Incidental Mutation 'R6010:Brms1l'
ID 479722
Institutional Source Beutler Lab
Gene Symbol Brms1l
Ensembl Gene ENSMUSG00000012076
Gene Name breast cancer metastasis-suppressor 1-like
Synonyms 0710008O11Rik, D12Ertd407e, BRMS1
MMRRC Submission 044187-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.939) question?
Stock # R6010 (G1)
Quality Score 225.009
Status Validated
Chromosome 12
Chromosomal Location 55883109-55916521 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 55914985 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 298 (F298S)
Ref Sequence ENSEMBL: ENSMUSP00000082500 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059250] [ENSMUST00000219419]
AlphaFold Q3U1T3
Predicted Effect possibly damaging
Transcript: ENSMUST00000059250
AA Change: F298S

PolyPhen 2 Score 0.546 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000082500
Gene: ENSMUSG00000012076
AA Change: F298S

DomainStartEndE-ValueType
low complexity region 24 55 N/A INTRINSIC
Pfam:Sds3 61 217 1.5e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000219419
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219575
Meta Mutation Damage Score 0.2040 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.7%
  • 20x: 92.9%
Validation Efficiency 100% (65/65)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene shows sequence similarity to the human breast carcinoma metastasis suppressor (BRMS1) protein and the mammalian Sds3 (suppressor of defective silencing 3) proteins. This protein is a component of the mSin3a family of histone deacetylase complexes (HDAC). [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actl7a A G 4: 56,743,870 (GRCm39) I132M possibly damaging Het
Agap2 A T 10: 126,926,779 (GRCm39) I939F probably damaging Het
Ahctf1 A G 1: 179,623,378 (GRCm39) V80A possibly damaging Het
Atxn3 T C 12: 101,914,285 (GRCm39) D67G probably damaging Het
Avl9 G A 6: 56,730,375 (GRCm39) V573M possibly damaging Het
Baz1b G A 5: 135,246,305 (GRCm39) E585K possibly damaging Het
Camk2d G A 3: 126,591,363 (GRCm39) V278I possibly damaging Het
Car10 A G 11: 93,490,149 (GRCm39) I297V possibly damaging Het
Cfap65 C T 1: 74,962,190 (GRCm39) C677Y probably damaging Het
Cfap74 T A 4: 155,538,495 (GRCm39) D872E possibly damaging Het
Cgrrf1 A C 14: 47,091,158 (GRCm39) Q227H probably damaging Het
Chil4 A G 3: 106,121,711 (GRCm39) I46T probably damaging Het
Chpf2 A T 5: 24,796,917 (GRCm39) H621L probably damaging Het
Cluap1 C T 16: 3,755,437 (GRCm39) R351W possibly damaging Het
Cnot6 A T 11: 49,574,066 (GRCm39) Y201* probably null Het
Col15a1 T C 4: 47,245,630 (GRCm39) V127A probably benign Het
Col6a3 C T 1: 90,701,219 (GRCm39) V2566I unknown Het
Cope T A 8: 70,761,162 (GRCm39) M88K probably damaging Het
Cops4 A G 5: 100,691,776 (GRCm39) I358M possibly damaging Het
Coro7 T C 16: 4,487,820 (GRCm39) E130G possibly damaging Het
Csrp3 A G 7: 48,485,213 (GRCm39) probably null Het
Cyp4f39 T C 17: 32,701,160 (GRCm39) F217L probably damaging Het
Dmac1 A G 4: 75,196,473 (GRCm39) S6P unknown Het
Drd4 A T 7: 140,874,709 (GRCm39) I367F probably damaging Het
Efcc1 T A 6: 87,730,711 (GRCm39) probably null Het
Emid1 A T 11: 5,085,389 (GRCm39) M119K possibly damaging Het
Fbn2 C T 18: 58,202,596 (GRCm39) D1237N probably benign Het
Fbxl18 C A 5: 142,858,153 (GRCm39) R761L probably damaging Het
Gbp10 A C 5: 105,372,205 (GRCm39) L185R probably damaging Het
Gm7247 C T 14: 51,601,805 (GRCm39) S26F probably benign Het
Gucd1 G T 10: 75,256,600 (GRCm39) probably benign Het
Helb G A 10: 119,941,788 (GRCm39) T300M probably damaging Het
Ifna11 A T 4: 88,738,278 (GRCm39) H28L probably benign Het
Kalrn T A 16: 33,830,950 (GRCm39) N723I probably benign Het
Kcnb2 C T 1: 15,780,790 (GRCm39) S554F possibly damaging Het
Med1 A C 11: 98,049,188 (GRCm39) V536G probably damaging Het
Nanog A C 6: 122,690,255 (GRCm39) N195T probably benign Het
Neu1 C T 17: 35,151,031 (GRCm39) S94F probably damaging Het
Nop58 T A 1: 59,740,071 (GRCm39) S154R probably damaging Het
