Incidental Mutation 'R6029:Nckap5'
| ID |
480219 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nckap5
|
| Ensembl Gene |
ENSMUSG00000049690 |
| Gene Name |
NCK-associated protein 5 |
| Synonyms |
LOC380609, D130011D22Rik, E030049G20Rik |
| MMRRC Submission |
044201-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R6029 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
125841373-126758529 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 125953523 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Proline
at position 1078
(T1078P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000108202
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000057846]
[ENSMUST00000094609]
[ENSMUST00000094610]
[ENSMUST00000112583]
[ENSMUST00000161954]
[ENSMUST00000162877]
|
| AlphaFold |
E9QAE1 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000057846
AA Change: T946P
PolyPhen 2
Score 0.838 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000062229
Gene: ENSMUSG00000049690
AA Change: T946P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
25 |
N/A |
INTRINSIC |
|
coiled coil region
|
108 |
186 |
N/A |
INTRINSIC |
|
low complexity region
|
321 |
332 |
N/A |
INTRINSIC |
|
low complexity region
|
755 |
771 |
N/A |
INTRINSIC |
|
low complexity region
|
950 |
971 |
N/A |
INTRINSIC |
|
low complexity region
|
1070 |
1085 |
N/A |
INTRINSIC |
|
low complexity region
|
1181 |
1200 |
N/A |
INTRINSIC |
|
Pfam:NCKAP5
|
1298 |
1602 |
1.8e-120 |
PFAM |
|
low complexity region
|
1728 |
1742 |
N/A |
INTRINSIC |
|
low complexity region
|
1757 |
1771 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000094609
|
| SMART Domains |
Protein: ENSMUSP00000092192
Gene: ENSMUSG00000049690
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
70 |
93 |
N/A |
INTRINSIC |
|
Pfam:NCKAP5
|
113 |
364 |
3.6e-36 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000094610
|
| SMART Domains |
Protein: ENSMUSP00000092193
Gene: ENSMUSG00000049690
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:NCKAP5
|
1 |
101 |
8.8e-42 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000112583
AA Change: T1078P
PolyPhen 2
Score 0.890 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000108202
Gene: ENSMUSG00000049690
AA Change: T1078P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
70 |
93 |
N/A |
INTRINSIC |
|
coiled coil region
|
176 |
254 |
N/A |
INTRINSIC |
|
low complexity region
|
301 |
324 |
N/A |
INTRINSIC |
|
low complexity region
|
453 |
464 |
N/A |
INTRINSIC |
|
low complexity region
|
887 |
903 |
N/A |
INTRINSIC |
|
low complexity region
|
1082 |
1103 |
N/A |
INTRINSIC |
|
low complexity region
|
1202 |
1217 |
N/A |
INTRINSIC |
|
low complexity region
|
1313 |
1332 |
N/A |
INTRINSIC |
|
Pfam:NCKAP5
|
1431 |
1733 |
5.3e-119 |
PFAM |
|
low complexity region
|
1860 |
1874 |
N/A |
INTRINSIC |
|
low complexity region
|
1889 |
1903 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000159934
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000161954
AA Change: T1010P
PolyPhen 2
Score 0.864 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000125624
Gene: ENSMUSG00000049690
AA Change: T1010P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
25 |
N/A |
