Incidental Mutation 'R6026:Clasp2'
ID 480051
Institutional Source Beutler Lab
Gene Symbol Clasp2
Ensembl Gene ENSMUSG00000033392
Gene Name CLIP associating protein 2
Synonyms CLASP2alpha, 1500004F14Rik, CLASP2gamma, CLASP2, CLASP2beta, 8030404L10Rik
MMRRC Submission 044198-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6026 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 113570541-113748750 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 113740646 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Aspartic acid at position 1208 (N1208D)
Ref Sequence ENSEMBL: ENSMUSP00000130201 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000111838] [ENSMUST00000163895] [ENSMUST00000166734] [ENSMUST00000213663] [ENSMUST00000214522] [ENSMUST00000215022]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000111838
AA Change: N1207D

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000107469
Gene: ENSMUSG00000033392
AA Change: N1207D

DomainStartEndE-ValueType
TOG 90 323 1.17e-8 SMART
low complexity region 382 395 N/A INTRINSIC
low complexity region 459 472 N/A INTRINSIC
low complexity region 473 484 N/A INTRINSIC
low complexity region 562 572 N/A INTRINSIC
low complexity region 614 634 N/A INTRINSIC
TOG 640 877 2.03e-1 SMART
low complexity region 995 1009 N/A INTRINSIC
TOG 1043 1274 1.49e-24 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000163895
AA Change: N1228D

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000128460
Gene: ENSMUSG00000033392
AA Change: N1228D

DomainStartEndE-ValueType
TOG 90 323 1.17e-8 SMART
low complexity region 382 395 N/A INTRINSIC
low complexity region 459 472 N/A INTRINSIC
low complexity region 473 484 N/A INTRINSIC
low complexity region 583 593 N/A INTRINSIC
low complexity region 635 655 N/A INTRINSIC
TOG 661 898 2.03e-1 SMART
low complexity region 1016 1030 N/A INTRINSIC
TOG 1064 1295 1.49e-24 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000166734
AA Change: N1208D

PolyPhen 2 Score 0.130 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000130201
Gene: ENSMUSG00000033392
AA Change: N1208D

DomainStartEndE-ValueType
TOG 90 323 1.17e-8 SMART
low complexity region 382 395 N/A INTRINSIC
low complexity region 459 472 N/A INTRINSIC
low complexity region 473 484 N/A INTRINSIC
low complexity region 562 572 N/A INTRINSIC
low complexity region 614 634 N/A INTRINSIC
TOG 640 878 7.51e-1 SMART
low complexity region 996 1010 N/A INTRINSIC
TOG 1044 1275 1.49e-24 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000213663
AA Change: N521D

PolyPhen 2 Score 0.025 (Sensitivity: 0.95; Specificity: 0.81)
Predicted Effect probably benign
Transcript: ENSMUST00000214522
AA Change: N1225D

