Incidental Mutation 'R2923:Susd3'
ID 477503
Institutional Source Beutler Lab
Gene Symbol Susd3
Ensembl Gene ENSMUSG00000021384
Gene Name sushi domain containing 3
Synonyms 1700017I11Rik, 2810440J20Rik
MMRRC Submission 040508-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.050) question?
Stock # R2923 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 49384166-49402182 bp(-) (GRCm39)
Type of Mutation start codon destroyed
DNA Base Change (assembly) A to T at 49401945 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 1 (M1K)
Ref Sequence ENSEMBL: ENSMUSP00000021816 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021816] [ENSMUST00000058196] [ENSMUST00000119721] [ENSMUST00000135784]
AlphaFold Q9D176
Predicted Effect probably null
Transcript: ENSMUST00000021816
AA Change: M1K

PolyPhen 2 Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000021816
Gene: ENSMUSG00000021384
AA Change: M1K

DomainStartEndE-ValueType
CCP 20 79 2.11e-9 SMART
transmembrane domain 95 117 N/A INTRINSIC
low complexity region 154 179 N/A INTRINSIC
low complexity region 218 231 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000058196
SMART Domains Protein: ENSMUSP00000061423
Gene: ENSMUSG00000021384

DomainStartEndE-ValueType
CCP 32 91 2.11e-9 SMART
transmembrane domain 107 129 N/A INTRINSIC
low complexity region 166 191 N/A INTRINSIC
low complexity region 230 243 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000119721
SMART Domains Protein: ENSMUSP00000113631
Gene: ENSMUSG00000021384

DomainStartEndE-ValueType
CCP 32 91 2.11e-9 SMART
transmembrane domain 107 129 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000135784
AA Change: M1K
SMART Domains Protein: ENSMUSP00000115888
Gene: ENSMUSG00000021384
AA Change: M1K

