Incidental Mutation 'R0510:Trpm1'
| ID |
47805 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Trpm1
|
| Ensembl Gene |
ENSMUSG00000030523 |
| Gene Name |
transient receptor potential cation channel, subfamily M, member 1 |
| Synonyms |
Mlsn1, melastatin, 4732499L03Rik, LTRPC1 |
| MMRRC Submission |
038704-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0510 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
63803583-63919523 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 63873506 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glycine to Aspartic acid
at position 587
(G587D)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000146226
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000085222]
[ENSMUST00000177102]
[ENSMUST00000205348]
[ENSMUST00000206277]
[ENSMUST00000205994]
[ENSMUST00000206263]
[ENSMUST00000206314]
|
| AlphaFold |
Q2TV84 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000085222
AA Change: G587D
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000082318
Gene: ENSMUSG00000030523
AA Change: G587D
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
8 |
28 |
N/A |
INTRINSIC |
|
low complexity region
|
183 |
195 |
N/A |
INTRINSIC |
|
low complexity region
|
289 |
307 |
N/A |
INTRINSIC |
|
low complexity region
|
456 |
491 |
N/A |
INTRINSIC |
|
Blast:ANK
|
505 |
533 |
1e-5 |
BLAST |
|
low complexity region
|
621 |
650 |
N/A |
INTRINSIC |
|
low complexity region
|
823 |
835 |
N/A |
INTRINSIC |
|
transmembrane domain
|
876 |
895 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans
|
907 |
1120 |
6e-16 |
PFAM |
|
transmembrane domain
|
1150 |
1167 |
N/A |
INTRINSIC |
|
low complexity region
|
1216 |
1225 |
N/A |
INTRINSIC |
|
PDB:3E7K|H
|
1228 |
1279 |
1e-7 |
PDB |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000107525
AA Change: G587D
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000103149
Gene: ENSMUSG00000030523
AA Change: G587D
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
8 |
28 |
N/A |
INTRINSIC |
|
low complexity region
|
183 |
195 |
N/A |
INTRINSIC |
|
low complexity region
|
289 |
307 |
N/A |
INTRINSIC |
|
low complexity region
|
456 |
491 |
N/A |
INTRINSIC |
|
Blast:ANK
|
505 |
533 |
1e-5 |
BLAST |
|
low complexity region
|
621 |
650 |
N/A |
INTRINSIC |
|
low complexity region
|
823 |
835 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans
|
876 |
1138 |
7.6e-22 |
PFAM |
|
transmembrane domain
|
1156 |
1173 |
N/A |
INTRINSIC |
|
Pfam:TRPM_tetra
|
1230 |
1285 |
9.4e-28 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000176623
AA Change: G95D
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000134805
Gene: ENSMUSG00000030523
AA Change: G95D
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:ANK
|
13 |
41 |
1e-6 |
BLAST |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000177102
AA Change: G471D
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000134947
Gene: ENSMUSG00000030523
AA Change: G471D
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
67 |
79 |
N/A |
INTRINSIC |
|
low complexity region
|
173 |
191 |
N/A |
INTRINSIC |
|
low complexity region
|
340 |
375 |
N/A |
INTRINSIC |
|
Blast:ANK
|
389 |
417 |
1e-5 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000205348
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000205434
