Incidental Mutation 'R6018:Mgl2'
ID 478729
Institutional Source Beutler Lab
Gene Symbol Mgl2
Ensembl Gene ENSMUSG00000040950
Gene Name macrophage galactose N-acetyl-galactosamine specific lectin 2
Synonyms CD301b
MMRRC Submission 044192-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6018 (G1)
Quality Score 225.009
Status Not validated
Chromosome 11
Chromosomal Location 70021155-70028376 bp(+) (GRCm39)
Type of Mutation makesense
DNA Base Change (assembly) T to C at 70027937 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Stop codon to Glutamine at position 382 (*382Q)
Ref Sequence ENSEMBL: ENSMUSP00000131344 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041550] [ENSMUST00000108584] [ENSMUST00000165951]
AlphaFold A9XX86
Predicted Effect probably null
Transcript: ENSMUST00000041550
AA Change: *333Q
SMART Domains Protein: ENSMUSP00000048568
Gene: ENSMUSG00000040950
AA Change: *333Q

DomainStartEndE-ValueType
Pfam:Lectin_N 6 179 4.6e-56 PFAM
CLECT 189 313 2.37e-35 SMART
Predicted Effect probably null
Transcript: ENSMUST00000108584
AA Change: *375Q
SMART Domains Protein: ENSMUSP00000104225
Gene: ENSMUSG00000040950
AA Change: *375Q

DomainStartEndE-ValueType
Pfam:Lectin_N 8 173 8.6e-56 PFAM
CLECT 183 355 5.76e-25 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132645
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147502
Predicted Effect probably null
Transcript: ENSMUST00000165951
AA Change: *382Q
SMART Domains Protein: ENSMUSP00000131344
Gene: ENSMUSG00000040950
AA Change: *382Q

