Incidental Mutation 'R3002:Lnx2'
ID 477303
Institutional Source Beutler Lab
Gene Symbol Lnx2
Ensembl Gene ENSMUSG00000016520
Gene Name ligand of numb-protein X 2
Synonyms
MMRRC Submission 040531-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R3002 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 146953465-147013385 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 146955825 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 657 (V657A)
Ref Sequence ENSEMBL: ENSMUSP00000016664 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000016664]
AlphaFold Q91XL2
Predicted Effect probably benign
Transcript: ENSMUST00000016664
AA Change: V657A

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000016664
Gene: ENSMUSG00000016520
AA Change: V657A

DomainStartEndE-ValueType
RING 51 88 2.06e-6 SMART
low complexity region 103 114 N/A INTRINSIC
PDZ 242 317 2.25e-17 SMART
PDZ 348 421 2.97e-17 SMART
PDZ 474 553 7.37e-13 SMART
PDZ 606 683 1.27e-16 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123092
Meta Mutation Damage Score 0.0849 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.1%
Validation Efficiency 100% (41/41)
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2810459M11Rik T C 1: 85,973,802 (GRCm39) W40R possibly damaging Het
A2m A G 6: 121,638,406 (GRCm39) S873G possibly damaging Het
Acd C T 8: 106,426,913 (GRCm39) probably null Het
Acly T C 11: 100,395,053 (GRCm39) K469E possibly damaging Het
Adcy6 T C 15: 98,494,541 (GRCm39) T767A probably benign Het
Bnip3 T C 7: 138,496,430 (GRCm39) I93V probably benign Het
Casq2 A G 3: 102,052,517 (GRCm39) D269G probably damaging Het
Ccdc180 A G 4: 45,899,988 (GRCm39) D182G probably benign Het
Cep112 A G 11: 108,331,329 (GRCm39) E178G probably damaging Het
Chrd T G 16: 20,556,195 (GRCm39) Y585* probably null Het
Cnksr3 T C 10: 7,102,856 (GRCm39) probably benign Het
Csmd1 A G 8: 16,246,184 (GRCm39) F1072L probably damaging Het
Dnai2 C T 11: 114,641,297 (GRCm39) P374L probably damaging Het
Eif4g1 T A 16: 20,511,134 (GRCm39) F1289I probably damaging Het
Eprs1 T C 1: 185,156,588 (GRCm39) probably null Het
Fasn T C 11: 120,700,671 (GRCm39) D2114G probably benign Het
Fbxl17 T A 17: 63,532,072 (GRCm39) E590D probably damaging Het
Flnb G T 14: 7,907,162 (GRCm38) R1245L probably benign Het
Folh1 A C 7: 86,372,519 (GRCm39) I678M probably damaging Het
Frrs1l G T 4: 56,990,139 (GRCm39) probably benign Het
Hal G A 10: 93,343,381 (GRCm39) A542T probably damaging Het
Hs3st2 T A 7: 121,099,910 (GRCm39) M252K probably damaging Het
Il27ra G T 8: 84,758,660 (GRCm39) S499* probably null Het
Klhdc1 T A 12: 69,302,983 (GRCm39) V173D possibly damaging Het
Knop1 CTCTTCTTCTTCTTCTTCTTCTTC CTCTTCTTCTTCTTCTTC 7: 118,451,672 (GRCm39) probably benign Het
Lct T C 1: 128,231,963 (GRCm39) M629V probably damaging Het
Lrig1 G A 6: 94,585,758 (GRCm39) S810L probably damaging Het
Lyst A T 13: 13,871,290 (GRCm39) M2676L probably benign Het
Mindy4 T A 6: 55,195,349 (GRCm39) S188T probably benign Het
Mrgprb3 C T 7: 48,293,232 (GRCm39) M106I probably benign Het
Ncam1 A G 9: 49,468,526 (GRCm39) I311T probably damaging Het
Ndufa8 T A 2: 35,926,571 (GRCm39) E155V possibly damaging Het
Nr4a1 A G 15: 101,168,853 (GRCm39) probably null Het
Or2a12 A G 6: 42,904,888 (GRCm39) H241R probably damaging Het
Orc3 T C 4: 34,571,790 (GRCm39) T660A probably benign Het
Otub2 T C 12: 103,370,536 (GRCm39) S273P probably damaging Het
Otulinl T C 15: 27,664,792 (GRCm39) T55A probably benign Het
Phf11c A G 14: 59,622,289 (GRCm39) L241P probably damaging Het
Pik3ca T A 3: 32,516,946 (GRCm39) I1058N probably damaging Het
Pkd2l1 A G 19: 44,143,996 (GRCm39) F359S possibly damaging Het
Plxnc1 A T 10: 94,629,080 (GRCm39) F1565I probably damaging Het
Polr1a A G 6: 71,890,000 (GRCm39) N73S probably benign Het
Polr1a T A 6: 71,942,628 (GRCm39) V1156E probably benign Het