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000205610
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000206277
AA Change: G587D
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000205994
AA Change: G95D
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000206263
AA Change: G471D
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000206740
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000206000
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000206314
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000205939
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.2%
- 10x: 96.0%
- 20x: 91.2%
|
| Validation Efficiency |
99% (102/103) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the transient receptor potential melastatin subfamily of transient receptor potential ion channels. The encoded protein is a calcium permeable cation channel that is expressed in melanocytes and may play a role in melanin synthesis. Specific mutations in this gene are the cause autosomal recessive complete congenital stationary night blindness-1C. The expression of this protein is inversely correlated with melanoma aggressiveness and as such it is used as a prognostic marker for melanoma metastasis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]
PHENOTYPE: Homozygous mutants have defects in rod and cone electrophysiology affecting the photoresponses. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 101 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcg3 |
A |
G |
5: 105,125,482 (GRCm39) |
I67T |
probably damaging |
Het |
| Acoxl |
G |
A |
2: 127,722,423 (GRCm39) |
|
probably null |
Het |
| Adam10 |
T |
A |
9: 70,655,530 (GRCm39) |
W333R |
probably damaging |
Het |
| Ahnak |
C |
T |
19: 8,995,596 (GRCm39) |
R5627* |
probably null |
Het |
| Alms1 |
A |
T |
6: 85,597,351 (GRCm39) |
R1195* |
probably null |
Het |
| Ap2m1 |
T |
A |
16: 20,360,990 (GRCm39) |
I334N |
possibly damaging |
Het |
| Brd8dc |
A |
T |
18: 34,729,204 (GRCm39) |
D42E |
probably damaging |
Het |
| Camta1 |
C |
A |
4: 151,159,597 (GRCm39) |
R1614L |
probably damaging |
Het |
| Ccdc110 |
T |
A |
8: 46,388,194 (GRCm39) |
N50K |
probably benign |
Het |
| Ccdc168 |
T |
A |
1: 44,100,257 (GRCm39) |
K280N |
possibly damaging |
Het |
| Cdhr1 |
T |
C |
14: 36,802,633 (GRCm39) |
Y610C |
probably damaging |
Het |
| Cdkal1 |
C |
A |
13: 29,875,579 (GRCm39) |
|
probably null |
Het |
| Celsr3 |
G |
A |
9: 108,704,204 (GRCm39) |
C229Y |
possibly damaging |
Het |
| Clca4b |
A |
T |
3: 144,619,112 (GRCm39) |
Y676N |
probably damaging |
Het |
| Col11a1 |
A |
T |
3: 113,899,105 (GRCm39) |
|
probably benign |
Het |
| Cpe |
T |
A |
8: 65,064,501 (GRCm39) |
I233F |
probably damaging |
Het |
| Cpsf1 |
A |
T |
15: 76,487,857 (GRCm39) |
|
probably benign |
Het |
| Cpsf2 |
T |
C |
12: 101,955,045 (GRCm39) |
V272A |
probably damaging |
Het |
| Creld2 |
A |
T |
15: 88,704,159 (GRCm39) |
N50I |
probably damaging |
Het |
| Cyb5r1 |
T |
C |
1: 134,337,430 (GRCm39) |
|
probably benign |
Het |
| Dcaf11 |
T |
C |
14: 55,806,537 (GRCm39) |
V446A |
probably damaging |
Het |
| Defa34 |
A |
G |
8: 22,155,988 (GRCm39) |
|
probably null |
Het |
| Dgat1 |
T |
C |
15: 76,395,767 (GRCm39) |
Y72C |
possibly damaging |
Het |
| Efr3b |
G |
T |
12: 4,032,058 (GRCm39) |
D183E |
probably benign |
