Incidental Mutation 'R2932:Oas1g'
| ID |
477477 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Oas1g
|
| Ensembl Gene |
ENSMUSG00000066861 |
| Gene Name |
2'-5' oligoadenylate synthetase 1G |
| Synonyms |
Oias-1, L2, Mmu-L2, Oias1, Oas1a, Mmu-L |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.052)
|
| Stock # |
R2932 (G1)
|
| Quality Score |
197 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
121014205-121025676 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 121017206 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Glutamine
at position 283
(K283Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000083555
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000086368]
[ENSMUST00000162096]
|
| AlphaFold |
Q8K469 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000086368
AA Change: K283Q
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000083555
Gene: ENSMUSG00000066861
AA Change: K283Q
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:NTP_transf_2
|
38 |
139 |
1.6e-13 |
PFAM |
|
Pfam:OAS1_C
|
164 |
349 |
6.9e-87 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000161809
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000162096
|
| SMART Domains |
Protein: ENSMUSP00000124597
Gene: ENSMUSG00000066861
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:NTP_transf_2
|
42 |
138 |
1.1e-9 |
PFAM |
|
Pfam:OAS1_C
|
163 |
231 |
1.4e-24 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 94.7%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: This gene encodes a member of the oligoadenylate synthetase family of proteins. This gene and several other family members are present in a gene cluster on chromosome 5. These proteins are believed to function in antiviral immunity through binding to viral dsRNA and subsequent synthesis of 2'-5'-oligoadenylates. The expression of this gene has been shown to be induced by interferon. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 20 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Alms1 |
A |
G |
6: 85,597,544 (GRCm39) |
D1259G |
possibly damaging |
Het |
| Arpp21 |
T |
C |
9: 112,008,173 (GRCm39) |
D106G |
probably damaging |
Het |
| Atp6v1a |
A |
G |
16: 43,909,406 (GRCm39) |
S542P |
probably benign |
Het |
| Ccar1 |
T |
C |
10: 62,612,538 (GRCm39) |
N209S |
probably benign |
Het |
| Ccdc15 |
G |
A |
9: 37,226,954 (GRCm39) |
T327I |
probably benign |
Het |
| Dhx15 |
G |
A |
5: 52,324,074 (GRCm39) |
P406L |
probably benign |
Het |
| Fat3 |
G |
A |
9: 16,287,240 (GRCm39) |
S761L |
probably damaging |
Het |
| Loricrin |
AGCCGCCGCCGCCGCCGCCGCCGCCGCC |
AGCCGCCGCCGCCGCCGCCGCCGCC |
3: 91,989,185 (GRCm39) |
|
probably benign |
Het |
| Lrrc1 |
T |
A |
9: 77,364,721 (GRCm39) |
H153L |
probably benign |
Het |
| Lrrc46 |
T |
C |
11: 96,931,935 (GRCm39) |
|
probably benign |
Het |
| Mrgprb2 |
A |
G |
7: 48,202,194 (GRCm39) |
L177S |
probably benign |
Het |
| Mtmr2 |
A |
T |
9: 13,660,413 (GRCm39) |
|
probably benign |
Het |
| Mtnr1b |
A |
T |
9: 15,785,620 (GRCm39) |
V46E |
probably damaging |
Het |
| Myo5a |
A |
G |
9: 75,103,418 (GRCm39) |
E207G |
possibly damaging |
Het |
| Nalcn |
A |
G |
14: 123,830,430 (GRCm39) |
S137P |
probably benign |
Het |
| Nipal1 |
A |
G |
5: 72,824,978 (GRCm39) |
I224V |
possibly damaging |
Het |
| Pex12 |
T |
A |
11: 83,187,049 (GRCm39) |
M300L |
probably benign |
Het |
| Phldb2 |
A |
G |
16: 45,569,148 (GRCm39) |
V1237A |
possibly damaging |
Het |
| Rc3h2 |
C |
A |
2: 37,268,371 (GRCm39) |
V920F |
probably benign |
Het |
| Ulk1 |
C |
T |
5: 110,937,223 (GRCm39) |
R691Q |
probably benign |
Het |
|
| Other mutations in Oas1g |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00339:Oas1g
|
APN |
5 |
121,024,109 (GRCm39) |
nonsense |
probably null |
|
|
R0389:Oas1g
|
UTSW |
5 |
121,025,592 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1433:Oas1g
|
UTSW |
5 |
121,020,012 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1468:Oas1g
|
UTSW |
5 |
121,020,069 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1468:Oas1g
|
UTSW |
5 |
121,020,069 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1926:Oas1g
|
UTSW |
5 |
121,017,205 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2062:Oas1g
|
UTSW |
5 |
121,023,946 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2063:Oas1g
|
UTSW |
5 |
121,023,946 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2064:Oas1g
|
UTSW |
5 |
121,023,946 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2067:Oas1g
|
UTSW |
5 |
121,023,946 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4296:Oas1g
|
UTSW |
5 |
121,017,230 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4808:Oas1g
|
UTSW |
5 |
121,017,385 (GRCm39) |
missense |
possibly damaging |
0.45 |
|
R5874:Oas1g
|
UTSW |
5 |
121,015,081 (GRCm39) |
missense |
probably benign |
|
|
R6842:Oas1g
|
UTSW |
5 |
121,025,621 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7314:Oas1g
|
UTSW |
5 |
121,016,526 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7729:Oas1g
|
UTSW |
5 |
121,024,063 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9353:Oas1g
|
UTSW |
5 |
121,023,986 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
Z1177:Oas1g
|
UTSW |
5 |
121,016,393 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
|
| Posted On |
2017-05-15 |
Incidental Mutation