Incidental Mutation 'R3435:Lrrc57'
ID475659
Institutional Source Beutler Lab
Gene Symbol Lrrc57
Ensembl Gene ENSMUSG00000027286
Gene Nameleucine rich repeat containing 57
Synonyms
MMRRC Submission 040653-MU
Accession Numbers
Is this an essential gene? Not available question?
Stock #R3435 (G1)
Quality Score225
Status Not validated
Chromosome2
Chromosomal Location120604238-120609520 bp(-) (GRCm38)
Type of Mutationunclassified
DNA Base Change (assembly) T to A at 120609381 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000117895 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028741] [ENSMUST00000102496] [ENSMUST00000102497] [ENSMUST00000102498] [ENSMUST00000102499] [ENSMUST00000110706] [ENSMUST00000124187] [ENSMUST00000133612] [ENSMUST00000135465]
Predicted Effect probably benign
Transcript: ENSMUST00000028741
SMART Domains Protein: ENSMUSP00000028741
Gene: ENSMUSG00000027285

DomainStartEndE-ValueType
Pfam:HAUS2 4 67 1.8e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000102496
SMART Domains Protein: ENSMUSP00000099554
Gene: ENSMUSG00000027286

DomainStartEndE-ValueType
LRR 37 60 9.48e0 SMART
LRR 61 83 6.77e0 SMART
LRR_TYP 84 106 9.58e-3 SMART
LRR 107 129 9.96e-1 SMART
LRR_TYP 130 153 9.44e-2 SMART
LRR 175 200 3.27e2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000102497
SMART Domains Protein: ENSMUSP00000099555
Gene: ENSMUSG00000027286

DomainStartEndE-ValueType
LRR 37 60 9.48e0 SMART
LRR 61 83 6.77e0 SMART
LRR_TYP 84 106 9.58e-3 SMART
LRR 107 129 9.96e-1 SMART
LRR_TYP 130 153 9.44e-2 SMART
LRR 175 200 3.27e2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000102498
SMART Domains Protein: ENSMUSP00000099556
Gene: ENSMUSG00000027286

DomainStartEndE-ValueType
LRR 37 60 9.48e0 SMART
LRR 61 83 6.77e0 SMART
LRR_TYP 84 106 9.58e-3 SMART
LRR 107 129 9.96e-1 SMART
LRR_TYP 130 153 9.44e-2 SMART
LRR 175 200 3.27e2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000102499
SMART Domains Protein: ENSMUSP00000099557
Gene: ENSMUSG00000027286

DomainStartEndE-ValueType
LRR 37 60 9.48e0 SMART
LRR 61 83 6.77e0 SMART
LRR_TYP 84 106 9.58e-3 SMART
LRR 107 129 9.96e-1 SMART
LRR_TYP 130 153 9.44e-2 SMART
LRR 175 200 3.27e2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000110706
SMART Domains Protein: ENSMUSP00000106334
Gene: ENSMUSG00000027285

DomainStartEndE-ValueType
Pfam:HAUS2 1 199 2.4e-81 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000124187
SMART Domains Protein: ENSMUSP00000117299
Gene: ENSMUSG00000027285

DomainStartEndE-ValueType
Pfam:HAUS2 5 215 1.2e-62 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000133612
SMART Domains Protein: ENSMUSP00000121638
Gene: ENSMUSG00000027286

DomainStartEndE-ValueType
LRR 37 60 9.48e0 SMART
LRR 61 83 6.77e0 SMART
LRR_TYP 84 106 9.58e-3 SMART
LRR 107 129 9.96e-1 SMART
LRR_TYP 130 153 9.44e-2 SMART
LRR 175 200 3.27e2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000135465
SMART Domains Protein: ENSMUSP00000117895
Gene: ENSMUSG00000027286

DomainStartEndE-ValueType
LRR 1 23 9.96e-1 SMART
LRR_TYP 24 47 9.44e-2 SMART
LRR 69 94 3.27e2 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141932
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency 100% (33/33)
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933409G03Rik A C 2: 68,601,845 D91A unknown Het
Abca9 T C 11: 110,154,430 E359G probably benign Het
Atp7a G A X: 106,094,857 R563K probably benign Het
Dnah1 T C 14: 31,316,674 D150G probably damaging Het
Fam47e T A 5: 92,585,362 V152D probably damaging Het
Gm19965 C A 1: 116,821,623 H345N possibly damaging Het
Ift74 A G 4: 94,621,852 probably null Het
Iqgap3 A G 3: 88,094,604 I384V probably benign Het
Mafk C T 5: 139,800,307 Q87* probably null Het
Mast2 A T 4: 116,308,095 S1314T probably benign Het
Mast4 A G 13: 102,787,379 I508T probably damaging Het
Mdn1 T C 4: 32,733,726 probably null Het
Mup6 G T 4: 60,004,116 probably null Het
Neurl1a T C 19: 47,257,525 V532A probably damaging Het
Nod2 A G 8: 88,664,009 R293G possibly damaging Het
Notch3 A T 17: 32,158,618 D161E possibly damaging Het
Olfr3 T A 2: 36,812,678 Q138L probably benign Het
Osbpl3 A T 6: 50,348,070 N149K possibly damaging Het
P2rx4 T A 5: 122,725,070 I202K probably damaging Het
Pbxip1 T C 3: 89,447,236 L354P probably damaging Het
Pld1 A T 3: 28,124,623 M889L probably benign Het
Ppp2r2b T A 18: 42,741,109 Q52L possibly damaging Het
Prob1 T C 18: 35,654,241 E320G possibly damaging Het
Stard13 A T 5: 151,042,179 L937Q probably damaging Het
Strn4 T C 7: 16,837,633 S563P possibly damaging Het
Syne1 T C 10: 5,348,565 D1114G probably damaging Het
Tmem117 T C 15: 95,094,692 I411T probably damaging Het
Tmx3 T A 18: 90,527,904 V203E probably damaging Het
Ttn T C 2: 76,878,718 probably benign Het
Vmn1r209 A T 13: 22,806,097 M141K probably benign Het
Other mutations in Lrrc57
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00924:Lrrc57 APN 2 120606051 missense possibly damaging 0.77
IGL01347:Lrrc57 APN 2 120608805 missense probably benign
IGL03258:Lrrc57 APN 2 120605222 missense probably damaging 1.00
R7413:Lrrc57 UTSW 2 120606096 missense probably damaging 1.00
Predicted Primers
Posted On2017-05-11