Incidental Mutation 'R6014:Arhgap21'
| ID |
479893 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Arhgap21
|
| Ensembl Gene |
ENSMUSG00000036591 |
| Gene Name |
Rho GTPase activating protein 21 |
| Synonyms |
ARHGAP10, 5530401C11Rik |
| MMRRC Submission |
044190-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.442)
|
| Stock # |
R6014 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
20852730-20973692 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 20886616 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glycine to Aspartic acid
at position 26
(G26D)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000133347
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000114594]
[ENSMUST00000141298]
[ENSMUST00000154230]
[ENSMUST00000173194]
[ENSMUST00000174584]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000114594
AA Change: G191D
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000110241
Gene: ENSMUSG00000036591
AA Change: G191D
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
58 |
159 |
1.03e-16 |
SMART |
|
low complexity region
|
351 |
362 |
N/A |
INTRINSIC |
|
low complexity region
|
445 |
459 |
N/A |
INTRINSIC |
|
low complexity region
|
625 |
635 |
N/A |
INTRINSIC |
|
low complexity region
|
911 |
925 |
N/A |
INTRINSIC |
|
PH
|
930 |
1040 |
2.09e-16 |
SMART |
|
RhoGAP
|
1157 |
1334 |
3.26e-62 |
SMART |
|
low complexity region
|
1381 |
1399 |
N/A |
INTRINSIC |
|
low complexity region
|
1448 |
1466 |
N/A |
INTRINSIC |
|
low complexity region
|
1533 |
1565 |
N/A |
INTRINSIC |
|
low complexity region
|
1573 |
1593 |
N/A |
INTRINSIC |
|
low complexity region
|
1891 |
1900 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000141298
AA Change: G197D
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000120357
Gene: ENSMUSG00000036591
AA Change: G197D
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
64 |
165 |
1.03e-16 |
SMART |
|
low complexity region
|
357 |
368 |
N/A |
INTRINSIC |
|
low complexity region
|
451 |
465 |
N/A |
INTRINSIC |
|
low complexity region
|
631 |
641 |
N/A |
INTRINSIC |
|
low complexity region
|
917 |
931 |
N/A |
INTRINSIC |
|
PH
|
936 |
1046 |
2.09e-16 |
SMART |
|
RhoGAP
|
1163 |
1340 |
3.26e-62 |
SMART |
|
low complexity region
|
1387 |
1405 |
N/A |
INTRINSIC |
|
low complexity region
|
1454 |
1472 |
N/A |
INTRINSIC |
|
low complexity region
|
1539 |
1571 |
N/A |
INTRINSIC |
|
low complexity region
|
1579 |
1599 |
N/A |
INTRINSIC |
|
low complexity region
|
1897 |
1906 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000154230
AA Change: G197D
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000122497
Gene: ENSMUSG00000036591
AA Change: G197D
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
64 |
165 |
1.03e-16 |
SMART |
|
low complexity region
|
357 |
368 |
N/A |
INTRINSIC |
|
low complexity region
|
451 |
465 |
N/A |
INTRINSIC |
|
low complexity region
|
631 |
641 |
N/A |
INTRINSIC |
|
low complexity region
|
917 |
931 |
N/A |
INTRINSIC |
|
PH
|
936 |
1046 |
2.09e-16 |
SMART |
|
RhoGAP
|
1163 |
1340 |
3.26e-62 |
SMART |
|
low complexity region
|
1387 |
1405 |
N/A |
INTRINSIC |
|
low complexity region
|
1454 |
1472 |
N/A |
INTRINSIC |
|
low complexity region
|
1539 |
1571 |
N/A |
INTRINSIC |
|
low complexity region
|
1579 |
1599 |
N/A |
INTRINSIC |
|
low complexity region
|
1897 |
1906 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000156142
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000173194
AA Change: G187D
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000133851
Gene: ENSMUSG00000036591
AA Change: G187D
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
64 |
165 |
1.03e-16 |
SMART |
|
low complexity region
|
347 |
358 |
N/A |
INTRINSIC |
|
low complexity region
|
441 |
455 |
N/A |
INTRINSIC |
|
low complexity region
|
621 |
631 |
N/A |
INTRINSIC |
|
low complexity region
|
907 |
921 |
N/A |
INTRINSIC |
|
PH
|
926 |
1036 |
2.09e-16 |
SMART |
