Incidental Mutation 'R6019:Rasgrp1'
| ID |
478764 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Rasgrp1
|
| Ensembl Gene |
ENSMUSG00000027347 |
| Gene Name |
RAS guanyl releasing protein 1 |
| Synonyms |
|
| MMRRC Submission |
044193-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.270)
|
| Stock # |
R6019 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
117110464-117173358 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 117122376 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 338
(D338G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000134592
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000102534]
[ENSMUST00000172901]
[ENSMUST00000173252]
[ENSMUST00000173541]
[ENSMUST00000174770]
[ENSMUST00000178884]
|
| AlphaFold |
Q9Z1S3 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000102534
AA Change: D338G
PolyPhen 2
Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000099593
Gene: ENSMUSG00000027347
AA Change: D338G
| Domain | Start | End | E-Value | Type |
|---|
|
RasGEFN
|
52 |
176 |
1.65e-33 |
SMART |
|
RasGEF
|
201 |
437 |
1.64e-96 |
SMART |
|
Pfam:EF-hand_5
|
474 |
499 |
3.2e-6 |
PFAM |
|
Pfam:EF-hand_6
|
474 |
502 |
5e-6 |
PFAM |
|
C1
|
542 |
591 |
5.77e-16 |
SMART |
|
PDB:4L9U|B
|
740 |
791 |
2e-23 |
PDB |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000172901
AA Change: D338G
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000133449
Gene: ENSMUSG00000027347
AA Change: D338G
| Domain | Start | End | E-Value | Type |
|---|
|
RasGEFN
|
52 |
176 |
1.65e-33 |
SMART |
|
RasGEF
|
201 |
437 |
1.64e-96 |
SMART |
|
Pfam:EF-hand_6
|
442 |
467 |
1.2e-5 |
PFAM |
|
C1
|
507 |
556 |
5.77e-16 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000173252
AA Change: D338G
PolyPhen 2
Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000134592
Gene: ENSMUSG00000027347
AA Change: D338G
| Domain | Start | End | E-Value | Type |
|---|
|
RasGEFN
|
52 |
176 |
1.65e-33 |
SMART |
|
RasGEF
|
201 |
437 |
1.64e-96 |
SMART |
|
Pfam:EF-hand_6
|
442 |
467 |
1.1e-5 |
PFAM |
|
Pfam:C1_1
|
507 |
539 |
3.4e-8 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000173541
AA Change: D338G
PolyPhen 2
Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000134027
Gene: ENSMUSG00000027347
AA Change: D338G
| Domain | Start | End | E-Value | Type |
|---|
|
RasGEFN
|
52 |
176 |
1.65e-33 |
SMART |
|
RasGEF
|
201 |
437 |
1.64e-96 |
SMART |
|
Pfam:EF-hand_5
|
441 |
464 |
1.6e-5 |
PFAM |
|
Pfam:EF-hand_6
|
442 |
467 |
1.6e-5 |
PFAM |
|
C1
|
507 |
556 |
5.77e-16 |
SMART |
|
PDB:4L9U|B
|
705 |
756 |
2e-23 |
PDB |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000174770
AA Change: D338G
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000134167
Gene: ENSMUSG00000027347
AA Change: D338G
| Domain | Start | End | E-Value | Type |
|---|
|
RasGEFN
|
52 |
176 |
1.65e-33 |
SMART |
|
RasGEF
|
201 |
437 |
1.64e-96 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000178884
AA Change: D338G
PolyPhen 2
Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000136423
Gene: ENSMUSG00000027347
AA Change: D338G
| Domain | Start | End | E-Value | Type |
|---|
|
RasGEFN
|
52 |
176 |
1.65e-33 |
SMART |
|
RasGEF
|
201 |
437 |
1.64e-96 |
SMART |
|
Pfam:EF-hand_5
|
474 |
499 |
3.2e-6 |
PFAM |
|
C1
|
542 |
591 |
5.77e-16 |
SMART |
|
PDB:4L9U|B
|
740 |
791 |
2e-23 |
PDB |
