1481 |
N/A |
INTRINSIC |
|
coiled coil region
|
1547 |
1657 |
N/A |
INTRINSIC |
|
coiled coil region
|
1681 |
1771 |
N/A |
INTRINSIC |
|
low complexity region
|
1934 |
1945 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176728
|
| SMART Domains |
Protein: ENSMUSP00000134992
Gene: ENSMUSG00000021188
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
26 |
N/A |
INTRINSIC |
|
Pfam:Orthopox_A5L
|
48 |
282 |
6.5e-9 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000177183
AA Change: L426R
PolyPhen 2
Score 0.865 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000134976
Gene: ENSMUSG00000021188
AA Change: L426R
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
33 |
158 |
N/A |
INTRINSIC |
|
coiled coil region
|
179 |
417 |
N/A |
INTRINSIC |
|
coiled coil region
|
469 |
705 |
N/A |
INTRINSIC |
|
coiled coil region
|
737 |
766 |
N/A |
INTRINSIC |
|
coiled coil region
|
911 |
976 |
N/A |
INTRINSIC |
|
low complexity region
|
1025 |
1037 |
N/A |
INTRINSIC |
|
coiled coil region
|
1051 |
1196 |
N/A |
INTRINSIC |
|
coiled coil region
|
1262 |
1372 |
N/A |
INTRINSIC |
|
coiled coil region
|
1396 |
1486 |
N/A |
INTRINSIC |
|
low complexity region
|
1649 |
1660 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177480
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177536
|
| SMART Domains |
Protein: ENSMUSP00000135669
Gene: ENSMUSG00000021188
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
26 |
N/A |
INTRINSIC |
|
coiled coil region
|
53 |
129 |
N/A |
INTRINSIC |
|
coiled coil region
|
166 |
193 |
N/A |
INTRINSIC |
|
coiled coil region
|
217 |
517 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 94.1%
|
| Validation Efficiency |
98% (119/121) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene was identified based on the interaction of its protein product with thyroid hormone receptor beta. This protein is associated with the Golgi apparatus. The N-terminal region of the protein binds Golgi membranes and the C-terminal region binds the minus ends of microtubules; thus, the protein is thought to play a role in assembly and maintenance of the Golgi ribbon structure around the centrosome. Mutations in this gene cause achondrogenesis type IA.[provided by RefSeq, Mar 2010]
PHENOTYPE: Mice homozygous for a null allele exhibit neonatal lethality associated with small size, lung hypoplasia, omphalocele, and ventricular septal defects. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(12) : Gene trapped(11) Chemically induced(1)
|
| Other mutations in this stock |
Total: 117 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca13 |
T |
C |
11: 9,241,058 (GRCm39) |
Y974H |
probably benign |
Het |
| Abca2 |
G |
T |
2: 25,324,906 (GRCm39) |
G300V |
probably benign |
Het |
| Abi1 |
A |
G |
2: 22,852,516 (GRCm39) |
|
probably benign |
Het |
| Actr10 |
T |
A |
12: 71,006,738 (GRCm39) |
Y332N |
probably damaging |
Het |
| Adam25 |
G |
T |
8: 41,208,261 (GRCm39) |
C509F |
probably damaging |
Het |
| Adck1 |
A |
T |
12: 88,338,461 (GRCm39) |
|
probably benign |
Het |
| Adgra3 |
A |
G |
5: 50,166,676 (GRCm39) |
|
probably null |
Het |
| Adgrl1 |
G |
T |
8: 84,661,279 (GRCm39) |
|
probably benign |
Het |
| Akr1c21 |
A |
G |
13: 4,626,306 (GRCm39) |
Y110C |
probably damaging |
Het |
| Arhgef25 |
T |
C |
10: 127,019,566 (GRCm39) |
I463V |
probably null |
Het |
| Atp6v1e2 |
C |
T |
17: 87,252,006 (GRCm39) |
V131M |
probably benign |
Het |
| Bdnf |
A |
G |
2: 109,505,688 (GRCm39) |
|
probably null |
Het |
| Bltp3b |
T |
C |
10: 89,627,305 (GRCm39) |
S145P |
probably damaging |
Het |
| C7 |
A |
T |
