Incidental Mutation 'R2904:Rassf10'
ID477233
Institutional Source Beutler Lab
Gene Symbol Rassf10
Ensembl Gene ENSMUSG00000098132
Gene NameRas association (RalGDS/AF-6) domain family (N-terminal) member 10
Synonyms4632411J06Rik
MMRRC Submission 040491-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.244) question?
Stock #R2904 (G1)
Quality Score212
Status Not validated
Chromosome7
Chromosomal Location112953962-112957457 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 112954549 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Valine at position 119 (D119V)
Ref Sequence ENSEMBL: ENSMUSP00000138103 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000182858]
Predicted Effect possibly damaging
Transcript: ENSMUST00000182858
AA Change: D119V

PolyPhen 2 Score 0.938 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000138103
Gene: ENSMUSG00000098132
AA Change: D119V

DomainStartEndE-ValueType
RA 2 133 2.25e-2 SMART
low complexity region 195 214 N/A INTRINSIC
coiled coil region 234 266 N/A INTRINSIC
coiled coil region 318 358 N/A INTRINSIC
coiled coil region 412 434 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000202360
AA Change: D119V
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.5%
Validation Efficiency 97% (30/31)
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abraxas1 T C 5: 100,809,807 E182G probably benign Het
Acot4 C G 12: 84,043,603 T358S probably benign Het
Ap2a2 A G 7: 141,619,478 K433E probably damaging Het
Card11 T A 5: 140,889,133 D592V probably benign Het
Col12a1 G T 9: 79,652,025 S1860R probably damaging Het
Crisp1 C T 17: 40,313,004 probably null Het
Dzip1l A G 9: 99,663,669 E657G probably damaging Het
Fam208b T C 13: 3,582,185 N772S possibly damaging Het
Gak T C 5: 108,624,214 N79S possibly damaging Het
Gm9791 T C 3: 34,005,187 noncoding transcript Het
Gmpr2 T C 14: 55,672,758 V15A probably damaging Het
Hectd4 T C 5: 121,292,724 probably benign Het
Kalrn C T 16: 33,989,810 D2525N possibly damaging Het
Kdm4b G A 17: 56,355,884 G152S probably benign Het
Kdm6b G A 11: 69,405,785 T552I possibly damaging Het
Kdr T C 5: 75,966,409 Y307C probably damaging Het
Kif11 T C 19: 37,403,655 probably benign Het
Kirrel C T 3: 87,089,151 M380I probably null Het
Madd C T 2: 91,175,672 V20M probably damaging Het
Mkrn3 C A 7: 62,418,459 R528L probably benign Het
Myom2 T C 8: 15,098,348 V508A probably benign Het
Nav1 T C 1: 135,585,238 D28G probably benign Het
Nlrp4b T A 7: 10,714,367 W166R probably damaging Het
Olfr113 A T 17: 37,574,814 L203Q possibly damaging Het
Olfr483 T C 7: 108,103,599 Y97H probably benign Het
Smarcc1 A G 9: 110,173,975 N378D possibly damaging Het
Tas2r118 A G 6: 23,969,802 F87L possibly damaging Het
Trim21 A G 7: 102,559,971 W282R probably benign Het
Ttc26 T C 6: 38,401,102 V283A possibly damaging Het
Uggt2 T A 14: 119,059,109 Y447F possibly damaging Het
Zfp160 G A 17: 21,025,649 V154I probably benign Het
Other mutations in Rassf10
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0905:Rassf10 UTSW 7 112955368 missense probably damaging 1.00
R2903:Rassf10 UTSW 7 112954549 missense possibly damaging 0.94
R4559:Rassf10 UTSW 7 112955131 missense probably benign
R4796:Rassf10 UTSW 7 112954528 missense probably damaging 1.00
R5063:Rassf10 UTSW 7 112954424 missense probably benign
R5166:Rassf10 UTSW 7 112954420 missense probably benign 0.00
R6478:Rassf10 UTSW 7 112955707 missense probably damaging 1.00
R6642:Rassf10 UTSW 7 112955577 missense probably benign 0.00
R6769:Rassf10 UTSW 7 112954428 missense probably benign
R6771:Rassf10 UTSW 7 112954428 missense probably benign
Predicted Primers
Posted On2017-05-15