Incidental Mutation 'LCD18:Unc5b'
ID 478202
Institutional Source Beutler Lab
Gene Symbol Unc5b
Ensembl Gene ENSMUSG00000020099
Gene Name unc-5 netrin receptor B
Synonyms Unc5h2, 6330415E02Rik, D10Bwg0792e
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # LCD18 (G1)
Quality Score 999
Status Validated
Chromosome 10
Chromosomal Location 60598373-60667360 bp(-) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) C to G at 60621950 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000151251 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077925] [ENSMUST00000218637]
AlphaFold Q8K1S3
Predicted Effect probably benign
Transcript: ENSMUST00000077925
SMART Domains Protein: ENSMUSP00000077080
Gene: ENSMUSG00000020099

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
IG_like 54 149 1.71e2 SMART
IGc2 165 232 2.58e-6 SMART
TSP1 249 300 8.21e-15 SMART
TSP1 305 354 2.61e-8 SMART
transmembrane domain 374 396 N/A INTRINSIC
low complexity region 491 504 N/A INTRINSIC
ZU5 541 644 1.91e-56 SMART
DEATH 852 943 5.55e-21 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000218316
Predicted Effect probably benign
Transcript: ENSMUST00000218637
Coding Region Coverage
  • 1x: 0.0%
  • 3x: 0.0%
  • 10x: 0.0%
  • 20x: 0.0%
Validation Efficiency 88% (169/191)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]
PHENOTYPE: Mice homozygous for a severely hypomorphic allele exhibit background sensitive lethality during organogenesis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 113 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A330008L17Rik A G 8: 100,450,057 (GRCm39) noncoding transcript Het
Aff2 C A X: 68,791,141 (GRCm39) probably benign Het
Aldh1a1 C A 19: 20,604,010 (GRCm39) probably benign Het
Anxa7 C T 14: 20,519,479 (GRCm39) G113E probably damaging Het
Apba2 A T 7: 64,271,908 (GRCm39) probably benign Het
Apc2 G C 10: 80,135,808 (GRCm39) probably benign Het
App C G 16: 84,822,300 (GRCm39) probably benign Het
Asic2 C A 11: 80,876,570 (GRCm39) probably benign Het
Btk T C X: 133,479,574 (GRCm39) probably benign Het
Car12 C A 9: 66,668,958 (GRCm39) probably benign Het
Ccdc121 GAGAAG GAG 5: 31,644,717 (GRCm39) probably benign Het
Ccdc191 G A 16: 43,742,164 (GRCm39) probably benign Het
Ccdc34 N 2: 110,016,318 (GRCm38) probably benign Het
Cd164 G T 10: 41,397,922 (GRCm39) A59S probably benign Het
Cd22 C T 7: 30,577,507 (GRCm39) R2H possibly damaging Het
Cdv3 C A 9: 103,242,553 (GRCm39) probably benign Het
Cdv3 A T 9: 103,242,542 (GRCm39) probably benign Het
Celf2 N 2: 6,779,076 (GRCm38) probably benign Het
Cfap299 G A 5: 98,855,367 (GRCm39) probably benign Het
Clec18a C A 8: 111,802,768 (GRCm39) probably benign Het
Cnpy3 GGATGGAT GGATAGATAGATAGATAGATGGAT 17: 47,048,462 (GRCm39) probably benign Het
Cntn4 A G 6: 106,530,901 (GRCm39) probably benign Het
Cntnap5c G C 17: 58,469,155 (GRCm39) probably benign Het
Col2a1 C A 15: 97,886,862 (GRCm39) probably null Het
Cpne3 G T 4: 19,563,382 (GRCm39) probably benign Het
Cracd GGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG GGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG 5: 76,806,589 (GRCm39) probably benign Het
Dab1 T G 4: 103,903,769 (GRCm39) probably benign Het
Dapp1 G A 3: 137,645,161 (GRCm39) probably benign Het
Dcc G A 18: 72,430,518 (GRCm39) probably benign Het
