Incidental Mutation 'R5271:Tmem163'
ID 475487
Institutional Source Beutler Lab
Gene Symbol Tmem163
Ensembl Gene ENSMUSG00000026347
Gene Name transmembrane protein 163
Synonyms 2610024A01Rik, SV31
MMRRC Submission 042861-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.086) question?
Stock # R5271 (G1)
Quality Score 33
Status Validated
Chromosome 1
Chromosomal Location 127418079-127605758 bp(-) (GRCm39)
Type of Mutation utr 3 prime
DNA Base Change (assembly) G to A at 127419289 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000140828 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027585] [ENSMUST00000038361] [ENSMUST00000160616] [ENSMUST00000185560]
AlphaFold Q8C996
Predicted Effect probably benign
Transcript: ENSMUST00000027585
SMART Domains Protein: ENSMUSP00000027585
Gene: ENSMUSG00000026347

DomainStartEndE-ValueType
low complexity region 6 42 N/A INTRINSIC
transmembrane domain 89 111 N/A INTRINSIC
transmembrane domain 116 138 N/A INTRINSIC
transmembrane domain 151 173 N/A INTRINSIC
transmembrane domain 188 210 N/A INTRINSIC
transmembrane domain 223 242 N/A INTRINSIC
transmembrane domain 246 268 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000038361
SMART Domains Protein: ENSMUSP00000038359
Gene: ENSMUSG00000036155

DomainStartEndE-ValueType
Pfam:DUF4525 2 138 3.4e-70 PFAM
Pfam:Glyco_transf_18 171 725 9.8e-268 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160111
Predicted Effect probably benign
Transcript: ENSMUST00000160616
SMART Domains Protein: ENSMUSP00000124307
Gene: ENSMUSG00000026347

DomainStartEndE-ValueType
low complexity region 6 42 N/A INTRINSIC
transmembrane domain 89 111 N/A INTRINSIC
transmembrane domain 116 138 N/A INTRINSIC
transmembrane domain 151 173 N/A INTRINSIC
transmembrane domain 188 210 N/A INTRINSIC
transmembrane domain 223 242 N/A INTRINSIC
transmembrane domain 246 268 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162406
Predicted Effect probably benign
Transcript: ENSMUST00000185560
SMART Domains Protein: ENSMUSP00000140828
Gene: ENSMUSG00000026347

