Incidental Mutation 'R6001:Parp4'
ID 480847
Institutional Source Beutler Lab
Gene Symbol Parp4
Ensembl Gene ENSMUSG00000054509
Gene Name poly (ADP-ribose) polymerase family, member 4
Synonyms VPARP, Adprtl1, C030027K23Rik, VAULT3, p193, PH5P, E230037B21Rik
MMRRC Submission 044180-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.146) question?
Stock # R6001 (G1)
Quality Score 225.009
Status Not validated
Chromosome 14
Chromosomal Location 56813076-56897251 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 56878740 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Leucine at position 1225 (H1225L)
Ref Sequence ENSEMBL: ENSMUSP00000124258 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000161553]
AlphaFold E9PYK3
Predicted Effect probably benign
Transcript: ENSMUST00000161553
AA Change: H1225L

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000124258
Gene: ENSMUSG00000054509
AA Change: H1225L

DomainStartEndE-ValueType
BRCT 3 84 4.32e-9 SMART
low complexity region 97 104 N/A INTRINSIC
SCOP:d1a26_1 252 352 2e-19 SMART
Pfam:PARP 371 559 1.8e-50 PFAM
VIT 600 728 1.5e-57 SMART
VWA 867 1030 6.08e-13 SMART
Blast:14_3_3 1149 1205 5e-10 BLAST
low complexity region 1255 1264 N/A INTRINSIC
low complexity region 1348 1362 N/A INTRINSIC
low complexity region 1371 1394 N/A INTRINSIC
internal_repeat_1 1395 1416 4.48e-6 PROSPERO
Pfam:Drf_FH1 1443 1542 3.3e-15 PFAM
low complexity region 1553 1587 N/A INTRINSIC
internal_repeat_2 1588 1608 2.45e-5 PROSPERO
low complexity region 1695 1708 N/A INTRINSIC
low complexity region 1739 1750 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.4%
  • 20x: 91.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mutants are helathy and fertile. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca1 G T 4: 53,075,555 (GRCm39) R999S possibly damaging Het
Ankrd31 T A 13: 96,962,717 (GRCm39) Y503N probably damaging Het
Anks4b A G 7: 119,781,941 (GRCm39) E324G probably benign Het
Arhgap44 CTGCT CTGCTTGCT 11: 64,922,910 (GRCm39) probably null Het
Atl1 A T 12: 69,979,057 (GRCm39) T162S possibly damaging Het
Atp2b2 A G 6: 113,770,728 (GRCm39) Y394H probably damaging Het
Dennd2d A G 3: 106,399,776 (GRCm39) H233R probably benign Het
Dhx16 G T 17: 36,194,766 (GRCm39) M462I probably damaging Het
Hif3a T C 7: 16,784,486 (GRCm39) Y253C probably damaging Het
Hsf4 G A 8: 105,999,541 (GRCm39) G277R possibly damaging Het
Impg1 T C 9: 80,223,454 (GRCm39) D754G probably benign Het
Keap1 T C 9: 21,142,135 (GRCm39) S580G possibly damaging Het
Lrp6 T C 6: 134,441,481 (GRCm39) K1162E probably benign Het
Lrrc31 C T 3: 30,745,318 (GRCm39) V110I possibly damaging Het
Muc5b G T 7: 141,426,118 (GRCm39) K4738N possibly damaging Het
Myo1a G T 10: 127,542,794 (GRCm39) probably null Het
Odad2 T C 18: 7,286,838 (GRCm39) D131G probably benign Het
Or10q1b A G 19: 13,682,424 (GRCm39) T78A probably damaging Het
Or52z14 T A 7: 103,253,179 (GRCm39) M106K probably damaging Het
Or7g19 A T 9: 18,856,340 (GRCm39) Y132F probably damaging Het
