Mutagenetix > Incidental Mutation

Incidental Mutation 'R2904:Rassf10'

477233

Institutional Source

Beutler Lab

Gene Symbol

Rassf10

Ensembl Gene

ENSMUSG00000098132

Gene Name

Ras association (RalGDS/AF-6) domain family (N-terminal) member 10

Synonyms

4632411J06Rik

MMRRC Submission

040491-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.117) question?

Stock #

R2904 (G1)

Quality Score

212

Status

Not validated

Chromosome

Chromosomal Location

112553169-112556664 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 112553756 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Valine at position 119 (D119V)

Ref Sequence

ENSEMBL: ENSMUSP00000138103 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000182858]

AlphaFold

Q8BL43

Predicted Effect

possibly damaging
Transcript: ENSMUST00000182858
AA Change: D119V

PolyPhen 2 Score 0.938 (Sensitivity: 0.80; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000138103
Gene: ENSMUSG00000098132
AA Change: D119V

Domain	Start	End	E-Value	Type
RA	2	133	2.25e-2	SMART
low complexity region	195	214	N/A	INTRINSIC
coiled coil region	234	266	N/A	INTRINSIC
coiled coil region	318	358	N/A	INTRINSIC
coiled coil region	412	434	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000202360
AA Change: D119V

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.4%
20x: 95.5%

Validation Efficiency

97% (30/31)

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abraxas1	T	C	5: 100,957,673 (GRCm39)	E182G	probably benign	Het
Acot4	C	G	12: 84,090,377 (GRCm39)	T358S	probably benign	Het
Ap2a2	A	G	7: 141,199,391 (GRCm39)	K433E	probably damaging	Het
Card11	T	A	5: 140,874,888 (GRCm39)	D592V	probably benign	Het
Col12a1	G	T	9: 79,559,307 (GRCm39)	S1860R	probably damaging	Het
Crisp1	C	T	17: 40,623,895 (GRCm39)		probably null	Het
Dzip1l	A	G	9: 99,545,722 (GRCm39)	E657G	probably damaging	Het
Gak	T	C	5: 108,772,080 (GRCm39)	N79S	possibly damaging	Het
Gm9791	T	C	3: 34,059,336 (GRCm39)		noncoding transcript	Het
Gmpr2	T	C	14: 55,910,215 (GRCm39)	V15A	probably damaging	Het
Hectd4	T	C	5: 121,430,787 (GRCm39)		probably benign	Het
Ift56	T	C	6: 38,378,037 (GRCm39)	V283A	possibly damaging	Het
Kalrn	C	T	16: 33,810,180 (GRCm39)	D2525N	possibly damaging	Het
Kdm4b	G	A	17: 56,662,884 (GRCm39)	G152S	probably benign	Het
Kdm6b	G	A	11: 69,296,611 (GRCm39)	T552I	possibly damaging	Het
Kdr	T	C	5: 76,127,069 (GRCm39)	Y307C	probably damaging	Het
Kif11	T	C	19: 37,392,103 (GRCm39)		probably benign	Het
Kirrel1	C	T	3: 86,996,458 (GRCm39)	M380I	probably null	Het
Madd	C	T	2: 91,006,017 (GRCm39)	V20M	probably damaging	Het
Mkrn3	C	A	7: 62,068,207 (GRCm39)	R528L	probably benign	Het
Myom2	T	C	8: 15,148,348 (GRCm39)	V508A	probably benign	Het
Nav1	T	C	1: 135,512,976 (GRCm39)	D28G	probably benign	Het
Nlrp4b	T	A	7: 10,448,294 (GRCm39)	W166R	probably damaging	Het
Or14j2	A	T	17: 37,885,705 (GRCm39)	L203Q	possibly damaging	Het
Or5p59	T	C	7: 107,702,806 (GRCm39)	Y97H	probably benign	Het
Smarcc1	A	G	9: 110,003,043 (GRCm39)	N378D	possibly damaging	Het
Tas2r118	A	G	6: 23,969,801 (GRCm39)	F87L	possibly damaging	Het
Tasor2	T	C	13: 3,632,185 (GRCm39)	N772S	possibly damaging	Het
Trim21	A	G	7: 102,209,178 (GRCm39)	W282R	probably benign	Het
Uggt2	T	A	14: 119,296,521 (GRCm39)	Y447F	possibly damaging	Het
Zfp160	G	A	17: 21,245,911 (GRCm39)	V154I	probably benign	Het

Other mutations in Rassf10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0905:Rassf10	UTSW	7	112,554,575 (GRCm39)	missense	probably damaging	1.00
R2903:Rassf10	UTSW	7	112,553,756 (GRCm39)	missense	possibly damaging	0.94
R4559:Rassf10	UTSW	7	112,554,338 (GRCm39)	missense	probably benign
R4796:Rassf10	UTSW	7	112,553,735 (GRCm39)	missense	probably damaging	1.00
R5063:Rassf10	UTSW	7	112,553,631 (GRCm39)	missense	probably benign
R5166:Rassf10	UTSW	7	112,553,627 (GRCm39)	missense	probably benign	0.00
R6478:Rassf10	UTSW	7	112,554,914 (GRCm39)	missense	probably damaging	1.00
R6642:Rassf10	UTSW	7	112,554,784 (GRCm39)	missense	probably benign	0.00
R6769:Rassf10	UTSW	7	112,553,635 (GRCm39)	missense	probably benign
R6771:Rassf10	UTSW	7	112,553,635 (GRCm39)	missense	probably benign
R7161:Rassf10	UTSW	7	112,553,707 (GRCm39)	missense	probably damaging	1.00
R8745:Rassf10	UTSW	7	112,554,083 (GRCm39)	missense	probably damaging	1.00
R8787:Rassf10	UTSW	7	112,554,738 (GRCm39)	missense	probably benign	0.00
R9064:Rassf10	UTSW	7	112,554,315 (GRCm39)	missense	probably benign	0.08
R9652:Rassf10	UTSW	7	112,554,784 (GRCm39)	missense	probably benign
Z1177:Rassf10	UTSW	7	112,554,364 (GRCm39)	missense	probably damaging	0.99

Predicted Primers

Posted On

2017-05-15