Het |
| Enpp3 |
A |
T |
10: 24,652,679 (GRCm39) |
D759E |
probably damaging |
Het |
| Epyc |
A |
G |
10: 97,485,625 (GRCm39) |
T22A |
probably benign |
Het |
| Etfbkmt |
C |
T |
6: 149,052,082 (GRCm39) |
R96W |
probably benign |
Het |
| Fam83b |
G |
T |
9: 76,400,108 (GRCm39) |
L332I |
possibly damaging |
Het |
| Fat3 |
C |
A |
9: 15,910,981 (GRCm39) |
E1674* |
probably null |
Het |
| Fbn1 |
A |
G |
2: 125,184,845 (GRCm39) |
|
probably benign |
Het |
| Gm5134 |
C |
A |
10: 75,810,079 (GRCm39) |
T120N |
probably benign |
Het |
| Gmip |
C |
T |
8: 70,268,259 (GRCm39) |
|
probably benign |
Het |
| Gpbp1 |
G |
T |
13: 111,577,279 (GRCm39) |
Q204K |
possibly damaging |
Het |
| Gpr108 |
T |
C |
17: 57,542,358 (GRCm39) |
D549G |
possibly damaging |
Het |
| Gsdme |
C |
A |
6: 50,223,107 (GRCm39) |
|
probably benign |
Het |
| Gucy2e |
T |
C |
11: 69,126,402 (GRCm39) |
D326G |
probably benign |
Het |
| H2-Eb2 |
C |
T |
17: 34,553,218 (GRCm39) |
Q135* |
probably null |
Het |
| Hectd4 |
T |
A |
5: 121,419,959 (GRCm39) |
Y635N |
possibly damaging |
Het |
| Hectd4 |
G |
A |
5: 121,443,736 (GRCm39) |
E1319K |
possibly damaging |
Het |
| Hs3st2 |
T |
C |
7: 121,099,792 (GRCm39) |
S213P |
probably damaging |
Het |
| Ikbkb |
A |
T |
8: 23,161,651 (GRCm39) |
C412* |
probably null |
Het |
| Itpr2 |
T |
C |
6: 146,319,477 (GRCm39) |
T188A |
possibly damaging |
Het |
| Kcnh1 |
T |
A |
1: 192,101,249 (GRCm39) |
|
probably benign |
Het |
| Kctd21 |
T |
C |
7: 96,996,748 (GRCm39) |
F74L |
probably damaging |
Het |
| Krt23 |
T |
A |
11: 99,377,608 (GRCm39) |
I133L |
probably damaging |
Het |
| Krt74 |
T |
C |
15: 101,671,751 (GRCm39) |
|
noncoding transcript |
Het |
| Krt81 |
C |
A |
15: 101,361,508 (GRCm39) |
R24L |
possibly damaging |
Het |
| Lmtk3 |
T |
A |
7: 45,443,536 (GRCm39) |
L740M |
possibly damaging |
Het |
| Lrrc10 |
T |
A |
10: 116,881,695 (GRCm39) |
L123Q |
probably damaging |
Het |
| Map1a |
A |
T |
2: 121,136,255 (GRCm39) |
H2357L |
probably benign |
Het |
| Mbl1 |
A |
G |
14: 40,880,706 (GRCm39) |
N198S |
probably damaging |
Het |
| Mcf2l |
A |
G |
8: 13,047,337 (GRCm39) |
D233G |
probably damaging |
Het |
| Msto1 |
A |
G |
3: 88,818,848 (GRCm39) |
L269P |
probably benign |
Het |
| Mtss1 |
A |
T |
15: 58,828,387 (GRCm39) |
D175E |
probably benign |
Het |
| Myef2 |
A |
T |
2: 124,950,954 (GRCm39) |
|
probably benign |
Het |
| Neb |
A |
T |
2: 52,180,755 (GRCm39) |
|
probably benign |
Het |
| Or14a259 |
T |
C |
7: 86,013,035 (GRCm39) |
N170S |
probably benign |
Het |
| Or4a39 |
A |
T |
2: 89,237,135 (GRCm39) |
M96K |
probably damaging |
Het |
| Or5w15 |
A |
G |
2: 87,567,825 (GRCm39) |
V281A |
probably damaging |
Het |
| Parp2 |
T |
A |
14: 51,057,130 (GRCm39) |
Y361N |
probably damaging |
Het |
| Parp3 |
A |
G |
9: 106,348,995 (GRCm39) |
F466L |
possibly damaging |
Het |
| Pcdh15 |
A |
T |
10: 74,126,808 (GRCm39) |
N296Y |
probably damaging |
Het |
| Pdzrn3 |
A |
T |
6: 101,128,014 (GRCm39) |
I884N |
probably damaging |
Het |
| Pim1 |
T |
C |
17: 29,712,883 (GRCm39) |
|
probably benign |
Het |
| Pou6f2 |
A |
G |
13: 18,314,308 (GRCm39) |
|
probably benign |
Het |
| Prelid3b |
A |
G |
2: 174,307,743 (GRCm39) |
|
probably benign |
Het |
| Proc |
G |
A |
18: 32,258,171 (GRCm39) |
T258I |
probably benign |
Het |
| Rab3gap2 |
T |
C |
1: 184,992,705 (GRCm39) |
