Incidental Mutation 'R6015:Prmt7'
ID 478566
Institutional Source Beutler Lab
Gene Symbol Prmt7
Ensembl Gene ENSMUSG00000060098
Gene Name protein arginine N-methyltransferase 7
Synonyms 4933402B05Rik
MMRRC Submission 043254-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.897) question?
Stock # R6015 (G1)
Quality Score 225.009
Status Not validated
Chromosome 8
Chromosomal Location 106937686-106978326 bp(+) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) T to G at 106961640 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000071592] [ENSMUST00000109297]
AlphaFold Q922X9
Predicted Effect probably benign
Transcript: ENSMUST00000071592
SMART Domains Protein: ENSMUSP00000071521
Gene: ENSMUSG00000060098

DomainStartEndE-ValueType
Pfam:PrmA 53 148 1.6e-7 PFAM
internal_repeat_1 382 652 1.71e-8 PROSPERO
Predicted Effect unknown
Transcript: ENSMUST00000109297
AA Change: H184Q
SMART Domains Protein: ENSMUSP00000104920
Gene: ENSMUSG00000060098
AA Change: H184Q

DomainStartEndE-ValueType
Pfam:PrmA 51 148 1.5e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000128201
SMART Domains Protein: ENSMUSP00000119992
Gene: ENSMUSG00000060098