INTRINSIC |
|
coiled coil region
|
108 |
186 |
N/A |
INTRINSIC |
|
low complexity region
|
233 |
256 |
N/A |
INTRINSIC |
|
low complexity region
|
385 |
396 |
N/A |
INTRINSIC |
|
low complexity region
|
819 |
835 |
N/A |
INTRINSIC |
|
low complexity region
|
1014 |
1035 |
N/A |
INTRINSIC |
|
low complexity region
|
1134 |
1149 |
N/A |
INTRINSIC |
|
low complexity region
|
1245 |
1264 |
N/A |
INTRINSIC |
|
Pfam:NCKAP5
|
1362 |
1666 |
2.1e-120 |
PFAM |
|
low complexity region
|
1792 |
1806 |
N/A |
INTRINSIC |
|
low complexity region
|
1821 |
1835 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000162877
|
| SMART Domains |
Protein: ENSMUSP00000124748
Gene: ENSMUSG00000049690
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:NCKAP5
|
9 |
296 |
6e-36 |
PFAM |
|
| Meta Mutation Damage Score |
0.1795 |
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.5%
- 10x: 97.7%
- 20x: 92.7%
|
| Validation Efficiency |
97% (87/90) |
| Allele List at MGI |
All alleles(1) : Gene trapped(1) |
| Other mutations in this stock |
Total: 90 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4932414N04Rik |
G |
A |
2: 68,524,370 (GRCm39) |
|
probably null |
Het |
| Adi1 |
G |
A |
12: 28,729,318 (GRCm39) |
|
probably benign |
Het |
| Afg3l2 |
G |
T |
18: 67,554,329 (GRCm39) |
L458M |
probably damaging |
Het |
| Apob |
A |
G |
12: 8,066,243 (GRCm39) |
E4371G |
probably damaging |
Het |
| Ash1l |
T |
C |
3: 88,892,326 (GRCm39) |
Y1402H |
probably damaging |
Het |
| Aspm |
T |
G |
1: 139,408,728 (GRCm39) |
C2538W |
possibly damaging |
Het |
| Brd10 |
A |
G |
19: 29,732,367 (GRCm39) |
|
probably benign |
Het |
| Btbd16 |
T |
C |
7: 130,420,802 (GRCm39) |
V353A |
probably benign |
Het |
| Cad |
C |
T |
5: 31,212,327 (GRCm39) |
S10L |
possibly damaging |
Het |
| Cdc42bpa |
T |
C |
1: 179,939,352 (GRCm39) |
S877P |
probably damaging |
Het |
| Cep152 |
A |
T |
2: 125,405,552 (GRCm39) |
V1660D |
probably benign |
Het |
| Clrn2 |
G |
T |
5: 45,617,528 (GRCm39) |
G133V |
probably damaging |
Het |
| Clstn2 |
T |
C |
9: 97,338,634 (GRCm39) |
I842V |
probably benign |
Het |
| Cpt1c |
C |
T |
7: 44,614,548 (GRCm39) |
A434T |
probably benign |
Het |
| D130052B06Rik |
G |
T |
11: 33,573,477 (GRCm39) |
V70L |
possibly damaging |
Het |
| Dlg1 |
T |
A |
16: 31,612,388 (GRCm39) |
V317E |
probably damaging |
Het |
| Dock10 |
T |
C |
1: 80,514,663 (GRCm39) |
E1084G |
possibly damaging |
Het |
| Dync2h1 |
A |
G |
9: 7,157,646 (GRCm39) |
V827A |
probably benign |
Het |
| E030030I06Rik |
A |
G |
10: 22,024,832 (GRCm39) |
L27P |
unknown |
Het |
| Ero1b |
T |
A |
13: 12,589,714 (GRCm39) |
L39Q |
probably damaging |
Het |
| Erp27 |
T |
C |
6: 136,888,609 (GRCm39) |
D123G |
probably damaging |
Het |
| Fasn |
G |
T |
11: 120,711,735 (GRCm39) |
F148L |
probably damaging |
Het |
| Fbxl5 |
T |
C |
5: 43,922,746 (GRCm39) |
E218G |
probably damaging |
Het |
| Fbxw28 |
A |
T |
9: 109,158,493 (GRCm39) |
D210E |
probably damaging |
Het |
| Gm10653 |
T |
A |
9: 62,748,796 (GRCm39) |
|
probably benign |
Het |
| Gm17067 |
A |
G |
7: 42,357,554 (GRCm39) |
L316S |
probably benign |
Het |
| Gm29106 |
T |
C |
1: 118,127,990 (GRCm39) |
S561P |
probably damaging |
Het |
| Hmcn1 |
C |
A |
1: 150,508,188 (GRCm39) |
