Mutagenetix > Incidental Mutation

Incidental Mutation 'R6038:Or11g25'

479326

Institutional Source

Beutler Lab

Gene Symbol

Or11g25

Ensembl Gene

ENSMUSG00000095765

Gene Name

olfactory receptor family 11 subfamily G member 25

Synonyms

MOR106-15, MOR106-10, Olfr741, GA_x6K02T2PMLR-6197851-6198786

MMRRC Submission

044208-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.093) question?

Stock #

R6038 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

50710514-50723852 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 50723677 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Proline at position 254 (L254P)

Ref Sequence

ENSEMBL: ENSMUSP00000151020 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071932] [ENSMUST00000205518] [ENSMUST00000213903]

AlphaFold

L7N1Y5

Predicted Effect

probably damaging
Transcript: ENSMUST00000071932
AA Change: L254P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000071824
Gene: ENSMUSG00000095765
AA Change: L254P

Domain	Start	End	E-Value	Type
Pfam:7tm_4	35	311	1.2e-55	PFAM
Pfam:7tm_1	45	294	2.4e-20	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000205518
AA Change: L254P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Predicted Effect

probably damaging
Transcript: ENSMUST00000213903
AA Change: L254P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Meta Mutation Damage Score

0.4492

Coding Region Coverage

1x: 99.8%
3x: 99.1%
10x: 93.7%
20x: 76.5%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 62 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc10	A	G	17: 46,615,286 (GRCm39)	C1327R	probably damaging	Het
Adcy7	A	G	8: 89,049,608 (GRCm39)	T704A	probably benign	Het
Adgra3	A	T	5: 50,156,487 (GRCm39)	Y414*	probably null	Het
Adgrf1	T	C	17: 43,606,100 (GRCm39)	S75P	probably benign	Het
Antxr1	C	A	6: 87,263,982 (GRCm39)		probably null	Het
Arid1b	A	T	17: 5,386,957 (GRCm39)	Y1470F	probably benign	Het
Baiap3	T	C	17: 25,465,308 (GRCm39)	D649G	probably damaging	Het
Cabin1	A	G	10: 75,575,200 (GRCm39)	V615A	probably benign	Het
Cntnap1	G	A	11: 101,075,462 (GRCm39)	R880Q	probably benign	Het
Col28a1	T	C	6: 8,013,140 (GRCm39)	T971A	probably benign	Het
Coro7	A	T	16: 4,497,414 (GRCm39)		probably null	Het
Cspg4b	G	A	13: 113,455,153 (GRCm39)	V400M	possibly damaging	Het
Defb19	T	G	2: 152,418,187 (GRCm39)		probably null	Het
Dnah17	T	C	11: 117,946,715 (GRCm39)	D3045G	probably benign	Het
Dock4	A	T	12: 40,783,350 (GRCm39)		probably null	Het
Egln3	A	G	12: 54,228,476 (GRCm39)	V210A	probably damaging	Het
Epb41l4a	T	C	18: 33,987,388 (GRCm39)	S330G	probably benign	Het
Epha7	G	A	4: 28,821,521 (GRCm39)	E229K	probably damaging	Het
Fetub	C	T	16: 22,751,081 (GRCm39)	R143C	probably damaging	Het
Garin4	C	T	1: 190,894,919 (GRCm39)	E575K	probably damaging	Het
Garin5a	C	T	7: 44,149,719 (GRCm39)	R147W	probably damaging	Het
Garin5b	T	C	7: 4,756,594 (GRCm39)		probably null	Het
Gxylt2	T	A	6: 100,781,555 (GRCm39)	L410Q	probably damaging	Het
H2-M10.3	C	A	17: 36,679,287 (GRCm39)	C6F	probably benign	Het
Hecw1	G	T	13: 14,520,647 (GRCm39)	Q197K	probably benign	Het
Hk3	T	C	13: 55,154,373 (GRCm39)	M778V	probably benign	Het
Hydin	A	G	8: 111,325,663 (GRCm39)	T4691A	probably benign	Het
Kndc1	CT	C	7: 139,503,691 (GRCm39)		probably null	Het
Larp1	A	G	11: 57,932,431 (GRCm39)	E204G	possibly damaging	Het
Lrp12	A	C	15: 39,735,776 (GRCm39)	W738G	probably damaging	Het
Marchf10	A	G	11: 105,292,877 (GRCm39)	S72P	probably damaging	Het
Mdga2	A	T	12: 66,676,827 (GRCm39)	D488E	probably damaging	Het
Mrc1	G	C	2: 14,261,882 (GRCm39)	W290C	probably damaging	Het
Mtrex	A	T	13: 113,027,824 (GRCm39)	S679T	probably benign	Het
Nhp2	T	C	11: 51,510,912 (GRCm39)	V55A	probably benign	Het
Or10ag54	T	A	2: 87,099,611 (GRCm39)	I141N	possibly damaging	Het
Or7e165	A	G	9: 19,694,858 (GRCm39)	Y143C	probably benign	Het
Osbpl7	C	T	11: 96,941,542 (GRCm39)	P22S	probably benign	Het
Pebp1	A	T	5: 117,422,170 (GRCm39)	L124Q	probably benign	Het
Pfkp	G	T	13: 6,648,005 (GRCm39)	H524N	probably benign	Het
Pnmt	G	A	11: 98,278,594 (GRCm39)	D187N	probably damaging	Het
Ppl	A	T	16: 4,920,445 (GRCm39)	I355K	possibly damaging	Het
Prom1	A	T	5: 44,159,135 (GRCm39)	Y836N	probably damaging	Het
Rubcnl	T	C	14: 75,269,410 (GRCm39)	S23P	probably benign	Het
Sap130	T	A	18: 31,813,539 (GRCm39)	I532N	probably damaging	Het
Serpina1e	A	T	12: 103,913,095 (GRCm39)		probably null	Het
Slc12a3	T	G	8: 95,057,100 (GRCm39)	S124R	probably benign	Het
Slc24a5	A	G	2: 124,927,651 (GRCm39)	T317A	probably benign	Het
Smarcad1	T	C	6: 65,050,232 (GRCm39)	S284P	possibly damaging	Het
Spag9	C	G	11: 94,002,918 (GRCm39)	R724G	probably damaging	Het
Speg	T	C	1: 75,395,103 (GRCm39)		probably null	Het
Steap3	A	G	1: 120,169,371 (GRCm39)	Y271H	probably damaging	Het
Syne2	C	T	12: 75,925,158 (GRCm39)	Q44*	probably null	Het
Syt16	G	A	12: 74,269,309 (GRCm39)		probably null	Het
Tas2r114	A	T	6: 131,666,444 (GRCm39)	C195S	possibly damaging	Het
Tcl1b4	T	C	12: 105,168,766 (GRCm39)	M10T	possibly damaging	Het
Tln1	G	C	4: 43,555,052 (GRCm39)	F259L	probably damaging	Het
Vmn2r60	C	A	7: 41,844,386 (GRCm39)	A583D	probably benign	Het
Wdhd1	T	C	14: 47,501,037 (GRCm39)	Q455R	possibly damaging	Het
Wdr17	A	G	8: 55,085,346 (GRCm39)		probably null	Het
Xbp1	T	C	11: 5,474,798 (GRCm39)	L233P	probably benign	Het
Zbtb17	A	G	4: 141,191,752 (GRCm39)	E288G	probably benign	Het