|
| Meta Mutation Damage Score |
0.0983 |
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.4%
- 10x: 97.2%
- 20x: 91.1%
|
| Validation Efficiency |
96% (81/84) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for spontaneous and targeted null mutations exhibit a lymphoproliferative autoimmune syndrome in which T cells fail to activate Ras or proliferate after antigen exposure, defects in positive selection, and enlarged spleen and lymph nodes. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 83 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcf3 |
C |
T |
16: 20,371,201 (GRCm39) |
H436Y |
possibly damaging |
Het |
| Acad10 |
A |
T |
5: 121,772,864 (GRCm39) |
H472Q |
possibly damaging |
Het |
| Ano8 |
G |
A |
8: 71,935,024 (GRCm39) |
R393C |
probably damaging |
Het |
| Arhgap18 |
T |
A |
10: 26,736,646 (GRCm39) |
V163E |
probably damaging |
Het |
| AW209491 |
C |
T |
13: 14,812,365 (GRCm39) |
A406V |
probably benign |
Het |
| Brix1 |
C |
T |
15: 10,476,675 (GRCm39) |
R267H |
probably benign |
Het |
| Cacng5 |
T |
C |
11: 107,775,214 (GRCm39) |
M52V |
probably benign |
Het |
| Casz1 |
T |
C |
4: 149,031,495 (GRCm39) |
C1249R |
probably damaging |
Het |
| Cenpj |
C |
T |
14: 56,772,272 (GRCm39) |
S1086N |
probably benign |
Het |
| Chi3l1 |
T |
C |
1: 134,117,310 (GRCm39) |
F367S |
probably benign |
Het |
| Copg2 |
A |
T |
6: 30,787,868 (GRCm39) |
I610N |
possibly damaging |
Het |
| Cpa6 |
T |
C |
1: 10,665,868 (GRCm39) |
K57E |
possibly damaging |
Het |
| D5Ertd579e |
C |
T |
5: 36,787,036 (GRCm39) |
A111T |
possibly damaging |
Het |
| Dgat2 |
A |
G |
7: 98,803,838 (GRCm39) |
M361T |
probably benign |
Het |
| Dnm3 |
G |
T |
1: 161,962,070 (GRCm39) |
F46L |
probably damaging |
Het |
| Dph7 |
T |
A |
2: 24,853,552 (GRCm39) |
C122* |
probably null |
Het |
| Dspp |
A |
T |
5: 104,325,905 (GRCm39) |
D756V |
unknown |
Het |
| Efcab3 |
T |
C |
11: 104,933,728 (GRCm39) |
|
probably null |
Het |
| Ep300 |
T |
A |
15: 81,525,583 (GRCm39) |
M1469K |
unknown |
Het |
| Fsip2 |
T |
C |
2: 82,818,283 (GRCm39) |
I4672T |
possibly damaging |
Het |
| Gapdh |
A |
T |
6: 125,139,996 (GRCm39) |
L67* |
probably null |
Het |
| Gpr75 |
A |
G |
11: 30,841,640 (GRCm39) |
R182G |
probably benign |
Het |
| Gsr |
G |
T |
8: 34,183,835 (GRCm39) |
A366S |
probably damaging |
Het |
| Gypc |
A |
G |
18: 32,663,248 (GRCm39) |
I33T |
probably damaging |
Het |
| Hapln1 |
A |
G |
13: 89,756,219 (GRCm39) |
D341G |
probably benign |
Het |
| Hnrnpd |
A |
G |
5: 100,115,095 (GRCm39) |
S148P |
probably benign |
Het |
| Hydin |
A |
T |
8: 111,293,252 (GRCm39) |
T3450S |
probably benign |
Het |
| Kif20b |
T |
C |
19: 34,927,864 (GRCm39) |
V1002A |
probably benign |
Het |
| Kif5c |
T |
C |
2: 49,625,521 (GRCm39) |
V597A |
probably benign |
Het |
| Kntc1 |
A |
G |
5: 123,900,579 (GRCm39) |
T226A |
probably benign |
Het |
| Krt75 |
C |
A |
15: 101,482,158 (GRCm39) |
V37L |
probably benign |
Het |
| L3mbtl2 |
A |
G |
15: 81,571,143 (GRCm39) |
I668V |
probably benign |
Het |
| Lrp1b |
G |
A |
2: 41,192,982 (GRCm39) |
A480V |
probably damaging |
Het |
| Lrp1b |
T |
A |
2: 41,366,821 (GRCm39) |
D485V |
probably damaging |
Het |
| Lrrc37a |
T |
C |
11: 103,347,422 (GRCm39) |
H3091R |
unknown |
Het |
| Msi1 |
A |
G |
5: 115,589,550 (GRCm39) |
Y361C |
probably damaging |
Het |
| Mtus1 |
G |
T |
8: 41,536,077 (GRCm39) |
