Incidental Mutation 'R6036:Krt87'
ID 479234
Institutional Source Beutler Lab
Gene Symbol Krt87
Ensembl Gene ENSMUSG00000047641
Gene Name keratin 87
Synonyms Krt2-25, Krt83
MMRRC Submission 043257-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R6036 (G1)
Quality Score 225.009
Status Not validated
Chromosome 15
Chromosomal Location 101329371-101336685 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 101385412 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Serine at position 320 (I320S)
Ref Sequence ENSEMBL: ENSMUSP00000023718 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023718]
AlphaFold Q6IMF0
Predicted Effect possibly damaging
Transcript: ENSMUST00000023718
AA Change: I320S

PolyPhen 2 Score 0.784 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000023718
Gene: ENSMUSG00000067613
AA Change: I320S

DomainStartEndE-ValueType
Pfam:Keratin_2_head 2 100 5.9e-16 PFAM
Filament 103 414 7.02e-149 SMART
low complexity region 422 436 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159029
Predicted Effect noncoding transcript
Transcript: ENSMUST00000230173
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.0%
  • 10x: 92.6%
  • 20x: 72.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abi3 T C 11: 95,723,684 (GRCm39) probably benign Het
Ago1 C T 4: 126,337,021 (GRCm39) R228H probably damaging Het
Alpk3 G A 7: 80,743,005 (GRCm39) V941M probably benign Het
Ano4 A G 10: 88,818,127 (GRCm39) W588R possibly damaging Het
Atp6v1a A G 16: 43,919,194 (GRCm39) Y464H probably benign Het
Barx2 A T 9: 31,824,304 (GRCm39) D28E probably damaging Het
Cabp5 A T 7: 13,135,260 (GRCm39) M67L probably damaging Het
Col10a1 A G 10: 34,271,278 (GRCm39) T417A probably benign Het
Dnah2 C T 11: 69,349,746 (GRCm39) R2399Q probably benign Het
Eif4enif1 T C 11: 3,189,420 (GRCm39) S227P probably damaging Het
Erv3 G A 2: 131,697,925 (GRCm39) H145Y possibly damaging Het
Exoc5 T C 14: 49,251,779 (GRCm39) T591A possibly damaging Het
F5 A T 1: 164,012,565 (GRCm39) E493V probably damaging Het
Gm8444 G T 15: 81,727,794 (GRCm39) probably benign Het
Gria4 T A 9: 4,537,646 (GRCm39) I221L probably benign Het
H2bc13 A T 13: 21,900,148 (GRCm39) S56T probably damaging Het
Hc T C 2: 34,929,696 (GRCm39) T249A probably benign Het
Herc2 A G 7: 55,717,801 (GRCm39) T48A probably benign Het
Hp A G 8: 110,303,406 (GRCm39) probably null Het
Ifna15 T G 4: 88,476,310 (GRCm39) D58A possibly damaging Het
Kcnj1 A T 9: 32,308,421 (GRCm39) M262L probably benign Het
Megf10 A G 18: 57,375,799 (GRCm39) N242D probably damaging Het
Nup155 A G 15: 8,157,895 (GRCm39) T451A probably benign Het
Or2ag2b A T 7: 106,417,667 (GRCm39) I126F probably damaging Het
Or4g7 T C 2: 111,309,333 (GRCm39) L68P probably damaging Het
Or4k35 C T 2: 111,099,957 (GRCm39) G252R probably damaging Het
Or51a25 T A 7: 102,373,692 (GRCm39) I2F probably benign Het
Or8d23 A G 9: 38,842,216 (GRCm39) I250V probably damaging Het
Pdzd8 G A 19: 59,293,641 (GRCm39) P403S probably damaging Het
Piezo2 G A 18: 63,248,019 (GRCm39) Q494* probably null Het
