Incidental Mutation 'U15987:Vmn1r29'
| ID |
478360 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r29
|
| Ensembl Gene |
ENSMUSG00000091734 |
| Gene Name |
vomeronasal 1 receptor 29 |
| Synonyms |
V1rc2 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.067)
|
| Stock # |
U15987 (G0')
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
58284282-58285193 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 58285080 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Leucine
at position 267
(F267L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000154278
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000168416]
[ENSMUST00000226971]
[ENSMUST00000227761]
[ENSMUST00000228038]
[ENSMUST00000228909]
|
| AlphaFold |
Q9EQ41 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000168416
AA Change: F267L
PolyPhen 2
Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
|
| SMART Domains |
Protein: ENSMUSP00000129069
Gene: ENSMUSG00000091734
AA Change: F267L
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
28 |
293 |
1.7e-53 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000226971
AA Change: F267L
PolyPhen 2
Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227761
AA Change: F267L
PolyPhen 2
Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228038
AA Change: F267L
PolyPhen 2
Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228909
AA Change: F267L
PolyPhen 2
Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
|
| Coding Region Coverage |
- 1x: 99.8%
- 3x: 99.3%
- 10x: 97.1%
- 20x: 90.8%
|
| Validation Efficiency |
95% (41/43) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 42 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 6820408C15Rik |
T |
C |
2: 152,282,790 (GRCm39) |
V215A |
probably damaging |
Het |
| Abcc8 |
T |
C |
7: 45,755,268 (GRCm39) |
M1511V |
probably benign |
Het |
| Abcc9 |
A |
G |
6: 142,585,301 (GRCm39) |
F801S |
probably damaging |
Het |
| Abhd14a |
A |
T |
9: 106,321,065 (GRCm39) |
S97T |
possibly damaging |
Het |
| Adam39 |
C |
T |
8: 41,277,630 (GRCm39) |
A7V |
probably benign |
Het |
| Adamts2 |
T |
A |
11: 50,647,533 (GRCm39) |
I302N |
probably damaging |
Het |
| Akap9 |
T |
C |
5: 4,117,924 (GRCm39) |
|
probably null |
Het |
| Cbfa2t3 |
T |
C |
8: 123,370,236 (GRCm39) |
H53R |
probably benign |
Het |
| Cdc20b |
T |
C |
13: 113,220,576 (GRCm39) |
F485S |
probably damaging |
Het |
| Ctnna1 |
T |
C |
18: 35,287,567 (GRCm39) |
V92A |
probably benign |
Het |
| Dlat |
A |
T |
9: 50,556,417 (GRCm39) |
|
probably null |
Het |
| Edc4 |
C |
T |
8: 106,614,180 (GRCm39) |
R19C |
probably benign |
Het |
| Fam90a1b |
T |
C |
X: 93,400,191 (GRCm39) |
N213S |
probably benign |
Het |
| Gcg |
A |
G |
2: 62,306,148 (GRCm39) |
S150P |
probably damaging |
Het |
| Gk5 |
C |
T |
9: 96,058,290 (GRCm39) |
Q424* |
probably null |
Het |
| Insm2 |
T |
C |
12: 55,646,799 (GRCm39) |
I181T |
probably damaging |
Het |
| Itgae |
A |
G |
11: 73,006,400 (GRCm39) |
E356G |
possibly damaging |
Het |
| Kitl |
G |
A |
10: 99,912,768 (GRCm39) |
|
probably null |
Het |
| Msl1 |
G |
T |
11: 98,689,519 (GRCm39) |
G9C |
probably benign |
Het |
| Muc4 |
T |
A |
16: 32,575,621 (GRCm39) |
|
probably benign |
Het |
| Muc4 |
C |
A |
16: 32,754,529 (GRCm38) |
H1468N |
probably benign |
Het |
| Myo3b |
T |
C |
2: 70,069,243 (GRCm39) |
V494A |
possibly damaging |
Het |
| Myo7a |
C |
T |
7: 97,714,997 (GRCm39) |
W1558* |
probably null |
Het |
| Nop14 |
T |
C |
5: 34,815,295 (GRCm39) |
D85G |
probably damaging |
Het |
| Or1ak2 |
G |
A |
2: 36,827,241 (GRCm39) |
V37I |
probably benign |
Het |
| Or5p81 |
T |
A |
7: 108,267,412 (GRCm39) |
V263E |
probably damaging |
Het |
| Pgk1 |
C |
A |
X: 105,238,098 (GRCm39) |
L85I |
possibly damaging |
Het |
| Pik3c2b |
G |
A |
1: 133,002,365 (GRCm39) |
|
probably null |
Het |
| Plagl1 |
G |
A |