PolyPhen 2 Score 0.127 (Sensitivity: 0.93; Specificity: 0.86)
Predicted Effect probably benign
Transcript: ENSMUST00000215022
Meta Mutation Damage Score 0.1055 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.9%
  • 20x: 93.5%
Validation Efficiency 97% (73/75)
MGI Phenotype PHENOTYPE: Targeted deletion of this gene leads to impaired formation of stable microtubules in a wound healing assay, and results in a 2-fold reduction of directionally persistent migration in mutant embryonic fibroblasts. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 74 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1810065E05Rik A G 11: 58,316,581 (GRCm39) D187G probably benign Het
4933421I07Rik A T 7: 42,095,708 (GRCm39) M180K probably benign Het
Aatk T C 11: 119,903,190 (GRCm39) H345R possibly damaging Het
Abcc8 T C 7: 45,816,424 (GRCm39) T239A probably benign Het
Abcf3 A G 16: 20,369,320 (GRCm39) E234G probably damaging Het
Actrt2 T C 4: 154,751,047 (GRCm39) D363G possibly damaging Het
Adam1a A T 5: 121,657,425 (GRCm39) C623S probably damaging Het
Afg3l2 G T 18: 67,554,329 (GRCm39) L458M probably damaging Het
Ash1l T C 3: 88,892,326 (GRCm39) Y1402H probably damaging Het
Barhl2 T A 5: 106,603,474 (GRCm39) K228N probably benign Het
Blvrb A G 7: 27,162,115 (GRCm39) H153R probably damaging Het
Capn9 A G 8: 125,332,601 (GRCm39) D480G probably damaging Het
Cct3 T C 3: 88,219,029 (GRCm39) I182T possibly damaging Het
Col26a1 A G 5: 136,876,354 (GRCm39) C89R probably damaging Het
Cops4 T A 5: 100,690,194 (GRCm39) probably benign Het
Cpox T A 16: 58,491,298 (GRCm39) W170R probably damaging Het
Ddx27 A G 2: 166,875,560 (GRCm39) K656E probably benign Het
Eif4e T C 3: 138,256,661 (GRCm39) I66T probably damaging Het
Ercc3 T C 18: 32,378,974 (GRCm39) probably null Het
Esp38 G A 17: 40,266,032 (GRCm39) C47Y probably damaging Het
Fancd2 T C 6: 113,528,731 (GRCm39) V380A possibly damaging Het
Fbxw7 T A 3: 84,859,948 (GRCm39) probably null Het
Fryl T G 5: 73,257,340 (GRCm39) R736S probably benign Het
Gad2 G A 2: 22,513,748 (GRCm39) V62M probably benign Het
Gigyf2 A G 1: 87,368,454 (GRCm39) T1045A probably damaging Het
Gm13090 T A 4: 151,175,157 (GRCm39) L78* probably null Het
Gm19410 G A 8: 36,279,580 (GRCm39) S1815N probably benign Het
Gm28051 A T 12: 102,686,444 (GRCm39) L72Q unknown Het
Gm44511 T C 6: 128,797,240 (GRCm39) T83A possibly damaging Het
Grk2 C T 19: 4,340,811 (GRCm39) V246I probably damaging Het
Grm7 C T 6: 111,478,500 (GRCm39) Q62* probably null Het
Gsdmc3 T A 15: 63,738,600 (GRCm39) E154V probably damaging Het
Gstz1 A C 12: 87,206,948 (GRCm39) Q114P probably damaging Het
Hax1 GTCATCATCATCATCATC GTCATCATCATCATCATCATC 3: 89,905,247 (GRCm39) probably benign Het
Hhip A T 8: 80,699,069 (GRCm39) C666S probably damaging Het
Hif1a A C 12: 73,979,055 (GRCm39) H193P probably damaging Het
Hyal2 A G 9: 107,449,398 (GRCm39) T385A probably benign Het
Ihh T C 1: 74,985,886 (GRCm39) T200A probably benign Het
Iqgap3 T A 3: 87,997,478 (GRCm39) V218E probably damaging Het
Lct A G 1: 128,227,755 (GRCm39) I1246T probably benign Het
Lmo7 T C 14: 102,118,426 (GRCm39) V217A probably benign Het
Lrp1 C T 10: 127,409,272 (GRCm39) D1616N probably damaging Het
Lrrfip2 A T 9: 111,043,239 (GRCm39) T165S probably damaging Het
Morc2b A G 17: 33,356,957 (GRCm39) Y272H possibly damaging Het
Muc16 A G 9: 18,571,154 (GRCm39) M455T unknown Het
Ncapg2 A T 12: 116,406,641 (GRCm39) D939V possibly damaging Het
Ncbp3 T C 11: 72,958,548 (GRCm39) V236A probably benign Het
Obscn T A 11: 58,957,916 (GRCm39) T3595S probably damaging Het
Odf2l T C 3: 144,854,797 (GRCm39) S545P possibly damaging Het
Or3a1 T A 11: 74,225,914 (GRCm39) I48F probably damaging Het