|
RhoGAP
|
1153 |
1330 |
3.26e-62 |
SMART |
|
low complexity region
|
1377 |
1395 |
N/A |
INTRINSIC |
|
low complexity region
|
1444 |
1462 |
N/A |
INTRINSIC |
|
low complexity region
|
1529 |
1561 |
N/A |
INTRINSIC |
|
low complexity region
|
1569 |
1589 |
N/A |
INTRINSIC |
|
low complexity region
|
1887 |
1896 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000174584
AA Change: G26D
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000133347
Gene: ENSMUSG00000036591
AA Change: G26D
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
186 |
197 |
N/A |
INTRINSIC |
|
low complexity region
|
280 |
294 |
N/A |
INTRINSIC |
|
low complexity region
|
460 |
470 |
N/A |
INTRINSIC |
|
low complexity region
|
746 |
760 |
N/A |
INTRINSIC |
|
PH
|
765 |
875 |
2.09e-16 |
SMART |
|
RhoGAP
|
992 |
1169 |
3.26e-62 |
SMART |
|
| Meta Mutation Damage Score |
0.5200 |
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.5%
- 10x: 97.8%
- 20x: 93.3%
|
| Validation Efficiency |
100% (67/67) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005 [PubMed 15793564]).[supplied by OMIM, Mar 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 67 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930568D16Rik |
A |
T |
2: 35,244,881 (GRCm39) |
M157K |
probably benign |
Het |
| A2ml1 |
C |
T |
6: 128,548,948 (GRCm39) |
C278Y |
probably damaging |
Het |
| Abcc2 |
A |
T |
19: 43,815,174 (GRCm39) |
Q1187L |
probably benign |
Het |
| Adcy9 |
A |
T |
16: 4,236,683 (GRCm39) |
Y6N |
probably damaging |
Het |
| Adh1 |
T |
C |
3: 137,992,559 (GRCm39) |
I225T |
probably benign |
Het |
| Akap11 |
A |
T |
14: 78,749,939 (GRCm39) |
I816K |
probably benign |
Het |
| Ap1b1 |
T |
A |
11: 4,969,364 (GRCm39) |
M240K |
possibly damaging |
Het |
| Apex1 |
A |
T |
14: 51,162,982 (GRCm39) |
T17S |
probably benign |
Het |
| Bahcc1 |
A |
G |
11: 120,180,615 (GRCm39) |
Y2613C |
probably benign |
Het |
| Baz1b |
C |
T |
5: 135,246,248 (GRCm39) |
R566W |
probably damaging |
Het |
| Casp8ap2 |
A |
T |
4: 32,641,400 (GRCm39) |
Y818F |
probably damaging |
Het |
| Col3a1 |
T |
A |
1: 45,360,739 (GRCm39) |
C56* |
probably null |
Het |
| Coro2a |
G |
A |
4: 46,542,261 (GRCm39) |
P371S |
probably damaging |
Het |
| Cyp2a22 |
T |
A |
7: 26,638,605 (GRCm39) |
|
probably null |
Het |
| Dpysl3 |
T |
A |
18: 43,494,132 (GRCm39) |
I183F |
probably damaging |
Het |
| Drc1 |
A |
T |
5: 30,502,993 (GRCm39) |
N172I |
probably damaging |
Het |
| Dst |
T |
C |
1: 34,303,915 (GRCm39) |
Y1378H |
probably damaging |
Het |
| Dync2i2 |
C |
T |
2: 29,921,763 (GRCm39) |
A533T |
probably benign |
Het |
| Eml2 |
G |
A |
7: 18,935,088 (GRCm39) |
V432I |
probably damaging |
Het |
| Epb41l3 |
A |
T |
17: 69,590,955 (GRCm39) |
T91S |
probably damaging |
Het |
| Exoc4 |
T |
C |
6: 33,452,932 (GRCm39) |
V474A |
probably benign |
Het |
| Fam229b |
G |
A |
10: 38,994,989 (GRCm39) |
T56I |
probably damaging |
Het |
| Gfm2 |
A |
G |
13: 97,288,169 (GRCm39) |
|
probably null |
Het |
| Git2 |
C |
T |
5: 114,871,938 (GRCm39) |
E152K |
probably benign |
Het |
| Golt1b |
T |
A |
6: 142,341,943 (GRCm39) |
I109N |
probably damaging |
Het |
| Grid2ip |
T |
A |
5: 143,373,578 (GRCm39) |
M783K |
possibly damaging |
Het |
| Inpp5a |
A |
G |
7: 139,154,898 (GRCm39) |
Y339C |
probably damaging |
Het |
| Isoc2a |
T |
C |
7: 4,894,625 (GRCm39) |
S103P |
probably damaging |
Het |
| Itih4 |
C |
A |
14: 30,614,586 (GRCm39) |
Q483K |
probably benign |
Het |
| Kansl2 |
A |
G |
15: 98,418,197 (GRCm39) |
|
probably null |
Het |
| Kdm5d |
G |
A |
Y: 921,528 (GRCm39) |
A509T |
probably benign |
Het |
| Krt13 |
A |
T |
11: 100,008,437 (GRCm39) |
D433E |
unknown |
Het |
| Lat2 |
C |
T |
5: 134,632,308 (GRCm39) |
V142M |
probably damaging |
Het |
| Lemd1 |
A |
C |
1: 132,184,463 (GRCm39) |
*102S |
probably null |
Het |
| Lrfn2 |
T |
C |
17: 49,376,934 (GRCm39) |
L5P |
possibly damaging |
Het |
| Lrrc4c |
T |
G |
2: 97,459,557 (GRCm39) |
|
probably null |
