Incidental Mutation 'R6023:Try4'
ID 479031
Institutional Source Beutler Lab
Gene Symbol Try4
Ensembl Gene ENSMUSG00000054106
Gene Name trypsin 4
Synonyms 0910001B19Rik, Td
MMRRC Submission 044195-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6023 (G1)
Quality Score 114.008
Status Validated
Chromosome 6
Chromosomal Location 41279206-41282467 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 41280355 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 60 (S60P)
Ref Sequence ENSEMBL: ENSMUSP00000031913 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031913]
AlphaFold Q9R0T7
Predicted Effect probably damaging
Transcript: ENSMUST00000031913
AA Change: S60P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000031913
Gene: ENSMUSG00000054106
AA Change: S60P

DomainStartEndE-ValueType
low complexity region 3 16 N/A INTRINSIC
Tryp_SPc 23 239 9.72e-105 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000193013
Meta Mutation Damage Score 0.5983 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.1%
  • 20x: 94.3%
Validation Efficiency 100% (51/51)
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc8 T C 7: 45,757,843 (GRCm39) N1302S possibly damaging Het
Aff3 A T 1: 38,257,451 (GRCm39) S424T probably damaging Het
Ap2b1 C T 11: 83,226,224 (GRCm39) T207M probably damaging Het
Appl2 T C 10: 83,484,393 (GRCm39) Q18R probably null Het
Atrn T C 2: 130,862,900 (GRCm39) F1327L probably benign Het
Birc6 A T 17: 74,961,372 (GRCm39) I47F probably benign Het
Cdh23 A T 10: 60,301,321 (GRCm39) I451N probably damaging Het
Clec3a A G 8: 115,144,883 (GRCm39) T20A possibly damaging Het
Cpz T A 5: 35,669,922 (GRCm39) I252F probably benign Het
Ctc1 A G 11: 68,913,433 (GRCm39) D143G probably benign Het
Dhrs1 A T 14: 55,981,127 (GRCm39) Y94* probably null Het
Dnajc25 A G 4: 59,013,752 (GRCm39) K157E possibly damaging Het
Dpp6 T C 5: 27,928,545 (GRCm39) I789T probably damaging Het
Duox1 T G 2: 122,168,165 (GRCm39) F1097V probably benign Het
Ercc8 A G 13: 108,315,111 (GRCm39) T242A probably damaging Het
Evc2 T A 5: 37,505,960 (GRCm39) M93K probably benign Het
Glra1 A T 11: 55,424,679 (GRCm39) V94E probably damaging Het
Got1l1 A T 8: 27,689,932 (GRCm39) Y151* probably null Het
Hcrtr2 T A 9: 76,137,886 (GRCm39) I410F probably benign Het
Ighv1-72 T A 12: 115,721,532 (GRCm39) probably benign Het
Kel C A 6: 41,674,409 (GRCm39) E340D probably benign Het
Kif11 A G 19: 37,379,158 (GRCm39) E283G probably damaging Het
Klk4 T G 7: 43,533,482 (GRCm39) F114V probably benign Het
Krt7 T C 15: 101,310,278 (GRCm39) probably benign Het
Lrrc74a A G 12: 86,805,380 (GRCm39) I401V probably damaging Het
Luzp2 T C 7: 54,707,815 (GRCm39) S68P possibly damaging Het
Naip1 T C 13: 100,562,694 (GRCm39) T824A probably benign Het
Nav3 T C 10: 109,659,376 (GRCm39) Q747R possibly damaging Het
Or13p4 T A 4: 118,547,271 (GRCm39) Y126F probably damaging Het
Or1j11 A G 2: 36,311,523 (GRCm39) T38A probably damaging Het
Or4c107 A G 2: 88,789,059 (GRCm39) D83G possibly damaging Het
Or51f1 T C 7: 102,506,169 (GRCm39) I107V possibly damaging Het
Or52h2 T C 7: 103,838,880 (GRCm39) H178R probably damaging Het
Or5b120 A G 19: 13,480,067 (GRCm39) D120G probably damaging Het
Or7g22 A C 9: 19,049,021 (GRCm39) H244P probably damaging Het
Pcdhb11 T C 18: 37,555,978 (GRCm39) I436T possibly damaging Het
Pfdn2 T C 1: 171,184,319 (GRCm39) Y65H probably damaging Het
Polr2h T C 16: 20,537,776 (GRCm39) Y58H probably benign Het
Prrt4 G A 6: 29,176,452 (GRCm39) P291L probably benign Het
Psg29 G T 7: 16,944,437 (GRCm39) V316L possibly damaging Het
Rnf112 T A 11: 61,340,555 (GRCm39) E525V probably damaging Het
Sgms1 T C 19: 32,101,773 (GRCm39) K411R probably benign Het
Sh3tc1 T A 5: 35,864,295 (GRCm39) K631* probably null Het
Syne1 T C 10: 5,393,223 (GRCm39) M48V probably benign Het
Thrb C T 14: 18,011,209 (GRCm38) T226I probably damaging Het
Trim67 A T 8: 125,541,843 (GRCm39) D347V probably damaging Het
Ttn G T 2: 76,565,744 (GRCm39) L19876I probably damaging Het
Vars1 C T 17: 35,220,585 (GRCm39) R56C probably damaging Het
Vmn1r9 A G 6: 57,048,239 (GRCm39) I105V probably benign Het
Vps8 C A 16: 21,279,988 (GRCm39) T313K probably benign Het
Other mutations in Try4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01773:Try4 APN 6 41,281,960 (GRCm39) missense probably damaging 1.00
IGL02216:Try4 APN 6 41,281,965 (GRCm39) missense probably benign
R0537:Try4 UTSW 6 41,281,296 (GRCm39) missense probably benign
R0731:Try4 UTSW 6 41,281,301 (GRCm39) missense probably benign 0.01
R1113:Try4 UTSW 6 41,282,308 (GRCm39) missense possibly damaging 0.90
R1833:Try4 UTSW 6 41,280,365 (GRCm39) missense probably damaging 0.98
R2246:Try4 UTSW 6 41,282,406 (GRCm39) missense possibly damaging 0.80
R4131:Try4 UTSW 6 41,282,335 (GRCm39) nonsense probably null
R4414:Try4 UTSW 6 41,281,905 (GRCm39) missense possibly damaging 0.84
R5457:Try4 UTSW 6 41,280,355 (GRCm39) missense probably damaging 1.00
R5707:Try4 UTSW 6 41,281,977 (GRCm39) missense possibly damaging 0.65
R7131:Try4 UTSW 6 41,281,337 (GRCm39) missense probably benign 0.03
R7783:Try4 UTSW 6 41,279,229 (GRCm39) missense possibly damaging 0.96
R8051:Try4 UTSW 6 41,281,996 (GRCm39) missense probably damaging 0.99
R9320:Try4 UTSW 6 41,282,008 (GRCm39) critical splice donor site probably null
R9730:Try4 UTSW 6 41,281,996 (GRCm39) missense probably damaging 1.00
RF007:Try4 UTSW 6 41,282,297 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGAGGGCTCCACCTAACAAC -3'
(R):5'- AATGATCTACCTTGGTGTGGAG -3'

Sequencing Primer
(F):5'- ACAACACCTTGAGGGATTGTC -3'
(R):5'- GGAGGGCTTCCTATTCTGTACTC -3'
Posted On 2017-06-26