Incidental Mutation 'R6039:Krt77'
ID 479375
Institutional Source Beutler Lab
Gene Symbol Krt77
Ensembl Gene ENSMUSG00000067594
Gene Name keratin 77
Synonyms 4732484G22Rik
MMRRC Submission 043259-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6039 (G1)
Quality Score 225.009
Status Not validated
Chromosome 15
Chromosomal Location 101767166-101778140 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 101769351 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Leucine at position 470 (R470L)
Ref Sequence ENSEMBL: ENSMUSP00000085311 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087996]
AlphaFold Q6IFZ6
Predicted Effect possibly damaging
Transcript: ENSMUST00000087996
AA Change: R470L

PolyPhen 2 Score 0.850 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000085311
Gene: ENSMUSG00000067594
AA Change: R470L

DomainStartEndE-ValueType
Pfam:Keratin_2_head 4 163 1.5e-46 PFAM
Filament 166 479 6.11e-149 SMART
low complexity region 485 497 N/A INTRINSIC
low complexity region 500 543 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000229995
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 98.9%
  • 10x: 92.2%
  • 20x: 71.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes an epithelial keratin that is expressed in the skin and eccrine sweat glands. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts9 C T 6: 92,885,527 (GRCm39) R416Q possibly damaging Het
Adgre1 C A 17: 57,713,859 (GRCm39) D181E probably benign Het
Arhgap24 T C 5: 103,028,652 (GRCm39) S183P probably damaging Het
Asb1 T C 1: 91,474,748 (GRCm39) L90P probably damaging Het
Bmp3 T C 5: 99,020,209 (GRCm39) F211L probably benign Het
C8a A G 4: 104,703,139 (GRCm39) I306T probably benign Het
Cdkn3 G A 14: 47,007,373 (GRCm39) G177R probably damaging Het
Chat A G 14: 32,170,984 (GRCm39) S172P probably damaging Het
Chd5 CAAGAAGAAGAAGAAGAA CAAGAAGAAGAAGAA 4: 152,438,078 (GRCm39) probably benign Het
Cyp4a12a T C 4: 115,184,420 (GRCm39) I265T probably damaging Het
Dlst T A 12: 85,165,664 (GRCm39) probably null Het
Dnmt1 A T 9: 20,837,716 (GRCm39) probably benign Het
Fbn1 C T 2: 125,205,800 (GRCm39) E1066K probably damaging Het
Fetub C T 16: 22,751,081 (GRCm39) R143C probably damaging Het
Fstl1 T A 16: 37,641,538 (GRCm39) S105T probably benign Het
Gm19410 C G 8: 36,276,518 (GRCm39) A1725G probably benign Het
Hspb7 A G 4: 141,151,215 (GRCm39) N119S probably damaging Het
Il20 T A 1: 130,838,478 (GRCm39) D73V possibly damaging Het
Insrr T C 3: 87,716,608 (GRCm39) I612T possibly damaging Het
Kcnma1 T C 14: 23,359,105 (GRCm39) Y1107C probably benign Het
Klhl32 A G 4: 24,792,615 (GRCm39) probably null Het
Muc1 T C 3: 89,139,336 (GRCm39) Y579H probably damaging Het
Myof T C 19: 37,966,132 (GRCm39) D396G probably damaging Het
Myom1 T G 17: 71,417,746 (GRCm39) D1316E probably damaging Het
Nbea T C 3: 55,912,538 (GRCm39) E1083G probably benign Het
Nek9 G A 12: 85,359,859 (GRCm39) A531V probably benign Het
Nlrp12 A T 7: 3,290,002 (GRCm39) I170N possibly damaging Het
Nup98 A G 7: 101,784,002 (GRCm39) I1093T probably benign Het
Ovch2 G A 7: 107,388,318 (GRCm39) L421F probably damaging Het
Paqr4 T C 17: 23,958,968 (GRCm39) D11G probably damaging Het
Parp8 A G 13: 117,014,134 (GRCm39) S561P probably damaging Het
Pcgf5 T A 19: 36,420,306 (GRCm39) F179L probably damaging Het
Pde4d A T 13: 110,084,876 (GRCm39) Q422L probably damaging Het
Pigs T A 11: 78,232,651 (GRCm39) V495E probably damaging Het
Polh C T 17: 46,498,959 (GRCm39) R252H probably benign Het
Psg28 T C 7: 18,160,107 (GRCm39) D363G possibly damaging Het
