Incidental Mutation 'R6016:Or5p5'
ID 478603
Institutional Source Beutler Lab
Gene Symbol Or5p5
Ensembl Gene ENSMUSG00000066242
Gene Name olfactory receptor family 5 subfamily P member 5
Synonyms MOR204-33P, Olfr467, GA_x6K02T2PBJ9-10144091-10145011
MMRRC Submission 043255-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.103) question?
Stock # R6016 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 107413793-107414713 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 107414219 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 143 (I143F)
Ref Sequence ENSEMBL: ENSMUSP00000149295 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084756] [ENSMUST00000208563] [ENSMUST00000214253]
AlphaFold L7N455
Predicted Effect probably benign
Transcript: ENSMUST00000084756
AA Change: I145F

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000081811
Gene: ENSMUSG00000066242
AA Change: I145F

DomainStartEndE-ValueType
Pfam:7tm_4 33 308 5.3e-52 PFAM
Pfam:7TM_GPCR_Srsx 37 307 8.3e-7 PFAM
Pfam:7tm_1 43 292 2.2e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207203
Predicted Effect probably benign
Transcript: ENSMUST00000208563
AA Change: I143F

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
Predicted Effect probably benign
Transcript: ENSMUST00000214253
AA Change: I143F

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.4%
  • 10x: 97.0%
  • 20x: 90.5%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Apol9b T C 15: 77,620,058 (GRCm39) S285P probably damaging Het
Casz1 C A 4: 149,019,041 (GRCm39) N447K probably damaging Het
Cltb T C 13: 54,754,480 (GRCm39) T71A possibly damaging Het
Dcaf12 A G 4: 41,313,267 (GRCm39) F93L probably damaging Het
Dnah5 T C 15: 28,328,030 (GRCm39) Y2135H probably damaging Het
Entpd2 C T 2: 25,288,568 (GRCm39) R191W probably damaging Het
Gm17067 G T 7: 42,357,654 (GRCm39) P283T probably benign Het
Gm3250 A G 10: 77,618,367 (GRCm39) probably benign Het
Gne T C 4: 44,039,063 (GRCm39) E532G probably damaging Het
Gsdmc3 T G 15: 63,740,261 (GRCm39) D86A probably benign Het
Hs3st2 A G 7: 121,099,922 (GRCm39) H256R probably damaging Het
Il19 T A 1: 130,863,718 (GRCm39) D16V probably damaging Het
Lats2 A T 14: 57,971,632 (GRCm39) N14K probably damaging Het
Mill2 G T 7: 18,590,373 (GRCm39) S151I probably benign Het
Ncapg2 G A 12: 116,390,227 (GRCm39) R392H probably damaging Het
Nop56 T C 2: 130,118,545 (GRCm39) probably null Het
Or14j8 A T 17: 38,262,967 (GRCm39) V316D probably benign Het
Or2bd2 A T 7: 6,443,613 (GRCm39) H238L probably benign Het
Pde1a T C 2: 79,695,406 (GRCm39) R446G probably benign Het
Pes1 T A 11: 3,928,004 (GRCm39) M552K possibly damaging Het
Plxnb2 T A 15: 89,045,225 (GRCm39) T1074S possibly damaging Het
Psg23 G T 7: 18,346,112 (GRCm39) H194Q probably benign Het
Rprd2 A G 3: 95,694,685 (GRCm39) V116A probably damaging Het
Shkbp1 A G 7: 27,053,826 (GRCm39) V124A possibly damaging Het
Slc38a8 A T 8: 120,221,044 (GRCm39) probably null Het
Slitrk6 A G 14: 110,987,958 (GRCm39) V583A probably benign Het
Sptbn5 G T 2: 119,880,573 (GRCm39) noncoding transcript Het
Stab1 A T 14: 30,880,950 (GRCm39) I614N probably damaging Het
Tgm6 A G 2: 129,983,148 (GRCm39) T246A probably damaging Het
Tnks1bp1 T C 2: 84,882,734 (GRCm39) L187P probably damaging Het
Vmn1r157 A G 7: 22,461,272 (GRCm39) R51G possibly damaging Het
Vmn2r68 A T 7: 84,871,453 (GRCm39) I610K probably damaging Het
Other mutations in Or5p5
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0110:Or5p5 UTSW 7 107,413,895 (GRCm39) missense probably damaging 1.00
R0450:Or5p5 UTSW 7 107,413,895 (GRCm39) missense probably damaging 1.00
R0707:Or5p5 UTSW 7 107,414,331 (GRCm39) missense probably damaging 0.99
R0918:Or5p5 UTSW 7 107,414,418 (GRCm39) missense probably benign 0.03
R1416:Or5p5 UTSW 7 107,414,469 (GRCm39) missense probably damaging 1.00
R1988:Or5p5 UTSW 7 107,413,907 (GRCm39) missense probably benign
R1989:Or5p5 UTSW 7 107,413,907 (GRCm39) missense probably benign
R2219:Or5p5 UTSW 7 107,414,429 (GRCm39) missense probably benign
R2241:Or5p5 UTSW 7 107,414,040 (GRCm39) missense possibly damaging 0.62
R2866:Or5p5 UTSW 7 107,414,126 (GRCm39) missense probably benign 0.06
R4946:Or5p5 UTSW 7 107,414,589 (GRCm39) missense possibly damaging 0.90
R4972:Or5p5 UTSW 7 107,413,953 (GRCm39) missense probably benign 0.10
R5099:Or5p5 UTSW 7 107,413,809 (GRCm39) missense probably benign 0.00
R5310:Or5p5 UTSW 7 107,414,171 (GRCm39) missense probably damaging 1.00
R5323:Or5p5 UTSW 7 107,413,883 (GRCm39) missense possibly damaging 0.96
R5531:Or5p5 UTSW 7 107,414,451 (GRCm39) missense probably benign 0.03
R5672:Or5p5 UTSW 7 107,413,844 (GRCm39) missense probably damaging 1.00
R5758:Or5p5 UTSW 7 107,414,022 (GRCm39) missense probably damaging 0.99
R5891:Or5p5 UTSW 7 107,414,387 (GRCm39) missense probably damaging 1.00
R6399:Or5p5 UTSW 7 107,413,961 (GRCm39) missense possibly damaging 0.78
R6466:Or5p5 UTSW 7 107,413,901 (GRCm39) missense probably benign
R6894:Or5p5 UTSW 7 107,414,271 (GRCm39) missense probably benign 0.25
R7543:Or5p5 UTSW 7 107,414,308 (GRCm39) missense probably damaging 1.00
R8316:Or5p5 UTSW 7 107,414,030 (GRCm39) missense possibly damaging 0.81
R9285:Or5p5 UTSW 7 107,413,821 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- GTCACACCTGTCATGATTGTGAG -3'
(R):5'- TGATGACGATGATGGAGCCTG -3'

Sequencing Primer
(F):5'- GTTTCCTGAGAGAGAGAACTGCC -3'
(R):5'- TGCTGAGATGGCAGGAGACATTTC -3'
Posted On 2017-06-26