Incidental Mutation 'R5994:Tut7'
ID 481023
Institutional Source Beutler Lab
Gene Symbol Tut7
Ensembl Gene ENSMUSG00000035248
Gene Name terminal uridylyl transferase 7
Synonyms Zcchc6, Tent3b, 6030448M23Rik
MMRRC Submission 044173-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.761) question?
Stock # R5994 (G1)
Quality Score 225.009
Status Not validated
Chromosome 13
Chromosomal Location 59919690-59971060 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 59937023 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Serine at position 806 (Y806S)
Ref Sequence ENSEMBL: ENSMUSP00000153376 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071703] [ENSMUST00000224480]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000071703
AA Change: Y1208S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000071623
Gene: ENSMUSG00000035248
AA Change: Y1208S

DomainStartEndE-ValueType
low complexity region 15 27 N/A INTRINSIC
low complexity region 176 190 N/A INTRINSIC
ZnF_C2H2 244 268 2.61e1 SMART
SCOP:d1f5aa2 284 497 4e-25 SMART
low complexity region 522 534 N/A INTRINSIC
Pfam:PAP_assoc 550 603 6.7e-14 PFAM
low complexity region 811 825 N/A INTRINSIC
low complexity region 846 857 N/A INTRINSIC
low complexity region 882 898 N/A INTRINSIC
ZnF_C2HC 960 976 3.3e-3 SMART
Pfam:NTP_transf_2 1022 1134 4e-8 PFAM
Pfam:PAP_assoc 1229 1282 1.7e-17 PFAM
ZnF_C2HC 1342 1358 2.09e-3 SMART
Pfam:TUTF7_u4 1359 1446 1.6e-42 PFAM
ZnF_C2HC 1448 1464 1.06e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224320
Predicted Effect probably damaging
Transcript: ENSMUST00000224480
AA Change: Y806S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225607
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.4%
  • 20x: 91.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m A T 6: 121,647,862 (GRCm39) H1118L probably benign Het
Abca8b A G 11: 109,840,592 (GRCm39) probably null Het
Abcb5 A T 12: 118,928,995 (GRCm39) probably null Het
Adcy6 A T 15: 98,491,545 (GRCm39) I1016N probably damaging Het
Afg3l2 A T 18: 67,562,140 (GRCm39) C312S probably damaging Het
Ano8 C T 8: 71,937,478 (GRCm39) V89M probably damaging Het
Arhgap21 C T 2: 20,886,187 (GRCm39) G330D possibly damaging Het
Caskin1 T C 17: 24,715,935 (GRCm39) L195P probably damaging Het
Cfap54 A G 10: 92,874,943 (GRCm39) I514T probably damaging Het
Ctdsp2 G A 10: 126,831,689 (GRCm39) probably benign Het
Cyp4x1 T C 4: 114,979,142 (GRCm39) I152V probably benign Het
Dglucy G A 12: 100,808,959 (GRCm39) R219Q probably benign Het
Disp3 G T 4: 148,338,741 (GRCm39) A810E possibly damaging Het
Dtx4 T C 19: 12,478,517 (GRCm39) Y22C probably damaging Het
Edaradd A T 13: 12,493,377 (GRCm39) I105N probably damaging Het
Eepd1 C T 9: 25,514,749 (GRCm39) P519S probably damaging Het
Fscn3 A T 6: 28,430,294 (GRCm39) S155C probably benign Het
Gm10134 A T 2: 28,396,258 (GRCm39) E51V probably damaging Het
Gm7247 C T 14: 51,601,805 (GRCm39) S26F probably benign Het