DomainStartEndE-ValueType
low complexity region 6 42 N/A INTRINSIC
transmembrane domain 89 111 N/A INTRINSIC
transmembrane domain 116 138 N/A INTRINSIC
transmembrane domain 151 173 N/A INTRINSIC
transmembrane domain 188 210 N/A INTRINSIC
transmembrane domain 223 242 N/A INTRINSIC
transmembrane domain 246 268 N/A INTRINSIC
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.6%
  • 20x: 93.6%
Validation Efficiency 97% (65/67)
MGI Phenotype PHENOTYPE: This transgene is useful in conjunction during breeding with mice carrying floxed alleles to produce germline excision of specific loxP-flanked sequences. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700003H04Rik T C 3: 124,373,496 (GRCm39) K33R possibly damaging Het
4632415L05Rik C T 3: 19,949,311 (GRCm39) noncoding transcript Het
4930542C16Rik A C 14: 24,665,598 (GRCm39) noncoding transcript Het
Adprh A T 16: 38,266,416 (GRCm39) L242* probably null Het
Anapc1 G A 2: 128,527,905 (GRCm39) Q18* probably null Het
Bfar T C 16: 13,510,261 (GRCm39) probably benign Het
Bmp1 T C 14: 70,745,568 (GRCm39) I206V probably benign Het
Cc2d1b T A 4: 108,480,826 (GRCm39) probably benign Het
Clock A G 5: 76,389,801 (GRCm39) I349T probably damaging Het
Cox11 A G 11: 90,534,558 (GRCm39) Y60C probably damaging Het
Cyp1a1 G A 9: 57,610,121 (GRCm39) V512M probably benign Het
Dcdc2a T C 13: 25,371,671 (GRCm39) F311S probably benign Het
Dnase1l3 T C 14: 7,993,843 (GRCm38) D48G probably damaging Het
Engase G T 11: 118,372,223 (GRCm39) A172S probably damaging Het
F2 T C 2: 91,465,466 (GRCm39) probably benign Het
Galnt2l A G 8: 122,997,872 (GRCm39) probably benign Het
Gcc2 T C 10: 58,105,517 (GRCm39) V215A possibly damaging Het
Gm11677 C T 11: 111,615,537 (GRCm39) noncoding transcript Het
Gm20671 T C 5: 32,977,303 (GRCm39) K1817R possibly damaging Het
Gm20939 T A 17: 95,184,583 (GRCm39) Y410* probably null Het
Gm27013 T C 6: 130,653,878 (GRCm39) Y528C probably damaging Het
Il23r T C 6: 67,400,680 (GRCm39) H550R probably benign Het
Iqgap1 A T 7: 80,383,896 (GRCm39) V1056E probably damaging Het
Lrit3 T A 3: 129,581,950 (GRCm39) Y679F probably damaging Het
Megf8 A T 7: 25,041,131 (GRCm39) E1120V probably damaging Het
Mta1 A G 12: 113,095,577 (GRCm39) E518G probably damaging Het
Myo9a A G 9: 59,814,665 (GRCm39) I2200M probably damaging Het
Ncoa7 T C 10: 30,598,725 (GRCm39) H66R probably benign Het
Ncor1 A G 11: 62,231,371 (GRCm39) V812A probably damaging Het
Ndnf T C 6: 65,680,650 (GRCm39) Y310H possibly damaging Het
Ndst1 G A 18: 60,838,204 (GRCm39) T347I probably benign Het
Or10a3m T C 7: 108,313,424 (GRCm39) L276S probably damaging Het
Or4c15b A T 2: 89,113,297 (GRCm39) F60Y probably benign Het
Pcdhb10 C A 18: 37,546,222 (GRCm39) Q433K probably benign Het
Pcdhb18 G A 18: 37,624,649 (GRCm39) V660M possibly damaging Het
Pds5b T A 5: 150,646,818 (GRCm39) N202K possibly damaging Het
Pira12 A T 7: 3,900,566 (GRCm39) Y61* probably null Het
Polk T C 13: 96,620,047 (GRCm39) S718G probably benign Het
Ptpdc1 T C 13: 48,744,174 (GRCm39) D149G probably damaging Het
Rb1cc1 T A 1: 6,319,417 (GRCm39) C35* probably null Het
Samd9l C T 6: 3,376,156 (GRCm39) M368I probably benign Het
Shroom3 T C 5: 93,110,107 (GRCm39) M1739T probably damaging Het
Slc18a3 A G 14: 32,185,705 (GRCm39) L226P probably damaging Het
St7l A T 3: 104,775,376 (GRCm39) Y84F probably damaging Het
Svil A T 18: 5,062,329 (GRCm39) N392I probably benign Het
Syngr1 T A 15: 79,982,240 (GRCm39) M9K probably benign Het
Taar2 T C 10: 23,816,930 (GRCm39) S157P probably damaging Het
Tagap1 G T 17: 7,223,495 (GRCm39) Y400* probably null Het
Tbc1d8 T A 1: 39,412,848 (GRCm39) E976V probably damaging Het
Tnfaip2 A G 12: 111,414,894 (GRCm39) probably benign Het
Ttn C T 2: 76,536,861 (GRCm39) S34988N possibly damaging Het
Tubg1 T G 11: 101,011,064 (GRCm39) N15K probably damaging Het
Unc93a2 T C 17: 7,637,081 (GRCm39) N149S possibly damaging Het
Vmn2r129 G T 4: 156,686,692 (GRCm39) noncoding transcript Het
Zap70 T A 1: 36,820,446 (GRCm39) V547D probably damaging Het
Zfp146 G T 7: 29,861,900 (GRCm39) N47K probably benign Het
Znrf1 T G 8: 112,335,976 (GRCm39) M159R probably benign Het
Other mutations in Tmem163
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01747:Tmem163 APN 1 127,596,457 (GRCm39) missense probably damaging 1.00
IGL02850:Tmem163 APN 1 127,427,984 (GRCm39) missense probably benign 0.00
R0201:Tmem163 UTSW 1 127,596,374 (GRCm39) splice site probably benign
R1723:Tmem163 UTSW 1 127,479,108 (GRCm39) missense probably damaging 1.00
R1834:Tmem163 UTSW 1 127,605,246 (GRCm39) missense probably benign 0.03
R1836:Tmem163 UTSW 1 127,605,246 (GRCm39) missense probably benign 0.03
R2289:Tmem163 UTSW 1 127,423,477 (GRCm39) missense possibly damaging 0.61
R4907:Tmem163 UTSW 1 127,447,107 (GRCm39) missense probably damaging 1.00
R4912:Tmem163 UTSW 1 127,419,362 (GRCm39) missense probably damaging 1.00
R5076:Tmem163 UTSW 1 127,428,013 (GRCm39) missense probably damaging 1.00
R5240:Tmem163 UTSW 1 127,419,289 (GRCm39) utr 3 prime probably benign
R5270:Tmem163 UTSW 1 127,419,289 (GRCm39) utr 3 prime probably benign
R5366:Tmem163 UTSW 1 127,428,042 (GRCm39) splice site probably benign
R5617:Tmem163 UTSW 1 127,479,067 (GRCm39) missense possibly damaging 0.89
R5928:Tmem163 UTSW 1 127,419,383 (GRCm39) missense probably damaging 0.99
R6115:Tmem163 UTSW 1 127,605,185 (GRCm39) missense possibly damaging 0.63
R6146:Tmem163 UTSW 1 127,447,126 (GRCm39) missense probably benign 0.01
R6316:Tmem163 UTSW 1 127,479,102 (GRCm39) missense probably benign 0.01
R6472:Tmem163 UTSW 1 127,423,471 (GRCm39) missense probably benign 0.09
R6604:Tmem163 UTSW 1 127,419,347 (GRCm39) missense possibly damaging 0.61
R6765:Tmem163 UTSW 1 127,479,078 (GRCm39) missense probably damaging 1.00
R6848:Tmem163 UTSW 1 127,479,117 (GRCm39) missense probably damaging 1.00
R7387:Tmem163 UTSW 1 127,447,180 (GRCm39) critical splice acceptor site probably null
R7737:Tmem163 UTSW 1 127,419,347 (GRCm39) missense possibly damaging 0.61
R9502:Tmem163 UTSW 1 127,480,529 (GRCm39) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- ATGTCACTTCCGGCTCAAGG -3'
(R):5'- ATAGCTCAGTTTTCTCAAAGTTCTC -3'

Sequencing Primer
(F):5'- GGGCAACGTCATCCTAACATGTTTG -3'
(R):5'- CTCAAAGTTCTCCTGGTGCTGAG -3'
Posted On 2017-04-28