Mutagenetix > Incidental Mutation

Incidental Mutation 'R4051:Trav7-3'

475395

Institutional Source

Beutler Lab

Gene Symbol

Trav7-3

Ensembl Gene

ENSMUSG00000096908

Gene Name

T cell receptor alpha variable 7-3

Synonyms

Gm13946

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.094) question?

Stock #

R4051 ()

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

53680771-53681296 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 53681203 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 82 (T82A)

Ref Sequence

ENSEMBL: ENSMUSP00000137590 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000177622]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000177622
AA Change: T82A

PolyPhen 2 Score 0.325 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000137590
Gene: ENSMUSG00000096908
AA Change: T82A

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
IGv	40	111	1.41e-12	SMART

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 97.0%
20x: 93.9%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 30 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc6	A	C	7: 45,635,987 (GRCm39)	L1020R	probably damaging	Het
Ahnak	A	C	19: 8,991,691 (GRCm39)	D4325A	probably damaging	Het
Chtf18	A	G	17: 25,938,168 (GRCm39)	V955A	probably damaging	Het
Dclk2	A	G	3: 86,738,129 (GRCm39)		probably null	Het
Disc1	A	G	8: 125,875,164 (GRCm39)	T547A	possibly damaging	Het
Eif4b	A	G	15: 101,995,039 (GRCm39)	Y211C	probably benign	Het
Fli1	T	G	9: 32,363,458 (GRCm39)	D176A	probably benign	Het
Hcn2	A	C	10: 79,569,521 (GRCm39)		probably null	Het
Ice1	A	G	13: 70,751,646 (GRCm39)	V1480A	probably damaging	Het
Ier5l	A	C	2: 30,363,324 (GRCm39)	S234A	probably benign	Het
Ino80b	G	C	6: 83,099,314 (GRCm39)	P178R	probably damaging	Het
Itga11	C	T	9: 62,662,933 (GRCm39)	Q550*	probably null	Het
Kdr	T	A	5: 76,129,068 (GRCm39)	M193L	probably benign	Het
Kif3b	G	A	2: 153,165,477 (GRCm39)	R628Q	probably damaging	Het
Ldlrad3	C	T	2: 101,783,507 (GRCm39)	D240N	probably damaging	Het
Met	T	C	6: 17,548,728 (GRCm39)	V924A	possibly damaging	Het
Or52m1	T	C	7: 102,290,233 (GRCm39)	V260A	possibly damaging	Het
Peg10	T	C	6: 4,754,534 (GRCm39)	L105P	probably benign	Het
Phtf1	A	G	3: 103,912,824 (GRCm39)	T717A	possibly damaging	Het
Ptafr	T	C	4: 132,307,305 (GRCm39)	W232R	probably benign	Het
Rnase4	A	G	14: 51,342,462 (GRCm39)	K62R	probably benign	Het
Slamf7	T	C	1: 171,464,951 (GRCm39)	K261E	possibly damaging	Het
Slc9c1	T	A	16: 45,363,593 (GRCm39)	Y120N	probably damaging	Het
Sstr2	A	C	11: 113,515,482 (GRCm39)	T134P	probably damaging	Het
Steap4	A	G	5: 8,030,404 (GRCm39)	Y420C	probably damaging	Het
Tbc1d9b	T	C	11: 50,062,070 (GRCm39)	C1210R	probably benign	Het
Tnfsf10	T	A	3: 27,389,503 (GRCm39)	I188N	probably damaging	Het
Usp46	T	C	5: 74,163,416 (GRCm39)	N283S	probably benign	Het
Vmn2r84	T	G	10: 130,226,767 (GRCm39)	N357T	probably damaging	Het
Zfp217	T	C	2: 169,954,536 (GRCm39)		probably null	Het

Other mutations in Trav7-3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R4052:Trav7-3	UTSW	14	53,681,203 (GRCm39)	missense	probably benign	0.32
R4207:Trav7-3	UTSW	14	53,681,203 (GRCm39)	missense	probably benign	0.32
R4208:Trav7-3	UTSW	14	53,681,203 (GRCm39)	missense	probably benign	0.32
R5261:Trav7-3	UTSW	14	53,681,207 (GRCm39)	missense	probably benign	0.05
R7809:Trav7-3	UTSW	14	53,681,072 (GRCm39)	missense	probably benign	0.00
R8199:Trav7-3	UTSW	14	53,681,099 (GRCm39)	missense	possibly damaging	0.52
R9707:Trav7-3	UTSW	14	53,681,189 (GRCm39)	missense	probably benign	0.03

Predicted Primers

Posted On

2017-04-14