Het |
| Lypla1 |
T |
A |
1: 4,878,594 (GRCm39) |
|
probably null |
Het |
| Magi2 |
G |
A |
5: 20,816,091 (GRCm39) |
G744R |
probably damaging |
Het |
| Myh14 |
T |
A |
7: 44,274,502 (GRCm39) |
E948V |
probably null |
Het |
| Myo5a |
C |
A |
9: 75,074,489 (GRCm39) |
Y799* |
probably null |
Het |
| Nacc1 |
A |
C |
8: 85,401,700 (GRCm39) |
M371R |
possibly damaging |
Het |
| Nlrp5 |
T |
G |
7: 23,109,372 (GRCm39) |
M106R |
probably benign |
Het |
| Oas1h |
C |
T |
5: 121,005,229 (GRCm39) |
H226Y |
possibly damaging |
Het |
| Obscn |
A |
C |
11: 58,929,690 (GRCm39) |
I5175R |
probably damaging |
Het |
| Pcdh7 |
T |
A |
5: 57,878,497 (GRCm39) |
I684N |
probably damaging |
Het |
| Pcdhb3 |
T |
A |
18: 37,435,706 (GRCm39) |
N557K |
probably damaging |
Het |
| Pde3b |
T |
C |
7: 114,015,675 (GRCm39) |
L297S |
probably damaging |
Het |
| Pigv |
G |
T |
4: 133,392,740 (GRCm39) |
H143Q |
probably benign |
Het |
| Ptk2 |
T |
G |
15: 73,176,293 (GRCm39) |
Y251S |
possibly damaging |
Het |
| Ralgds |
A |
G |
2: 28,433,673 (GRCm39) |
N219S |
probably damaging |
Het |
| Sardh |
C |
A |
2: 27,087,540 (GRCm39) |
|
probably null |
Het |
| Serpina3b |
A |
T |
12: 104,097,356 (GRCm39) |
K212N |
possibly damaging |
Het |
| Sh3bp2 |
A |
G |
5: 34,716,971 (GRCm39) |
N461D |
probably benign |
Het |
| Shisa2 |
A |
T |
14: 59,867,357 (GRCm39) |
Q203L |
probably damaging |
Het |
| Shmt1 |
C |
A |
11: 60,688,383 (GRCm39) |
G255V |
probably damaging |
Het |
| Socs1 |
T |
A |
16: 10,602,357 (GRCm39) |
I127F |
possibly damaging |
Het |
| Srcap |
A |
T |
7: 127,137,922 (GRCm39) |
T1091S |
probably benign |
Het |
| Syt14 |
A |
G |
1: 192,613,003 (GRCm39) |
I599T |
probably damaging |
Het |
| Tep1 |
A |
T |
14: 51,084,457 (GRCm39) |
N907K |
probably benign |
Het |
| Themis2 |
A |
G |
4: 132,513,291 (GRCm39) |
Y312H |
probably benign |
Het |
| Tubgcp5 |
T |
G |
7: 55,473,357 (GRCm39) |
S812A |
probably benign |
Het |
| Ush2a |
A |
T |
1: 188,582,237 (GRCm39) |
I3767F |
probably damaging |
Het |
| Usp40 |
T |
A |
1: 87,907,738 (GRCm39) |
E626V |
probably damaging |
Het |
| Utrn |
T |
C |
10: 12,566,620 (GRCm39) |
R1181G |
probably benign |
Het |
| Vmn2r117 |
T |
A |
17: 23,698,535 (GRCm39) |
I13F |
probably damaging |
Het |
| Wdr48 |
G |
T |
9: 119,753,775 (GRCm39) |
V646F |
probably damaging |
Het |
| Wdr64 |
T |
C |
1: 175,633,556 (GRCm39) |
F936L |
possibly damaging |
Het |
|
| Other mutations in Arhgap21 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01382:Arhgap21
|
APN |
2 |
20,860,511 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01472:Arhgap21
|
APN |
2 |
20,854,392 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01634:Arhgap21
|
APN |
2 |
20,919,455 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01766:Arhgap21
|
APN |
2 |
20,854,448 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL02097:Arhgap21
|
APN |
2 |
20,884,813 (GRCm39) |
missense |
probably benign |
0.39 |
|
IGL02197:Arhgap21
|
APN |
2 |
20,885,117 (GRCm39) |
missense |
probably benign |
|
|
IGL02264:Arhgap21
|
APN |
2 |
20,864,850 (GRCm39) |
splice site |
probably null |
|
|
IGL02346:Arhgap21
|
APN |
2 |
20,884,762 (GRCm39) |
splice site |
probably benign |
|
|
IGL02418:Arhgap21
|
APN |
2 |
20,885,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02605:Arhgap21
|
APN |
2 |
20,860,399 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02701:Arhgap21
|
APN |
2 |
20,896,902 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03019:Arhgap21
|
APN |
2 |
20,865,874 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03085:Arhgap21
|
APN |
2 |
20,919,532 (GRCm39) |
missense |
probably benign |
|
|
IGL03265:Arhgap21
|
APN |
2 |
20,854,439 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL03379:Arhgap21
|
APN |
2 |
20,885,500 (GRCm39) |
missense |
probably benign |
0.41 |
|
R0304:Arhgap21
|
UTSW |
2 |
20,864,612 (GRCm39) |
splice site |
probably benign |
|
|
R0363:Arhgap21
|
UTSW |
2 |