|
probably benign |
Het |
| Rb1cc1 |
A |
C |
1: 6,319,395 (GRCm39) |
K938T |
probably benign |
Het |
| Rem2 |
T |
C |
14: 54,713,754 (GRCm39) |
|
probably benign |
Het |
| Rif1 |
GCCACCA |
GCCA |
2: 52,000,336 (GRCm39) |
|
probably benign |
Het |
| Rin2 |
A |
G |
2: 145,702,953 (GRCm39) |
K550E |
probably benign |
Het |
| Rps6ka4 |
G |
T |
19: 6,817,866 (GRCm39) |
T17N |
probably benign |
Het |
| Rtn4 |
T |
A |
11: 29,683,849 (GRCm39) |
|
probably benign |
Het |
| Ruvbl2 |
C |
T |
7: 45,080,730 (GRCm39) |
|
probably benign |
Het |
| Scaper |
A |
G |
9: 55,665,346 (GRCm39) |
|
probably benign |
Het |
| Sdc2 |
T |
C |
15: 33,017,235 (GRCm39) |
|
probably benign |
Het |
| Semp2l1 |
T |
A |
1: 32,584,956 (GRCm39) |
N318I |
possibly damaging |
Het |
| Slc35e1 |
T |
C |
8: 73,246,415 (GRCm39) |
|
probably benign |
Het |
| Slco2b1 |
T |
A |
7: 99,310,743 (GRCm39) |
M603L |
probably benign |
Het |
| Smpdl3b |
A |
G |
4: 132,472,449 (GRCm39) |
V108A |
probably damaging |
Het |
| Sptbn4 |
C |
T |
7: 27,060,991 (GRCm39) |
|
probably null |
Het |
| Srrm1 |
G |
A |
4: 135,065,854 (GRCm39) |
|
probably benign |
Het |
| Ssh1 |
A |
T |
5: 114,084,766 (GRCm39) |
D448E |
probably benign |
Het |
| Ssmem1 |
A |
T |
6: 30,519,547 (GRCm39) |
|
probably null |
Het |
| Sv2b |
T |
G |
7: 74,786,140 (GRCm39) |
M427L |
probably benign |
Het |
| Syne1 |
A |
G |
10: 5,317,600 (GRCm39) |
L498P |
probably damaging |
Het |
| Syne2 |
T |
C |
12: 75,900,923 (GRCm39) |
|
probably null |
Het |
| Taf6l |
G |
T |
19: 8,755,885 (GRCm39) |
H254Q |
probably benign |
Het |
| Traf3ip3 |
T |
A |
1: 192,860,539 (GRCm39) |
|
probably null |
Het |
| Ttn |
A |
G |
2: 76,560,756 (GRCm39) |
V29215A |
probably damaging |
Het |
| Ubr4 |
T |
G |
4: 139,157,534 (GRCm39) |
S2364A |
probably benign |
Het |
| Ush2a |
T |
A |
1: 188,466,860 (GRCm39) |
|
probably benign |
Het |
| Vmn2r100 |
C |
A |
17: 19,742,382 (GRCm39) |
P252Q |
possibly damaging |
Het |
| Vmn2r57 |
A |
T |
7: 41,077,216 (GRCm39) |
S317T |
possibly damaging |
Het |
| Vwa2 |
A |
G |
19: 56,886,500 (GRCm39) |
|
probably benign |
Het |
| Wdr73 |
G |
A |
7: 80,547,698 (GRCm39) |
Q107* |
probably null |
Het |
| Zbtb10 |
T |
A |
3: 9,329,728 (GRCm39) |
V362E |
probably damaging |
Het |
| Zfp217 |
C |
T |
2: 169,957,382 (GRCm39) |
A539T |
probably benign |
Het |
| Zfp296 |
A |
T |
7: 19,311,831 (GRCm39) |
M113L |
probably benign |
Het |
| Zfp729b |
A |
T |
13: 67,739,253 (GRCm39) |
V1004E |
probably benign |
Het |
|
| Other mutations in Trpm1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00093:Trpm1
|
APN |
7 |
63,893,198 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00465:Trpm1
|
APN |
7 |
63,897,215 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL01118:Trpm1
|
APN |
7 |
63,885,572 (GRCm39) |
missense |
probably benign |
0.24 |
|
IGL01148:Trpm1
|
APN |
7 |
63,893,312 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01303:Trpm1
|
APN |
7 |
63,860,578 (GRCm39) |
critical splice acceptor site |
probably benign |
0.00 |
|
IGL01432:Trpm1
|
APN |
7 |
63,884,767 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL01433:Trpm1
|
APN |
7 |
63,854,276 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01506:Trpm1
|
APN |
7 |
63,893,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01626:Trpm1
|
APN |
7 |