K3699N |
probably benign |
Het |
| Itch |
T |
A |
2: 155,021,009 (GRCm39) |
|
probably null |
Het |
| Itpr3 |
C |
T |
17: 27,317,145 (GRCm39) |
A800V |
probably damaging |
Het |
| Kdm2b |
A |
T |
5: 123,017,650 (GRCm39) |
M1052K |
probably damaging |
Het |
| Kdm4b |
T |
C |
17: 56,703,576 (GRCm39) |
M712T |
probably damaging |
Het |
| Kmt5b |
A |
G |
19: 3,852,104 (GRCm39) |
E137G |
probably damaging |
Het |
| Krt33a |
G |
A |
11: 99,903,289 (GRCm39) |
T251I |
probably benign |
Het |
| Lrrc4b |
G |
T |
7: 44,111,754 (GRCm39) |
R542L |
probably benign |
Het |
| Macf1 |
C |
A |
4: 123,401,126 (GRCm39) |
S653I |
probably damaging |
Het |
| Macrod2 |
G |
A |
2: 142,160,367 (GRCm39) |
V408M |
probably damaging |
Het |
| Macroh2a2 |
T |
C |
10: 61,583,541 (GRCm39) |
T200A |
possibly damaging |
Het |
| Mapkapk3 |
G |
T |
9: 107,166,425 (GRCm39) |
A40E |
possibly damaging |
Het |
| Mmp20 |
G |
A |
9: 7,639,302 (GRCm39) |
V157I |
probably benign |
Het |
| Mrps28 |
T |
C |
3: 8,988,805 (GRCm39) |
R18G |
possibly damaging |
Het |
| Msrb2 |
T |
A |
2: 19,399,122 (GRCm39) |
C162S |
probably damaging |
Het |
| Naa80 |
A |
G |
9: 107,460,753 (GRCm39) |
Y216C |
probably damaging |
Het |
| Nectin3 |
T |
C |
16: 46,256,763 (GRCm39) |
Y91C |
probably benign |
Het |
| Nf2 |
G |
T |
11: 4,734,566 (GRCm39) |
|
probably null |
Het |
| Or10d1b |
G |
A |
9: 39,613,696 (GRCm39) |
A123V |
probably damaging |
Het |
| Or13a23-ps1 |
A |
T |
7: 140,118,789 (GRCm39) |
M120L |
unknown |
Het |
| Or1e16 |
AGCGGTCGTAGGC |
AGC |
11: 73,286,480 (GRCm39) |
|
probably null |
Het |
| Or2y10 |
A |
T |
11: 49,455,428 (GRCm39) |
I227F |
possibly damaging |
Het |
| Or4c29 |
T |
C |
2: 88,740,380 (GRCm39) |
D119G |
probably damaging |
Het |
| Or4g7 |
T |
A |
2: 111,309,310 (GRCm39) |
Y60* |
probably null |
Het |
| Or8b36 |
ATTGCTGTTT |
ATTGCTGTTTGCTGTTT |
9: 37,937,836 (GRCm39) |
|
probably null |
Het |
| Oxr1 |
T |
G |
15: 41,689,297 (GRCm39) |
L507W |
probably damaging |
Het |
| Plxna2 |
A |
T |
1: 194,481,883 (GRCm39) |
K1451M |
probably damaging |
Het |
| Plxna2 |
A |
G |
1: 194,476,735 (GRCm39) |
M1184V |
probably benign |
Het |
| Pofut1 |
G |
A |
2: 153,101,713 (GRCm39) |
|
probably null |
Het |
| Ppp1r16b |
T |
C |
2: 158,597,137 (GRCm39) |
V257A |
possibly damaging |
Het |
| Prss56 |
G |
A |
1: 87,115,279 (GRCm39) |
W498* |
probably null |
Het |
| Ptpru |
A |
G |
4: 131,498,604 (GRCm39) |
F1329S |
probably damaging |
Het |
| Pusl1 |
A |
G |
4: 155,973,920 (GRCm39) |
F278S |
probably damaging |
Het |
| Qars1 |
A |
T |
9: 108,390,889 (GRCm39) |
L470F |
probably damaging |
Het |
| Rbm8a2 |
T |
C |
1: 175,806,312 (GRCm39) |
D55G |
probably benign |
Het |
| Rora |
T |
A |
9: 69,271,734 (GRCm39) |
N181K |
probably benign |
Het |
| Rufy3 |
A |
G |
5: 88,775,114 (GRCm39) |
D262G |
probably damaging |
Het |
| Sh3gl2 |
G |
A |
4: 85,299,651 (GRCm39) |
V212M |
probably damaging |
Het |
| Sis |
G |
A |
3: 72,835,641 (GRCm39) |
T907I |
probably benign |
Het |
| Slc38a3 |
A |
T |
9: 107,529,374 (GRCm39) |
I456N |
probably damaging |
Het |
| Slc4a8 |
T |
A |
15: 100,705,220 (GRCm39) |
C809S |
probably benign |
Het |
| Snap91 |
A |
T |
9: 86,707,133 (GRCm39) |
|
probably null |
Het |
| Spaca6 |
A |
G |