15: 5,023,624 (GRCm39) |
|
probably benign |
Het |
| Cdc27 |
T |
C |
11: 104,419,114 (GRCm39) |
T273A |
probably benign |
Het |
| Cdo1 |
T |
A |
18: 46,848,678 (GRCm39) |
I187F |
probably benign |
Het |
| Cep104 |
A |
T |
4: 154,080,761 (GRCm39) |
T742S |
probably benign |
Het |
| Ckm |
A |
T |
7: 19,153,377 (GRCm39) |
K223* |
probably null |
Het |
| Cmtr1 |
C |
T |
17: 29,895,259 (GRCm39) |
P586L |
probably benign |
Het |
| Csmd1 |
C |
T |
8: 16,042,758 (GRCm39) |
R2325Q |
probably damaging |
Het |
| Dcpp1 |
A |
T |
17: 24,101,568 (GRCm39) |
I106L |
possibly damaging |
Het |
| Diaph3 |
A |
C |
14: 87,328,400 (GRCm39) |
|
probably benign |
Het |
| Dnah11 |
A |
G |
12: 118,070,245 (GRCm39) |
V1520A |
probably damaging |
Het |
| Dnajc25 |
T |
A |
4: 59,020,438 (GRCm39) |
M168K |
|
Het |
| Dpp3 |
T |
C |
19: 4,964,682 (GRCm39) |
N542D |
probably damaging |
Het |
| Ebf2 |
A |
T |
14: 67,609,185 (GRCm39) |
K199* |
probably null |
Het |
| Eeig2 |
T |
C |
3: 108,887,520 (GRCm39) |
E248G |
probably benign |
Het |
| Efcab11 |
T |
A |
12: 99,685,294 (GRCm39) |
Q160L |
probably benign |
Het |
| Eif2ak4 |
T |
A |
2: 118,261,517 (GRCm39) |
S686T |
probably benign |
Het |
| Epha6 |
C |
T |
16: 60,026,095 (GRCm39) |
S449N |
possibly damaging |
Het |
| Ercc4 |
T |
C |
16: 12,944,331 (GRCm39) |
V329A |
probably benign |
Het |
| Faf1 |
T |
C |
4: 109,697,600 (GRCm39) |
F309L |
possibly damaging |
Het |
| G6pd2 |
C |
A |
5: 61,966,910 (GRCm39) |
D228E |
probably benign |
Het |
| Ggt1 |
T |
G |
10: 75,421,791 (GRCm39) |
V546G |
probably damaging |
Het |
| Gpatch4 |
G |
T |
3: 87,958,524 (GRCm39) |
V3F |
probably damaging |
Het |
| Gprin3 |
A |
G |
6: 59,330,372 (GRCm39) |
L645P |
probably damaging |
Het |
| Hyal2 |
A |
G |
9: 107,449,270 (GRCm39) |
Y342C |
probably benign |
Het |
| Igf2bp2 |
A |
G |
16: 21,907,849 (GRCm39) |
I16T |
possibly damaging |
Het |
| Inca1 |
T |
C |
11: 70,581,025 (GRCm39) |
Y61C |
probably damaging |
Het |
| Ipo5 |
T |
C |
14: 121,180,145 (GRCm39) |
W860R |
possibly damaging |
Het |
| Kcnj9 |
C |
T |
1: 172,150,591 (GRCm39) |
A341T |
probably benign |
Het |
| Kdm5b |
T |
C |
1: 134,530,309 (GRCm39) |
V440A |
probably damaging |
Het |
| L3mbtl1 |
C |
T |
2: 162,789,255 (GRCm39) |
|
probably benign |
Het |
| Lin54 |
G |
A |
5: 100,600,152 (GRCm39) |
T307I |
probably damaging |
Het |
| Lrrc18 |
C |
A |
14: 32,731,096 (GRCm39) |
Q212K |
probably benign |
Het |
| Lrrc37a |
A |
G |
11: 103,393,851 (GRCm39) |
S525P |
probably benign |
Het |
| Lrrc71 |
T |
A |
3: 87,653,006 (GRCm39) |
S137C |
probably damaging |
Het |
| Lrrk1 |
A |
T |
7: 65,940,656 (GRCm39) |
|
probably null |
Het |
| Man2b2 |
G |
A |
5: 36,973,542 (GRCm39) |
S58L |
probably benign |
Het |
| Masp1 |
T |
A |
16: 23,276,888 (GRCm39) |
H539L |
probably benign |
Het |
| Med1 |
G |
A |
11: 98,047,730 (GRCm39) |
P1022L |
probably damaging |
Het |
| Meis1 |
T |
A |
11: 18,961,360 (GRCm39) |
H171L |
probably damaging |
Het |
| Mier1 |
T |
A |
4: 103,012,820 (GRCm39) |
|
probably benign |
Het |
| Mmp13 |
A |
T |
9: 7,272,929 (GRCm39) |
R96S |
probably damaging |
Het |
| Mms19 |
G |
A |
19: 41,942,173 (GRCm39) |
T38I |
probably damaging |
Het |
| Mrc1 |
G |
A |
2: 14,314,843 (GRCm39) |
C976Y |
probably damaging |
Het |
| Mrtfb |
C |
T |
16: 13,230,390 (GRCm39) |
T1025I |
possibly damaging |
Het |
| Naalad2 |
A |
G |
9: 18,297,191 (GRCm39) |
Y32H |
probably benign |
Het |
| Ndufs1 |
A |
G |
1: 63,183,085 (GRCm39) |
|
probably benign |
Het |
| Nefm |
C |
T |
14: 68,361,608 (GRCm39) |
D219N |
probably damaging |
Het |
| Nwd1 |
C |
T |
8: 73,388,965 (GRCm39) |