Dcun1d1 GAAAAAAAAA GAAAAAAAAAA 3: 35,992,154 (GRCm39) probably benign Het
Dennd1b G A 1: 139,042,502 (GRCm39) probably benign Het
Dhdds TAA TA 4: 133,697,674 (GRCm39) probably benign Het
Dnah12 G T 14: 26,571,342 (GRCm39) G2817V probably damaging Het
Dnm3 CATATATATATATATATATATATA CATATATATATATATATATATA 1: 162,234,130 (GRCm39) probably benign Het
Dock10 N 1: 80,716,623 (GRCm38) probably benign Het
Dusp10 G T 1: 183,769,253 (GRCm39) C73F probably damaging Het
Fgf20 A C 8: 40,745,359 (GRCm39) probably benign Het
Ftsj3 G T 11: 106,140,885 (GRCm39) probably benign Het
Gls T G 1: 52,222,526 (GRCm39) probably benign Het
Gm12130 T C 11: 38,397,750 (GRCm39) noncoding transcript Het
Gm14936 G A X: 111,908,447 (GRCm39) noncoding transcript Het
Gm16630 C T 6: 48,118,203 (GRCm39) noncoding transcript Het
Gm22194 AGTGTGTGTGTGTGTGTGTGTGTGTGTGTG AGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG 10: 11,816,707 (GRCm39) noncoding transcript Het
Gm26917 C G 17: 40,154,862 (GRCm39) noncoding transcript Het
Gm35048 GACACACACACACACACACACACACACACACACACACAC GACACACACACACACACACACACACACACACACACAC 1: 90,449,248 (GRCm39) noncoding transcript Het
Gm37311 G A 16: 77,415,169 (GRCm39) noncoding transcript Het
Gm37928 AACACACACACACACACACACACACACACACACA AACACACACACACACACACACACACACACACACACA 3: 118,328,206 (GRCm39) noncoding transcript Het
Gm4302 T C 10: 100,177,306 (GRCm39) W197R probably benign Het
H2-Q4 G A 17: 35,599,381 (GRCm39) D155N probably damaging Het
H2-T23 T C 17: 36,342,108 (GRCm39) probably benign Het
Hgs CTTTTTTT CTTTTTT 11: 120,360,404 (GRCm39) probably benign Het
Ighv5-9 C T 12: 113,625,497 (GRCm39) S82N probably benign Het
Il1rap C A 16: 26,450,343 (GRCm39) probably benign Het
Inhbc N 10: 127,367,140 (GRCm38) probably benign Het
Inpp4b C T 8: 82,419,639 (GRCm39) probably benign Het
Kars1 N 8: 111,993,708 (GRCm38) probably benign Het
Kcng4 G T 8: 120,360,258 (GRCm39) Y39* probably null Het
Kcnh7 A G 2: 62,880,143 (GRCm39) probably benign Het
Klhl1 G C 14: 96,555,166 (GRCm39) probably benign Het
Lrch1 C T 14: 75,142,461 (GRCm39) probably benign Het
Lrp1b G C 2: 42,127,574 (GRCm39) probably benign Het
Lsm8 G A 6: 18,844,315 (GRCm39) probably benign Het
Lsm8 G A 6: 18,854,320 (GRCm39) probably benign Het
Magi2 T C 5: 20,159,509 (GRCm39) probably benign Het
Matcap2 N 9: 22,442,083 (GRCm38) probably benign Het
Mef2c G A 13: 83,753,942 (GRCm39) probably benign Het
Mei4 A G 9: 82,069,012 (GRCm39) probably benign Het
Mid1 T A X: 168,788,560 (GRCm39) probably benign Het
Mndal G C 1: 173,707,784 (GRCm39) probably benign Het
Mpped2 C A 2: 106,551,773 (GRCm39) probably benign Het
Mtarc2 TAGGCAGCCAATCAGAGCACTGCCTCTCAGCGCCAGGCAGCCAATCAGAGCACTGCCTCTCAGCGCCAGGCA TAGGCAGCCAATCAGAGCACTGCCTCTCAGCGCCAGGCA 1: 184,554,985 (GRCm39) probably benign Het
Mtf1 A G 4: 124,723,109 (GRCm39) probably benign Het
Mxd1 T C 6: 86,644,388 (GRCm39) probably benign Het
Nbea G T 3: 55,608,948 (GRCm39) probably benign Het
Ncor1 N 11: 62,419,782 (GRCm38) probably benign Het
Nox4 A G 7: 86,892,275 (GRCm39) probably benign Het
Ocln C T 13: 100,657,075 (GRCm39) probably benign Het
Ofcc1 G A 13: 40,246,443 (GRCm39) probably benign Het
Or5af2 T A 11: 58,708,266 (GRCm39) V144D possibly damaging Het
Paics N 5: 76,956,744 (GRCm38) probably null Het
Paqr8 G T 1: 20,984,882 (GRCm39) probably benign Het
Pate9 T C 9: 36,444,849 (GRCm39) probably benign Het