DomainStartEndE-ValueType
transmembrane domain 32 54 N/A INTRINSIC
low complexity region 91 116 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.5%
  • 20x: 95.6%
Validation Efficiency 98% (46/47)
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam4 A T 12: 81,467,518 (GRCm39) C368S probably damaging Het
Adamts3 T C 5: 90,009,393 (GRCm39) D90G possibly damaging Het
Astn2 T C 4: 65,832,010 (GRCm39) Y500C probably damaging Het
Atp12a A T 14: 56,612,079 (GRCm39) T418S probably benign Het
Atp6v0a2 C T 5: 124,794,981 (GRCm39) T656M possibly damaging Het
Camsap2 G A 1: 136,208,547 (GRCm39) P971S possibly damaging Het
Ccdc116 T C 16: 16,960,307 (GRCm39) H170R probably benign Het
Ccn5 G A 2: 163,674,266 (GRCm39) R222Q probably benign Het
Cemip2 A G 19: 21,795,303 (GRCm39) D732G possibly damaging Het
Clpb A G 7: 101,372,035 (GRCm39) D257G probably benign Het
Cpb2 T C 14: 75,493,473 (GRCm39) probably null Het
D430041D05Rik G A 2: 104,085,660 (GRCm39) T164I possibly damaging Het
Dhx40 T G 11: 86,680,089 (GRCm39) Q416P probably benign Het
Dnah17 A G 11: 117,984,373 (GRCm39) F1636S probably damaging Het
Fhl3 T C 4: 124,599,463 (GRCm39) S13P probably damaging Het
Gapvd1 A T 2: 34,578,875 (GRCm39) I1249N probably damaging Het
Gm10604 C T 4: 11,980,122 (GRCm39) A61T unknown Het
Gm20939 T A 17: 95,184,721 (GRCm39) H456Q probably damaging Het
Golga4 T A 9: 118,388,411 (GRCm39) S1844R possibly damaging Het
Grm6 G C 11: 50,755,348 (GRCm39) G827R probably damaging Het
Grm7 T A 6: 111,472,866 (GRCm39) probably null Het
Hdc G A 2: 126,435,910 (GRCm39) P654S probably damaging Het
Hoxb1 T C 11: 96,257,119 (GRCm39) L156P probably benign Het
Ipo9 G T 1: 135,327,867 (GRCm39) Q515K probably benign Het
Kcnk3 T C 5: 30,779,414 (GRCm39) S155P probably damaging Het
Mboat2 T A 12: 25,004,239 (GRCm39) W347R probably damaging Het
Mib1 C T 18: 10,760,831 (GRCm39) Q374* probably null Het
Ncor2 A G 5: 125,132,855 (GRCm39) F44S probably damaging Het
Nipal3 A T 4: 135,204,776 (GRCm39) I125N probably damaging Het
Or4c113 A G 2: 88,884,843 (GRCm39) V309A probably benign Het
Or51a43 A G 7: 103,717,794 (GRCm39) V148A probably benign Het
Ovch2 A G 7: 107,389,596 (GRCm39) L317P possibly damaging Het
Pnpla2 T A 7: 141,035,380 (GRCm39) C61S probably benign Het
Ppp1r16b G T 2: 158,598,877 (GRCm39) L312F probably damaging Het
Rdm1 T A 11: 101,521,716 (GRCm39) L157H possibly damaging Het
Rpl22 C A 4: 152,412,002 (GRCm39) T26N possibly damaging Het
Rptn A G 3: 93,306,015 (GRCm39) Y1116C possibly damaging Het
Serpinb5 G A 1: 106,803,770 (GRCm39) S152N probably benign Het
Setx GTGGCT GT 2: 29,044,073 (GRCm39) 1814 probably null Het
St8sia1 A T 6: 142,774,963 (GRCm39) F205L probably damaging Het
Stab2 A G 10: 86,697,325 (GRCm39) Y1988H probably damaging Het
Syne3 A T 12: 104,934,343 (GRCm39) L55Q probably damaging Het
Tmx1 T A 12: 70,512,895 (GRCm39) C268S probably benign Het
Ttll1 T C 15: 83,376,760 (GRCm39) K321R probably damaging Het
Zdhhc18 G T 4: 133,360,455 (GRCm39) H82Q probably benign Het
Zhx1 T C 15: 57,917,077 (GRCm39) I390V probably damaging Het
Other mutations in Susd3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00553:Susd3 APN 13 49,384,614 (GRCm39) makesense probably null
IGL03336:Susd3 APN 13 49,392,258 (GRCm39) missense probably benign 0.09
R2122:Susd3 UTSW 13 49,384,626 (GRCm39) missense probably damaging 1.00
R2343:Susd3 UTSW 13 49,392,335 (GRCm39) missense probably damaging 0.99
R4591:Susd3 UTSW 13 49,384,736 (GRCm39) missense possibly damaging 0.57
R4661:Susd3 UTSW 13 49,384,778 (GRCm39) splice site probably null
R5006:Susd3 UTSW 13 49,392,181 (GRCm39) intron probably benign
R5841:Susd3 UTSW 13 49,392,202 (GRCm39) intron probably benign
R6285:Susd3 UTSW 13 49,390,997 (GRCm39) missense probably damaging 1.00
R6796:Susd3 UTSW 13 49,391,041 (GRCm39) frame shift probably null
R7193:Susd3 UTSW 13 49,384,679 (GRCm39) missense probably damaging 1.00
R7311:Susd3 UTSW 13 49,401,906 (GRCm39) missense probably benign 0.00
R7572:Susd3 UTSW 13 49,384,638 (GRCm39) missense probably benign 0.31
R7697:Susd3 UTSW 13 49,391,074 (GRCm39) missense probably damaging 1.00
R8239:Susd3 UTSW 13 49,384,731 (GRCm39) missense probably benign
R8479:Susd3 UTSW 13 49,390,952 (GRCm39) missense probably benign 0.10
Predicted Primers
Posted On 2017-05-15