20,885,944 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0498:Arhgap21
|
UTSW |
2 |
20,867,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0539:Arhgap21
|
UTSW |
2 |
20,919,610 (GRCm39) |
nonsense |
probably null |
|
|
R0633:Arhgap21
|
UTSW |
2 |
20,860,198 (GRCm39) |
nonsense |
probably null |
|
|
R0905:Arhgap21
|
UTSW |
2 |
20,854,745 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R1550:Arhgap21
|
UTSW |
2 |
20,886,576 (GRCm39) |
nonsense |
probably null |
|
|
R1570:Arhgap21
|
UTSW |
2 |
20,885,651 (GRCm39) |
missense |
probably benign |
|
|
R1686:Arhgap21
|
UTSW |
2 |
20,886,659 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1746:Arhgap21
|
UTSW |
2 |
20,865,910 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1864:Arhgap21
|
UTSW |
2 |
20,866,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1865:Arhgap21
|
UTSW |
2 |
20,866,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2209:Arhgap21
|
UTSW |
2 |
20,854,331 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2211:Arhgap21
|
UTSW |
2 |
20,886,451 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R2276:Arhgap21
|
UTSW |
2 |
20,868,037 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2277:Arhgap21
|
UTSW |
2 |
20,868,037 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2279:Arhgap21
|
UTSW |
2 |
20,868,037 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2336:Arhgap21
|
UTSW |
2 |
20,884,862 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2516:Arhgap21
|
UTSW |
2 |
20,859,809 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3722:Arhgap21
|
UTSW |
2 |
20,855,102 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3877:Arhgap21
|
UTSW |
2 |
20,864,717 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4017:Arhgap21
|
UTSW |
2 |
20,896,915 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4232:Arhgap21
|
UTSW |
2 |
20,891,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4233:Arhgap21
|
UTSW |
2 |
20,891,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4234:Arhgap21
|
UTSW |
2 |
20,891,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4235:Arhgap21
|
UTSW |
2 |
20,891,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4236:Arhgap21
|
UTSW |
2 |
20,891,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4434:Arhgap21
|
UTSW |
2 |
20,972,146 (GRCm39) |
missense |
probably benign |
|
|
R4686:Arhgap21
|
UTSW |
2 |
20,868,033 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4817:Arhgap21
|
UTSW |
2 |
20,854,967 (GRCm39) |
missense |
probably benign |
|
|
R4834:Arhgap21
|
UTSW |
2 |
20,870,130 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4845:Arhgap21
|
UTSW |
2 |
20,885,998 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4889:Arhgap21
|
UTSW |
2 |
20,885,279 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4904:Arhgap21
|
UTSW |
2 |
20,854,872 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4911:Arhgap21
|
UTSW |
2 |
20,863,800 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4994:Arhgap21
|
UTSW |
2 |
20,854,701 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5067:Arhgap21
|
UTSW |
2 |
20,884,848 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5086:Arhgap21
|
UTSW |
2 |
20,853,645 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5281:Arhgap21
|
UTSW |
2 |
20,854,127 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5364:Arhgap21
|
UTSW |
2 |
20,854,533 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5420:Arhgap21
|
UTSW |
2 |
20,885,897 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5476:Arhgap21
|
UTSW |
2 |
20,885,497 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5831:Arhgap21
|
UTSW |
2 |
20,868,024 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5949:Arhgap21
|
UTSW |
2 |
20,853,852 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5994:Arhgap21
|
UTSW |
2 |
20,886,187 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R6739:Arhgap21
|
UTSW |
2 |