N546K |
probably benign |
Het |
| Mup17 |
T |
A |
4: 61,511,936 (GRCm39) |
T113S |
probably benign |
Het |
| Myh11 |
T |
A |
16: 14,023,938 (GRCm39) |
D1479V |
probably damaging |
Het |
| Ncor1 |
C |
T |
11: 62,263,987 (GRCm39) |
E198K |
probably benign |
Het |
| Nrde2 |
A |
G |
12: 100,098,501 (GRCm39) |
V722A |
probably benign |
Het |
| Or13a28 |
T |
C |
7: 140,217,925 (GRCm39) |
F104L |
probably benign |
Het |
| Or51f23 |
C |
T |
7: 102,453,491 (GRCm39) |
R269* |
probably null |
Het |
| Or5ac24 |
C |
T |
16: 59,165,798 (GRCm39) |
D89N |
possibly damaging |
Het |
| Otog |
A |
G |
7: 45,938,374 (GRCm39) |
M2028V |
probably benign |
Het |
| Paox |
T |
A |
7: 139,711,655 (GRCm39) |
V169E |
probably damaging |
Het |
| Pcsk9 |
T |
G |
4: 106,314,073 (GRCm39) |
D174A |
probably benign |
Het |
| Pde4b |
A |
G |
4: 102,427,966 (GRCm39) |
E41G |
possibly damaging |
Het |
| Pip4k2c |
A |
G |
10: 127,034,943 (GRCm39) |
I419T |
probably damaging |
Het |
| Plekhg3 |
G |
T |
12: 76,624,715 (GRCm39) |
E1186* |
probably null |
Het |
| Pole |
C |
A |
5: 110,472,380 (GRCm39) |
P1548T |
probably benign |
Het |
| Pole |
C |
T |
5: 110,472,381 (GRCm39) |
P1548L |
probably benign |
Het |
| Polq |
A |
G |
16: 36,882,126 (GRCm39) |
E1430G |
probably damaging |
Het |
| Potefam3c |
A |
T |
8: 69,881,966 (GRCm39) |
C337S |
probably benign |
Het |
| Pramel47 |
G |
A |
5: 95,488,072 (GRCm39) |
S2N |
probably damaging |
Het |
| Ptgr2 |
T |
C |
12: 84,344,920 (GRCm39) |
S98P |
probably damaging |
Het |
| Ralgapa1 |
A |
G |
12: 55,730,827 (GRCm39) |
Y1903H |
possibly damaging |
Het |
| Rif1 |
C |
G |
2: 51,985,856 (GRCm39) |
L614V |
probably damaging |
Het |
| Rnase13 |
C |
T |
14: 52,159,860 (GRCm39) |
C93Y |
probably damaging |
Het |
| Rnd2 |
C |
T |
11: 101,359,825 (GRCm39) |
L57F |
probably damaging |
Het |
| S100z |
T |
A |
13: 95,613,934 (GRCm39) |
M59L |
probably benign |
Het |
| Ska1 |
T |
A |
18: 74,332,992 (GRCm39) |
D142V |
probably benign |
Het |
| Slc16a3 |
T |
C |
11: 120,847,931 (GRCm39) |
|
probably null |
Het |
| Snd1 |
T |
C |
6: 28,880,233 (GRCm39) |
V669A |
probably benign |
Het |
| Snrpd3 |
A |
T |
10: 75,368,029 (GRCm39) |
T49S |
probably damaging |
Het |
| Sort1 |
T |
C |
3: 108,264,549 (GRCm39) |
L856P |
possibly damaging |
Het |
| Srek1ip1 |
T |
A |
13: 104,970,830 (GRCm39) |
|
probably null |
Het |
| Ssrp1 |
T |
C |
2: 84,875,796 (GRCm39) |
S552P |
probably damaging |
Het |
| Stab2 |
A |
G |
10: 86,838,886 (GRCm39) |
V60A |
probably benign |
Het |
| Stard9 |
GCCC |
GCC |
2: 120,524,196 (GRCm39) |
|
probably null |
Het |
| Tll1 |
A |
C |
8: 64,494,525 (GRCm39) |
H743Q |
possibly damaging |
Het |
| Tpo |
G |
T |
12: 30,144,980 (GRCm39) |
R590S |
possibly damaging |
Het |
| Trbv12-1 |
A |
T |
6: 41,090,780 (GRCm39) |
T51S |
probably benign |
Het |
| Trbv30 |
C |
T |
6: 41,258,708 (GRCm39) |
A40V |
probably benign |
Het |
| Tulp4 |
T |
A |
17: 6,283,490 (GRCm39) |
V1173E |
possibly damaging |
Het |
| Upk1a |
A |
T |
7: 30,311,810 (GRCm39) |
|
probably null |
Het |
| Vinac1 |
T |
C |
2: 128,879,610 (GRCm39) |
Q772R |
probably benign |
Het |
| Vmn1r199 |
A |
G |
13: 22,566,769 (GRCm39) |
D21G |
possibly damaging |
Het |
| Vmn2r7 |
T |
C |
3: 64,623,643 (GRCm39) |
T317A |
probably damaging |
Het |
| Wdfy3 |
A |
G |
5: 101,997,289 (GRCm39) |
V3112A |
probably damaging |
Het |