Pon2 A G 6: 5,268,976 (GRCm39) probably null Het
Ptcd1 G A 5: 145,096,386 (GRCm39) L236F probably damaging Het
Rgl2 A G 17: 34,151,579 (GRCm39) I208V probably benign Het
Rhox2e C A X: 36,712,516 (GRCm39) P69Q probably damaging Het
Rptor G A 11: 119,763,197 (GRCm39) R927Q possibly damaging Het
Sec14l5 A G 16: 4,989,746 (GRCm39) Y230C probably damaging Het
Sele G T 1: 163,881,140 (GRCm39) G447C probably damaging Het
Slc17a1 G A 13: 24,062,564 (GRCm39) probably null Het
Slc2a4 A T 11: 69,836,751 (GRCm39) Y159* probably null Het
Slitrk5 A G 14: 111,917,014 (GRCm39) K213E probably damaging Het
Tdrd1 C A 19: 56,850,182 (GRCm39) Y981* probably null Het
Tex15 T C 8: 34,064,556 (GRCm39) Y1329H probably benign Het
Tgif2 C G 2: 156,686,114 (GRCm39) S2W probably damaging Het
Thoc5 A G 11: 4,878,688 (GRCm39) M620V probably benign Het
Tmeff2 C T 1: 51,220,994 (GRCm39) A323V probably damaging Het
Tmem181a T A 17: 6,346,061 (GRCm39) L185H probably damaging Het
Tmem68 A C 4: 3,569,588 (GRCm39) L34W probably damaging Het
Tmtc4 A T 14: 123,170,230 (GRCm39) probably null Het
Trpm2 A T 10: 77,766,368 (GRCm39) probably null Het
Tut4 G A 4: 108,370,125 (GRCm39) E714K probably damaging Het
Tyk2 C A 9: 21,020,617 (GRCm39) R938L probably benign Het
Usp33 A T 3: 152,063,579 (GRCm39) T18S probably damaging Het
V1rd19 A T 7: 23,703,310 (GRCm39) I259F probably benign Het
Vmn2r24 A C 6: 123,781,231 (GRCm39) Q479P probably benign Het
Vmn2r98 A G 17: 19,286,125 (GRCm39) M208V probably benign Het
Wfdc6a C T 2: 164,422,225 (GRCm39) V125I probably benign Het
Zkscan17 A G 11: 59,378,077 (GRCm39) C369R probably damaging Het
Other mutations in Lnx2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02593:Lnx2 APN 5 146,969,825 (GRCm39) missense possibly damaging 0.81
IGL02657:Lnx2 APN 5 146,964,984 (GRCm39) missense probably damaging 1.00
IGL02820:Lnx2 APN 5 146,978,877 (GRCm39) missense probably damaging 0.98
R0051:Lnx2 UTSW 5 146,966,163 (GRCm39) missense probably damaging 0.96
R0389:Lnx2 UTSW 5 146,955,850 (GRCm39) missense possibly damaging 0.51
R0482:Lnx2 UTSW 5 146,955,771 (GRCm39) missense probably damaging 0.99
R1601:Lnx2 UTSW 5 146,970,329 (GRCm39) missense probably damaging 0.99
R1604:Lnx2 UTSW 5 146,966,135 (GRCm39) missense probably benign 0.02
R1647:Lnx2 UTSW 5 146,964,152 (GRCm39) missense probably benign 0.04
R3001:Lnx2 UTSW 5 146,955,825 (GRCm39) missense probably benign 0.00
R4734:Lnx2 UTSW 5 146,965,947 (GRCm39) missense probably damaging 1.00
R4960:Lnx2 UTSW 5 146,955,850 (GRCm39) missense probably benign 0.09
R5387:Lnx2 UTSW 5 146,964,964 (GRCm39) missense probably benign 0.00
R5689:Lnx2 UTSW 5 146,965,961 (GRCm39) missense probably damaging 1.00
R5950:Lnx2 UTSW 5 146,961,160 (GRCm39) critical splice donor site probably null
R6161:Lnx2 UTSW 5 146,978,836 (GRCm39) splice site probably null
R6623:Lnx2 UTSW 5 146,961,297 (GRCm39) missense probably damaging 1.00
R7086:Lnx2 UTSW 5 146,956,988 (GRCm39) splice site probably null
R7320:Lnx2 UTSW 5 146,956,943 (GRCm39) missense possibly damaging 0.71
R7701:Lnx2 UTSW 5 146,961,333 (GRCm39) missense probably damaging 1.00
R7887:Lnx2 UTSW 5 146,955,853 (GRCm39) missense probably damaging 1.00
R8153:Lnx2 UTSW 5 146,964,906 (GRCm39) missense probably benign
R8267:Lnx2 UTSW 5 146,965,901 (GRCm39) missense probably damaging 1.00
R8298:Lnx2 UTSW 5 146,961,327 (GRCm39) missense probably benign 0.05
R8384:Lnx2 UTSW 5 146,966,138 (GRCm39) missense probably benign 0.01
R8446:Lnx2 UTSW 5 146,970,169 (GRCm39) missense probably benign
R8971:Lnx2 UTSW 5 146,970,236 (GRCm39) missense probably benign
R9378:Lnx2 UTSW 5 146,961,180 (GRCm39) missense probably benign 0.16
R9468:Lnx2 UTSW 5 146,979,289 (GRCm39) start gained probably benign
R9711:Lnx2 UTSW 5 146,961,376 (GRCm39) missense probably damaging 1.00
Predicted Primers
Posted On 2017-05-15