20,885,543 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6817:Arhgap21
|
UTSW |
2 |
20,885,107 (GRCm39) |
missense |
probably benign |
0.23 |
|
R6821:Arhgap21
|
UTSW |
2 |
20,853,659 (GRCm39) |
missense |
probably benign |
|
|
R6844:Arhgap21
|
UTSW |
2 |
20,886,116 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6870:Arhgap21
|
UTSW |
2 |
20,885,321 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6891:Arhgap21
|
UTSW |
2 |
20,855,142 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7011:Arhgap21
|
UTSW |
2 |
20,853,689 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R7144:Arhgap21
|
UTSW |
2 |
20,870,198 (GRCm39) |
missense |
probably benign |
|
|
R7237:Arhgap21
|
UTSW |
2 |
20,854,783 (GRCm39) |
nonsense |
probably null |
|
|
R7261:Arhgap21
|
UTSW |
2 |
20,885,177 (GRCm39) |
missense |
probably benign |
|
|
R7558:Arhgap21
|
UTSW |
2 |
20,860,421 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7566:Arhgap21
|
UTSW |
2 |
20,917,102 (GRCm39) |
missense |
probably benign |
0.17 |
|
R7738:Arhgap21
|
UTSW |
2 |
20,855,169 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7738:Arhgap21
|
UTSW |
2 |
20,854,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7820:Arhgap21
|
UTSW |
2 |
20,867,983 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7822:Arhgap21
|
UTSW |
2 |
20,885,524 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R7965:Arhgap21
|
UTSW |
2 |
20,854,007 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7986:Arhgap21
|
UTSW |
2 |
20,867,967 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8028:Arhgap21
|
UTSW |
2 |
20,885,216 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8209:Arhgap21
|
UTSW |
2 |
20,876,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8226:Arhgap21
|
UTSW |
2 |
20,876,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8251:Arhgap21
|
UTSW |
2 |
20,854,221 (GRCm39) |
missense |
probably benign |
|
|
R8486:Arhgap21
|
UTSW |
2 |
20,865,236 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8487:Arhgap21
|
UTSW |
2 |
20,886,116 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8508:Arhgap21
|
UTSW |
2 |
20,858,991 (GRCm39) |
missense |
probably benign |
0.17 |
|
R8835:Arhgap21
|
UTSW |
2 |
20,972,144 (GRCm39) |
nonsense |
probably null |
|
|
R9140:Arhgap21
|
UTSW |
2 |
20,886,025 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9190:Arhgap21
|
UTSW |
2 |
20,858,983 (GRCm39) |
missense |
probably null |
0.04 |
|
R9204:Arhgap21
|
UTSW |
2 |
20,885,816 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9227:Arhgap21
|
UTSW |
2 |
20,860,469 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9230:Arhgap21
|
UTSW |
2 |
20,860,469 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9308:Arhgap21
|
UTSW |
2 |
20,854,061 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9374:Arhgap21
|
UTSW |
2 |
20,886,397 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9449:Arhgap21
|
UTSW |
2 |
20,885,464 (GRCm39) |
missense |
probably benign |
|
|
R9454:Arhgap21
|
UTSW |
2 |
20,870,153 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9499:Arhgap21
|
UTSW |
2 |
20,886,397 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9544:Arhgap21
|
UTSW |
2 |
20,858,938 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R9552:Arhgap21
|
UTSW |
2 |
20,886,397 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9567:Arhgap21
|
UTSW |
2 |
20,896,953 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9588:Arhgap21
|
UTSW |
2 |
20,858,938 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R9749:Arhgap21
|
UTSW |
2 |
20,854,026 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1191:Arhgap21
|
UTSW |
2 |
20,886,283 (GRCm39) |
missense |
probably benign |
0.30 |
|
| Predicted Primers |
PCR Primer
(F):5'- CAATGACGGTCCTCACACTC -3'
(R):5'- AAGAATGTACCCTGTGCTGTG -3'
Sequencing Primer
(F):5'- ACGGAGGCACTTGTATTTCC -3'
(R):5'- GTTTTGCATGCGCGCCAC -3'
|
| Posted On |
2017-06-26 |
Incidental Mutation