Ptgir A T 7: 16,640,815 (GRCm39) I36F possibly damaging Het
Ptprr G A 10: 116,072,668 (GRCm39) probably null Het
Rax C T 18: 66,068,418 (GRCm39) G229D unknown Het
Secisbp2l T A 2: 125,615,136 (GRCm39) H163L probably benign Het
Sf3a2 A G 10: 80,637,297 (GRCm39) Y45C probably damaging Het
Sgo2a C T 1: 58,055,775 (GRCm39) T653I possibly damaging Het
Slc38a9 A T 13: 112,806,231 (GRCm39) I26F probably damaging Het
Slc5a8 A G 10: 88,722,436 (GRCm39) I90V probably benign Het
Slx4 G A 16: 3,803,911 (GRCm39) H968Y possibly damaging Het
Stam2 T C 2: 52,599,611 (GRCm39) T233A probably benign Het
Tln1 G C 4: 43,555,052 (GRCm39) F259L probably damaging Het
Trav4-2 G A 14: 53,655,866 (GRCm39) V8M possibly damaging Het
Ttll5 T A 12: 85,878,729 (GRCm39) H45Q probably damaging Het
Ttn C T 2: 76,714,762 (GRCm39) probably benign Het
Ush2a T A 1: 188,051,217 (GRCm39) F234L possibly damaging Het
Vmn2r74 T A 7: 85,607,526 (GRCm39) probably null Het
Wdr6 CTG C 9: 108,450,994 (GRCm39) probably null Het
Zfp644 A G 5: 106,783,291 (GRCm39) S997P possibly damaging Het
Zfp853 G A 5: 143,274,529 (GRCm39) Q364* probably null Het
Other mutations in Krt77
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01060:Krt77 APN 15 101,769,315 (GRCm39) splice site probably benign
IGL01912:Krt77 APN 15 101,772,286 (GRCm39) splice site probably benign
IGL02505:Krt77 APN 15 101,769,381 (GRCm39) missense probably damaging 1.00
IGL02875:Krt77 APN 15 101,777,584 (GRCm39) missense probably damaging 1.00
R0266:Krt77 UTSW 15 101,777,813 (GRCm39) missense possibly damaging 0.71
R0347:Krt77 UTSW 15 101,768,304 (GRCm39) missense unknown
R0762:Krt77 UTSW 15 101,769,561 (GRCm39) splice site probably null
R1528:Krt77 UTSW 15 101,769,523 (GRCm39) missense probably damaging 1.00
R1556:Krt77 UTSW 15 101,769,713 (GRCm39) missense probably damaging 0.96
R1973:Krt77 UTSW 15 101,769,679 (GRCm39) missense probably damaging 1.00
R4434:Krt77 UTSW 15 101,773,904 (GRCm39) missense probably damaging 1.00
R4436:Krt77 UTSW 15 101,773,904 (GRCm39) missense probably damaging 1.00
R4946:Krt77 UTSW 15 101,777,998 (GRCm39) missense unknown
R5405:Krt77 UTSW 15 101,769,523 (GRCm39) missense probably damaging 0.96
R5507:Krt77 UTSW 15 101,769,665 (GRCm39) missense probably benign 0.03
R5888:Krt77 UTSW 15 101,773,888 (GRCm39) missense probably benign 0.29
R5978:Krt77 UTSW 15 101,771,363 (GRCm39) missense probably benign 0.07
R5994:Krt77 UTSW 15 101,771,290 (GRCm39) missense probably damaging 1.00
R6039:Krt77 UTSW 15 101,769,351 (GRCm39) missense possibly damaging 0.85
R6241:Krt77 UTSW 15 101,773,988 (GRCm39) missense probably damaging 1.00
R6260:Krt77 UTSW 15 101,772,807 (GRCm39) nonsense probably null
R6280:Krt77 UTSW 15 101,773,910 (GRCm39) missense probably damaging 1.00
R6500:Krt77 UTSW 15 101,772,772 (GRCm39) missense probably damaging 0.99
R6563:Krt77 UTSW 15 101,771,358 (GRCm39) missense probably damaging 1.00
R7153:Krt77 UTSW 15 101,773,931 (GRCm39) missense probably benign 0.18
R7156:Krt77 UTSW 15 101,773,931 (GRCm39) missense probably benign 0.18
R7205:Krt77 UTSW 15 101,777,806 (GRCm39) missense probably benign 0.00
R7379:Krt77 UTSW 15 101,769,709 (GRCm39) missense probably damaging 1.00
R7407:Krt77 UTSW 15 101,768,530 (GRCm39) missense unknown
R8297:Krt77 UTSW 15 101,768,407 (GRCm39) small deletion probably benign
R9221:Krt77 UTSW 15 101,774,064 (GRCm39) missense probably damaging 1.00
R9513:Krt77 UTSW 15 101,769,779 (GRCm39) missense probably damaging 1.00
R9516:Krt77 UTSW 15 101,769,779 (GRCm39) missense probably damaging 1.00
Predicted Primers
Posted On 2017-06-26