17: 18,051,458 (GRCm39) |
T45A |
probably benign |
Het |
| Speer1m |
A |
T |
5: 11,970,680 (GRCm39) |
L84F |
probably damaging |
Het |
| Spry1 |
T |
C |
3: 37,696,997 (GRCm39) |
I80T |
possibly damaging |
Het |
| St8sia2 |
A |
G |
7: 73,610,458 (GRCm39) |
L275P |
possibly damaging |
Het |
| Supt7l |
C |
A |
5: 31,684,331 (GRCm39) |
|
probably null |
Het |
| Tdo2 |
T |
A |
3: 81,868,747 (GRCm39) |
K304N |
probably damaging |
Het |
| Tdrd12 |
A |
T |
7: 35,184,655 (GRCm39) |
Y753N |
probably damaging |
Het |
| Topbp1 |
A |
T |
9: 103,222,152 (GRCm39) |
Q1341L |
probably benign |
Het |
| Trim14 |
G |
T |
4: 46,506,998 (GRCm39) |
A406E |
probably benign |
Het |
| Trp63 |
C |
T |
16: 25,686,964 (GRCm39) |
R393W |
probably damaging |
Het |
| Trrap |
T |
C |
5: 144,754,489 (GRCm39) |
V1932A |
possibly damaging |
Het |
| Trrap |
T |
C |
5: 144,762,724 (GRCm39) |
M2399T |
possibly damaging |
Het |
| Unc45b |
A |
G |
11: 82,804,153 (GRCm39) |
N110S |
probably damaging |
Het |
| Usp32 |
G |
T |
11: 84,916,408 (GRCm39) |
H845Q |
probably damaging |
Het |
| Usp44 |
G |
A |
10: 93,682,494 (GRCm39) |
D268N |
probably damaging |
Het |
| Vmn1r18 |
T |
G |
6: 57,367,451 (GRCm39) |
R34S |
possibly damaging |
Het |
| Vmn2r103 |
T |
A |
17: 20,014,478 (GRCm39) |
Y423* |
probably null |
Het |
| Wapl |
A |
T |
14: 34,461,204 (GRCm39) |
E1054V |
possibly damaging |
Het |
| Zbtb8b |
A |
G |
4: 129,322,286 (GRCm39) |
Y392H |
probably damaging |
Het |
| Zdhhc2 |
A |
T |
8: 40,925,968 (GRCm39) |
Q321L |
probably null |
Het |
| Zfp983 |
A |
G |
17: 21,881,401 (GRCm39) |
D443G |
probably benign |
Het |
|
| Other mutations in Nckap5 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00833:Nckap5
|
APN |
1 |
125,954,889 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00956:Nckap5
|
APN |
1 |
125,952,755 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01414:Nckap5
|
APN |
1 |
126,456,450 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01482:Nckap5
|
APN |
1 |
125,950,897 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01508:Nckap5
|
APN |
1 |
125,953,309 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02071:Nckap5
|
APN |
1 |
125,909,305 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02129:Nckap5
|
APN |
1 |
125,955,432 (GRCm39) |
nonsense |
probably null |
|
|
IGL02821:Nckap5
|
APN |
1 |
125,955,553 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03174:Nckap5
|
APN |
1 |
125,909,383 (GRCm39) |
missense |
probably damaging |
1.00 |
|
F5493:Nckap5
|
UTSW |
1 |
125,953,564 (GRCm39) |
missense |
probably benign |
|
|
G5030:Nckap5
|
UTSW |
1 |
125,953,591 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0033:Nckap5
|
UTSW |
1 |
125,867,979 (GRCm39) |
intron |
probably benign |
|
|
R0164:Nckap5
|
UTSW |
1 |
125,952,144 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R0164:Nckap5
|
UTSW |
1 |
125,952,144 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R0349:Nckap5
|
UTSW |
1 |
125,954,171 (GRCm39) |
missense |
probably benign |
|
|
R0482:Nckap5
|
UTSW |
1 |
125,954,102 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0508:Nckap5
|
UTSW |
1 |
125,909,121 (GRCm39) |
splice site |
probably null |
|
|
R0541:Nckap5
|
UTSW |
1 |
