Incidental Mutation 'R6007:A830018L16Rik'
| ID |
479514 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
A830018L16Rik
|
| Ensembl Gene |
ENSMUSG00000057715 |
| Gene Name |
RIKEN cDNA A830018L16 gene |
| Synonyms |
|
| MMRRC Submission |
044184-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.054)
|
| Stock # |
R6007 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
11484329-12046125 bp(+) (GRCm39) |
| Type of Mutation |
critical splice acceptor site |
| DNA Base Change (assembly) |
A to G
at 11582140 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000137287
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000048613]
[ENSMUST00000135014]
[ENSMUST00000135014]
[ENSMUST00000137824]
[ENSMUST00000141512]
[ENSMUST00000171690]
[ENSMUST00000171690]
[ENSMUST00000179089]
[ENSMUST00000179089]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably null
Transcript: ENSMUST00000048613
|
| SMART Domains |
Protein: ENSMUSP00000043857
Gene: ENSMUSG00000057715
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
58 |
73 |
N/A |
INTRINSIC |
|
low complexity region
|
213 |
223 |
N/A |
INTRINSIC |
|
low complexity region
|
233 |
248 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000135014
|
| SMART Domains |
Protein: ENSMUSP00000119143
Gene: ENSMUSG00000057715
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
58 |
73 |
N/A |
INTRINSIC |
|
low complexity region
|
213 |
223 |
N/A |
INTRINSIC |
|
low complexity region
|
233 |
248 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000135014
|
| SMART Domains |
Protein: ENSMUSP00000119143
Gene: ENSMUSG00000057715
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
58 |
73 |
N/A |
INTRINSIC |
|
low complexity region
|
213 |
223 |
N/A |
INTRINSIC |
|
low complexity region
|
233 |
248 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000137824
|
| SMART Domains |
Protein: ENSMUSP00000117421
Gene: ENSMUSG00000057715
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
58 |
73 |
N/A |
INTRINSIC |
|
low complexity region
|
213 |
223 |
N/A |
INTRINSIC |
|
low complexity region
|
233 |
248 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000141512
|
| SMART Domains |
Protein: ENSMUSP00000139635
Gene: ENSMUSG00000057715
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
58 |
73 |
N/A |
INTRINSIC |
|
low complexity region
|
213 |
223 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000142117
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000150870
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000171690
|
| SMART Domains |
Protein: ENSMUSP00000132334
Gene: ENSMUSG00000057715
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
58 |
73 |
N/A |
INTRINSIC |
|
low complexity region
|
213 |
223 |
N/A |
INTRINSIC |
|
low complexity region
|
233 |
248 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000171690
|
| SMART Domains |
Protein: ENSMUSP00000132334
Gene: ENSMUSG00000057715
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
58 |
73 |
N/A |
INTRINSIC |
|
low complexity region
|
213 |
223 |
N/A |
INTRINSIC |
|
low complexity region
|
233 |
248 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000179089
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000179089
|
| Meta Mutation Damage Score |
0.9485 |
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.4%
- 10x: 97.1%
- 20x: 90.6%
|
| Validation Efficiency |
100% (54/54) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that is related to the cyclic AMP dependent protein kinase regulators. Naturally occurring mutations in this gene are associated with an increased risk for severe toxicities, such as diarrhea and neutropenia, in patients undergoing chemotherapeutic treatment. [provided by RefSeq, Mar 2017]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 53 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700003E16Rik |
G |
T |
6: 83,137,900 (GRCm39) |
A9S |
possibly damaging |
Het |
| 4930407I10Rik |
C |
G |
15: 81,946,940 (GRCm39) |
T279S |
probably benign |
Het |
| Abcg5 |
T |
G |
17: 84,976,392 (GRCm39) |
I482L |
probably benign |
Het |
| Adgrf5 |
T |
A |
17: 43,748,462 (GRCm39) |
D44E |
probably damaging |
Het |
| Amh |
A |
G |
10: 80,641,305 (GRCm39) |
N75S |
probably benign |
Het |
| Arl8a |
T |