Plag1 T C 4: 3,904,618 (GRCm39) E191G possibly damaging Het
Pou4f2 A T 8: 79,162,103 (GRCm39) S167T probably damaging Het
Scd4 G A 19: 44,333,231 (GRCm39) D319N probably damaging Het
Senp2 A T 16: 21,847,308 (GRCm39) R279* probably null Het
Sh3rf3 G A 10: 58,649,806 (GRCm39) G137D probably benign Het
Simc1 C T 13: 54,672,434 (GRCm39) P261S probably benign Het
Slc26a1 T A 5: 108,821,436 (GRCm39) D151V probably damaging Het
Snx29 A G 16: 11,556,301 (GRCm39) probably null Het
Stard9 C T 2: 120,530,556 (GRCm39) A2271V probably benign Het
Stat6 A G 10: 127,491,313 (GRCm39) N485D possibly damaging Het
Tpcn2 T C 7: 144,822,606 (GRCm39) T280A possibly damaging Het
Ttc23 A G 7: 67,361,114 (GRCm39) I378V possibly damaging Het
Ttc29 A G 8: 79,052,205 (GRCm39) D362G probably benign Het
Ttll7 A G 3: 146,645,917 (GRCm39) I592V probably benign Het
Ugt3a1 A T 15: 9,306,172 (GRCm39) H107L probably benign Het
Vmn1r70 A G 7: 10,367,830 (GRCm39) Q87R probably damaging Het
Wdfy4 G T 14: 32,868,947 (GRCm39) S360R probably damaging Het
Zfp780b A G 7: 27,662,993 (GRCm39) Y521H probably damaging Het
Other mutations in Krt87
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00481:Krt87 APN 15 101,386,092 (GRCm39) missense probably benign 0.17
IGL00987:Krt87 APN 15 101,336,327 (GRCm39) missense probably benign 0.00
IGL01019:Krt87 APN 15 101,336,312 (GRCm39) missense possibly damaging 0.84
IGL01066:Krt87 APN 15 101,336,266 (GRCm39) critical splice donor site probably null
IGL01087:Krt87 APN 15 101,329,706 (GRCm39) missense probably benign 0.27
IGL01315:Krt87 APN 15 101,384,848 (GRCm39) splice site probably benign
IGL01572:Krt87 APN 15 101,334,414 (GRCm39) missense probably benign 0.33
IGL01702:Krt87 APN 15 101,389,099 (GRCm39) missense probably benign 0.18
IGL02123:Krt87 APN 15 101,385,466 (GRCm39) missense possibly damaging 0.49
IGL02353:Krt87 APN 15 101,383,339 (GRCm39) missense probably benign
IGL02360:Krt87 APN 15 101,383,339 (GRCm39) missense probably benign
IGL02395:Krt87 APN 15 101,385,833 (GRCm39) missense probably benign 0.18
IGL02633:Krt87 APN 15 101,389,095 (GRCm39) missense probably damaging 1.00
IGL02716:Krt87 APN 15 101,332,485 (GRCm39) missense possibly damaging 0.52
IGL03287:Krt87 APN 15 101,330,218 (GRCm39) splice site probably benign
R0144:Krt87 UTSW 15 101,336,542 (GRCm39) missense probably benign 0.04
R0357:Krt87 UTSW 15 101,384,900 (GRCm39) missense probably benign 0.17
R0650:Krt87 UTSW 15 101,384,921 (GRCm39) missense probably damaging 0.99
R0928:Krt87 UTSW 15 101,389,161 (GRCm39) missense probably benign 0.00
R1126:Krt87 UTSW 15 101,385,363 (GRCm39) missense probably damaging 0.98
R1196:Krt87 UTSW 15 101,389,314 (GRCm39) missense probably benign 0.03
R1252:Krt87 UTSW 15 101,385,711 (GRCm39) missense probably damaging 1.00
R1513:Krt87 UTSW 15 101,387,538 (GRCm39) missense probably benign 0.30
R1612:Krt87 UTSW 15 101,386,092 (GRCm39) missense probably benign 0.17
R1870:Krt87 UTSW 15 101,385,071 (GRCm39) missense probably benign
R2173:Krt87 UTSW 15 101,385,818 (GRCm39) missense probably damaging 0.98