Or8b36 ATTGCTGTTT ATTGCTGTTTGCTGTTT 9: 37,937,836 (GRCm39) probably null Het
Pdzrn3 A C 6: 101,339,105 (GRCm39) C269G probably benign Het
Pear1 T A 3: 87,664,220 (GRCm39) N278Y probably damaging Het
Phb1 C T 11: 95,562,245 (GRCm39) R41* probably null Het
Pikfyve T C 1: 65,311,856 (GRCm39) V2031A probably damaging Het
Plxna2 A G 1: 194,482,122 (GRCm39) I1465V probably damaging Het
Ppp6r2 A G 15: 89,167,113 (GRCm39) N776S probably benign Het
Prkce A T 17: 86,800,658 (GRCm39) E358V probably benign Het
Prl5a1 A T 13: 28,335,247 (GRCm39) I219F probably benign Het
Prss3 T C 6: 41,354,488 (GRCm39) probably null Het
Ptprc A T 1: 137,998,987 (GRCm39) M858K probably damaging Het
Retreg3 T C 11: 100,997,226 (GRCm39) T85A probably damaging Het
Rfc2 T A 5: 134,624,185 (GRCm39) C265S probably damaging Het
Smarcd1 G T 15: 99,603,619 (GRCm39) V256L probably damaging Het
Stat5a T C 11: 100,771,142 (GRCm39) F574L probably damaging Het
Tcirg1 T C 19: 3,947,487 (GRCm39) H624R probably benign Het
Tcstv1a C A 13: 120,355,987 (GRCm39) probably benign Het
Tenm2 C T 11: 35,963,556 (GRCm39) probably null Het
Tomm40 A G 7: 19,444,889 (GRCm39) V164A probably benign Het
Txnl4a T C 18: 80,250,482 (GRCm39) V26A probably damaging Het
Ugt2a3 A T 5: 87,484,336 (GRCm39) F229L probably benign Het
Utp20 T C 10: 88,604,541 (GRCm39) T1785A probably benign Het
Vmn1r22 T A 6: 57,877,390 (GRCm39) I196L probably benign Het
Zfp652 T G 11: 95,640,788 (GRCm39) C238G possibly damaging Het
Other mutations in Clasp2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00772:Clasp2 APN 9 113,735,060 (GRCm39) splice site probably benign
IGL00885:Clasp2 APN 9 113,740,484 (GRCm39) missense probably damaging 1.00
IGL01314:Clasp2 APN 9 113,735,195 (GRCm39) missense possibly damaging 0.89
IGL01344:Clasp2 APN 9 113,642,360 (GRCm39) splice site probably null
IGL01567:Clasp2 APN 9 113,709,164 (GRCm39) missense probably damaging 1.00
IGL02238:Clasp2 APN 9 113,709,088 (GRCm39) missense probably damaging 1.00
IGL02299:Clasp2 APN 9 113,709,057 (GRCm39) missense probably damaging 1.00
IGL02323:Clasp2 APN 9 113,697,794 (GRCm39) splice site probably benign
IGL02635:Clasp2 APN 9 113,737,910 (GRCm39) missense probably damaging 0.98
IGL02645:Clasp2 APN 9 113,719,129 (GRCm39) missense probably damaging 1.00
IGL02976:Clasp2 APN 9 113,735,204 (GRCm39) missense probably damaging 1.00
IGL03190:Clasp2 APN 9 113,673,208 (GRCm39) nonsense probably null
IGL03219:Clasp2 APN 9 113,677,545 (GRCm39) splice site probably benign
PIT4810001:Clasp2 UTSW 9 113,735,135 (GRCm39) missense probably damaging 1.00
R0067:Clasp2 UTSW 9 113,689,209 (GRCm39) splice site probably benign
R0067:Clasp2 UTSW 9 113,689,209 (GRCm39) splice site probably benign
R0421:Clasp2 UTSW 9 113,683,370 (GRCm39) missense probably benign 0.02
R0432:Clasp2 UTSW 9 113,738,487 (GRCm39) missense probably benign 0.00
R0458:Clasp2 UTSW 9 113,735,292 (GRCm39) splice site probably null
R0865:Clasp2 UTSW 9 113,740,568 (GRCm39) missense possibly damaging 0.57
R0972:Clasp2 UTSW 9 113,676,773 (GRCm39) missense possibly damaging 0.58
R1037:Clasp2 UTSW 9 113,725,702 (GRCm39) splice site probably benign
R1925:Clasp2 UTSW 9 113,735,265 (GRCm39) missense possibly damaging 0.88
R2015:Clasp2 UTSW 9 113,740,568 (GRCm39) missense possibly damaging 0.57
R2066:Clasp2 UTSW 9 113,735,225 (GRCm39) missense possibly damaging 0.86
R2330:Clasp2 UTSW 9 113,705,372 (GRCm39) missense probably damaging 1.00
R2568:Clasp2 UTSW 9 113,707,832 (GRCm39) missense probably benign
R3011:Clasp2 UTSW 9 113,730,581 (GRCm39) missense probably damaging 1.00
R3879:Clasp2 UTSW 9 113,719,029 (GRCm39) missense probably damaging 0.98
R3915:Clasp2 UTSW 9 113,737,805 (GRCm39) missense probably damaging 0.99