63,918,637 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01640:Trpm1
|
APN |
7 |
63,876,645 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01899:Trpm1
|
APN |
7 |
63,884,742 (GRCm39) |
missense |
probably benign |
0.24 |
|
IGL01959:Trpm1
|
APN |
7 |
63,858,723 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL02210:Trpm1
|
APN |
7 |
63,860,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02268:Trpm1
|
APN |
7 |
63,867,362 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02331:Trpm1
|
APN |
7 |
63,884,800 (GRCm39) |
missense |
probably benign |
0.30 |
|
IGL02334:Trpm1
|
APN |
7 |
63,895,690 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
IGL02407:Trpm1
|
APN |
7 |
63,868,869 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02425:Trpm1
|
APN |
7 |
63,890,175 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02485:Trpm1
|
APN |
7 |
63,918,862 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
IGL02635:Trpm1
|
APN |
7 |
63,848,972 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02640:Trpm1
|
APN |
7 |
63,868,881 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02827:Trpm1
|
APN |
7 |
63,868,908 (GRCm39) |
missense |
probably null |
1.00 |
|
PIT4458001:Trpm1
|
UTSW |
7 |
63,918,309 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
PIT4544001:Trpm1
|
UTSW |
7 |
63,848,998 (GRCm39) |
intron |
probably benign |
|
|
R0012:Trpm1
|
UTSW |
7 |
63,918,339 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0014:Trpm1
|
UTSW |
7 |
63,897,970 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0056:Trpm1
|
UTSW |
7 |
63,893,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0445:Trpm1
|
UTSW |
7 |
63,894,590 (GRCm39) |
unclassified |
probably benign |
|
|
R0463:Trpm1
|
UTSW |
7 |
63,870,002 (GRCm39) |
missense |
probably benign |
0.05 |
|
R0469:Trpm1
|
UTSW |
7 |
63,873,506 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1301:Trpm1
|
UTSW |
7 |
63,852,801 (GRCm39) |
splice site |
probably null |
|
|
R1397:Trpm1
|
UTSW |
7 |
63,867,406 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1588:Trpm1
|
UTSW |
7 |
63,873,565 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1618:Trpm1
|
UTSW |
7 |
63,890,283 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1724:Trpm1
|
UTSW |
7 |
63,885,569 (GRCm39) |
nonsense |
probably null |
|
|
R1827:Trpm1
|
UTSW |
7 |
63,884,755 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1829:Trpm1
|
UTSW |
7 |
63,876,530 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1835:Trpm1
|
UTSW |
7 |
63,880,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1864:Trpm1
|
UTSW |
7 |
63,917,764 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1895:Trpm1
|
UTSW |
7 |
63,873,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1946:Trpm1
|
UTSW |
7 |
63,873,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1959:Trpm1
|
UTSW |
7 |
63,879,978 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1960:Trpm1
|
UTSW |
7 |
63,879,978 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1980:Trpm1
|
UTSW |
7 |
63,858,182 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R1989:Trpm1
|
UTSW |
7 |
63,858,780 (GRCm39) |
intron |
probably null |
|
|
R2054:Trpm1
|
UTSW |
7 |
63,890,303 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R2156:Trpm1
|
UTSW |
7 |