Golga7 T C 8: 23,740,281 (GRCm39) E83G probably benign Het
Gpr12 T C 5: 146,520,241 (GRCm39) H227R probably damaging Het
Hoxa2 T G 6: 52,141,372 (GRCm39) S85R possibly damaging Het
Hrnr T C 3: 93,239,607 (GRCm39) S3282P unknown Het
Ift74 C A 4: 94,579,961 (GRCm39) T543K possibly damaging Het
Klf10 C A 15: 38,296,285 (GRCm39) R420L probably damaging Het
Krt77 T A 15: 101,771,290 (GRCm39) I338F probably damaging Het
Limch1 A T 5: 67,131,965 (GRCm39) S152C probably damaging Het
Mgat4e T A 1: 134,469,234 (GRCm39) H270L probably benign Het
Myrf A T 19: 10,196,481 (GRCm39) L504Q probably null Het
Nckipsd A G 9: 108,691,176 (GRCm39) Q366R probably benign Het
Npy5r A T 8: 67,134,751 (GRCm39) V14D probably benign Het
Nrap T A 19: 56,340,031 (GRCm39) R830* probably null Het
Ogfrl1 A T 1: 23,418,070 (GRCm39) Y103N probably damaging Het
Or10g7 A T 9: 39,905,519 (GRCm39) R138* probably null Het
P2rx4 T A 5: 122,863,142 (GRCm39) L232H probably damaging Het
Pabpc2 A T 18: 39,906,947 (GRCm39) T71S probably benign Het
Paip2b C A 6: 83,785,867 (GRCm39) S121I probably damaging Het
Pofut1 C T 2: 153,103,149 (GRCm39) T261I possibly damaging Het
Ppp6c G T 2: 39,101,004 (GRCm39) T46K possibly damaging Het
Prkd2 C A 7: 16,584,261 (GRCm39) H371Q probably benign Het
Prrc2c A T 1: 162,501,725 (GRCm39) probably null Het
Psd3 C T 8: 68,172,620 (GRCm39) A894T probably damaging Het
Pygm A T 19: 6,448,073 (GRCm39) probably null Het
Pzp A T 6: 128,468,560 (GRCm39) M989K probably damaging Het
Ralgapa2 A T 2: 146,203,373 (GRCm39) S1159T probably benign Het
Rapgefl1 T C 11: 98,740,986 (GRCm39) F575L probably benign Het
Rassf6 A G 5: 90,765,627 (GRCm39) L28S probably damaging Het
Rbp3 G T 14: 33,676,857 (GRCm39) K268N probably damaging Het
Rela C T 19: 5,697,092 (GRCm39) T433M possibly damaging Het
Rnf103 T A 6: 71,473,894 (GRCm39) S102R probably damaging Het
Scarf2 A G 16: 17,624,243 (GRCm39) N516S probably damaging Het
Sdcbp2 T C 2: 151,429,403 (GRCm39) I241T probably damaging Het
Septin7 T C 9: 25,199,494 (GRCm39) I131T possibly damaging Het
Sh3pxd2b T C 11: 32,357,570 (GRCm39) F191L probably damaging Het
Siglec15 C A 18: 78,090,590 (GRCm39) C236F probably damaging Het
Slc11a2 T C 15: 100,295,562 (GRCm39) T520A probably benign Het
Slc26a11 C A 11: 119,270,738 (GRCm39) F553L probably benign Het
Smchd1 G A 17: 71,672,404 (GRCm39) P1596S possibly damaging Het
Taar7b A G 10: 23,876,246 (GRCm39) H137R probably damaging Het
Thap12 T A 7: 98,365,237 (GRCm39) C468* probably null Het
Timp4 C T 6: 115,224,315 (GRCm39) G118D probably damaging Het
Tnnt3 A G 7: 142,065,003 (GRCm39) K48E probably damaging Het
Trmt10a T A 3: 137,862,475 (GRCm39) I255N probably damaging Het
Ttll10 T C 4: 156,133,189 (GRCm39) probably null Het
Ube4b A G 4: 149,457,389 (GRCm39) Y283H probably damaging Het
Ucp1 G T 8: 84,020,567 (GRCm39) V126L possibly damaging Het