DomainStartEndE-ValueType
Pfam:PrmA 37 132 3.2e-8 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134151
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147063
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153272
Predicted Effect noncoding transcript
Transcript: ENSMUST00000180410
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.3%
  • 20x: 95.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Arginine methylation is an apparently irreversible protein modification catalyzed by arginine methyltransferases, such as PMT7, using S-adenosylmethionine (AdoMet) as the methyl donor. Arginine methylation is implicated in signal transduction, RNA transport, and RNA splicing (Miranda et al., 2004 [PubMed 15044439]).[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ano5 A C 7: 51,224,525 (GRCm39) S480R probably benign Het
Aqr A G 2: 114,005,646 (GRCm39) M1T probably null Het
Arhgef28 A G 13: 98,211,530 (GRCm39) V151A possibly damaging Het
Atp6v1b2 T A 8: 69,555,148 (GRCm39) I170N probably damaging Het
Atxn2 T A 5: 121,949,055 (GRCm39) V817D probably damaging Het
Cdh23 A C 10: 60,143,761 (GRCm39) I2950S probably damaging Het
Ces1h A G 8: 94,083,691 (GRCm39) L417P unknown Het
Cimap3 T C 3: 105,906,937 (GRCm39) D154G possibly damaging Het
Csf1r A G 18: 61,242,784 (GRCm39) E49G possibly damaging Het
Eml2 G A 7: 18,935,088 (GRCm39) V432I probably damaging Het
Fat3 A G 9: 16,287,346 (GRCm39) S726P possibly damaging Het
Grik2 A T 10: 49,399,959 (GRCm39) probably null Het
Il9r A G 11: 32,142,674 (GRCm39) V287A probably benign Het
Inpp5b T C 4: 124,692,143 (GRCm39) C909R possibly damaging Het
Kat7 G A 11: 95,174,860 (GRCm39) H384Y probably damaging Het
Lama5 A G 2: 179,827,185 (GRCm39) S2272P probably benign Het
Megf10 A G 18: 57,386,100 (GRCm39) H371R probably benign Het
Moxd2 A T 6: 40,860,688 (GRCm39) Y310N probably damaging Het
Ntrk2 A T 13: 59,208,209 (GRCm39) E685V probably damaging Het
Ogfr G T 2: 180,236,467 (GRCm39) G351W probably damaging Het
Or52ac1 G T 7: 104,245,915 (GRCm39) P158T probably damaging Het
Parp3 C T 9: 106,351,481 (GRCm39) V207M possibly damaging Het
Pfkfb3 T C 2: 11,486,146 (GRCm39) probably null Het
Pigr T C 1: 130,774,998 (GRCm39) V475A probably benign Het
Pik3ap1 T A 19: 41,316,640 (GRCm39) Y250F probably benign Het
Ppp1r3c A T 19: 36,711,206 (GRCm39) I188N probably damaging Het
Psapl1 T C 5: 36,361,594 (GRCm39) V62A probably benign Het
Relch T C 1: 105,619,683 (GRCm39) L280S probably damaging Het
Rpp14 G A 14: 8,090,462 (GRCm38) V129I probably benign Het
Sema4f A G 6: 82,916,553 (GRCm39) probably benign Het
Serpinb13 C A 1: 106,928,337 (GRCm39) A319E probably benign Het
Sez6l2 A T 7: 126,552,625 (GRCm39) S134C probably damaging Het
Slc4a10 T A 2: 62,059,046 (GRCm39) H184Q probably benign Het
Slc9a9 G T 9: 94,821,602 (GRCm39) A330S probably benign Het
Sord T C 2: 122,087,424 (GRCm39) V176A probably damaging Het
Ssbp2 G T 13: 91,817,862 (GRCm39) probably null Het
Stab2 G T 10: 86,773,906 (GRCm39) N808K probably damaging Het
Syne1 A G 10: 5,296,819 (GRCm39) probably null Het
Tpcn2 A G 7: 144,820,588 (GRCm39) V341A probably damaging Het
Unc13b C A 4: 43,177,995 (GRCm39) S2941* probably null Het
Utrn T A 10: 12,354,168 (GRCm39) H2806L possibly damaging Het
Vmn1r40 C A 6: 89,691,588 (GRCm39) A135D probably damaging Het
Vmn1r68 C T 7: 10,261,616 (GRCm39) V161M probably benign Het
Wiz T A 17: 32,606,574 (GRCm39) I54F probably damaging Het
Other mutations in Prmt7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01080:Prmt7 APN 8 106,963,846 (GRCm39) splice site probably benign
IGL01565:Prmt7 APN 8 106,977,041 (GRCm39) missense probably damaging 0.97
IGL02245:Prmt7 APN 8 106,963,937 (GRCm39) missense probably benign 0.10
R0104:Prmt7 UTSW 8 106,963,982 (GRCm39) missense probably damaging 0.99
R0255:Prmt7 UTSW 8 106,953,839 (GRCm39) splice site probably benign
R1432:Prmt7 UTSW 8 106,963,916 (GRCm39) nonsense probably null
R1551:Prmt7 UTSW 8 106,964,014 (GRCm39) missense probably benign
R1848:Prmt7 UTSW 8 106,963,640 (GRCm39) missense probably benign
R2117:Prmt7 UTSW 8 106,953,930 (GRCm39) missense probably damaging 0.96
R3784:Prmt7 UTSW 8 106,968,768 (GRCm39) missense probably benign 0.01
R4599:Prmt7 UTSW 8 106,976,961 (GRCm39) missense possibly damaging 0.80
R4940:Prmt7 UTSW 8 106,963,910 (GRCm39) missense probably benign 0.01
R4983:Prmt7 UTSW 8 106,976,995 (GRCm39) missense probably damaging 1.00
R5285:Prmt7 UTSW 8 106,974,991 (GRCm39) missense probably benign 0.15
R6520:Prmt7 UTSW 8 106,961,516 (GRCm39) missense probably damaging 1.00
R7097:Prmt7 UTSW 8 106,961,732 (GRCm39) missense unknown
R7122:Prmt7 UTSW 8 106,961,732 (GRCm39) missense unknown
R7233:Prmt7 UTSW 8 106,946,642 (GRCm39) missense probably damaging 0.99
R7538:Prmt7 UTSW 8 106,964,018 (GRCm39) missense probably benign 0.02
R7577:Prmt7 UTSW 8 106,968,835 (GRCm39) missense probably damaging 1.00
R7659:Prmt7 UTSW 8 106,963,918 (GRCm39) missense probably benign 0.00
R7858:Prmt7 UTSW 8 106,971,320 (GRCm39) missense possibly damaging 0.47
R8991:Prmt7 UTSW 8 106,943,874 (GRCm39) critical splice acceptor site probably null
R9041:Prmt7 UTSW 8 106,963,460 (GRCm39) missense possibly damaging 0.87
R9188:Prmt7 UTSW 8 106,961,486 (GRCm39) missense probably damaging 1.00
R9338:Prmt7 UTSW 8 106,961,665 (GRCm39) missense unknown
R9406:Prmt7 UTSW 8 106,970,435 (GRCm39) missense probably damaging 1.00
R9517:Prmt7 UTSW 8 106,953,930 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- ATCTGCTCTCAATGGCCTGAAC -3'
(R):5'- ATCATTCTGCATGCATCTCCAG -3'

Sequencing Primer
(F):5'- GCGCATGATTCCTGAACATG -3'
(R):5'- ATGCATCTCCAGGCCCTG -3'
Posted On 2017-06-26