63,884,736 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2251:Trpm1
|
UTSW |
7 |
63,859,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3051:Trpm1
|
UTSW |
7 |
63,918,849 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3148:Trpm1
|
UTSW |
7 |
63,884,760 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3195:Trpm1
|
UTSW |
7 |
63,849,061 (GRCm39) |
nonsense |
probably null |
|
|
R3615:Trpm1
|
UTSW |
7 |
63,893,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3616:Trpm1
|
UTSW |
7 |
63,893,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3623:Trpm1
|
UTSW |
7 |
63,894,601 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3624:Trpm1
|
UTSW |
7 |
63,894,601 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3721:Trpm1
|
UTSW |
7 |
63,867,475 (GRCm39) |
intron |
probably benign |
|
|
R3822:Trpm1
|
UTSW |
7 |
63,867,451 (GRCm39) |
intron |
probably benign |
|
|
R4441:Trpm1
|
UTSW |
7 |
63,851,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4490:Trpm1
|
UTSW |
7 |
63,858,660 (GRCm39) |
nonsense |
probably null |
|
|
R4666:Trpm1
|
UTSW |
7 |
63,852,782 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4701:Trpm1
|
UTSW |
7 |
63,893,248 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4781:Trpm1
|
UTSW |
7 |
63,884,800 (GRCm39) |
missense |
probably benign |
0.30 |
|
R4811:Trpm1
|
UTSW |
7 |
63,858,054 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5017:Trpm1
|
UTSW |
7 |
63,894,580 (GRCm39) |
unclassified |
probably benign |
|
|
R5030:Trpm1
|
UTSW |
7 |
63,885,579 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5195:Trpm1
|
UTSW |
7 |
63,887,441 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R5238:Trpm1
|
UTSW |
7 |
63,918,702 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5304:Trpm1
|
UTSW |
7 |
63,858,694 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5575:Trpm1
|
UTSW |
7 |
63,870,018 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5613:Trpm1
|
UTSW |
7 |
63,858,159 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5855:Trpm1
|
UTSW |
7 |
63,918,710 (GRCm39) |
nonsense |
probably null |
|
|
R5947:Trpm1
|
UTSW |
7 |
63,873,547 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5988:Trpm1
|
UTSW |
7 |
63,876,553 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6054:Trpm1
|
UTSW |
7 |
63,918,450 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6088:Trpm1
|
UTSW |
7 |
63,917,724 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6259:Trpm1
|
UTSW |
7 |
63,918,226 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R6379:Trpm1
|
UTSW |
7 |
63,848,942 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6380:Trpm1
|
UTSW |
7 |
63,918,045 (GRCm39) |
missense |
probably benign |
0.24 |
|
R6429:Trpm1
|
UTSW |
7 |
63,918,252 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6600:Trpm1
|
UTSW |
7 |
63,803,781 (GRCm39) |
start codon destroyed |
probably null |
0.56 |
|
R6622:Trpm1
|
UTSW |
7 |
63,890,343 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6939:Trpm1
|
UTSW |
7 |
63,918,045 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6944:Trpm1
|
UTSW |
7 |
63,893,181 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7025:Trpm1
|
UTSW |
7 |
63,876,462 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7112:Trpm1
|
UTSW |
7 |
63,885,593 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7168:Trpm1