126,623,459 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R0609:Nckap5
|
UTSW |
1 |
125,955,025 (GRCm39) |
nonsense |
probably null |
|
|
R0701:Nckap5
|
UTSW |
1 |
125,953,094 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0782:Nckap5
|
UTSW |
1 |
125,909,278 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1389:Nckap5
|
UTSW |
1 |
125,954,447 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1401:Nckap5
|
UTSW |
1 |
125,942,398 (GRCm39) |
splice site |
probably benign |
|
|
R1436:Nckap5
|
UTSW |
1 |
125,953,798 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R1506:Nckap5
|
UTSW |
1 |
125,953,650 (GRCm39) |
nonsense |
probably null |
|
|
R1528:Nckap5
|
UTSW |
1 |
125,952,659 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1942:Nckap5
|
UTSW |
1 |
125,952,039 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1968:Nckap5
|
UTSW |
1 |
125,942,367 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2055:Nckap5
|
UTSW |
1 |
125,954,635 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2105:Nckap5
|
UTSW |
1 |
125,954,255 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2214:Nckap5
|
UTSW |
1 |
125,953,487 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R2311:Nckap5
|
UTSW |
1 |
126,456,489 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2403:Nckap5
|
UTSW |
1 |
125,955,146 (GRCm39) |
missense |
probably benign |
0.18 |
|
R2430:Nckap5
|
UTSW |
1 |
125,842,494 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2914:Nckap5
|
UTSW |
1 |
125,954,274 (GRCm39) |
splice site |
probably null |
|
|
R3782:Nckap5
|
UTSW |
1 |
125,952,811 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4133:Nckap5
|
UTSW |
1 |
126,150,443 (GRCm39) |
missense |
probably benign |
0.13 |
|
R4249:Nckap5
|
UTSW |
1 |
125,955,376 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4448:Nckap5
|
UTSW |
1 |
125,953,463 (GRCm39) |
nonsense |
probably null |
|
|
R4456:Nckap5
|
UTSW |
1 |
125,842,472 (GRCm39) |
unclassified |
probably benign |
|
|
R4682:Nckap5
|
UTSW |
1 |
126,030,279 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4817:Nckap5
|
UTSW |
1 |
125,954,952 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R4907:Nckap5
|
UTSW |
1 |
125,953,889 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4908:Nckap5
|
UTSW |
1 |
125,955,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4924:Nckap5
|
UTSW |
1 |
125,954,765 (GRCm39) |
nonsense |
probably null |
|
|
R4926:Nckap5
|
UTSW |
1 |
126,456,378 (GRCm39) |
intron |
probably benign |
|
|
R5032:Nckap5
|
UTSW |
1 |
125,904,786 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R5133:Nckap5
|
UTSW |
1 |
125,961,697 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5197:Nckap5
|
UTSW |
1 |
126,150,410 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R5238:Nckap5
|
UTSW |
1 |
125,955,461 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5257:Nckap5
|
UTSW |
1 |
125,952,245 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5277:Nckap5
|
UTSW |
1 |
125,954,277 (GRCm39) |
nonsense |
probably null |
|
|
R5512:Nckap5
|
UTSW |
1 |
125,955,481 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R5700:Nckap5
|
UTSW |
1 |
125,904,662 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5789:Nckap5
