Incidental Mutation 'R6012:Or2w1'
ID 479824
Institutional Source Beutler Lab
Gene Symbol Or2w1
Ensembl Gene ENSMUSG00000071522
Gene Name olfactory receptor family 2 subfamily W member 1
Synonyms GA_x6K02T2QHY8-12114828-12113875, MOR256-61, Olfr263, GA_x6K02T2N5E5-9379-8514, Olfr263-ps1, IA3, Olfr42, MOR256-37P, MOR256-31
MMRRC Submission 044188-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.101) question?
Stock # R6012 (G1)
Quality Score 225.009
Status Validated
Chromosome 13
Chromosomal Location 21316947-21317900 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 21316978 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 11 (V11A)
Ref Sequence ENSEMBL: ENSMUSP00000149892 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000096006] [ENSMUST00000215804]
AlphaFold Q7TQT8
Predicted Effect probably benign
Transcript: ENSMUST00000096006
AA Change: V11A

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000093705
Gene: ENSMUSG00000071522
AA Change: V11A

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1.4e-46 PFAM
Pfam:7tm_1 41 290 4.2e-30 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215804
AA Change: V11A

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.5%
  • 20x: 92.4%
Validation Efficiency 100% (55/55)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abat T A 16: 8,400,691 (GRCm39) Y97N probably damaging Het
Adrm1b C A 3: 92,336,791 (GRCm39) probably null Het
Akr1b10 A T 6: 34,364,715 (GRCm39) I59F probably damaging Het
Als2 A T 1: 59,224,374 (GRCm39) D1076E probably damaging Het
Bank1 T C 3: 135,919,598 (GRCm39) D266G probably benign Het
Bmp2k T A 5: 97,211,467 (GRCm39) probably null Het
Cdc42bpa A G 1: 179,892,655 (GRCm39) Y273C probably damaging Het
Chfr G T 5: 110,292,517 (GRCm39) probably null Het
Dapk1 A T 13: 60,909,476 (GRCm39) Q1363L probably benign Het
Ddx23 A T 15: 98,548,651 (GRCm39) D352E possibly damaging Het
Ect2 T C 3: 27,152,474 (GRCm39) probably benign Het
Efcab10 A C 12: 33,448,592 (GRCm39) D107A probably damaging Het
Fcgr4 G A 1: 170,853,233 (GRCm39) G146D possibly damaging Het
Fgd5 A G 6: 91,966,322 (GRCm39) T694A possibly damaging Het
Ghr T C 15: 3,370,409 (GRCm39) D152G probably damaging Het
Gli2 A C 1: 118,765,445 (GRCm39) L902R probably damaging Het
Glis2 G A 16: 4,429,172 (GRCm39) G125D possibly damaging Het
Gmcl1 A G 6: 86,698,394 (GRCm39) Y168H probably damaging Het
Golga4 A G 9: 118,388,764 (GRCm39) K1962R possibly damaging Het
Hebp1 T A 6: 135,145,055 (GRCm39) E14V probably damaging Het
Hhla1 A C 15: 65,820,339 (GRCm39) I137S probably damaging Het
Hivep1 A G 13: 42,337,934 (GRCm39) H2671R possibly damaging Het
Hltf A G 3: 20,113,098 (GRCm39) Y19C probably damaging Het
Hsd3b2 A T 3: 98,619,333 (GRCm39) M204K probably benign Het
Hspa4l A T 3: 40,736,031 (GRCm39) I551F probably benign Het
Itpkc A T 7: 26,927,490 (GRCm39) D141E probably damaging Het
Kcnc3 A G 7: 44,248,296 (GRCm39) D757G probably benign Het
Mettl16 A T 11: 74,678,474 (GRCm39) Y141F probably damaging Het