Pcgf2 T C 11: 97,583,606 (GRCm39) Y52C possibly damaging Het
Pkn3 T C 2: 29,978,596 (GRCm39) probably null Het
Psen2 C A 1: 180,073,234 (GRCm39) R29L possibly damaging Het
Rfx6 A G 10: 51,594,307 (GRCm39) probably null Het
Rps13 T C 7: 115,930,808 (GRCm39) T145A probably benign Het
Rsf1 G A 7: 97,229,117 (GRCm39) probably benign Het
Rsf1 GCG GCGACG 7: 97,229,114 (GRCm39) probably benign Het
Rsf1 A ACGGCGACGG 7: 97,229,111 (GRCm39) probably null Het
Smarca4 C T 9: 21,544,205 (GRCm39) probably benign Het
Stat4 A T 1: 52,136,026 (GRCm39) E445V probably damaging Het
Taf13 T A 3: 108,488,387 (GRCm39) I90N probably damaging Het
Tas2r124 T A 6: 132,732,416 (GRCm39) Y242N probably damaging Het
Tmem151b T C 17: 45,856,711 (GRCm39) Y243C probably damaging Het
Wasl T C 6: 24,619,573 (GRCm39) T316A unknown Het
Zbtb44 T C 9: 30,965,090 (GRCm39) C167R probably damaging Het
Zc3h7b T C 15: 81,676,236 (GRCm39) L714P possibly damaging Het
Zfp35 T A 18: 24,135,816 (GRCm39) H53Q probably benign Het
Zfp804b A G 5: 6,819,043 (GRCm39) V1340A probably benign Het
Other mutations in Parp4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00479:Parp4 APN 14 56,853,917 (GRCm39) missense possibly damaging 0.82
IGL00571:Parp4 APN 14 56,884,810 (GRCm39) missense unknown
IGL00737:Parp4 APN 14 56,821,620 (GRCm39) missense probably damaging 0.99
IGL00793:Parp4 APN 14 56,840,334 (GRCm39) missense possibly damaging 0.73
IGL01108:Parp4 APN 14 56,844,897 (GRCm39) missense probably benign 0.01
IGL01131:Parp4 APN 14 56,823,217 (GRCm39) splice site probably benign
IGL01485:Parp4 APN 14 56,859,661 (GRCm39) missense possibly damaging 0.54
IGL01704:Parp4 APN 14 56,839,783 (GRCm39) missense probably damaging 0.99
IGL01993:Parp4 APN 14 56,848,245 (GRCm39) missense possibly damaging 0.82
IGL02125:Parp4 APN 14 56,827,959 (GRCm39) missense probably benign 0.33
IGL02851:Parp4 APN 14 56,886,326 (GRCm39) missense unknown
IGL02863:Parp4 APN 14 56,886,243 (GRCm39) missense unknown
IGL03065:Parp4 APN 14 56,875,326 (GRCm39) missense probably benign 0.09
IGL03117:Parp4 APN 14 56,840,313 (GRCm39) missense probably benign 0.17
IGL03271:Parp4 APN 14 56,823,082 (GRCm39) missense probably benign 0.10
IGL03309:Parp4 APN 14 56,825,265 (GRCm39) missense probably benign 0.11
IGL03408:Parp4 APN 14 56,839,865 (GRCm39) missense probably damaging 0.99
poisonous UTSW 14 56,873,205 (GRCm39) missense possibly damaging 0.65
R0515_Parp4_195 UTSW 14 56,851,124 (GRCm39) missense probably damaging 1.00
toxic UTSW 14 56,866,615 (GRCm39) missense probably benign 0.28
venomous UTSW 14 56,827,355 (GRCm39) missense possibly damaging 0.92
virulent UTSW 14 56,825,235 (GRCm39) missense probably damaging 0.97
R0278:Parp4 UTSW 14 56,844,980 (GRCm39) missense probably damaging 0.99
R0320:Parp4 UTSW 14 56,825,953 (GRCm39) critical splice donor site probably null
R0445:Parp4 UTSW 14 56,840,205 (GRCm39) splice site probably null
R0452:Parp4 UTSW 14 56,886,300 (GRCm39) missense unknown
R0511:Parp4 UTSW 14 56,873,172 (GRCm39) splice site probably benign
