Incidental Mutation 'R2903:Rassf10'
| ID |
477231 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Rassf10
|
| Ensembl Gene |
ENSMUSG00000098132 |
| Gene Name |
Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 |
| Synonyms |
4632411J06Rik |
| MMRRC Submission |
040490-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.117)
|
| Stock # |
R2903 (G1)
|
| Quality Score |
196 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
112553169-112556664 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 112553756 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Valine
at position 119
(D119V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000138103
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000182858]
|
| AlphaFold |
Q8BL43 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000182858
AA Change: D119V
PolyPhen 2
Score 0.938 (Sensitivity: 0.80; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000138103
Gene: ENSMUSG00000098132
AA Change: D119V
| Domain | Start | End | E-Value | Type |
|---|
|
RA
|
2 |
133 |
2.25e-2 |
SMART |
|
low complexity region
|
195 |
214 |
N/A |
INTRINSIC |
|
coiled coil region
|
234 |
266 |
N/A |
INTRINSIC |
|
coiled coil region
|
318 |
358 |
N/A |
INTRINSIC |
|
coiled coil region
|
412 |
434 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000202360
AA Change: D119V
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.4%
- 20x: 95.4%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 26 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 9230112D13Rik |
A |
T |
14: 34,233,898 (GRCm39) |
V131E |
unknown |
Het |
| Ccnk |
T |
C |
12: 108,168,647 (GRCm39) |
|
probably benign |
Het |
| Cd276 |
A |
G |
9: 58,444,603 (GRCm39) |
F123L |
probably benign |
Het |
| Ddr2 |
T |
A |
1: 169,825,730 (GRCm39) |
N290I |
probably damaging |
Het |
| Ecpas |
A |
G |
4: 58,828,622 (GRCm39) |
V937A |
possibly damaging |
Het |
| G530012D18Rik |
CAGAGAGA |
CAGAGAGAGA |
1: 85,504,945 (GRCm39) |
|
probably null |
Het |
| Gpt |
A |
G |
15: 76,582,666 (GRCm39) |
D37G |
probably damaging |
Het |
| Grik3 |
T |
A |
4: 125,564,437 (GRCm39) |
L473Q |
probably damaging |
Het |
| Hsp90b1 |
A |
C |
10: 86,539,349 (GRCm39) |
I90S |
probably damaging |
Het |
| Ift56 |
T |
C |
6: 38,378,037 (GRCm39) |
V283A |
possibly damaging |
Het |
| Ing5 |
G |
A |
1: 93,731,710 (GRCm39) |
|
probably benign |
Het |
| Kalrn |
C |
T |
16: 33,810,180 (GRCm39) |
D2525N |
possibly damaging |
Het |
| Kdr |
T |
C |
5: 76,127,069 (GRCm39) |
Y307C |
probably damaging |
Het |
| Or51t4 |
A |
T |
7: 102,598,661 (GRCm39) |
M320L |
probably benign |
Het |
| Rapgef5 |
A |
G |
12: 117,677,854 (GRCm39) |
K161R |
probably damaging |
Het |
| Samhd1 |
A |
T |
2: 156,965,335 (GRCm39) |
F160Y |
possibly damaging |
Het |
| Sh3bp2 |
T |
A |
5: 34,700,900 (GRCm39) |
C34* |
probably null |
Het |
| Six3 |
A |
G |
17: 85,931,283 (GRCm39) |
E313G |
probably damaging |
Het |
| Tas2r118 |
A |
G |
6: 23,969,801 (GRCm39) |
F87L |
possibly damaging |
Het |
| Tmem131 |
A |
G |
1: 36,864,378 (GRCm39) |
L591P |
probably damaging |
Het |
| Trav17 |
A |
C |
14: 54,044,123 (GRCm39) |
S10R |
probably benign |
Het |
| Ttll3 |
T |
C |
6: 113,384,284 (GRCm39) |
F534S |
probably damaging |
Het |
| Umodl1 |
T |
A |
17: 31,211,147 (GRCm39) |
V890E |
probably damaging |
Het |
| Uso1 |
G |
A |
5: 92,343,294 (GRCm39) |
|
probably null |
Het |
| Utrn |
A |
G |
10: 12,519,172 (GRCm39) |
I2260T |
probably damaging |
Het |
| Vav1 |
A |
G |
17: 57,613,187 (GRCm39) |
N620D |
probably benign |
Het |
|
| Other mutations in Rassf10 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
R0905:Rassf10
|
UTSW |
7 |
112,554,575 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2904:Rassf10
|
UTSW |
7 |
112,553,756 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4559:Rassf10
|
UTSW |
7 |
112,554,338 (GRCm39) |
missense |
probably benign |
|
|
R4796:Rassf10
|
UTSW |
7 |
112,553,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5063:Rassf10
|
UTSW |
7 |
112,553,631 (GRCm39) |
missense |
probably benign |
|
|
R5166:Rassf10
|
UTSW |
7 |
112,553,627 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6478:Rassf10
|
UTSW |
7 |
112,554,914 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6642:Rassf10
|
UTSW |
7 |
112,554,784 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6769:Rassf10
|
UTSW |
7 |
112,553,635 (GRCm39) |
missense |
probably benign |
|
|
R6771:Rassf10
|
UTSW |
7 |
112,553,635 (GRCm39) |
missense |
probably benign |
|
|
R7161:Rassf10
|
UTSW |
7 |
112,553,707 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8745:Rassf10
|
UTSW |
7 |
112,554,083 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8787:Rassf10
|
UTSW |
7 |
112,554,738 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9064:Rassf10
|
UTSW |
7 |
112,554,315 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9652:Rassf10
|
UTSW |
7 |
112,554,784 (GRCm39) |
missense |
probably benign |
|
|
Z1177:Rassf10
|
UTSW |
7 |
112,554,364 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
|
| Posted On |
2017-05-15 |
Incidental Mutation