Pdss1 C T 2: 22,790,980 (GRCm39) probably benign Het
Piezo1 G A 8: 123,222,308 (GRCm39) R503W probably damaging Het
Pkhd1 G A 1: 20,681,638 (GRCm39) probably benign Het
Ppp1r3f C A X: 7,426,575 (GRCm39) G562V probably damaging Het
Prr16 C T 18: 51,333,396 (GRCm39) probably benign Het
Prss38 T G 11: 59,266,467 (GRCm39) probably benign Het
Prxl2c G A 13: 64,435,099 (GRCm39) probably benign Het
Ptprk T C 10: 28,450,983 (GRCm39) probably benign Het
Pum1 N 4: 130,730,549 (GRCm38) probably benign Het
Rabgef1 N 5: 130,187,586 (GRCm38) probably null Het
Rgs16 G A 1: 153,619,976 (GRCm39) probably benign Het
Riok3 G T 18: 12,263,039 (GRCm39) probably benign Het
Rn18s-rs5 T C 17: 40,159,446 (GRCm39) noncoding transcript Het
Robo2 N 16: 74,055,954 (GRCm38) probably benign Het
Rps6ka3 A G X: 158,062,211 (GRCm39) probably benign Het
Rptn T A 3: 93,304,848 (GRCm39) L727Q probably benign Het
Slc25a46 C A 18: 31,730,366 (GRCm39) probably benign Het
Spata31f1e T C 4: 42,792,885 (GRCm39) T416A probably benign Het
Spsb1 C T 4: 150,036,943 (GRCm39) probably benign Het
Tbc1d19 A C 5: 53,974,051 (GRCm39) probably benign Het
Trav7-4 C T 14: 53,698,975 (GRCm39) L41F probably benign Het
Trip12 N 1: 84,754,482 (GRCm38) probably benign Het
Ttc13 G A 8: 125,402,605 (GRCm39) probably benign Het
Ttll6 C T 11: 96,046,084 (GRCm39) probably benign Het
Vmn2r87 C T 10: 130,314,583 (GRCm39) M334I probably benign Het
Vps13b G T 15: 35,847,103 (GRCm39) A2629S probably damaging Het
Wars2 N 3: 99,214,774 (GRCm38) probably null Het
Zdhhc3 AACACACACACACACACACACACACACACACAC AACACACACACACACACACACACACACACACACAC 9: 122,912,087 (GRCm39) probably benign Het
Zfp26 C A 9: 20,349,842 (GRCm39) A241S probably benign Het
Zfp442 C T 2: 150,261,768 (GRCm39) probably benign Het
Zfp808 C T 13: 62,314,465 (GRCm39) probably benign Het
Other mutations in Unc5b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00485:Unc5b APN 10 60,618,995 (GRCm39) missense possibly damaging 0.73
IGL00578:Unc5b APN 10 60,602,834 (GRCm39) missense probably damaging 1.00
IGL01895:Unc5b APN 10 60,602,864 (GRCm39) missense probably damaging 1.00
IGL01955:Unc5b APN 10 60,614,034 (GRCm39) missense probably benign 0.30
IGL01980:Unc5b APN 10 60,615,966 (GRCm39) missense probably damaging 1.00
IGL02277:Unc5b APN 10 60,610,521 (GRCm39) missense probably benign
R0021:Unc5b UTSW 10 60,614,698 (GRCm39) missense probably benign 0.17
R0021:Unc5b UTSW 10 60,614,698 (GRCm39) missense probably benign 0.17
R0026:Unc5b UTSW 10 60,610,371 (GRCm39) missense possibly damaging 0.86
R0147:Unc5b UTSW 10 60,608,076 (GRCm39) missense probably damaging 0.96
R0305:Unc5b UTSW 10 60,615,437 (GRCm39) splice site probably benign
R0306:Unc5b UTSW 10 60,615,437 (GRCm39) splice site probably benign
R0373:Unc5b UTSW 10 60,614,719 (GRCm39) missense possibly damaging 0.78
R0662:Unc5b UTSW 10 60,608,362 (GRCm39) missense possibly damaging 0.68
R1208:Unc5b UTSW 10 60,602,771 (GRCm39) missense probably damaging 1.00
R1208:Unc5b UTSW 10 60,602,771 (GRCm39) missense probably damaging 1.00
R1512:Unc5b UTSW 10 60,667,254 (GRCm39) unclassified probably benign
R1532:Unc5b UTSW 10 60,605,011 (GRCm39) missense probably damaging 0.99
R1916:Unc5b UTSW 10 60,614,027 (GRCm39) missense probably damaging 1.00
R1931:Unc5b UTSW 10 60,608,348 (GRCm39) missense probably benign 0.30