R3928:Clasp2 UTSW 9 113,735,173 (GRCm39) missense probably benign 0.28
R4323:Clasp2 UTSW 9 113,719,027 (GRCm39) missense possibly damaging 0.91
R4571:Clasp2 UTSW 9 113,676,789 (GRCm39) missense probably damaging 1.00
R4975:Clasp2 UTSW 9 113,732,984 (GRCm39) missense probably damaging 1.00
R5445:Clasp2 UTSW 9 113,733,014 (GRCm39) missense probably damaging 1.00
R5564:Clasp2 UTSW 9 113,641,836 (GRCm39) critical splice donor site probably null
R5697:Clasp2 UTSW 9 113,689,190 (GRCm39) missense probably benign 0.01
R5780:Clasp2 UTSW 9 113,679,220 (GRCm39) missense probably damaging 0.99
R5787:Clasp2 UTSW 9 113,691,310 (GRCm39) missense probably damaging 1.00
R6011:Clasp2 UTSW 9 113,705,315 (GRCm39) missense probably benign 0.07
R6090:Clasp2 UTSW 9 113,681,803 (GRCm39) missense probably benign 0.06
R6262:Clasp2 UTSW 9 113,705,420 (GRCm39) critical splice donor site probably null
R6427:Clasp2 UTSW 9 113,721,512 (GRCm39) missense probably damaging 1.00
R6464:Clasp2 UTSW 9 113,602,785 (GRCm39) missense probably damaging 1.00
R6586:Clasp2 UTSW 9 113,642,332 (GRCm39) missense probably damaging 1.00
R6628:Clasp2 UTSW 9 113,725,788 (GRCm39) missense probably damaging 1.00
R6745:Clasp2 UTSW 9 113,704,338 (GRCm39) nonsense probably null
R7032:Clasp2 UTSW 9 113,683,391 (GRCm39) missense probably benign 0.04
R7165:Clasp2 UTSW 9 113,615,467 (GRCm39) splice site probably null
R7221:Clasp2 UTSW 9 113,681,825 (GRCm39) missense probably damaging 0.99
R7336:Clasp2 UTSW 9 113,705,421 (GRCm39) splice site probably null
R7583:Clasp2 UTSW 9 113,737,755 (GRCm39) missense probably benign 0.02
R7774:Clasp2 UTSW 9 113,677,804 (GRCm39) splice site probably null
R7895:Clasp2 UTSW 9 113,733,016 (GRCm39) missense probably benign 0.03
R8084:Clasp2 UTSW 9 113,676,823 (GRCm39) missense probably benign 0.16
R8109:Clasp2 UTSW 9 113,740,588 (GRCm39) missense probably damaging 1.00
R8171:Clasp2 UTSW 9 113,732,974 (GRCm39) missense possibly damaging 0.88
R8230:Clasp2 UTSW 9 113,721,482 (GRCm39) missense possibly damaging 0.73
R8810:Clasp2 UTSW 9 113,728,649 (GRCm39) missense probably damaging 1.00
R8879:Clasp2 UTSW 9 113,602,773 (GRCm39) missense probably benign 0.39
R8888:Clasp2 UTSW 9 113,732,936 (GRCm39) missense possibly damaging 0.54
R8889:Clasp2 UTSW 9 113,709,251 (GRCm39) missense probably damaging 1.00
R8892:Clasp2 UTSW 9 113,709,251 (GRCm39) missense probably damaging 1.00
R8922:Clasp2 UTSW 9 113,725,728 (GRCm39) nonsense probably null
R9042:Clasp2 UTSW 9 113,735,065 (GRCm39) missense probably benign
R9195:Clasp2 UTSW 9 113,671,045 (GRCm39) missense probably benign 0.06
R9355:Clasp2 UTSW 9 113,664,309 (GRCm39) missense probably damaging 1.00
R9481:Clasp2 UTSW 9 113,670,669 (GRCm39) missense probably damaging 1.00
R9502:Clasp2 UTSW 9 113,737,866 (GRCm39) missense probably benign 0.01
R9523:Clasp2 UTSW 9 113,705,372 (GRCm39) missense probably damaging 0.98
R9525:Clasp2 UTSW 9 113,740,677 (GRCm39) missense probably damaging 1.00
R9653:Clasp2 UTSW 9 113,670,993 (GRCm39) missense probably benign 0.01
R9699:Clasp2 UTSW 9 113,738,614 (GRCm39) critical splice donor site probably null
R9738:Clasp2 UTSW 9 113,590,665 (GRCm39) nonsense probably null
R9775:Clasp2 UTSW 9 113,725,740 (GRCm39) missense probably benign
X0022:Clasp2 UTSW 9 113,681,740 (GRCm39) missense probably damaging 1.00
Z1177:Clasp2 UTSW 9 113,599,289 (GRCm39) missense probably damaging 1.00
Z1177:Clasp2 UTSW 9 113,737,863 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- AGGTGGTGAGATCTGCTGAG -3'
(R):5'- TCCTAAATGATAGAGTGAAAATCCGA -3'

Sequencing Primer
(F):5'- AGGAAGCTGCCTCCGTATTG -3'
(R):5'- CTGACCATCGACATTAGTGATGG -3'
Posted On 2017-06-26