P172L |
probably damaging |
Het |
| Nwd2 |
T |
A |
5: 63,962,454 (GRCm39) |
D679E |
probably damaging |
Het |
| Ogdh |
T |
A |
11: 6,289,936 (GRCm39) |
|
probably benign |
Het |
| Olfm3 |
T |
A |
3: 114,916,330 (GRCm39) |
S421T |
possibly damaging |
Het |
| Opn5 |
T |
G |
17: 42,903,844 (GRCm39) |
T164P |
possibly damaging |
Het |
| Or4k37 |
A |
T |
2: 111,159,673 (GRCm39) |
N303I |
probably benign |
Het |
| Or51a25 |
T |
A |
7: 102,373,236 (GRCm39) |
I154F |
probably damaging |
Het |
| Or52a24 |
T |
C |
7: 103,381,583 (GRCm39) |
V150A |
probably benign |
Het |
| Or5ak20 |
A |
G |
2: 85,184,093 (GRCm39) |
M59T |
possibly damaging |
Het |
| Or5b12b |
T |
C |
19: 12,861,443 (GRCm39) |
L66P |
probably damaging |
Het |
| Or5b12b |
A |
G |
19: 12,861,910 (GRCm39) |
T222A |
probably damaging |
Het |
| Pde7b |
C |
T |
10: 20,314,492 (GRCm39) |
V166M |
probably damaging |
Het |
| Peds1 |
A |
T |
2: 167,486,907 (GRCm39) |
|
probably benign |
Het |
| Pik3ap1 |
T |
C |
19: 41,313,003 (GRCm39) |
N370S |
probably damaging |
Het |
| Pkhd1l1 |
A |
T |
15: 44,452,814 (GRCm39) |
D3913V |
probably damaging |
Het |
| Pld1 |
A |
G |
3: 28,174,971 (GRCm39) |
I90V |
possibly damaging |
Het |
| Plxna2 |
A |
G |
1: 194,326,656 (GRCm39) |
T197A |
possibly damaging |
Het |
| Plxna4 |
A |
T |
6: 32,179,054 (GRCm39) |
M987K |
probably benign |
Het |
| Pmch |
A |
G |
10: 87,927,221 (GRCm39) |
N75D |
probably benign |
Het |
| Prom2 |
T |
A |
2: 127,374,787 (GRCm39) |
Q583L |
possibly damaging |
Het |
| Pyroxd1 |
T |
A |
6: 142,299,288 (GRCm39) |
M148K |
possibly damaging |
Het |
| R3hdm2 |
C |
T |
10: 127,293,569 (GRCm39) |
L158F |
probably damaging |
Het |
| Rapgef6 |
A |
T |
11: 54,516,789 (GRCm39) |
T349S |
probably benign |
Het |
| Rfx5 |
C |
T |
3: 94,863,666 (GRCm39) |
T105I |
probably damaging |
Het |
| Rif1 |
C |
A |
2: 52,000,749 (GRCm39) |
P1401Q |
probably damaging |
Het |
| Robo3 |
G |
A |
9: 37,328,055 (GRCm39) |
|
probably benign |
Het |
| Rpn1 |
T |
A |
6: 88,067,224 (GRCm39) |
S195T |
probably benign |
Het |
| Rslcan18 |
C |
A |
13: 67,250,183 (GRCm39) |
K17N |
probably benign |
Het |
| Rsph3b |
A |
T |
17: 7,209,126 (GRCm39) |
I48N |
probably damaging |
Het |
| Sbf2 |
A |
T |
7: 109,998,550 (GRCm39) |
Y628N |
probably damaging |
Het |
| Sis |
T |
C |
3: 72,867,629 (GRCm39) |
T139A |
probably benign |
Het |
| Slc22a14 |
A |
G |
9: 119,001,100 (GRCm39) |
|
probably benign |
Het |
| Slitrk6 |
A |
T |
14: 110,987,364 (GRCm39) |
L781H |
probably damaging |
Het |
| Smarcb1 |
T |
C |
10: 75,732,900 (GRCm39) |
T372A |
probably damaging |
Het |
| Spidr |
T |
A |
16: 15,855,531 (GRCm39) |
H328L |
probably damaging |
Het |
| Sun5 |
T |
A |
2: 153,712,872 (GRCm39) |
D16V |
probably damaging |
Het |
| Syde2 |
G |
A |
3: 145,720,135 (GRCm39) |
E1053K |
possibly damaging |
Het |
| Syne2 |
T |
C |
12: 76,146,238 (GRCm39) |
S6419P |
probably damaging |
Het |
| Tenm3 |
G |
A |
8: 48,794,195 (GRCm39) |
|
probably benign |
Het |
| Timm44 |
C |
A |
8: 4,310,532 (GRCm39) |
E407* |
probably null |
Het |
| Tnpo2 |
A |
G |
8: 85,773,991 (GRCm39) |
T342A |
probably benign |
Het |
| Trio |
A |
G |
15: 27,767,993 (GRCm39) |
C1964R |
probably benign |
Het |
| Trp53bp1 |
A |
T |
2: 121,100,450 (GRCm39) |
H101Q |
probably damaging |
Het |
| Trpm6 |
A |
G |
19: 18,851,266 (GRCm39) |
|
probably benign |
Het |
| Ttn |
A |
T |
2: 76,680,335 (GRCm39) |
|
probably benign |
Het |
| Ucp1 |
T |
A |
8: 84,021,936 (GRCm39) |
M256K |
possibly damaging |
Het |
| Unc5a |
T |
A |
13: 55,152,767 (GRCm39) |
S838T |
probably damaging |
Het |
| Uxs1 |
T |
C |