Unc13b T A 4: 43,172,596 (GRCm39) probably benign Het
Vps13b T C 15: 35,875,918 (GRCm39) S2768P probably damaging Het
Zfp101 T A 17: 33,599,936 (GRCm39) M607L probably benign Het
Zfp292 C T 4: 34,805,464 (GRCm39) V2527M possibly damaging Het
Zfp503 T A 14: 22,035,630 (GRCm39) T429S possibly damaging Het
Other mutations in Tut7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00088:Tut7 APN 13 59,964,512 (GRCm39) missense probably damaging 1.00
IGL01361:Tut7 APN 13 59,933,614 (GRCm39) missense probably damaging 1.00
IGL02002:Tut7 APN 13 59,929,910 (GRCm39) missense possibly damaging 0.76
IGL02015:Tut7 APN 13 59,937,072 (GRCm39) missense probably damaging 1.00
IGL02029:Tut7 APN 13 59,932,702 (GRCm39) unclassified probably benign
IGL02216:Tut7 APN 13 59,948,237 (GRCm39) missense probably benign 0.01
IGL02705:Tut7 APN 13 59,937,017 (GRCm39) missense probably damaging 1.00
IGL02742:Tut7 APN 13 59,964,156 (GRCm39) missense probably damaging 0.99
IGL02810:Tut7 APN 13 59,929,830 (GRCm39) critical splice donor site probably null
IGL02942:Tut7 APN 13 59,959,335 (GRCm39) missense probably damaging 0.98
IGL03104:Tut7 APN 13 59,962,717 (GRCm39) missense probably benign 0.04
R0025:Tut7 UTSW 13 59,953,142 (GRCm39) missense probably benign 0.08
R0025:Tut7 UTSW 13 59,953,142 (GRCm39) missense probably benign 0.08
R0153:Tut7 UTSW 13 59,930,150 (GRCm39) nonsense probably null
R0269:Tut7 UTSW 13 59,964,669 (GRCm39) splice site probably null
R0358:Tut7 UTSW 13 59,929,918 (GRCm39) missense probably damaging 0.99
R0555:Tut7 UTSW 13 59,948,131 (GRCm39) missense probably benign 0.00
R0599:Tut7 UTSW 13 59,957,301 (GRCm39) missense probably damaging 1.00
R0609:Tut7 UTSW 13 59,947,596 (GRCm39) nonsense probably null
R0617:Tut7 UTSW 13 59,964,669 (GRCm39) splice site probably null
R0680:Tut7 UTSW 13 59,948,413 (GRCm39) missense possibly damaging 0.79
R0699:Tut7 UTSW 13 59,929,828 (GRCm39) splice site probably benign
R1214:Tut7 UTSW 13 59,953,140 (GRCm39) missense possibly damaging 0.76
R1271:Tut7 UTSW 13 59,969,669 (GRCm39) missense probably damaging 0.99
R1556:Tut7 UTSW 13 59,948,054 (GRCm39) missense probably benign 0.02
R1662:Tut7 UTSW 13 59,947,717 (GRCm39) missense possibly damaging 0.93
R1777:Tut7 UTSW 13 59,939,635 (GRCm39) missense probably damaging 1.00
R1834:Tut7 UTSW 13 59,962,749 (GRCm39) nonsense probably null
R1928:Tut7 UTSW 13 59,964,548 (GRCm39) missense probably damaging 1.00
R2012:Tut7 UTSW 13 59,959,352 (GRCm39) missense probably damaging 0.99
R2045:Tut7 UTSW 13 59,948,470 (GRCm39) missense probably damaging 1.00
R2336:Tut7 UTSW 13 59,946,868 (GRCm39) missense probably damaging 1.00
R3764:Tut7 UTSW 13 59,948,194 (GRCm39) missense probably damaging 0.98
R3899:Tut7 UTSW 13 59,937,069 (GRCm39) nonsense probably null
R3918:Tut7 UTSW 13 59,929,838 (GRCm39) missense probably damaging 1.00
R4423:Tut7 UTSW 13 59,969,863 (GRCm39) missense probably damaging 0.96