C |
1: 135,080,606 (GRCm39) |
|
probably null |
Het |
| Bpifb4 |
T |
C |
2: 153,784,480 (GRCm39) |
Y63H |
possibly damaging |
Het |
| Chd5 |
A |
T |
4: 152,463,878 (GRCm39) |
E1449V |
probably null |
Het |
| Chml |
A |
G |
1: 175,515,594 (GRCm39) |
V109A |
probably benign |
Het |
| Crybg3 |
G |
T |
16: 59,374,837 (GRCm39) |
S2139* |
probably null |
Het |
| Cyp2c68 |
T |
C |
19: 39,722,780 (GRCm39) |
D256G |
probably damaging |
Het |
| Dchs2 |
G |
T |
3: 83,253,534 (GRCm39) |
V2315L |
probably damaging |
Het |
| Ddx20 |
T |
C |
3: 105,590,736 (GRCm39) |
I227V |
possibly damaging |
Het |
| Drg2 |
T |
C |
11: 60,353,451 (GRCm39) |
V266A |
possibly damaging |
Het |
| Flcn |
C |
A |
11: 59,683,448 (GRCm39) |
E576D |
probably benign |
Het |
| Fstl5 |
T |
A |
3: 76,317,899 (GRCm39) |
D188E |
probably damaging |
Het |
| Gm14496 |
A |
G |
2: 181,639,323 (GRCm39) |
Q471R |
probably benign |
Het |
| Gm43772 |
T |
C |
5: 66,332,334 (GRCm39) |
|
probably benign |
Het |
| Gpc6 |
C |
T |
14: 118,188,673 (GRCm39) |
H436Y |
probably damaging |
Het |
| Gpr179 |
A |
T |
11: 97,226,628 (GRCm39) |
C1842* |
probably null |
Het |
| Ints8 |
G |
A |
4: 11,208,845 (GRCm39) |
T934I |
possibly damaging |
Het |
| Iqsec1 |
G |
T |
6: 90,637,969 (GRCm39) |
C1050* |
probably null |
Het |
| Larp4b |
T |
C |
13: 9,218,793 (GRCm39) |
V510A |
probably benign |
Het |
| Map3k13 |
A |
T |
16: 21,723,933 (GRCm39) |
D305V |
possibly damaging |
Het |
| Mc5r |
A |
T |
18: 68,472,318 (GRCm39) |
I226F |
possibly damaging |
Het |
| Mme |
G |
A |
3: 63,250,929 (GRCm39) |
W323* |
probably null |
Het |
| Mrpl24 |
A |
G |
3: 87,829,705 (GRCm39) |
Y97C |
probably benign |
Het |
| Mslnl |
G |
A |
17: 25,965,749 (GRCm39) |
S541N |
probably benign |
Het |
| Npepl1 |
T |
C |
2: 173,962,850 (GRCm39) |
V412A |
probably benign |
Het |
| Nrg3 |
T |
A |
14: 39,194,409 (GRCm39) |
K117* |
probably null |
Het |
| Or11j4 |
G |
T |
14: 50,630,948 (GRCm39) |
C245F |
probably damaging |
Het |
| Or4f52 |
T |
C |
2: 111,061,275 (GRCm39) |
T288A |
probably benign |
Het |
| Orc2 |
A |
T |
1: 58,506,851 (GRCm39) |
M447K |
probably benign |
Het |
| Phf3 |
A |
T |
1: 30,843,426 (GRCm39) |
H1844Q |
probably damaging |
Het |
| Plxnc1 |
T |
C |
10: 94,629,152 (GRCm39) |
I1541V |
possibly damaging |
Het |
| Rapgef4 |
T |
C |
2: 72,010,293 (GRCm39) |
Y284H |
possibly damaging |
Het |
| Rnf180 |
C |
A |
13: 105,317,957 (GRCm39) |
|
probably null |
Het |
| Secisbp2 |
T |
C |
13: 51,819,395 (GRCm39) |
I325T |
probably damaging |
Het |
| Sertad2 |
G |
A |
11: 20,597,884 (GRCm39) |
G27S |
probably benign |
Het |
| Slc4a10 |
A |
G |
2: 62,099,216 (GRCm39) |
M625V |
probably benign |
Het |
| Synpo |
T |
A |
18: 60,736,687 (GRCm39) |
M420L |
probably benign |
Het |
| Tmem116 |
A |
C |
5: 121,655,955 (GRCm39) |
*147C |
probably null |
Het |
| Top2b |
G |
A |
14: 16,423,779 (GRCm38) |
|
probably null |
Het |
| Trp53bp2 |
T |
A |
1: 182,283,305 (GRCm39) |
C1014S |
probably damaging |
Het |
| Unc5b |
A |
G |
10: 60,601,139 (GRCm39) |
F896L |
probably damaging |
Het |
| Vil1 |
T |
C |
1: 74,459,026 (GRCm39) |
W177R |
probably damaging |
Het |
| Vmn2r107 |
A |
T |
17: 20,595,316 (GRCm39) |
Y623F |
probably benign |
Het |
| Vmn2r86 |
T |
C |
10: 130,289,535 (GRCm39) |
Y120C |
probably damaging |
Het |
| Wdr18 |
A |
G |
10: 79,801,177 (GRCm39) |
T197A |
possibly damaging |
Het |
| Ylpm1 |
A |
G |
12: 85,076,064 (GRCm39) |
M472V |
probably benign |
Het |
| Zfp647 |
G |
A |
15: 76,796,285 (GRCm39) |
P125L |
probably damaging |
Het |
| Zfp677 |
A |
G |
17: 21,617,918 (GRCm39) |
Y325C |
probably damaging |
Het |
| Zfyve1 |
A |
G |
12: 83,605,478 (GRCm39) |
F407S |
probably damaging |
Het |
|
| Other mutations in A830018L16Rik |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00426:A830018L16Rik
|
APN |
1 |
11,818,278 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01916:A830018L16Rik
|
APN |
1 |
11,818,331 (GRCm39) |
splice site |
probably benign |
|
|
IGL02040:A830018L16Rik
|
APN |
1 |
12,003,822 (GRCm39) |
intron |
probably benign |
|
|
IGL02432:A830018L16Rik
|
APN |
1 |
11,818,303 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02693:A830018L16Rik
|
APN |
1 |
11,666,506 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02736:A830018L16Rik