1: 43,804,046 (GRCm39) |
|
probably null |
Het |
| Vmn2r108 |
A |
T |
17: 20,683,096 (GRCm39) |
C703S |
possibly damaging |
Het |
| Zc3hav1 |
C |
T |
6: 38,309,599 (GRCm39) |
G408R |
probably damaging |
Het |
| Zfp1004 |
T |
A |
2: 150,035,000 (GRCm39) |
C471* |
probably null |
Het |
| Zfp609 |
G |
A |
9: 65,610,744 (GRCm39) |
L740F |
possibly damaging |
Het |
| Zfp69 |
T |
C |
4: 120,788,292 (GRCm39) |
E341G |
probably damaging |
Het |
| Zfp707 |
A |
T |
15: 75,847,105 (GRCm39) |
H312L |
probably damaging |
Het |
| Zfp773 |
T |
C |
7: 7,136,023 (GRCm39) |
D191G |
probably benign |
Het |
| Zgrf1 |
C |
A |
3: 127,366,887 (GRCm39) |
D755E |
probably benign |
Het |
| Zscan5b |
T |
A |
7: 6,242,074 (GRCm39) |
I431N |
probably damaging |
Het |
|
| Other mutations in Trip11 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00430:Trip11
|
APN |
12 |
101,852,406 (GRCm39) |
missense |
probably benign |
0.37 |
|
IGL00484:Trip11
|
APN |
12 |
101,851,570 (GRCm39) |
nonsense |
probably null |
|
|
IGL00972:Trip11
|
APN |
12 |
101,860,596 (GRCm39) |
missense |
probably null |
1.00 |
|
IGL01476:Trip11
|
APN |
12 |
101,865,170 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01591:Trip11
|
APN |
12 |
101,849,604 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01667:Trip11
|
APN |
12 |
101,845,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01764:Trip11
|
APN |
12 |
101,850,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01789:Trip11
|
APN |
12 |
101,838,090 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01814:Trip11
|
APN |
12 |
101,850,747 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01898:Trip11
|
APN |
12 |
101,851,935 (GRCm39) |
missense |
probably benign |
|
|
IGL01924:Trip11
|
APN |
12 |
101,853,143 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL02020:Trip11
|
APN |
12 |
101,850,572 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02475:Trip11
|
APN |
12 |
101,861,942 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02544:Trip11
|
APN |
12 |
101,859,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02678:Trip11
|
APN |
12 |
101,849,649 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02714:Trip11
|
APN |
12 |
101,850,260 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02718:Trip11
|
APN |
12 |
101,852,284 (GRCm39) |
missense |
probably benign |
0.24 |
|
IGL02904:Trip11
|
APN |
12 |
101,853,097 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03012:Trip11
|
APN |
12 |
101,850,195 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03191:Trip11
|
APN |
12 |
101,865,184 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03327:Trip11
|
APN |
12 |
101,849,677 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL03337:Trip11
|
APN |
12 |
101,851,278 (GRCm39) |
missense |
probably damaging |
1.00 |
|
NA:Trip11
|
UTSW |
12 |
101,860,580 (GRCm39) |
splice site |
probably null |
|
|
R0027:Trip11
|
UTSW |
12 |
101,851,428 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0028:Trip11
|
UTSW |
12 |
101,851,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0238:Trip11
|
UTSW |
12 |
101,850,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0238:Trip11
|
UTSW |
12 |
101,850,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0239:Trip11
|
UTSW |
12 |
101,850,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0239:Trip11
|
UTSW |
12 |
101,850,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0556:Trip11
|
UTSW |
12 |
101,850,777 (GRCm39) |
nonsense |
probably null |
|
|
R0573:Trip11
|
UTSW |
12 |
101,853,119 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0626:Trip11
