Incidental Mutation 'R6036:Senp2'
ID 479235
Institutional Source Beutler Lab
Gene Symbol Senp2
Ensembl Gene ENSMUSG00000022855
Gene Name SUMO/sentrin specific peptidase 2
Synonyms 4930538C18Rik, 2310007L05Rik
MMRRC Submission 043257-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R6036 (G1)
Quality Score 115.008
Status Not validated
Chromosome 16
Chromosomal Location 21828234-21868019 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 21847308 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Stop codon at position 279 (R279*)
Ref Sequence ENSEMBL: ENSMUSP00000023561 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023561] [ENSMUST00000231724] [ENSMUST00000232534] [ENSMUST00000232679]
AlphaFold Q91ZX6
Predicted Effect probably null
Transcript: ENSMUST00000023561
AA Change: R279*
SMART Domains Protein: ENSMUSP00000023561
Gene: ENSMUSG00000022855
AA Change: R279*

DomainStartEndE-ValueType
low complexity region 23 40 N/A INTRINSIC
low complexity region 101 118 N/A INTRINSIC
low complexity region 325 340 N/A INTRINSIC
Pfam:Peptidase_C48 408 587 1.5e-40 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000231724
Predicted Effect probably benign
Transcript: ENSMUST00000231798
Predicted Effect probably benign
Transcript: ENSMUST00000232263
Predicted Effect probably benign
Transcript: ENSMUST00000232534
Predicted Effect probably benign
Transcript: ENSMUST00000232679
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.0%
  • 10x: 92.6%
  • 20x: 72.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM, Apr 2004]
PHENOTYPE: Homozygous null mice are embryonic lethal due to placental defects resulting from abnormal trophoblast maturation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abi3 T C 11: 95,723,684 (GRCm39) probably benign Het
Ago1 C T 4: 126,337,021 (GRCm39) R228H probably damaging Het
Alpk3 G A 7: 80,743,005 (GRCm39) V941M probably benign Het
Ano4 A G 10: 88,818,127 (GRCm39) W588R possibly damaging Het
Atp6v1a A G 16: 43,919,194 (GRCm39) Y464H probably benign Het
Barx2 A T 9: 31,824,304 (GRCm39) D28E probably damaging Het
Cabp5 A T 7: 13,135,260 (GRCm39) M67L probably damaging Het
Col10a1 A G 10: 34,271,278 (GRCm39) T417A probably benign Het
Dnah2 C T 11: 69,349,746 (GRCm39) R2399Q probably benign Het
Eif4enif1 T C 11: 3,189,420 (GRCm39) S227P probably damaging Het
Erv3 G A 2: 131,697,925 (GRCm39) H145Y possibly damaging Het
Exoc5 T C 14: 49,251,779 (GRCm39) T591A possibly damaging Het
F5 A T 1: 164,012,565 (GRCm39) E493V probably damaging Het
Gm8444 G T 15: 81,727,794 (GRCm39) probably benign Het
Gria4 T A 9: 4,537,646 (GRCm39) I221L probably benign Het
H2bc13 A T 13: 21,900,148 (GRCm39) S56T probably damaging Het
Hc T C 2: 34,929,696 (GRCm39) T249A probably benign Het
Herc2 A G 7: 55,717,801 (GRCm39) T48A probably benign Het
Hp A G 8: 110,303,406 (GRCm39) probably null Het
Ifna15 T G 4: 88,476,310 (GRCm39) D58A possibly damaging Het
Kcnj1 A T 9: 32,308,421 (GRCm39) M262L probably benign Het
Krt87 A C 15: 101,385,412 (GRCm39) I320S possibly damaging Het
Megf10 A G 18: 57,375,799 (GRCm39) N242D probably damaging Het
Nup155 A G 15: 8,157,895 (GRCm39) T451A probably benign Het
Or2ag2b A T 7: 106,417,667 (GRCm39) I126F probably damaging Het
Or4g7 T C 2: 111,309,333 (GRCm39) L68P probably damaging Het
Or4k35 C T 2: 111,099,957 (GRCm39) G252R probably damaging Het
Or51a25 T A 7: 102,373,692 (GRCm39) I2F probably benign Het
Or8d23 A G 9: 38,842,216 (GRCm39) I250V probably damaging Het
Pdzd8 G A 19: 59,293,641 (GRCm39) P403S probably damaging Het
Piezo2 G A 18: 63,248,019 (GRCm39) Q494* probably null Het
Plag1 T C 4: 3,904,618 (GRCm39) E191G possibly damaging Het
Pou4f2 A T 8: 79,162,103 (GRCm39) S167T probably damaging Het
Scd4 G A 19: 44,333,231 (GRCm39) D319N probably damaging Het
Sh3rf3 G A 10: 58,649,806 (GRCm39) G137D probably benign Het
Simc1 C T 13: 54,672,434 (GRCm39) P261S probably benign Het
Slc26a1 T A 5: 108,821,436 (GRCm39) D151V probably damaging Het
Snx29 A G 16: 11,556,301 (GRCm39) probably null Het