R2196:Krt87 UTSW 15 101,336,314 (GRCm39) missense probably damaging 0.99
R2209:Krt87 UTSW 15 101,330,989 (GRCm39) missense probably benign 0.42
R2432:Krt87 UTSW 15 101,386,037 (GRCm39) nonsense probably null
R2568:Krt87 UTSW 15 101,385,708 (GRCm39) missense possibly damaging 0.67
R2696:Krt87 UTSW 15 101,384,890 (GRCm39) missense probably benign 0.01
R3508:Krt87 UTSW 15 101,386,039 (GRCm39) missense probably benign 0.04
R4364:Krt87 UTSW 15 101,385,395 (GRCm39) missense probably benign
R4366:Krt87 UTSW 15 101,385,395 (GRCm39) missense probably benign
R4606:Krt87 UTSW 15 101,384,930 (GRCm39) missense probably benign 0.18
R4721:Krt87 UTSW 15 101,385,863 (GRCm39) missense probably damaging 1.00
R4784:Krt87 UTSW 15 101,385,837 (GRCm39) missense probably damaging 1.00
R4987:Krt87 UTSW 15 101,384,890 (GRCm39) missense probably benign
R5008:Krt87 UTSW 15 101,389,105 (GRCm39) missense probably damaging 1.00
R5101:Krt87 UTSW 15 101,385,391 (GRCm39) missense probably benign 0.14
R5367:Krt87 UTSW 15 101,384,875 (GRCm39) missense probably damaging 1.00
R5516:Krt87 UTSW 15 101,385,002 (GRCm39) nonsense probably null
R5651:Krt87 UTSW 15 101,331,910 (GRCm39) missense possibly damaging 0.94
R5949:Krt87 UTSW 15 101,385,476 (GRCm39) missense probably damaging 0.99
R5972:Krt87 UTSW 15 101,385,467 (GRCm39) missense probably benign
R6036:Krt87 UTSW 15 101,385,412 (GRCm39) missense possibly damaging 0.78
R6135:Krt87 UTSW 15 101,385,415 (GRCm39) missense probably damaging 1.00
R6437:Krt87 UTSW 15 101,336,273 (GRCm39) missense possibly damaging 0.95
R6615:Krt87 UTSW 15 101,334,443 (GRCm39) missense probably benign 0.02
R6680:Krt87 UTSW 15 101,331,859 (GRCm39) missense probably damaging 1.00
R7151:Krt87 UTSW 15 101,387,529 (GRCm39) missense probably damaging 1.00
R7186:Krt87 UTSW 15 101,385,083 (GRCm39) splice site probably null
R7297:Krt87 UTSW 15 101,387,528 (GRCm39) missense probably benign 0.42
R7541:Krt87 UTSW 15 101,336,515 (GRCm39) missense probably damaging 1.00
R7617:Krt87 UTSW 15 101,336,426 (GRCm39) missense probably benign 0.38
R7708:Krt87 UTSW 15 101,385,813 (GRCm39) missense probably benign 0.00
R7796:Krt87 UTSW 15 101,383,865 (GRCm39) missense possibly damaging 0.95
R8172:Krt87 UTSW 15 101,383,284 (GRCm39) missense probably benign 0.25
R8463:Krt87 UTSW 15 101,332,506 (GRCm39) missense probably benign 0.05
R8669:Krt87 UTSW 15 101,385,777 (GRCm39) missense probably benign 0.00
R8695:Krt87 UTSW 15 101,331,901 (GRCm39) missense probably benign 0.00
R8771:Krt87 UTSW 15 101,385,779 (GRCm39) missense probably benign 0.00
R9478:Krt87 UTSW 15 101,385,449 (GRCm39) missense probably benign 0.06
R9489:Krt87 UTSW 15 101,336,484 (GRCm39) nonsense probably null
R9592:Krt87 UTSW 15 101,386,060 (GRCm39) missense probably benign
R9605:Krt87 UTSW 15 101,336,484 (GRCm39) nonsense probably null
R9629:Krt87 UTSW 15 101,389,048 (GRCm39) missense probably benign 0.01
R9642:Krt87 UTSW 15 101,385,074 (GRCm39) missense probably benign 0.00
Predicted Primers
Posted On 2017-06-26