|
UTSW |
12 |
101,852,235 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R1519:Trip11
|
UTSW |
12 |
101,852,419 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1530:Trip11
|
UTSW |
12 |
101,879,026 (GRCm39) |
missense |
unknown |
|
|
R1647:Trip11
|
UTSW |
12 |
101,850,651 (GRCm39) |
nonsense |
probably null |
|
|
R1648:Trip11
|
UTSW |
12 |
101,850,651 (GRCm39) |
nonsense |
probably null |
|
|
R1856:Trip11
|
UTSW |
12 |
101,849,592 (GRCm39) |
nonsense |
probably null |
|
|
R2013:Trip11
|
UTSW |
12 |
101,803,981 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2017:Trip11
|
UTSW |
12 |
101,851,619 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2206:Trip11
|
UTSW |
12 |
101,839,701 (GRCm39) |
missense |
probably benign |
0.25 |
|
R2207:Trip11
|
UTSW |
12 |
101,839,701 (GRCm39) |
missense |
probably benign |
0.25 |
|
R2304:Trip11
|
UTSW |
12 |
101,865,236 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R2328:Trip11
|
UTSW |
12 |
101,845,086 (GRCm39) |
makesense |
probably null |
|
|
R2513:Trip11
|
UTSW |
12 |
101,803,986 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R3499:Trip11
|
UTSW |
12 |
101,859,953 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4105:Trip11
|
UTSW |
12 |
101,860,581 (GRCm39) |
nonsense |
probably null |
|
|
R4124:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4126:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4128:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4175:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4176:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4181:Trip11
|
UTSW |
12 |
101,860,027 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4296:Trip11
|
UTSW |
12 |
101,852,127 (GRCm39) |
nonsense |
probably null |
|
|
R4302:Trip11
|
UTSW |
12 |
101,860,027 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4306:Trip11
|
UTSW |
12 |
101,853,198 (GRCm39) |
missense |
probably benign |
|
|
R4342:Trip11
|
UTSW |
12 |
101,850,575 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4576:Trip11
|
UTSW |
12 |
101,852,499 (GRCm39) |
nonsense |
probably null |
|
|
R4586:Trip11
|
UTSW |
12 |
101,849,600 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R4634:Trip11
|
UTSW |
12 |
101,803,875 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4696:Trip11
|
UTSW |
12 |
101,851,549 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4792:Trip11
|
UTSW |
12 |
101,851,705 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4903:Trip11
|
UTSW |
12 |
101,853,065 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5001:Trip11
|
UTSW |
12 |
101,851,169 (GRCm39) |
nonsense |
probably null |
|
|
R5017:Trip11
|
UTSW |
12 |
101,812,879 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5227:Trip11
|
UTSW |
12 |
101,851,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5231:Trip11
|
UTSW |
12 |
101,851,860 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5539:Trip11
|
UTSW |
12 |
101,851,386 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5754:Trip11
|
UTSW |
12 |
101,851,924 (GRCm39) |
nonsense |
probably null |
|
|
R5755:Trip11
|
UTSW |
12 |
101,851,924 (GRCm39) |
nonsense |
probably null |
|
|
R5890:Trip11
|
UTSW |
12 |
101,852,231 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5910:Trip11
|
UTSW |
12 |
101,849,738 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6083:Trip11
|
UTSW |
12 |
101,856,001 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6208:Trip11
|
UTSW |
12 |
101,865,154 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6216:Trip11
|
UTSW |
12 |
101,856,859 (GRCm39) |