R0515:Parp4 UTSW 14 56,851,124 (GRCm39) missense probably damaging 1.00
R0608:Parp4 UTSW 14 56,839,861 (GRCm39) missense probably damaging 1.00
R0800:Parp4 UTSW 14 56,827,408 (GRCm39) missense probably benign 0.00
R0959:Parp4 UTSW 14 56,885,576 (GRCm39) missense unknown
R1207:Parp4 UTSW 14 56,885,339 (GRCm39) missense unknown
R1207:Parp4 UTSW 14 56,885,339 (GRCm39) missense unknown
R1342:Parp4 UTSW 14 56,827,854 (GRCm39) missense probably damaging 1.00
R1520:Parp4 UTSW 14 56,835,863 (GRCm39) missense probably damaging 1.00
R1565:Parp4 UTSW 14 56,827,329 (GRCm39) splice site probably benign
R1574:Parp4 UTSW 14 56,839,752 (GRCm39) missense probably damaging 0.98
R1574:Parp4 UTSW 14 56,839,752 (GRCm39) missense probably damaging 0.98
R1649:Parp4 UTSW 14 56,827,885 (GRCm39) missense possibly damaging 0.95
R1666:Parp4 UTSW 14 56,861,620 (GRCm39) missense possibly damaging 0.91
R1781:Parp4 UTSW 14 56,864,838 (GRCm39) splice site probably null
R1799:Parp4 UTSW 14 56,885,589 (GRCm39) missense unknown
R1823:Parp4 UTSW 14 56,827,329 (GRCm39) splice site probably benign
R1859:Parp4 UTSW 14 56,886,372 (GRCm39) missense unknown
R1919:Parp4 UTSW 14 56,861,474 (GRCm39) missense probably damaging 1.00
R2000:Parp4 UTSW 14 56,851,181 (GRCm39) missense probably damaging 0.98
R2032:Parp4 UTSW 14 56,866,553 (GRCm39) missense possibly damaging 0.71
R2034:Parp4 UTSW 14 56,871,720 (GRCm39) missense probably damaging 1.00
R2177:Parp4 UTSW 14 56,896,746 (GRCm39) missense unknown
R2291:Parp4 UTSW 14 56,851,274 (GRCm39) missense probably damaging 1.00
R2865:Parp4 UTSW 14 56,851,181 (GRCm39) missense probably damaging 0.98
R3012:Parp4 UTSW 14 56,832,873 (GRCm39) critical splice donor site probably null
R3841:Parp4 UTSW 14 56,825,235 (GRCm39) missense probably damaging 0.97
R3913:Parp4 UTSW 14 56,857,975 (GRCm39) missense probably damaging 1.00
R4064:Parp4 UTSW 14 56,861,597 (GRCm39) missense probably benign 0.06
R4201:Parp4 UTSW 14 56,829,848 (GRCm39) missense possibly damaging 0.95
R4288:Parp4 UTSW 14 56,844,951 (GRCm39) missense probably damaging 1.00
R4360:Parp4 UTSW 14 56,866,661 (GRCm39) missense possibly damaging 0.89
R4506:Parp4 UTSW 14 56,889,761 (GRCm39) missense unknown
R4577:Parp4 UTSW 14 56,827,867 (GRCm39) missense probably benign 0.33
R4633:Parp4 UTSW 14 56,885,048 (GRCm39) missense unknown
R4762:Parp4 UTSW 14 56,848,267 (GRCm39) missense probably damaging 1.00
R4836:Parp4 UTSW 14 56,823,195 (GRCm39) missense probably benign 0.00
R4974:Parp4 UTSW 14 56,827,355 (GRCm39) missense possibly damaging 0.92
R5049:Parp4 UTSW 14 56,873,188 (GRCm39) missense possibly damaging 0.81
R5479:Parp4 UTSW 14 56,861,552 (GRCm39) missense probably benign 0.01
R5683:Parp4 UTSW 14 56,884,886 (GRCm39) nonsense probably null
R5884:Parp4 UTSW 14 56,852,207 (GRCm39) missense probably damaging 1.00
R5965:Parp4 UTSW 14 56,861,489 (GRCm39) missense probably benign 0.11
R6027:Parp4 UTSW 14 56,866,615 (GRCm39) missense probably benign 0.28
