Incidental Mutation 'R2874:Prdx4'
ID 477086
Institutional Source Beutler Lab
Gene Symbol Prdx4
Ensembl Gene ENSMUSG00000025289
Gene Name peroxiredoxin 4
Synonyms Prx4, Prx IV, AOE372, Prx-iv
MMRRC Submission 040462-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.086) question?
Stock # R2874 (G1)
Quality Score 222
Status Not validated
Chromosome X
Chromosomal Location 154106914-154123750 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 154123460 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 15 (V15A)
Ref Sequence ENSEMBL: ENSMUSP00000122997 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026328] [ENSMUST00000130349]
AlphaFold O08807
Predicted Effect probably benign
Transcript: ENSMUST00000026328
SMART Domains Protein: ENSMUSP00000026328
Gene: ENSMUSG00000025289

DomainStartEndE-ValueType
signal peptide 1 40 N/A INTRINSIC
Pfam:AhpC-TSA 84 217 4.3e-36 PFAM
Pfam:Redoxin 84 232 4.4e-15 PFAM
Pfam:1-cysPrx_C 237 272 9.6e-16 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123915
Predicted Effect probably benign
Transcript: ENSMUST00000130349
AA Change: V15A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000122997
Gene: ENSMUSG00000025289
AA Change: V15A

DomainStartEndE-ValueType
low complexity region 32 47 N/A INTRINSIC
Pfam:AhpC-TSA 67 200 2.9e-37 PFAM
Pfam:Redoxin 68 217 9.6e-16 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.3%
Validation Efficiency 100% (57/57)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele exhibit decreased testicular weight, testis atrophy, and oligozoospermia due to increased apoptosis associated with oxidative damage. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A930029G22Rik T A 17: 69,725,106 (GRCm39) noncoding transcript Het
Ankrd42 T C 7: 92,254,566 (GRCm39) K348E possibly damaging Het
Arhgef10 T C 8: 15,025,093 (GRCm39) probably null Het
Arhgef10 A G 8: 15,025,666 (GRCm39) I459V probably benign Het
Cd6 A G 19: 10,771,990 (GRCm39) I307T possibly damaging Het
Cebpz A T 17: 79,239,532 (GRCm39) probably benign Het
Clcn4 A G 7: 7,293,520 (GRCm39) I412T probably benign Het
Clstn3 T A 6: 124,415,294 (GRCm39) D690V probably damaging Het
Col12a1 A T 9: 79,606,831 (GRCm39) F531I probably damaging Het
Dennd2b A T 7: 109,156,637 (GRCm39) Y38N probably benign Het
Dhx57 A T 17: 80,558,805 (GRCm39) D1051E probably benign Het
Ext2 A G 2: 93,570,031 (GRCm39) V460A possibly damaging Het
Frmpd4 A T X: 166,260,243 (GRCm39) D1166E probably benign Het
Fscb T C 12: 64,520,210 (GRCm39) K419E probably benign Het
Ftdc1 A T 16: 58,434,342 (GRCm39) I125K probably benign Het
Ggct G T 6: 54,969,759 (GRCm39) A21D probably damaging Het
Gm10717 A G 9: 3,025,532 (GRCm39) Y39C probably benign Het
Grid2ip C A 5: 143,343,684 (GRCm39) Q127K probably benign Het
Ighv2-2 G A 12: 113,552,118 (GRCm39) T40I possibly damaging Het
Itpr2 T C 6: 146,327,996 (GRCm39) K79R possibly damaging Het
Klf8 A T X: 152,165,678 (GRCm39) E82D probably damaging Het
Kpna7 T C 5: 144,930,745 (GRCm39) T367A probably benign Het
Lactbl1 G A 4: 136,354,097 (GRCm39) C37Y probably damaging Het
Lrp1b A G 2: 40,741,705 (GRCm39) L3188P probably damaging Het
Matcap1 A G 8: 106,008,664 (GRCm39) M451T possibly damaging Het
Myo9b G A 8: 71,786,981 (GRCm39) R721Q probably benign Het
Noc4l A G 5: 110,796,969 (GRCm39) V465A probably benign Het
Notch1 A G 2: 26,350,247 (GRCm39) C2298R possibly damaging Het
Or10z1 T C 1: 174,078,092 (GRCm39) S134G probably benign Het
Parp1 A G 1: 180,401,230 (GRCm39) D45G probably damaging Het
Plxna3 T A X: 73,383,002 (GRCm39) probably benign Het
Prps1 C T X: 139,372,743 (GRCm39) probably benign Het
Psmb8 T C 17: 34,419,144 (GRCm39) I146T probably damaging Het
Qng1 T A 13: 58,530,384 (GRCm39) I209F probably damaging Het
Ralgds A G 2: 28,438,781 (GRCm39) probably null Het
Rasl12 A G 9: 65,315,605 (GRCm39) N83S probably benign Het
Rnf6 T C 5: 146,147,215 (GRCm39) Y601C probably benign Het
Rreb1 T C 13: 38,100,484 (GRCm39) I205T probably benign Het
Sgk2 A G 2: 162,836,449 (GRCm39) probably benign Het
Spsb4 G T 9: 96,878,071 (GRCm39) T84K probably damaging Het
St7 C T 6: 17,819,276 (GRCm39) P60L probably damaging Het
Stx3 A T 19: 11,766,938 (GRCm39) V91D probably damaging Het
Tbc1d8 A G 1: 39,444,398 (GRCm39) F187S probably damaging Het
Tep1 A G 14: 51,088,107 (GRCm39) I85T possibly damaging Het
Trpa1 A G 1: 14,957,844 (GRCm39) C705R probably damaging Het
Vmn2r68 A C 7: 84,882,834 (GRCm39) M306R probably benign Het
Vwa7 G A 17: 35,240,218 (GRCm39) M395I probably damaging Het
Zfp53 A T 17: 21,728,340 (GRCm39) E124D probably benign Het
Other mutations in Prdx4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02536:Prdx4 APN X 154,115,443 (GRCm39) missense probably damaging 1.00
R2869:Prdx4 UTSW X 154,123,460 (GRCm39) missense probably benign 0.00
R2869:Prdx4 UTSW X 154,123,460 (GRCm39) missense probably benign 0.00
R2871:Prdx4 UTSW X 154,123,460 (GRCm39) missense probably benign 0.00
R2871:Prdx4 UTSW X 154,123,460 (GRCm39) missense probably benign 0.00
R2872:Prdx4 UTSW X 154,123,460 (GRCm39) missense probably benign 0.00
R2872:Prdx4 UTSW X 154,123,460 (GRCm39) missense probably benign 0.00
R3115:Prdx4 UTSW X 154,113,407 (GRCm39) missense probably damaging 1.00
Predicted Primers
Posted On 2017-05-15