10: 13,003,490 (GRCm39) |
G253R |
probably damaging |
Het |
| Ppp4r1 |
G |
A |
17: 66,121,343 (GRCm39) |
V268I |
possibly damaging |
Het |
| Pramel27 |
T |
G |
4: 143,578,155 (GRCm39) |
H87Q |
possibly damaging |
Het |
| Rad23b |
C |
T |
4: 55,370,400 (GRCm39) |
A142V |
probably damaging |
Het |
| Satl1 |
T |
C |
X: 111,315,613 (GRCm39) |
T281A |
probably benign |
Het |
| Slc13a1 |
T |
C |
6: 24,133,656 (GRCm39) |
T199A |
probably benign |
Het |
| Spmap2 |
A |
G |
10: 79,420,589 (GRCm39) |
S159P |
probably damaging |
Het |
| Synrg |
A |
G |
11: 83,915,126 (GRCm39) |
E1044G |
probably damaging |
Het |
| Syt12 |
T |
C |
19: 4,506,896 (GRCm39) |
D83G |
probably benign |
Het |
| Tbx5 |
T |
C |
5: 120,021,211 (GRCm39) |
S406P |
probably benign |
Het |
| Tfe3 |
T |
C |
X: 7,637,288 (GRCm39) |
L231P |
probably damaging |
Het |
| Tns2 |
C |
T |
15: 102,017,369 (GRCm39) |
R281C |
probably damaging |
Het |
| Vmn2r79 |
T |
A |
7: 86,653,319 (GRCm39) |
V528D |
possibly damaging |
Het |
| Zfp1 |
T |
C |
8: 112,396,975 (GRCm39) |
F299S |
probably damaging |
Het |
|
| Other mutations in Vmn1r29 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02504:Vmn1r29
|
APN |
6 |
58,284,655 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL03351:Vmn1r29
|
APN |
6 |
58,284,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0457:Vmn1r29
|
UTSW |
6 |
58,285,072 (GRCm39) |
missense |
probably benign |
0.35 |
|
R0594:Vmn1r29
|
UTSW |
6 |
58,284,757 (GRCm39) |
missense |
probably benign |
0.35 |
|
R0735:Vmn1r29
|
UTSW |
6 |
58,284,717 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1422:Vmn1r29
|
UTSW |
6 |
58,284,871 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1476:Vmn1r29
|
UTSW |
6 |
58,284,663 (GRCm39) |
missense |
probably benign |
0.23 |
|
R1679:Vmn1r29
|
UTSW |
6 |
58,285,003 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1831:Vmn1r29
|
UTSW |
6 |
58,284,692 (GRCm39) |
nonsense |
probably null |
|
|
R1925:Vmn1r29
|
UTSW |
6 |
58,285,087 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R1933:Vmn1r29
|
UTSW |
6 |
58,284,405 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4582:Vmn1r29
|
UTSW |
6 |
58,285,017 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4677:Vmn1r29
|
UTSW |
6 |
58,284,285 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4706:Vmn1r29
|
UTSW |
6 |
58,285,136 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5023:Vmn1r29
|
UTSW |
6 |
58,285,052 (GRCm39) |
nonsense |
probably null |
|
|
R5542:Vmn1r29
|
UTSW |
6 |
58,285,108 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5649:Vmn1r29
|
UTSW |
6 |
58,284,676 (GRCm39) |
missense |
probably benign |
0.13 |
|
R5656:Vmn1r29
|
UTSW |
6 |
58,285,152 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5906:Vmn1r29
|
UTSW |
6 |
58,284,736 (GRCm39) |
missense |
probably benign |
0.19 |
|
R6078:Vmn1r29
|
UTSW |
6 |
58,285,080 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6349:Vmn1r29
|
UTSW |
6 |
58,284,412 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7946:Vmn1r29
|
UTSW |
6 |
58,284,834 (GRCm39) |
missense |
probably benign |
0.18 |
|
R8554:Vmn1r29
|
UTSW |
6 |
58,285,191 (GRCm39) |
makesense |
probably null |
|
|
R8944:Vmn1r29
|
UTSW |
6 |
58,284,274 (GRCm39) |
start gained |
probably benign |
|
|
R8955:Vmn1r29
|
UTSW |
6 |
58,284,284 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
R9268:Vmn1r29
|
UTSW |
6 |
58,284,577 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9688:Vmn1r29
|
UTSW |
6 |
58,284,739 (GRCm39) |
missense |
probably benign |
0.02 |
|
RF020:Vmn1r29
|
UTSW |
6 |
58,284,528 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCAAGCATCTTCATAGCATCAG -3'
(R):5'- TCTTACCTCTGTGGGCACTAG -3'
Sequencing Primer
(F):5'- AGCTATCTGAGAGCATCCCCTG -3'
(R):5'- CCTCTGTGGGCACTAGGAATATAC -3'
|
| Posted On |
2017-06-26 |
Incidental Mutation