missense |
probably benign |
0.31 |
|
R6315:Trip11
|
UTSW |
12 |
101,851,837 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6413:Trip11
|
UTSW |
12 |
101,851,790 (GRCm39) |
missense |
probably benign |
0.12 |
|
R6590:Trip11
|
UTSW |
12 |
101,851,710 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6690:Trip11
|
UTSW |
12 |
101,851,710 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6914:Trip11
|
UTSW |
12 |
101,812,879 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6938:Trip11
|
UTSW |
12 |
101,803,886 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7015:Trip11
|
UTSW |
12 |
101,859,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7023:Trip11
|
UTSW |
12 |
101,852,126 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7133:Trip11
|
UTSW |
12 |
101,850,329 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7271:Trip11
|
UTSW |
12 |
101,850,611 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7424:Trip11
|
UTSW |
12 |
101,851,457 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7431:Trip11
|
UTSW |
12 |
101,850,278 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R7472:Trip11
|
UTSW |
12 |
101,851,639 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7491:Trip11
|
UTSW |
12 |
101,851,694 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7752:Trip11
|
UTSW |
12 |
101,853,233 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7763:Trip11
|
UTSW |
12 |
101,811,114 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7779:Trip11
|
UTSW |
12 |
101,849,796 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7844:Trip11
|
UTSW |
12 |
101,844,403 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8055:Trip11
|
UTSW |
12 |
101,803,924 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8076:Trip11
|
UTSW |
12 |
101,849,741 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8288:Trip11
|
UTSW |
12 |
101,860,643 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8294:Trip11
|
UTSW |
12 |
101,811,160 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8318:Trip11
|
UTSW |
12 |
101,879,063 (GRCm39) |
missense |
unknown |
|
|
R8690:Trip11
|
UTSW |
12 |
101,839,656 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R8879:Trip11
|
UTSW |
12 |
101,828,857 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8964:Trip11
|
UTSW |
12 |
101,811,315 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9005:Trip11
|
UTSW |
12 |
101,845,131 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9013:Trip11
|
UTSW |
12 |
101,851,377 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9020:Trip11
|
UTSW |
12 |
101,850,770 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R9041:Trip11
|
UTSW |
12 |
101,845,127 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9234:Trip11
|
UTSW |
12 |
101,811,990 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9447:Trip11
|
UTSW |
12 |
101,850,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9631:Trip11
|
UTSW |
12 |
101,859,807 (GRCm39) |
missense |
probably benign |
|
|
R9641:Trip11
|
UTSW |
12 |
101,859,957 (GRCm39) |
nonsense |
probably null |
|
|
R9691:Trip11
|
UTSW |
12 |
101,850,123 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9751:Trip11
|
UTSW |
12 |
101,850,765 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
X0020:Trip11
|
UTSW |
12 |
101,852,172 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- ACAGCTCAGACTCCAGCTCGGT -3'
(R):5'- CCAGCAGGAACGTGAAGGATGACTT -3'
Sequencing Primer
(F):5'- AGATGACAAAGTCTCCTTGGTTCG -3'
(R):5'- AACGTGAAGGATGACTTACTTAAAG -3'
|
| Posted On |
2013-06-12 |
Incidental Mutation