|
UTSW |
7 |
63,918,445 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7219:Trpm1
|
UTSW |
7 |
63,854,333 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R7224:Trpm1
|
UTSW |
7 |
63,868,854 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7285:Trpm1
|
UTSW |
7 |
63,859,729 (GRCm39) |
nonsense |
probably null |
|
|
R7367:Trpm1
|
UTSW |
7 |
63,918,549 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7449:Trpm1
|
UTSW |
7 |
63,858,723 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7466:Trpm1
|
UTSW |
7 |
63,890,330 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7498:Trpm1
|
UTSW |
7 |
63,858,657 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7581:Trpm1
|
UTSW |
7 |
63,854,303 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7776:Trpm1
|
UTSW |
7 |
63,897,939 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8062:Trpm1
|
UTSW |
7 |
63,851,689 (GRCm39) |
missense |
probably benign |
0.18 |
|
R8069:Trpm1
|
UTSW |
7 |
63,858,718 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R8157:Trpm1
|
UTSW |
7 |
63,849,017 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8219:Trpm1
|
UTSW |
7 |
63,851,699 (GRCm39) |
missense |
probably benign |
0.35 |
|
R8258:Trpm1
|
UTSW |
7 |
63,918,777 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8259:Trpm1
|
UTSW |
7 |
63,918,777 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8320:Trpm1
|
UTSW |
7 |
63,918,541 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R8536:Trpm1
|
UTSW |
7 |
63,897,155 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8544:Trpm1
|
UTSW |
7 |
63,874,356 (GRCm39) |
splice site |
probably null |
|
|
R8813:Trpm1
|
UTSW |
7 |
63,851,756 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R8912:Trpm1
|
UTSW |
7 |
63,918,628 (GRCm39) |
missense |
probably benign |
0.06 |
|
R8954:Trpm1
|
UTSW |
7 |
63,858,089 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9139:Trpm1
|
UTSW |
7 |
63,848,943 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9205:Trpm1
|
UTSW |
7 |
63,890,319 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R9258:Trpm1
|
UTSW |
7 |
63,884,713 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9283:Trpm1
|
UTSW |
7 |
63,873,623 (GRCm39) |
missense |
probably benign |
0.18 |
|
R9394:Trpm1
|
UTSW |
7 |
63,918,480 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9430:Trpm1
|
UTSW |
7 |
63,873,446 (GRCm39) |
missense |
probably benign |
0.38 |
|
R9537:Trpm1
|
UTSW |
7 |
63,803,616 (GRCm39) |
unclassified |
probably benign |
|
|
R9616:Trpm1
|
UTSW |
7 |
63,858,132 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9774:Trpm1
|
UTSW |
7 |
63,898,041 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
X0026:Trpm1
|
UTSW |
7 |
63,918,658 (GRCm39) |
missense |
probably benign |
0.05 |
|
Z1176:Trpm1
|
UTSW |
7 |
63,854,342 (GRCm39) |
critical splice donor site |
probably null |
|
|
Z1176:Trpm1
|
UTSW |
7 |
63,852,879 (GRCm39) |
critical splice donor site |
probably null |
|
|
Z1177:Trpm1
|
UTSW |
7 |
63,867,439 (GRCm39) |
missense |
unknown |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AATACATCTGCTTTTAGGCCGGGG -3'
(R):5'- TTTGGGGAAGCACATCAAGGAACC -3'
Sequencing Primer
(F):5'- GGATATAATTCAACCTGTCATTCCCG -3'
(R):5'- ACCACATGTTACTCTGGGAGG -3'
|
| Posted On |
2013-06-12 |
Incidental Mutation