Other mutations in Or11g25

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01773:Or11g25	APN	14	50,723,230 (GRCm39)	missense	probably damaging	0.98
IGL01796:Or11g25	APN	14	50,722,998 (GRCm39)	missense	probably benign	0.28
IGL01916:Or11g25	APN	14	50,722,950 (GRCm39)	missense	probably benign	0.01
IGL02686:Or11g25	APN	14	50,723,426 (GRCm39)	missense	probably benign	0.01
IGL02874:Or11g25	APN	14	50,723,686 (GRCm39)	missense	possibly damaging	0.57
IGL02898:Or11g25	APN	14	50,723,643 (GRCm39)	missense	probably damaging	1.00
PIT4515001:Or11g25	UTSW	14	50,723,536 (GRCm39)	missense	probably benign	0.03
R0085:Or11g25	UTSW	14	50,723,791 (GRCm39)	missense	probably benign	0.16
R1777:Or11g25	UTSW	14	50,723,757 (GRCm39)	missense	probably benign	0.08
R1850:Or11g25	UTSW	14	50,723,055 (GRCm39)	missense	probably benign
R2270:Or11g25	UTSW	14	50,723,494 (GRCm39)	missense	probably damaging	1.00
R2338:Or11g25	UTSW	14	50,723,097 (GRCm39)	missense	possibly damaging	0.47
R2971:Or11g25	UTSW	14	50,723,065 (GRCm39)	missense	probably damaging	0.99
R4594:Or11g25	UTSW	14	50,723,619 (GRCm39)	missense	probably benign	0.00
R5383:Or11g25	UTSW	14	50,723,509 (GRCm39)	nonsense	probably null
R5708:Or11g25	UTSW	14	50,723,452 (GRCm39)	missense	probably damaging	1.00
R6038:Or11g25	UTSW	14	50,723,677 (GRCm39)	missense	probably damaging	1.00
R7116:Or11g25	UTSW	14	50,723,025 (GRCm39)	missense	probably benign	0.00
R7702:Or11g25	UTSW	14	50,723,751 (GRCm39)	missense	possibly damaging	0.79
R8169:Or11g25	UTSW	14	50,723,692 (GRCm39)	missense	probably benign	0.13
R9040:Or11g25	UTSW	14	50,722,995 (GRCm39)	missense	probably benign	0.00
R9139:Or11g25	UTSW	14	50,723,707 (GRCm39)	missense	probably damaging	0.98

Predicted Primers

Posted On

2017-06-26