| Zbtb8os |
T |
C |
4: 129,234,542 (GRCm39) |
V40A |
possibly damaging |
Het |
| Zfp1002 |
T |
A |
2: 150,097,132 (GRCm39) |
H99L |
probably damaging |
Het |
| Zwint |
A |
G |
10: 72,492,685 (GRCm39) |
K108E |
possibly damaging |
Het |
|
| Other mutations in Rasgrp1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00504:Rasgrp1
|
APN |
2 |
117,136,272 (GRCm39) |
nonsense |
probably null |
|
|
IGL00901:Rasgrp1
|
APN |
2 |
117,115,611 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01083:Rasgrp1
|
APN |
2 |
117,115,549 (GRCm39) |
missense |
probably benign |
0.22 |
|
IGL01325:Rasgrp1
|
APN |
2 |
117,129,010 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01520:Rasgrp1
|
APN |
2 |
117,119,144 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01776:Rasgrp1
|
APN |
2 |
117,117,321 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01780:Rasgrp1
|
APN |
2 |
117,115,359 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01859:Rasgrp1
|
APN |
2 |
117,119,899 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01892:Rasgrp1
|
APN |
2 |
117,124,323 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02068:Rasgrp1
|
APN |
2 |
117,131,059 (GRCm39) |
splice site |
probably benign |
|
|
IGL02684:Rasgrp1
|
APN |
2 |
117,113,057 (GRCm39) |
missense |
probably benign |
0.03 |
|
bukhansan
|
UTSW |
2 |
117,122,178 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
Commendatore
|
UTSW |
2 |
117,113,132 (GRCm39) |
missense |
probably benign |
0.03 |
|
dragged
|
UTSW |
2 |
117,129,026 (GRCm39) |
missense |
probably damaging |
1.00 |
|
grouper
|
UTSW |
2 |
117,132,485 (GRCm39) |
nonsense |
probably null |
|
|
Gyeryandsan
|
UTSW |
2 |
117,118,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Haddock
|
UTSW |
2 |
117,122,376 (GRCm39) |
missense |
probably damaging |
0.99 |
|
jovial
|
UTSW |
2 |
117,119,158 (GRCm39) |
missense |
probably benign |
0.01 |
|
mercurial
|
UTSW |
2 |
117,118,314 (GRCm39) |
nonsense |
probably null |
|
|
naejangsan
|
UTSW |
2 |
117,122,273 (GRCm39) |
nonsense |
probably null |
|
|
sea_bass
|
UTSW |
2 |
117,113,135 (GRCm39) |
missense |
probably benign |
0.02 |
|
venutian
|
UTSW |
2 |
117,115,410 (GRCm39) |
nonsense |
probably null |
|
|
R0067:Rasgrp1
|
UTSW |
2 |
117,125,301 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0067:Rasgrp1
|
UTSW |
2 |
117,125,301 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0538:Rasgrp1
|
UTSW |
2 |
117,115,428 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0786:Rasgrp1
|
UTSW |
2 |
117,130,980 (GRCm39) |
missense |
probably benign |
|
|
R1068:Rasgrp1
|
UTSW |
2 |
117,113,057 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1165:Rasgrp1
|
UTSW |
2 |
117,115,420 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R1491:Rasgrp1
|
UTSW |
2 |
117,113,100 (GRCm39) |
nonsense |
probably null |
|
|
R1707:Rasgrp1
|
UTSW |
2 |
117,129,028 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1869:Rasgrp1
|
UTSW |
2 |
117,120,828 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2214:Rasgrp1
|
UTSW |
2 |
117,115,646 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2425:Rasgrp1
|
UTSW |
2 |
117,119,931 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R3236:Rasgrp1
|
UTSW |
2 |
117,122,293 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3915:Rasgrp1
|
UTSW |
2 |