R6230:Parp4 UTSW 14 56,844,990 (GRCm39) missense probably damaging 1.00
R6242:Parp4 UTSW 14 56,832,856 (GRCm39) nonsense probably null
R6355:Parp4 UTSW 14 56,839,757 (GRCm39) missense possibly damaging 0.61
R6414:Parp4 UTSW 14 56,864,838 (GRCm39) splice site probably null
R6418:Parp4 UTSW 14 56,858,108 (GRCm39) critical splice donor site probably null
R6477:Parp4 UTSW 14 56,884,694 (GRCm39) missense probably benign 0.00
R6542:Parp4 UTSW 14 56,885,339 (GRCm39) missense unknown
R6759:Parp4 UTSW 14 56,857,947 (GRCm39) missense probably benign 0.10
R6995:Parp4 UTSW 14 56,851,196 (GRCm39) missense probably damaging 0.97
R7002:Parp4 UTSW 14 56,839,861 (GRCm39) missense probably damaging 1.00
R7026:Parp4 UTSW 14 56,858,049 (GRCm39) missense probably benign 0.01
R7062:Parp4 UTSW 14 56,852,216 (GRCm39) missense possibly damaging 0.48
R7101:Parp4 UTSW 14 56,827,430 (GRCm39) missense probably benign 0.02
R7124:Parp4 UTSW 14 56,840,256 (GRCm39) missense probably benign 0.11
R7162:Parp4 UTSW 14 56,886,333 (GRCm39) missense unknown
R7293:Parp4 UTSW 14 56,885,303 (GRCm39) small deletion probably benign
R7297:Parp4 UTSW 14 56,885,138 (GRCm39) missense not run
R7337:Parp4 UTSW 14 56,839,852 (GRCm39) missense probably damaging 1.00
R7539:Parp4 UTSW 14 56,873,212 (GRCm39) missense probably damaging 1.00
R7575:Parp4 UTSW 14 56,875,375 (GRCm39) missense probably benign 0.28
R7808:Parp4 UTSW 14 56,873,205 (GRCm39) missense possibly damaging 0.65
R7854:Parp4 UTSW 14 56,896,805 (GRCm39) missense unknown
R7960:Parp4 UTSW 14 56,832,708 (GRCm39) splice site probably null
R8152:Parp4 UTSW 14 56,884,703 (GRCm39) missense probably benign 0.00
R8344:Parp4 UTSW 14 56,886,186 (GRCm39) missense unknown
R8416:Parp4 UTSW 14 56,825,271 (GRCm39) critical splice donor site probably null
R8726:Parp4 UTSW 14 56,866,556 (GRCm39) missense probably benign 0.04
R8752:Parp4 UTSW 14 56,886,073 (GRCm39) missense unknown
R8804:Parp4 UTSW 14 56,853,900 (GRCm39) nonsense probably null
R9046:Parp4 UTSW 14 56,864,927 (GRCm39) missense probably damaging 0.98
R9176:Parp4 UTSW 14 56,873,274 (GRCm39) missense possibly damaging 0.54
R9303:Parp4 UTSW 14 56,852,224 (GRCm39) critical splice donor site probably null
R9303:Parp4 UTSW 14 56,832,790 (GRCm39) frame shift probably null
R9305:Parp4 UTSW 14 56,852,224 (GRCm39) critical splice donor site probably null
R9305:Parp4 UTSW 14 56,832,790 (GRCm39) frame shift probably null
R9360:Parp4 UTSW 14 56,878,775 (GRCm39) critical splice donor site probably null
R9430:Parp4 UTSW 14 56,866,673 (GRCm39) missense probably damaging 1.00
R9491:Parp4 UTSW 14 56,832,828 (GRCm39) missense probably damaging 0.99
R9729:Parp4 UTSW 14 56,885,888 (GRCm39) missense unknown
RF020:Parp4 UTSW 14 56,884,806 (GRCm39) missense unknown
Z1177:Parp4 UTSW 14 56,829,824 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CAAGTGCATTTGCTTATTGGCAG -3'
(R):5'- CAAATGGCAGCCAAGGACTG -3'

Sequencing Primer
(F):5'- GCATTTGCTTATTGGCAGACTTTC -3'
(R):5'- CACCATGCATCGTTCTGT -3'
Posted On 2017-06-26