R1954:Unc5b UTSW 10 60,605,044 (GRCm39) splice site probably benign
R2350:Unc5b UTSW 10 60,613,979 (GRCm39) missense probably benign 0.04
R3419:Unc5b UTSW 10 60,614,593 (GRCm39) missense probably damaging 1.00
R4116:Unc5b UTSW 10 60,610,479 (GRCm39) missense probably damaging 0.99
R4258:Unc5b UTSW 10 60,601,150 (GRCm39) missense probably damaging 0.99
R4329:Unc5b UTSW 10 60,618,969 (GRCm39) missense probably damaging 1.00
R4605:Unc5b UTSW 10 60,610,182 (GRCm39) missense probably benign 0.01
R4828:Unc5b UTSW 10 60,608,127 (GRCm39) missense possibly damaging 0.90
R5134:Unc5b UTSW 10 60,610,879 (GRCm39) missense probably benign 0.09
R5190:Unc5b UTSW 10 60,608,072 (GRCm39) missense probably benign 0.04
R5240:Unc5b UTSW 10 60,610,419 (GRCm39) missense probably damaging 0.99
R5342:Unc5b UTSW 10 60,614,046 (GRCm39) nonsense probably null
R5522:Unc5b UTSW 10 60,613,974 (GRCm39) missense possibly damaging 0.91
R5694:Unc5b UTSW 10 60,609,526 (GRCm39) missense probably benign 0.02
R5822:Unc5b UTSW 10 60,608,306 (GRCm39) missense possibly damaging 0.71
R5909:Unc5b UTSW 10 60,608,138 (GRCm39) missense probably damaging 1.00
R6007:Unc5b UTSW 10 60,601,139 (GRCm39) missense probably damaging 1.00
R6115:Unc5b UTSW 10 60,613,325 (GRCm39) missense probably benign 0.33
R6182:Unc5b UTSW 10 60,601,015 (GRCm39) missense probably damaging 1.00
R6187:Unc5b UTSW 10 60,608,003 (GRCm39) missense probably damaging 1.00
R6294:Unc5b UTSW 10 60,614,110 (GRCm39) missense possibly damaging 0.82
R6319:Unc5b UTSW 10 60,614,580 (GRCm39) missense probably damaging 1.00
R6366:Unc5b UTSW 10 60,614,091 (GRCm39) missense probably benign
R6532:Unc5b UTSW 10 60,614,607 (GRCm39) missense possibly damaging 0.95
R6827:Unc5b UTSW 10 60,616,011 (GRCm39) missense probably benign
R6912:Unc5b UTSW 10 60,666,871 (GRCm39) missense probably benign
R7032:Unc5b UTSW 10 60,614,587 (GRCm39) missense probably damaging 0.99
R7082:Unc5b UTSW 10 60,610,867 (GRCm39) missense probably damaging 0.98
R7089:Unc5b UTSW 10 60,613,265 (GRCm39) missense probably damaging 1.00
R7270:Unc5b UTSW 10 60,608,002 (GRCm39) nonsense probably null
R7587:Unc5b UTSW 10 60,618,899 (GRCm39) missense probably damaging 1.00
R7716:Unc5b UTSW 10 60,613,217 (GRCm39) missense probably damaging 1.00
R7750:Unc5b UTSW 10 60,610,823 (GRCm39) missense probably benign 0.00
R7810:Unc5b UTSW 10 60,601,020 (GRCm39) missense probably benign
R7895:Unc5b UTSW 10 60,615,509 (GRCm39) missense possibly damaging 0.65
R7942:Unc5b UTSW 10 60,613,322 (GRCm39) missense probably damaging 1.00
R8264:Unc5b UTSW 10 60,604,113 (GRCm39) missense probably benign 0.22
R9100:Unc5b UTSW 10 60,604,152 (GRCm39) missense probably damaging 1.00
R9188:Unc5b UTSW 10 60,609,550 (GRCm39) missense probably damaging 1.00
R9287:Unc5b UTSW 10 60,609,532 (GRCm39) missense possibly damaging 0.88
R9441:Unc5b UTSW 10 60,608,028 (GRCm39) missense probably damaging 1.00
R9664:Unc5b UTSW 10 60,613,322 (GRCm39) missense probably damaging 1.00
RF019:Unc5b UTSW 10 60,618,962 (GRCm39) missense probably damaging 1.00
X0027:Unc5b UTSW 10 60,613,238 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACCTTCCAGGAGCCTTTCTG -3'
(R):5'- TCCAAGACTAGTGACATGGCTGG -3'

Sequencing Primer
(F):5'- AGACTCGCTACACTCTAGGTAGGTG -3'
(R):5'- GTCCCAGAGACTAGGAAGCTTTGTG -3'
Posted On 2017-05-26