Stard9 C T 2: 120,530,556 (GRCm39) A2271V probably benign Het
Stat6 A G 10: 127,491,313 (GRCm39) N485D possibly damaging Het
Tpcn2 T C 7: 144,822,606 (GRCm39) T280A possibly damaging Het
Ttc23 A G 7: 67,361,114 (GRCm39) I378V possibly damaging Het
Ttc29 A G 8: 79,052,205 (GRCm39) D362G probably benign Het
Ttll7 A G 3: 146,645,917 (GRCm39) I592V probably benign Het
Ugt3a1 A T 15: 9,306,172 (GRCm39) H107L probably benign Het
Vmn1r70 A G 7: 10,367,830 (GRCm39) Q87R probably damaging Het
Wdfy4 G T 14: 32,868,947 (GRCm39) S360R probably damaging Het
Zfp780b A G 7: 27,662,993 (GRCm39) Y521H probably damaging Het
Other mutations in Senp2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00788:Senp2 APN 16 21,837,114 (GRCm39) missense probably damaging 1.00
IGL01562:Senp2 APN 16 21,828,437 (GRCm39) missense probably damaging 1.00
IGL01757:Senp2 APN 16 21,828,414 (GRCm39) missense probably benign 0.13
IGL02593:Senp2 APN 16 21,863,021 (GRCm39) missense probably damaging 1.00
IGL02896:Senp2 APN 16 21,837,118 (GRCm39) nonsense probably null
IGL03219:Senp2 APN 16 21,833,014 (GRCm39) splice site probably benign
IGL03244:Senp2 APN 16 21,859,329 (GRCm39) missense probably damaging 0.97
Jessie UTSW 16 21,837,114 (GRCm39) missense probably damaging 1.00
wrangler UTSW 16 21,847,344 (GRCm39) critical splice donor site probably null
wrestler UTSW 16 21,857,372 (GRCm39) missense probably damaging 1.00
PIT1430001:Senp2 UTSW 16 21,832,864 (GRCm39) splice site probably benign
R0410:Senp2 UTSW 16 21,828,444 (GRCm39) missense probably damaging 0.99
R0511:Senp2 UTSW 16 21,855,320 (GRCm39) missense probably benign 0.01
R1186:Senp2 UTSW 16 21,830,254 (GRCm39) missense probably damaging 0.99
R1689:Senp2 UTSW 16 21,845,416 (GRCm39) missense probably damaging 0.98
R1723:Senp2 UTSW 16 21,846,792 (GRCm39) missense probably benign 0.00
R1776:Senp2 UTSW 16 21,861,810 (GRCm39) splice site probably benign
R2056:Senp2 UTSW 16 21,832,949 (GRCm39) missense probably damaging 1.00
R2058:Senp2 UTSW 16 21,832,949 (GRCm39) missense probably damaging 1.00
R2371:Senp2 UTSW 16 21,837,125 (GRCm39) missense possibly damaging 0.86
R3838:Senp2 UTSW 16 21,828,485 (GRCm39) missense probably damaging 0.99
R3839:Senp2 UTSW 16 21,828,485 (GRCm39) missense probably damaging 0.99
R4001:Senp2 UTSW 16 21,847,318 (GRCm39) missense possibly damaging 0.95
R4190:Senp2 UTSW 16 21,865,417 (GRCm39) missense probably damaging 1.00
R4191:Senp2 UTSW 16 21,865,417 (GRCm39) missense probably damaging 1.00
R4193:Senp2 UTSW 16 21,865,417 (GRCm39) missense probably damaging 1.00
R4231:Senp2 UTSW 16 21,830,304 (GRCm39) critical splice donor site probably null
R4435:Senp2 UTSW 16 21,832,991 (GRCm39) missense possibly damaging 0.83
R4847:Senp2 UTSW 16 21,857,386 (GRCm39) missense possibly damaging 0.90
R5207:Senp2 UTSW 16 21,860,130 (GRCm39) missense possibly damaging 0.52
R5509:Senp2 UTSW 16 21,859,272 (GRCm39) missense probably damaging 1.00
R6036:Senp2 UTSW 16 21,847,308 (GRCm39) nonsense probably null
R6475:Senp2 UTSW 16 21,842,550 (GRCm39) missense probably damaging 1.00
R6517:Senp2 UTSW 16 21,845,474 (GRCm39) missense possibly damaging 0.95
R6923:Senp2 UTSW 16 21,830,326 (GRCm39) intron probably benign
R7287:Senp2 UTSW 16 21,837,114 (GRCm39) missense probably damaging 1.00
R7747:Senp2 UTSW 16 21,857,372 (GRCm39) missense probably damaging 1.00
R7884:Senp2 UTSW 16 21,832,981 (GRCm39) missense probably benign 0.39
R8037:Senp2 UTSW 16 21,832,888 (GRCm39) nonsense probably null
R8393:Senp2 UTSW 16 21,850,864 (GRCm39) missense probably damaging 0.99
R8805:Senp2 UTSW 16 21,846,789 (GRCm39) missense probably benign
R9216:Senp2 UTSW 16 21,847,344 (GRCm39) critical splice donor site probably null
R9426:Senp2 UTSW 16 21,828,491 (GRCm39) missense probably damaging 0.98
R9479:Senp2 UTSW 16 21,842,398 (GRCm39) missense probably damaging 0.99
R9592:Senp2 UTSW 16 21,845,435 (GRCm39) missense possibly damaging 0.54
Z1177:Senp2 UTSW 16 21,828,455 (GRCm39) missense probably benign 0.44
Predicted Primers
Posted On 2017-06-26