Incidental Mutation 'R6001:Tas2r124'
ID |
480826 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Tas2r124
|
Ensembl Gene |
ENSMUSG00000060412 |
Gene Name |
taste receptor, type 2, member 124 |
Synonyms |
mt2r50, mGR24, Tas2r24, T2R24 |
MMRRC Submission |
044180-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.056)
|
Stock # |
R6001 (G1)
|
Quality Score |
225.009 |
Status
|
Not validated
|
Chromosome |
6 |
Chromosomal Location |
132731693-132732622 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 132732416 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Tyrosine to Asparagine
at position 242
(Y242N)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000075509
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000076150]
|
AlphaFold |
Q7M718 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000076150
AA Change: Y242N
PolyPhen 2
Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
|
SMART Domains |
Protein: ENSMUSP00000075509 Gene: ENSMUSG00000060412 AA Change: Y242N
Domain | Start | End | E-Value | Type |
Pfam:TAS2R
|
1 |
298 |
2.3e-92 |
PFAM |
|
Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.5%
- 10x: 97.4%
- 20x: 91.8%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 38 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abca1 |
G |
T |
4: 53,075,555 (GRCm39) |
R999S |
possibly damaging |
Het |
Ankrd31 |
T |
A |
13: 96,962,717 (GRCm39) |
Y503N |
probably damaging |
Het |
Anks4b |
A |
G |
7: 119,781,941 (GRCm39) |
E324G |
probably benign |
Het |
Arhgap44 |
CTGCT |
CTGCTTGCT |
11: 64,922,910 (GRCm39) |
|
probably null |
Het |
Atl1 |
A |
T |
12: 69,979,057 (GRCm39) |
T162S |
possibly damaging |
Het |
Atp2b2 |
A |
G |
6: 113,770,728 (GRCm39) |
Y394H |
probably damaging |
Het |
Dennd2d |
A |
G |
3: 106,399,776 (GRCm39) |
H233R |
probably benign |
Het |
Dhx16 |
G |
T |
17: 36,194,766 (GRCm39) |
M462I |
probably damaging |
Het |
Hif3a |
T |
C |
7: 16,784,486 (GRCm39) |
Y253C |
probably damaging |
Het |
Hsf4 |
G |
A |
8: 105,999,541 (GRCm39) |
G277R |
possibly damaging |
Het |
Impg1 |
T |
C |
9: 80,223,454 (GRCm39) |
D754G |
probably benign |
Het |
Keap1 |
T |
C |
9: 21,142,135 (GRCm39) |
S580G |
possibly damaging |
Het |
Lrp6 |
T |
C |
6: 134,441,481 (GRCm39) |
K1162E |
probably benign |
Het |
Lrrc31 |
C |
T |
3: 30,745,318 (GRCm39) |
V110I |
possibly damaging |
Het |
Muc5b |
G |
T |
7: 141,426,118 (GRCm39) |
K4738N |
possibly damaging |
Het |
Myo1a |
G |
T |
10: 127,542,794 (GRCm39) |
|
probably null |
Het |
Odad2 |
T |
C |
18: 7,286,838 (GRCm39) |
D131G |
probably benign |
Het |
Or10q1b |
A |
G |
19: 13,682,424 (GRCm39) |
T78A |
probably damaging |
Het |
Or52z14 |
T |
A |
7: 103,253,179 (GRCm39) |
M106K |
probably damaging |
Het |
Or7g19 |
A |
T |
9: 18,856,340 (GRCm39) |
Y132F |
probably damaging |
Het |
Parp4 |
A |
T |
14: 56,878,740 (GRCm39) |
H1225L |
probably benign |
Het |
Pcgf2 |
T |
C |
11: 97,583,606 (GRCm39) |
Y52C |
possibly damaging |
Het |
Pkn3 |
T |
C |
2: 29,978,596 (GRCm39) |
|
probably null |
Het |
Psen2 |
C |
A |
1: 180,073,234 (GRCm39) |
R29L |
possibly damaging |
Het |
Rfx6 |
A |
G |
10: 51,594,307 (GRCm39) |
|
probably null |
Het |
Rps13 |
T |
C |
7: 115,930,808 (GRCm39) |
T145A |
probably benign |
Het |
Rsf1 |
G |
A |
7: 97,229,117 (GRCm39) |
|
probably benign |
Het |
Rsf1 |
GCG |
GCGACG |
7: 97,229,114 (GRCm39) |
|
probably benign |
Het |
Rsf1 |
A |
ACGGCGACGG |
7: 97,229,111 (GRCm39) |
|
probably null |
Het |
Smarca4 |
C |
T |
9: 21,544,205 (GRCm39) |
|