117,119,122 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4079:Rasgrp1
|
UTSW |
2 |
117,115,510 (GRCm39) |
missense |
probably benign |
0.19 |
|
R4163:Rasgrp1
|
UTSW |
2 |
117,113,135 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4781:Rasgrp1
|
UTSW |
2 |
117,122,190 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4782:Rasgrp1
|
UTSW |
2 |
117,115,356 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5028:Rasgrp1
|
UTSW |
2 |
117,132,485 (GRCm39) |
nonsense |
probably null |
|
|
R6220:Rasgrp1
|
UTSW |
2 |
117,115,410 (GRCm39) |
nonsense |
probably null |
|
|
R6294:Rasgrp1
|
UTSW |
2 |
117,122,273 (GRCm39) |
nonsense |
probably null |
|
|
R6335:Rasgrp1
|
UTSW |
2 |
117,124,351 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6948:Rasgrp1
|
UTSW |
2 |
117,129,085 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7165:Rasgrp1
|
UTSW |
2 |
117,168,885 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7246:Rasgrp1
|
UTSW |
2 |
117,168,835 (GRCm39) |
nonsense |
probably null |
|
|
R7372:Rasgrp1
|
UTSW |
2 |
117,115,635 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7400:Rasgrp1
|
UTSW |
2 |
117,129,026 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7432:Rasgrp1
|
UTSW |
2 |
117,118,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7448:Rasgrp1
|
UTSW |
2 |
117,122,178 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R7448:Rasgrp1
|
UTSW |
2 |
117,118,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7449:Rasgrp1
|
UTSW |
2 |
117,118,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7450:Rasgrp1
|
UTSW |
2 |
117,118,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7475:Rasgrp1
|
UTSW |
2 |
117,116,589 (GRCm39) |
missense |
probably benign |
|
|
R7487:Rasgrp1
|
UTSW |
2 |
117,118,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7573:Rasgrp1
|
UTSW |
2 |
117,118,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7672:Rasgrp1
|
UTSW |
2 |
117,118,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8016:Rasgrp1
|
UTSW |
2 |
117,118,314 (GRCm39) |
nonsense |
probably null |
|
|
R8199:Rasgrp1
|
UTSW |
2 |
117,124,293 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8527:Rasgrp1
|
UTSW |
2 |
117,168,785 (GRCm39) |
missense |
probably benign |
0.07 |
|
R8692:Rasgrp1
|
UTSW |
2 |
117,115,353 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8725:Rasgrp1
|
UTSW |
2 |
117,119,158 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8727:Rasgrp1
|
UTSW |
2 |
117,119,158 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8880:Rasgrp1
|
UTSW |
2 |
117,115,425 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9280:Rasgrp1
|
UTSW |
2 |
117,113,132 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9675:Rasgrp1
|
UTSW |
2 |
117,173,190 (GRCm39) |
start codon destroyed |
probably benign |
0.00 |
|
R9792:Rasgrp1
|
UTSW |
2 |
117,118,429 (GRCm39) |
missense |
probably benign |
0.32 |
|
R9793:Rasgrp1
|
UTSW |
2 |
117,118,429 (GRCm39) |
missense |
probably benign |
0.32 |
|
R9795:Rasgrp1
|
UTSW |
2 |
117,118,429 (GRCm39) |
missense |
probably benign |
0.32 |
|
Z1176:Rasgrp1
|
UTSW |
2 |
117,132,455 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCAGCTGGACCAATTCATTG -3'
(R):5'- TACCCTCTGACATTTGATGTAGCTG -3'
Sequencing Primer
(F):5'- GCAGCTGGACCAATTCATTGATATG -3'
(R):5'- TTGGGGAGTTGTAGTAGATACTAAC -3'
|
| Posted On |
2017-06-26 |
Incidental Mutation