|
APN |
1 |
12,042,275 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL03293:A830018L16Rik
|
APN |
1 |
11,615,375 (GRCm39) |
splice site |
probably null |
|
|
IGL02835:A830018L16Rik
|
UTSW |
1 |
12,042,279 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R1203:A830018L16Rik
|
UTSW |
1 |
11,588,818 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1216:A830018L16Rik
|
UTSW |
1 |
11,868,716 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1548:A830018L16Rik
|
UTSW |
1 |
11,588,818 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1644:A830018L16Rik
|
UTSW |
1 |
11,484,814 (GRCm39) |
nonsense |
probably null |
|
|
R1855:A830018L16Rik
|
UTSW |
1 |
11,818,195 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1858:A830018L16Rik
|
UTSW |
1 |
12,045,177 (GRCm39) |
missense |
unknown |
|
|
R2265:A830018L16Rik
|
UTSW |
1 |
12,042,328 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2296:A830018L16Rik
|
UTSW |
1 |
11,582,275 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2484:A830018L16Rik
|
UTSW |
1 |
11,666,526 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3730:A830018L16Rik
|
UTSW |
1 |
11,615,450 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3752:A830018L16Rik
|
UTSW |
1 |
11,588,904 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3861:A830018L16Rik
|
UTSW |
1 |
11,658,778 (GRCm39) |
splice site |
probably benign |
|
|
R4305:A830018L16Rik
|
UTSW |
1 |
12,042,300 (GRCm39) |
nonsense |
probably null |
|
|
R4306:A830018L16Rik
|
UTSW |
1 |
12,042,300 (GRCm39) |
nonsense |
probably null |
|
|
R4307:A830018L16Rik
|
UTSW |
1 |
12,042,300 (GRCm39) |
nonsense |
probably null |
|
|
R4558:A830018L16Rik
|
UTSW |
1 |
12,042,300 (GRCm39) |
nonsense |
probably null |
|
|
R4598:A830018L16Rik
|
UTSW |
1 |
11,818,188 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4652:A830018L16Rik
|
UTSW |
1 |
11,607,566 (GRCm39) |
intron |
probably benign |
|
|
R5492:A830018L16Rik
|
UTSW |
1 |
11,615,431 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5493:A830018L16Rik
|
UTSW |
1 |
11,615,431 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5802:A830018L16Rik
|
UTSW |
1 |
12,021,188 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6082:A830018L16Rik
|
UTSW |
1 |
11,868,752 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6376:A830018L16Rik
|
UTSW |
1 |
11,868,718 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6453:A830018L16Rik
|
UTSW |
1 |
11,868,782 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6757:A830018L16Rik
|
UTSW |
1 |
11,666,558 (GRCm39) |
makesense |
probably null |
|
|
R6833:A830018L16Rik
|
UTSW |
1 |
11,658,733 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7163:A830018L16Rik
|
UTSW |
1 |
11,484,848 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7272:A830018L16Rik
|
UTSW |
1 |
11,658,695 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7566:A830018L16Rik
|
UTSW |
1 |
12,021,252 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7665:A830018L16Rik
|
UTSW |
1 |
12,042,323 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8004:A830018L16Rik
|
UTSW |
1 |
12,021,286 (GRCm39) |
splice site |
probably benign |
|
|
R8754:A830018L16Rik
|
UTSW |
1 |
11,615,472 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8944:A830018L16Rik
|
UTSW |
1 |
11,484,706 (GRCm39) |
unclassified |
probably benign |
|
|
R8993:A830018L16Rik
|
UTSW |
1 |
11,615,491 (GRCm39) |
nonsense |
probably null |
|
|
R8997:A830018L16Rik
|
UTSW |
1 |
11,615,491 (GRCm39) |
nonsense |
probably null |
|
|
R9098:A830018L16Rik
|
UTSW |
1 |
11,633,211 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9640:A830018L16Rik
|
UTSW |
1 |
12,021,200 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9704:A830018L16Rik
|
UTSW |
1 |
11,588,913 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9705:A830018L16Rik
|
UTSW |
1 |
11,588,913 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:A830018L16Rik
|
UTSW |
1 |
11,588,849 (GRCm39) |
missense |
probably damaging |
0.96 |
|
| Predicted Primers |
PCR Primer
(F):5'- AATTCCAGCATGTTCTTTGGG -3'
(R):5'- ATTCAAAAGTTTGGTTTCCTCCACC -3'
Sequencing Primer
(F):5'- GTTTCTAATGGGATTCCTTGAAAGAG -3'
(R):5'- TCCACCCAATTACCTGATGATTCAC -3'
|
| Posted On |
2017-06-26 |
Incidental Mutation