Mfng G A 15: 78,640,840 (GRCm39) R302C probably damaging Het
Mogs T A 6: 83,094,363 (GRCm39) S393R probably damaging Het
Mrps28 A G 3: 8,965,044 (GRCm39) probably null Het
Nfat5 T C 8: 108,093,765 (GRCm39) S150P probably benign Het
Or7d10 A T 9: 19,832,237 (GRCm39) H244L probably damaging Het
Pcdh12 A G 18: 38,416,805 (GRCm39) S107P probably damaging Het
Phf21a G A 2: 92,182,120 (GRCm39) D463N probably damaging Het
Picalm A C 7: 89,844,908 (GRCm39) I567L probably benign Het
Pla2g4a T A 1: 149,808,428 (GRCm39) D5V possibly damaging Het
Sspo C T 6: 48,428,305 (GRCm39) T222M probably benign Het
Stard9 T C 2: 120,535,067 (GRCm39) S3775P probably damaging Het
Stk31 A T 6: 49,446,243 (GRCm39) D982V probably damaging Het
Tas2r113 C T 6: 132,870,644 (GRCm39) T224I probably damaging Het
Tbc1d15 T C 10: 115,055,112 (GRCm39) D310G probably damaging Het
Tcf12 G T 9: 71,766,229 (GRCm39) T468K possibly damaging Het
Tenm4 A G 7: 96,171,640 (GRCm39) probably benign Het
Tet2 A G 3: 133,172,542 (GRCm39) Y1907H possibly damaging Het
Thsd7a T C 6: 12,379,388 (GRCm39) probably null Het
Tln1 T A 4: 43,539,508 (GRCm39) T1605S probably benign Het
Trp53bp1 T C 2: 121,087,083 (GRCm39) Y191C probably benign Het
Ugcg T A 4: 59,220,272 (GRCm39) I355N probably damaging Het
Vmn1r21 A T 6: 57,820,891 (GRCm39) D184E probably damaging Het
Vsig10l T A 7: 43,117,439 (GRCm39) D575E probably damaging Het
Zan G A 5: 137,462,791 (GRCm39) T796I unknown Het
Zfp639 A G 3: 32,573,271 (GRCm39) D61G probably damaging Het
Other mutations in Or2w1
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1880:Or2w1 UTSW 13 21,317,802 (GRCm39) missense probably damaging 1.00
R2012:Or2w1 UTSW 13 21,317,659 (GRCm39) missense probably benign 0.13
R3113:Or2w1 UTSW 13 21,317,299 (GRCm39) missense probably damaging 1.00
R4210:Or2w1 UTSW 13 21,317,607 (GRCm39) missense possibly damaging 0.78
R4934:Or2w1 UTSW 13 21,317,241 (GRCm39) missense probably benign
R4952:Or2w1 UTSW 13 21,317,514 (GRCm39) missense probably benign 0.00
R5755:Or2w1 UTSW 13 21,317,695 (GRCm39) missense probably damaging 0.98
R6077:Or2w1 UTSW 13 21,317,463 (GRCm39) missense probably benign 0.02
R6168:Or2w1 UTSW 13 21,317,399 (GRCm39) missense possibly damaging 0.53
R6325:Or2w1 UTSW 13 21,317,245 (GRCm39) missense probably damaging 0.97
R6829:Or2w1 UTSW 13 21,317,023 (GRCm39) missense possibly damaging 0.69
R7130:Or2w1 UTSW 13 21,317,416 (GRCm39) missense probably benign 0.41
R7257:Or2w1 UTSW 13 21,317,427 (GRCm39) missense probably benign 0.34
R8113:Or2w1 UTSW 13 21,317,371 (GRCm39) missense probably benign 0.00
R9348:Or2w1 UTSW 13 21,317,131 (GRCm39) missense possibly damaging 0.95
R9359:Or2w1 UTSW 13 21,317,865 (GRCm39) missense probably benign 0.00
R9403:Or2w1 UTSW 13 21,317,865 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- AACCTAACTTCTTCCACTGCAG -3'
(R):5'- ACCAGCATCTGAGGGACAATG -3'

Sequencing Primer
(F):5'- GCAGCTAATTCTGTATCTTACCAG -3'
(R):5'- GGACAATGCTTGTTGTGAAACAC -3'
Posted On 2017-06-26