R4664:Tut7 UTSW 13 59,948,413 (GRCm39) missense possibly damaging 0.79
R4673:Tut7 UTSW 13 59,944,659 (GRCm39) missense probably damaging 1.00
R4770:Tut7 UTSW 13 59,920,698 (GRCm39) unclassified probably benign
R4884:Tut7 UTSW 13 59,937,266 (GRCm39) missense probably damaging 1.00
R5186:Tut7 UTSW 13 59,964,470 (GRCm39) critical splice donor site probably null
R5337:Tut7 UTSW 13 59,939,666 (GRCm39) missense probably damaging 1.00
R5385:Tut7 UTSW 13 59,937,660 (GRCm39) critical splice donor site probably null
R5452:Tut7 UTSW 13 59,948,471 (GRCm39) missense probably damaging 1.00
R5534:Tut7 UTSW 13 59,936,367 (GRCm39) missense probably damaging 1.00
R5566:Tut7 UTSW 13 59,936,443 (GRCm39) nonsense probably null
R5928:Tut7 UTSW 13 59,969,880 (GRCm39) missense probably benign 0.16
R6415:Tut7 UTSW 13 59,964,110 (GRCm39) splice site probably null
R6495:Tut7 UTSW 13 59,947,753 (GRCm39) missense possibly damaging 0.95
R6577:Tut7 UTSW 13 59,955,975 (GRCm39) missense probably damaging 1.00
R7205:Tut7 UTSW 13 59,936,364 (GRCm39) missense probably damaging 1.00
R7286:Tut7 UTSW 13 59,969,463 (GRCm39) missense probably benign 0.18
R7355:Tut7 UTSW 13 59,969,616 (GRCm39) missense probably benign 0.00
R7369:Tut7 UTSW 13 59,929,867 (GRCm39) missense possibly damaging 0.71
R7455:Tut7 UTSW 13 59,969,871 (GRCm39) missense probably benign 0.03
R7557:Tut7 UTSW 13 59,936,280 (GRCm39) missense possibly damaging 0.89
R7635:Tut7 UTSW 13 59,947,904 (GRCm39) missense probably benign 0.03
R7727:Tut7 UTSW 13 59,947,496 (GRCm39) missense probably benign 0.00
R7798:Tut7 UTSW 13 59,963,389 (GRCm39) missense possibly damaging 0.81
R7912:Tut7 UTSW 13 59,946,819 (GRCm39) missense probably damaging 1.00
R7915:Tut7 UTSW 13 59,932,628 (GRCm39) missense probably benign 0.12
R8035:Tut7 UTSW 13 59,937,004 (GRCm39) missense probably benign 0.00
R8531:Tut7 UTSW 13 59,937,074 (GRCm39) missense probably damaging 1.00
R8777:Tut7 UTSW 13 59,933,597 (GRCm39) missense probably benign 0.15
R8777-TAIL:Tut7 UTSW 13 59,933,597 (GRCm39) missense probably benign 0.15
R8850:Tut7 UTSW 13 59,937,011 (GRCm39) missense possibly damaging 0.83
R8929:Tut7 UTSW 13 59,947,942 (GRCm39) missense probably benign
R9254:Tut7 UTSW 13 59,936,288 (GRCm39) missense possibly damaging 0.48
R9313:Tut7 UTSW 13 59,947,798 (GRCm39) missense probably benign 0.01
R9373:Tut7 UTSW 13 59,944,681 (GRCm39) missense probably damaging 1.00
R9379:Tut7 UTSW 13 59,936,288 (GRCm39) missense possibly damaging 0.48
R9404:Tut7 UTSW 13 59,947,701 (GRCm39) missense probably benign 0.00
R9461:Tut7 UTSW 13 59,963,512 (GRCm39) missense probably damaging 1.00
R9462:Tut7 UTSW 13 59,929,957 (GRCm39) missense possibly damaging 0.89
R9661:Tut7 UTSW 13 59,937,332 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTTACTAACTACCAAGAACCAGCTG -3'
(R):5'- ATGGTCTAAGCCAGCCTCTG -3'

Sequencing Primer
(F):5'- TGGTACAGCGCCTGGAACAC -3'
(R):5'- CTGCTTCTGCTAATATGTTATTGGTC -3'
Posted On 2017-06-26