|
UTSW |
1 |
125,955,439 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6249:Nckap5
|
UTSW |
1 |
125,952,667 (GRCm39) |
missense |
probably benign |
|
|
R6292:Nckap5
|
UTSW |
1 |
125,842,752 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6521:Nckap5
|
UTSW |
1 |
126,309,909 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6875:Nckap5
|
UTSW |
1 |
125,950,931 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7017:Nckap5
|
UTSW |
1 |
126,030,398 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7018:Nckap5
|
UTSW |
1 |
125,952,785 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7054:Nckap5
|
UTSW |
1 |
126,186,449 (GRCm39) |
splice site |
probably null |
|
|
R7204:Nckap5
|
UTSW |
1 |
125,954,104 (GRCm39) |
missense |
probably benign |
|
|
R7336:Nckap5
|
UTSW |
1 |
125,953,786 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7544:Nckap5
|
UTSW |
1 |
125,953,948 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7590:Nckap5
|
UTSW |
1 |
125,954,270 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7684:Nckap5
|
UTSW |
1 |
125,954,594 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7749:Nckap5
|
UTSW |
1 |
125,952,383 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7773:Nckap5
|
UTSW |
1 |
125,954,581 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7813:Nckap5
|
UTSW |
1 |
125,953,163 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7970:Nckap5
|
UTSW |
1 |
125,952,758 (GRCm39) |
nonsense |
probably null |
|
|
R7992:Nckap5
|
UTSW |
1 |
125,954,547 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8278:Nckap5
|
UTSW |
1 |
125,955,509 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8373:Nckap5
|
UTSW |
1 |
125,954,032 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8414:Nckap5
|
UTSW |
1 |
125,942,357 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8755:Nckap5
|
UTSW |
1 |
125,954,279 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8845:Nckap5
|
UTSW |
1 |
125,909,423 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R9016:Nckap5
|
UTSW |
1 |
126,623,491 (GRCm39) |
start codon destroyed |
probably null |
0.01 |
|
R9209:Nckap5
|
UTSW |
1 |
125,867,928 (GRCm39) |
missense |
unknown |
|
|
R9214:Nckap5
|
UTSW |
1 |
125,942,376 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9300:Nckap5
|
UTSW |
1 |
125,909,423 (GRCm39) |
nonsense |
probably null |
|
|
R9464:Nckap5
|
UTSW |
1 |
125,952,494 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9572:Nckap5
|
UTSW |
1 |
125,955,454 (GRCm39) |
missense |
probably benign |
0.41 |
|
R9721:Nckap5
|
UTSW |
1 |
125,955,017 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9748:Nckap5
|
UTSW |
1 |
125,953,939 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Nckap5
|
UTSW |
1 |
125,952,569 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
Z1176:Nckap5
|
UTSW |
1 |
126,456,418 (GRCm39) |
critical splice donor site |
probably null |
|
|
Z1177:Nckap5
|
UTSW |
1 |
126,150,396 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GCTACACAGCTTCGAGATGC -3'
(R):5'- TCACCATGCACTAGGAACTGC -3'
Sequencing Primer
(F):5'- CAGCTTCGAGATGCTTCATTTAAAC -3'
(R):5'- CTAGGAACTGCCCACATGG -3'
|
| Posted On |
2017-06-26 |
Incidental Mutation