Npl A T 1: 153,388,314 (GRCm39) L239* probably null Het
Nrg1 G A 8: 32,308,600 (GRCm39) T483M probably damaging Het
Nup98 G T 7: 101,829,636 (GRCm39) F391L probably damaging Het
Or4c122 A T 2: 89,079,087 (GRCm39) I305K probably benign Het
Or5ar1 T C 2: 85,671,905 (GRCm39) I77V probably benign Het
Or5d47 A T 2: 87,804,886 (GRCm39) V41E probably damaging Het
Or5g26 T C 2: 85,494,374 (GRCm39) I135V probably benign Het
Pacsin2 A G 15: 83,266,020 (GRCm39) V59A possibly damaging Het
Pcsk9 C T 4: 106,311,469 (GRCm39) R254H possibly damaging Het
Pierce2 A T 9: 72,887,488 (GRCm39) probably null Het
Psme2 C A 14: 55,824,980 (GRCm39) probably null Het
Ptprc T A 1: 138,028,794 (GRCm39) H468L probably benign Het
Rbp3 T A 14: 33,676,604 (GRCm39) I184N probably damaging Het
Serpinb1c A G 13: 33,066,042 (GRCm39) L301P probably damaging Het
Smim6 G T 11: 115,804,219 (GRCm39) G2V probably damaging Het
Snrpb2 A G 2: 142,912,815 (GRCm39) D146G possibly damaging Het
Svep1 T A 4: 58,115,832 (GRCm39) S954C possibly damaging Het
Telo2 G T 17: 25,323,852 (GRCm39) T568N possibly damaging Het
Tpp2 T C 1: 43,990,373 (GRCm39) probably null Het
Upf1 A G 8: 70,789,675 (GRCm39) V720A probably damaging Het
Vmn1r81 T C 7: 11,994,349 (GRCm39) I86M possibly damaging Het
Vps8 T A 16: 21,363,955 (GRCm39) probably benign Het
Wdr70 T C 15: 7,916,900 (GRCm39) probably null Het
Zfp385c A T 11: 100,548,363 (GRCm39) S30T probably benign Het
Zfp607a T A 7: 27,577,254 (GRCm39) L108* probably null Het
Other mutations in Brms1l
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00922:Brms1l APN 12 55,892,111 (GRCm39) missense probably benign 0.15
IGL00951:Brms1l APN 12 55,912,834 (GRCm39) missense possibly damaging 0.54
IGL02199:Brms1l APN 12 55,907,957 (GRCm39) critical splice donor site probably benign
IGL02669:Brms1l APN 12 55,888,401 (GRCm39) missense probably damaging 1.00
IGL03158:Brms1l APN 12 55,883,320 (GRCm39) missense possibly damaging 0.83
IGL03184:Brms1l APN 12 55,915,062 (GRCm39) makesense probably null
R0445:Brms1l UTSW 12 55,908,191 (GRCm39) nonsense probably null
R0568:Brms1l UTSW 12 55,908,173 (GRCm39) critical splice acceptor site probably null
R0942:Brms1l UTSW 12 55,912,742 (GRCm39) missense probably benign 0.00
R0968:Brms1l UTSW 12 55,912,798 (GRCm39) missense possibly damaging 0.73
R1240:Brms1l UTSW 12 55,891,293 (GRCm39) missense probably damaging 1.00
R1580:Brms1l UTSW 12 55,915,007 (GRCm39) missense probably damaging 1.00
R1694:Brms1l UTSW 12 55,888,385 (GRCm39) missense probably damaging 1.00
R1926:Brms1l UTSW 12 55,909,946 (GRCm39) missense possibly damaging 0.69
R4626:Brms1l UTSW 12 55,909,958 (GRCm39) missense probably benign 0.01
R4669:Brms1l UTSW 12 55,888,356 (GRCm39) missense possibly damaging 0.83
R4987:Brms1l UTSW 12 55,912,800 (GRCm39) missense probably benign 0.15
R6129:Brms1l UTSW 12 55,914,970 (GRCm39) missense probably benign 0.03
R7429:Brms1l UTSW 12 55,892,084 (GRCm39) missense probably damaging 1.00
R7430:Brms1l UTSW 12 55,892,084 (GRCm39) missense probably damaging 1.00
R7510:Brms1l UTSW 12 55,892,107 (GRCm39) nonsense probably null
R7543:Brms1l UTSW 12 55,914,997 (GRCm39) missense probably damaging 1.00
R7855:Brms1l UTSW 12 55,912,838 (GRCm39) missense possibly damaging 0.90
R8200:Brms1l UTSW 12 55,891,183 (GRCm39) missense probably damaging 1.00
R8376:Brms1l UTSW 12 55,888,414 (GRCm39) missense probably benign 0.03
R8532:Brms1l UTSW 12 55,891,264 (GRCm39) missense probably damaging 1.00
R9131:Brms1l UTSW 12 55,906,913 (GRCm39) missense possibly damaging 0.93
R9335:Brms1l UTSW 12 55,888,431 (GRCm39) missense possibly damaging 0.96
R9433:Brms1l UTSW 12 55,912,863 (GRCm39) critical splice donor site probably null
R9577:Brms1l UTSW 12 55,906,876 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTAGTATAAACCGGGTGGAGGC -3'
(R):5'- TAGAAGACACAGTCTCTCATGAC -3'

Sequencing Primer
(F):5'- AGGCAAGCTCAGGGCCAAC -3'
(R):5'- GACTGGATGAAATTATTAAGCTGCTG -3'
Posted On 2017-06-26