probably benign |
Het |
Stat4 |
A |
T |
1: 52,136,026 (GRCm39) |
E445V |
probably damaging |
Het |
Taf13 |
T |
A |
3: 108,488,387 (GRCm39) |
I90N |
probably damaging |
Het |
Tmem151b |
T |
C |
17: 45,856,711 (GRCm39) |
Y243C |
probably damaging |
Het |
Wasl |
T |
C |
6: 24,619,573 (GRCm39) |
T316A |
unknown |
Het |
Zbtb44 |
T |
C |
9: 30,965,090 (GRCm39) |
C167R |
probably damaging |
Het |
Zc3h7b |
T |
C |
15: 81,676,236 (GRCm39) |
L714P |
possibly damaging |
Het |
Zfp35 |
T |
A |
18: 24,135,816 (GRCm39) |
H53Q |
probably benign |
Het |
Zfp804b |
A |
G |
5: 6,819,043 (GRCm39) |
V1340A |
probably benign |
Het |
|
Other mutations in Tas2r124 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00985:Tas2r124
|
APN |
6 |
132,732,492 (GRCm39) |
missense |
probably benign |
0.02 |
IGL01343:Tas2r124
|
APN |
6 |
132,732,378 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01646:Tas2r124
|
APN |
6 |
132,732,332 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL01743:Tas2r124
|
APN |
6 |
132,731,798 (GRCm39) |
missense |
probably benign |
0.01 |
IGL02251:Tas2r124
|
APN |
6 |
132,732,524 (GRCm39) |
missense |
probably benign |
0.02 |
IGL03081:Tas2r124
|
APN |
6 |
132,732,497 (GRCm39) |
missense |
possibly damaging |
0.61 |
IGL03309:Tas2r124
|
APN |
6 |
132,731,898 (GRCm39) |
missense |
probably benign |
0.01 |
IGL03374:Tas2r124
|
APN |
6 |
132,732,081 (GRCm39) |
missense |
probably benign |
0.00 |
P0012:Tas2r124
|
UTSW |
6 |
132,732,503 (GRCm39) |
missense |
possibly damaging |
0.70 |
R1450:Tas2r124
|
UTSW |
6 |
132,732,019 (GRCm39) |
missense |
probably damaging |
1.00 |
R1804:Tas2r124
|
UTSW |
6 |
132,732,488 (GRCm39) |
missense |
probably benign |
0.11 |
R2048:Tas2r124
|
UTSW |
6 |
132,731,858 (GRCm39) |
missense |
possibly damaging |
0.94 |
R2846:Tas2r124
|
UTSW |
6 |
132,732,230 (GRCm39) |
missense |
possibly damaging |
0.73 |
R3415:Tas2r124
|
UTSW |
6 |
132,732,601 (GRCm39) |
missense |
probably benign |
0.00 |
R3416:Tas2r124
|
UTSW |
6 |
132,732,601 (GRCm39) |
missense |
probably benign |
0.00 |
R3417:Tas2r124
|
UTSW |
6 |
132,732,601 (GRCm39) |
missense |
probably benign |
0.00 |
R4306:Tas2r124
|
UTSW |
6 |
132,731,954 (GRCm39) |
missense |
probably benign |
0.03 |
R4308:Tas2r124
|
UTSW |
6 |
132,731,954 (GRCm39) |
missense |
probably benign |
0.03 |
R4823:Tas2r124
|
UTSW |
6 |
132,732,509 (GRCm39) |
missense |
probably damaging |
0.98 |
R4867:Tas2r124
|
UTSW |
6 |
132,732,156 (GRCm39) |
missense |
probably damaging |
0.98 |
R4949:Tas2r124
|
UTSW |
6 |
132,731,858 (GRCm39) |
missense |
possibly damaging |
0.94 |
R5242:Tas2r124
|
UTSW |
6 |
132,732,503 (GRCm39) |
missense |
possibly damaging |
0.70 |
R6263:Tas2r124
|
UTSW |
6 |
132,731,867 (GRCm39) |
missense |
probably benign |
0.45 |
R6313:Tas2r124
|
UTSW |
6 |
132,732,410 (GRCm39) |
missense |
probably benign |
0.00 |
R6394:Tas2r124
|
UTSW |
6 |
132,732,039 (GRCm39) |
missense |
probably damaging |
1.00 |
R7685:Tas2r124
|
UTSW |
6 |
132,732,056 (GRCm39) |
missense |
probably damaging |
0.97 |
R8354:Tas2r124
|
UTSW |
6 |
132,732,410 (GRCm39) |
missense |
probably benign |
0.10 |
R9045:Tas2r124
|
UTSW |
6 |
132,732,034 (GRCm39) |
missense |
probably damaging |
0.99 |
R9615:Tas2r124
|
UTSW |
6 |
132,732,492 (GRCm39) |
missense |
probably benign |
0.02 |
|
Predicted Primers |
PCR Primer
(F):5'- TGTAAATTCCATGGAGACTGAGTTC -3'
(R):5'- AGCTGCCTCATTACCCAAAG -3'
Sequencing Primer
(F):5'- CCATGGAGACTGAGTTCTCAATTTTG -3'
(R):5'- TCATTACCCAAAGAGAGGTCTG -3'
|
Posted On |
2017-06-26 |