DomainStartEndE-ValueType
Pfam:Lectin_N 21 133 2.1e-35 PFAM
Pfam:Lectin_N 129 180 5.4e-19 PFAM
CLECT 190 362 5.76e-25 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.3%
  • 20x: 91.6%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice that are either homozygous or heterozygous for a reporter allele are viable and fertile. In heterozygotes, transient depletion of CD301b+ dermal dendritic cells by injection of diptheria toxin results in impaired T helper 2 (Th2) cell mediated immunity. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700006A11Rik A T 3: 124,210,448 (GRCm39) Y155N probably damaging Het
1700019A02Rik C T 1: 53,202,405 (GRCm39) probably null Het
2310022B05Rik A G 8: 125,365,853 (GRCm39) F297L probably benign Het
Acbd3 T C 1: 180,579,903 (GRCm39) S516P possibly damaging Het
Agbl3 A G 6: 34,776,190 (GRCm39) N227S probably damaging Het
Ak6 C T 13: 100,802,459 (GRCm39) Q151* probably null Het
Ano4 A G 10: 88,865,128 (GRCm39) L297P probably benign Het
Anxa5 T C 3: 36,504,807 (GRCm39) T252A probably benign Het
Ap5s1 G A 2: 131,054,915 (GRCm39) W212* probably null Het
Arl9 A G 5: 77,155,253 (GRCm39) Q113R probably damaging Het
Atg2b T C 12: 105,627,430 (GRCm39) H519R probably damaging Het
Atp1a2 A G 1: 172,125,579 (GRCm39) probably benign Het
Atp2b1 G A 10: 98,846,622 (GRCm39) A808T probably damaging Het
Bckdhb C A 9: 83,951,237 (GRCm39) T342K probably benign Het
Bdp1 T C 13: 100,174,732 (GRCm39) H1996R probably benign Het
Brix1 C T 15: 10,476,675 (GRCm39) R267H probably benign Het
Ccdc180 A G 4: 45,926,235 (GRCm39) I1148M probably damaging Het
Csf3r T A 4: 125,937,414 (GRCm39) M766K probably benign Het
Ctnnd1 T A 2: 84,480,812 (GRCm39) probably benign Het
Cyp2c39 A T 19: 39,499,436 (GRCm39) N41I probably damaging Het
D2hgdh G T 1: 93,754,182 (GRCm39) V52L probably benign Het
Dppa4 T A 16: 48,109,490 (GRCm39) Y77* probably null Het
Eif4enif1 T C 11: 3,192,481 (GRCm39) S770P probably damaging Het
Fbxl16 A T 17: 26,036,709 (GRCm39) D230V probably damaging Het
Gm4847 G A 1: 166,471,017 (GRCm39) A11V probably damaging Het
Gm9978 C T 10: 78,322,915 (GRCm39) noncoding transcript Het
Gpatch8 A G 11: 102,371,741 (GRCm39) L599P unknown Het
Hdac4 A G 1: 91,886,120 (GRCm39) L254P probably damaging Het
Heatr1 A G 13: 12,419,828 (GRCm39) I384V probably benign Het
Heatr1 A T 13: 12,420,939 (GRCm39) Q410L probably benign Het
Hmcn2 A G 2: 31,260,804 (GRCm39) I1065V probably benign Het
Igkv6-14 A G 6: 70,412,024 (GRCm39) S87P probably damaging Het
Il2rb G T 15: 78,366,266 (GRCm39) Q344K possibly damaging Het
Ipo4 A G 14: 55,863,609 (GRCm39) probably null Het
Ipo9 A G 1: 135,318,274 (GRCm39) probably null Het
Khdrbs1 T C 4: 129,613,887 (GRCm39) T374A probably benign Het
Lamc3 G T 2: 31,795,724 (GRCm39) G370W probably damaging Het
Lipn T A 19: 34,054,335 (GRCm39) L191Q probably damaging Het
Lpl T C 8: 69,353,940 (GRCm39) V427A probably benign Het
Magi3 T C 3: 104,013,128 (GRCm39) S120G probably damaging Het
Nab2 G A 10: 127,500,793 (GRCm39) Q100* probably null Het
Nfat5 T A 8: 108,082,283 (GRCm39) probably null Het
Nqo1 T C 8: 108,115,500 (GRCm39) H259R probably damaging Het
Nrdc T A 4: 108,870,944 (GRCm39) D190E probably benign Het
Or5m5 T A 2: 85,815,148 (GRCm39) probably benign Het
Osmr G A 15: 6,845,276 (GRCm39) P830L probably damaging Het
Parp14 G A 16: 35,661,827 (GRCm39) P1403S probably benign Het
Pde11a T A 2: 75,848,194 (GRCm39) M878L probably benign Het
Pik3ap1 T C 19: 41,373,455 (GRCm39) probably benign Het
Pla2g3 T C 11: 3,441,916 (GRCm39) L360P probably damaging Het
Plxnc1 A G 10: 94,779,710 (GRCm39) V244A probably benign Het
Pramel16 C T 4: 143,677,469 (GRCm39) A37T possibly damaging Het
Ptpra T C 2: 130,345,422 (GRCm39) V8A probably benign Het
Rbbp5 T C 1: 132,422,078 (GRCm39) V199A probably damaging Het
Rnd2 C T 11: 101,359,825 (GRCm39) L57F probably damaging Het
Rp1 A G 1: 4,423,059 (GRCm39) V7A possibly damaging Het
Sdk2 T C 11: 113,720,889 (GRCm39) T1347A probably benign Het
Sgo2a T A 1: 58,056,118 (GRCm39) H767Q probably benign Het
Sis G A 3: 72,820,525 (GRCm39) P1413L possibly damaging Het
Slc22a5 G T 11: 53,766,846 (GRCm39) A214E probably damaging Het
Snx13 G T 12: 35,097,318 (GRCm39) probably benign Het
Sun5 T A 2: 153,700,363 (GRCm39) I295F probably damaging Het
Themis3 C T 17: 66,900,204 (GRCm39) A55T probably damaging Het
Tmem255b T C 8: 13,505,138 (GRCm39) Y148H probably benign Het
Tmem74b A G 2: 151,548,639 (GRCm39) E122G probably damaging Het
Top3b T C 16: 16,710,756 (GRCm39) V862A probably damaging Het
Trim35 A T 14: 66,546,199 (GRCm39) D322V probably damaging Het
Trpm2 A G 10: 77,753,547 (GRCm39) F1319S probably benign Het
Ttn T A 2: 76,785,020 (GRCm39) R756S probably benign Het
Vmn2r108 A T 17: 20,683,268 (GRCm39) N645K possibly damaging Het
Vmn2r73 A G 7: 85,521,875 (GRCm39) S155P possibly damaging Het
Vstm4 G A 14: 32,585,627 (GRCm39) A65T probably benign Het
Other mutations in Mgl2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00677:Mgl2 APN 11 70,027,932 (GRCm39) missense probably benign 0.33
IGL00757:Mgl2 APN 11 70,025,976 (GRCm39) missense probably damaging 1.00
IGL00838:Mgl2 APN 11 70,025,038 (GRCm39) missense probably benign 0.00
IGL01118:Mgl2 APN 11 70,025,015 (GRCm39) missense probably benign 0.00
IGL01613:Mgl2 APN 11 70,024,984 (GRCm39) missense probably benign 0.08
IGL02094:Mgl2 APN 11 70,027,923 (GRCm39) missense possibly damaging 0.73
IGL03000:Mgl2 APN 11 70,025,026 (GRCm39) nonsense probably null
R1893:Mgl2 UTSW 11 70,024,993 (GRCm39) splice site probably null
R3767:Mgl2 UTSW 11 70,026,659 (GRCm39) missense probably damaging 1.00
R3768:Mgl2 UTSW 11 70,026,659 (GRCm39) missense probably damaging 1.00
R3769:Mgl2 UTSW 11 70,026,659 (GRCm39) missense probably damaging 1.00
R5467:Mgl2 UTSW 11 70,025,878 (GRCm39) missense possibly damaging 0.46
R5742:Mgl2 UTSW 11 70,027,510 (GRCm39) missense probably benign 0.00
R7189:Mgl2 UTSW 11 70,027,869 (GRCm39) missense probably damaging 1.00
R7270:Mgl2 UTSW 11 70,026,506 (GRCm39) missense probably damaging 1.00
R7536:Mgl2 UTSW 11 70,027,833 (GRCm39) missense probably benign 0.02
R8330:Mgl2 UTSW 11 70,026,785 (GRCm39) missense probably benign 0.03
R9174:Mgl2 UTSW 11 70,026,606 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TGGTAACATGGCTGATGGC -3'
(R):5'- TTGACAATCACAGGCTGAACAC -3'

Sequencing Primer
(F):5'- ATTTTCAGGAATTGGAGGCCAC -3'
(R):5'- TCACAGGCTGAACACTGTAC -3'
Posted On 2017-06-26